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1.
Rev. CES psicol ; 15(1): 24-43, ene.-abr. 2022. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1376228

ABSTRACT

Resumen Antecedentes: la esquizofrenia es una enfermedad crónica que genera gran discapacidad, para la cual se han reportado biomarcadores potenciales, pero sin suficiente validez clínica. El mismatch negativity (MMN) y el P3a son potenciales relacionados con eventos que han demostrado ser indicadores neurofisiológicos del procesamiento auditivo pre-atencional y potenciales biomarcadores. Objetivo: evaluar el MMN y P3a en pacientes con diagnóstico de esquizofrenia y su relación con variables sociodemográficas y clínicas. Método: estudio cuantitativo transversal de 23 sujetos con esquizofrenia (ESQ) y 22 controles sanos (SN). Las amplitudes promedio y latencias del MMN/P3a para la condición infrecuente en duración y frecuencia fueron obtenidas mediante un paradigma oddball auditivo en un EEG de 32 canales. Resultados: se encontraron diferencias para la condición frecuencia en la amplitud del MMN (p=0.046; CI 95% 0.009; 0.87) y la amplitud del P3a (p=0.042; CI 95% 0.025; 1.24) entre los grupos; la amplitud del MMN fue menor en el grupo ESQ (-0.36 DE 0.51 µV) en comparación con los participantes del grupo de SN (-0.81 DE 0.89 µV), mientras que la amplitud del P3a fue menor en el grupo SN (0.18 DE 0.97 µV) versus el grupo ESQ (0.82 DE 1.05 µV). En relación con las variables sociodemográficas y clínicas, las asociaciones con el P3a fueron moderadas y con el MMN débiles. Conclusiones: la reducción de la amplitud del MMN a la condición frecuencia exhibe mayor utilidad que el P3a como medida de alta estabilidad en pacientes con esquizofrenia, lo que reitera su posible uso como biomarcador.


Abstract Background: schizophrenia is a chronic disease that generates great disability, which currently has potential biomarkers but without sufficient clinical validity. Mismatch negativity (MMN) and P3a are event-related potentials that have been shown to be neurophysiological indicators of pre-attentional auditory processing and potential biomarkers. Objective: to evaluate MMN and P3a in patients with a diagnosis of schizophrenia and their relationship with sociodemographic and clinical variables. Method: a quantitative cross-sectional study of 23 subjects with schizophrenia and 22 healthy controls was performed. The average amplitudes and latencies of the MMN/P3a for the condition infrequent in duration and infrequent in frequency were obtained using an auditory oddball paradigm on a 32-channel EEG. Results: differences were found for the frequency condition in the amplitude of the MMN (p=0.046; 95% CI 0.009; 0.87) and the amplitude of the P3a (p=0.042; 95% CI 0.025; 1.24) between the groups; MMN amplitude was lower in schizophrenia (-0.36 SD 0.51 µV) compared to healthy controls (-0.81 SD 0.89 µV), while P3a amplitude was lower in healthy controls (0.18 SD 0.97 µV) versus the group with schizophrenia (0.82 SD 1.05 µV). In regard to sociodemographic and clinical variables, the associations with P3a were moderate, and showed weak MMN. Conclusions: MMN amplitude reduction to the frequency condition exhibits greater utility than P3a as a measure of high stability in schizophrenia, restating its potential use as a biomarker.

2.
Int. arch. otorhinolaryngol. (Impr.) ; 25(2): 284-288, Apr.-June 2021. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1286755

ABSTRACT

Abstract Introduction Learning a second language is an essential task in today's world, and is experienced by many children. The cognitive auditory-evoked potential (P300) is related to cognitive activity, attention and concentration, enabling the investigation of the effect of a second language on the central auditory pathway. Objective To analyze the effects of learning English on P300 latency and amplitude in children and to correlate them with age, time of exposure to English, and time in class. Method An observational, descriptive, cross-sectional and quantitative study, in which 33 children, aged between 5 and 9 years and 11 months, of both genders participated, 14 of them in the process of learning English (study group) and 19 without this experience (control group). All subjects had their P300 evaluated using the Intelligent Hearing Systems (IHS, Miami, FL, US) Smart EP equipment. A total of 300 binaural stimuli were used in 75 dBnHL, as well as 240 frequent and 60 rare stimuli, using the pairs /ba/ and /di/ respectively. Results There was a statistically significant difference regarding P300 latency between the groups, and children exposed to English classes had lower latency in this component. No statistical difference was found between P300 amplitudes. No correlation was observed regarding age, time of exposure to English, time in class, and electrophysiological responses. Conclusion The Children exposed to English classes had the most stimulating auditory pathway, because their P300 had lower latency, being a resource for the speech therapy clinic.

3.
Article in Chinese | WPRIM | ID: wpr-909503

ABSTRACT

Alzheimer's disease (AD) is one of the major diseases that harmful to healthy elderly, and mild cognitive impairment (MCI) is the early clinical stage of AD. There is a lag in the clinical diagnosis of both diseases. An objective and reliable auxiliary diagnostic method is urgently needed to provide early diagnosis and differential indicators for AD and MCI, to predict the probability of individuals suffering from AD and MCI transforming into AD, and to reduce the overall incidence of AD and reduce the huge medical and economic burden for the country and society. Event-related potential is widely used in AD and MCI, and the resolution at the millisecond level can truly reflect the time course of cognitive processing and the degree of impairment of cognitive function in patients. In this study, we investigated the differences in the amplitude and latency of ERP components in healthy elderly, MCI and AD patients, and the correlation between ERP components and cognitive impairment. Early N170 and P200 showed high sensitivity and specificity in differentiating MCI from healthy elderly or MCI from AD. The late perception-related ERPs also showed high sensitivity and specificity in differentiating healthy elderly from MCI/AD. The differences in ERPs between MCI and AD may be related to the etiology, the degree of disease progression and the site of brain damage. The specific brain mechanism still need to be further explored and will be the focus of future research. With the progress of the research, the relationship between the specific ERP manifestations and the mechanism of brain injury as well as the impairment of cognitive function will be more clear. It is believed that the application of ERP in clinical will bring more benefits to AD and its early clinical MCI.

4.
Int. arch. otorhinolaryngol. (Impr.) ; 24(2): 138-145, Apr.-June 2020. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1134130

ABSTRACT

Abstract Introduction Cochlear implantation has been considered a viable option to restore hearing perception in adults with severe to profound postlingual hearing loss. Objectives To analyze behavioral hearing responses and P300 latency and amplitude measurements in adults with bilateral sensorineural hearing loss at two phases, first when they were using hearing aids (HAs) and, then, after 12 months of cochlear implant (CI) use. The associationbetweenbehavioral and electrophysiological evaluationswas explored, as it is believed that the study of auditory processing with different hearing devices can contribute to future CI adjustments and fittings, especially for patients who cannot give subjective feedback (such as small children and individuals with multiple disabilities). Methods Prospective comparative study (Ethical approval 11489/2014). Twelve adults were assessed, 7 males and 5 females, in the 22 to 76 years old age range, who had undergone CI surgery after HA experience. Results The analyses showed an improvement of hearing thresholds when patients started using CIs. Comparing data from P300 latency measurements, there was an increase of the P300 wave post-CI at Cz and Fz. Regarding the amplitude, P300 mean values decreased at Cz, but increased at Fz. There was no significant correlation between behavioral and electrophysiological assessment and the variables age, gender, auditory deprivation, and electronic device used. Conclusion There was a significant improvement of hearing thresholds after twelve months of CI experience. The mean latency values of P300 after 12 months of CI use increased at Cz and Fz, while mean amplitude values decreased at Cz and increased at Fz.

5.
Int. j. morphol ; 38(2): 356-362, abr. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1056447

ABSTRACT

El suicidio es un problema de salud a nivel mundial, siendo la conducta suicida uno de los predictores de mortalidad por suicidio; sin embargo, su valoración aún sigue siendo compleja. Aunque la cantidad de literatura que ha abordado distintas perspectivas de la conducta suicida es abundante, se requiere ahondar en nuevos métodos que permitan una valoración rápida y objetiva de ésta, proporcionando a los clínicos y pacientes, un sistema de evaluación que registre los cambios de estados emocionales de manera dinámica. El objetivo de este manuscrito fue proporcionar una visión general de la morfología de los potenciales evocados auditivos de latencia tardía p300 y su rol en la evaluación de la conducta suicida.


Suicide is a global health problem, with suicidal behavior being one of the predictors of suicide mortality; however, its assessment is still complex. Although the amount of literature that has addressed different perspectives of suicidal behavior is abundant, it is necessary to deepen new methods that allow a rapid and objective assessment of it, providing clinicians and patients with an evaluation system that allows changes in emotional state to be recorded dynamically. The aim of this manuscript was to provide an overview of morphological patterns of auditory evoked potential P300 latency late in the assessment of suicidal behavior.


Subject(s)
Adolescent Behavior/physiology , Event-Related Potentials, P300/physiology , Suicidal Ideation , Reference Values , Electrophysiology , Evoked Potentials, Auditory/physiology
6.
Braz. j. otorhinolaryngol. (Impr.) ; 86(1): 119-126, Jan.-Feb. 2020. tab
Article in English | LILACS | ID: biblio-1089359

ABSTRACT

Abstract Introduction Tinnitus is sound perception in the absence of a sound source. Changes in parameters of latency and amplitude on the auditory event related potentials or long latency potentials waves have been cited in tinnitus patients when compared to a control group. Objective To perform an assessment of scientific evidence that verifies the possibility of alterations in latency or amplitude of the waves of event related potentials in individuals with tinnitus. Methods By using SciELO, Lilacs, ISI Web and PubMed, scientific databases, a review was performed. Articles published in English, Portuguese, French and Spanish that correlated tinnitus with changes in event related potentials were included in this review. Results Twelve articles were located, however only eight fulfilled the criteria for inclusion. Conclusion The sample of selected studies demonstrate that the long latency auditory evoked potentials related to events between the control and tinnitus patients showed some changes in latency and or amplitude in tinnitus patients. There are changes in event-related potentials when comparing patients with tinnitus and the control group. These changes take place considering the severity of tinnitus, tinnitus site of lesion, and capacity for changes after interventions. The event related potentials can help to determine the neurotransmitter involved in tinnitus generation and evaluate tinnitus treatments.


Resumo Introdução O zumbido é a percepção de um som na ausência de uma fonte sonora. Mudanças nos parâmetros de latência e amplitude nas ondas dos potenciais evocados auditivos relacionados a eventos ou potenciais de longa latência foram citadas em pacientes com zumbido quando comparados a um grupo controle. Objetivo Realizar uma avaliação de evidências científicas que verifiquem a possibilidade de alterações na latência ou amplitude das ondas de potenciais evocados auditivos relacionados a eventos em indivíduos com zumbido. Método Foi feita uma revisão a partir dos bancos de dados científicos SciELO, Lilacs, ISI Web e PubMed. Artigos publicados em inglês, português, francês e espanhol que correlacionavam zumbido com alterações nos potenciais evocados auditivos relacionados a eventos foram incluídos. Resultados Foram localizados 12 artigos, porém apenas oito preencheram os critérios de inclusão. Conclusão A amostra de estudos selecionados demonstra que os potenciais evocados auditivos de longa latência relacionados a eventos entre os pacientes-controle e com zumbido apresentaram algumas alterações na latência e/ou amplitude nos pacientes com zumbido. Há mudanças nos potenciais relacionados a eventos ao comparar pacientes com zumbido e o grupo controle. Essas alterações consideram a gravidade do zumbido, o local da lesão do zumbido e a capacidade de alterações após as intervenções. Os potenciais evocados auditivos relacionados a eventos podem ajudar a determinar o neurotransmissor envolvido na geração do zumbido e avaliar os tratamentos para o zumbido.


Subject(s)
Humans , Tinnitus/physiopathology , Evoked Potentials/physiology , Evoked Potentials, Auditory/physiology , Attention , Tinnitus/psychology , Event-Related Potentials, P300/physiology , Evidence-Based Medicine
7.
Article in Chinese | WPRIM | ID: wpr-872430

ABSTRACT

Objective: To explore the mechanism of acupuncture in regulating cognitive deficits in insomnia rats by observing the effect of acupuncture on microglia in thalamic reticular nucleus (TRN). Methods: Thirty rats were randomly divided into a control group, a model group and an acupuncture group, with 10 rats in each group. The insomnia model was established by intraperitoneal injection of para-chlorophenylalanine (PCPA) once a day for 2 d. Rats in the control group were intraperitoneally injected with the same amount of normal saline. Rats in the acupuncture group received acupuncture at Neiguan (PC 6) and Zusanli (ST 36) for 5 consecutive days. The CLOCKLAB 2 data acquisition system was used to dynamically observe the sleep of the rats throughout the experiment. The cognition of rats was evaluated by event-related potentials (ERPs). After intervention, brain tissue was extracted. Immunofluorescence was used to test the fluorescence expression in TRN region. The concentrations of interleukin (IL)-1β and tumor necrosis factor (TNF)-α were detected by enzyme-linked immunosorbent assay. Results: After intraperitoneal injection of PCPA suspension, the spontaneous activity in light period of rats in the model group and acupuncture group increased significantly compared with the control group (both P<0.01). After acupuncture treatment, the rats in the acupuncture group had much less spontaneous activity during the light period than those in the model group (P<0.01), and the results indicated that acupuncture could effectively improve the sleep quality of insomnia rats. Compared with the control group, rats in the model group showed that the P3 latency, the average optical density of microglia, and the concentrations of IL-1β and TNF-α increased significantly (all P<0.05), and the P3 amplitude decreased significantly (P<0.01). Compared with the model group, rats in the acupuncture group presented that the P3 latency, the average optical density of microglia, and the concentrations of IL-1β and TNF-α were significantly decreased (all P<0.05), and the amplitude of P3 was significantly increased (P<0.05). Conclusion: Acupuncture possesses an ability to improve the cognitive state in insomnia rats. The mechanism may be related to inhibiting the microglial activation, diminishing the levels of pro-inflammatory mediators like IL-1β and TNF-α, and promoting the recovery of central nervous system function.

8.
Article in Chinese | WPRIM | ID: wpr-905389

ABSTRACT

Severe brain-injured patients would suffer severe disorders of consciousness for a long time. It is needed to prognose their brain function and outcomes. P300 wave of event-related potentials may feature as long latency and short amplitude in disorders of consciousness, which respond to the residual cognitive function. The dynamic changes of P300 wave amplitude and latency can be used to determine the recovery of cognitive function. The P300 waves induced by special stimulus may help to differentiate the vegetative state from the minimally conscious state.

9.
Pensam. psicol ; 17(1): 7-17, ene.-jun. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1020098

ABSTRACT

Resumen Objetivo. Identificar las diferencias en el procesamiento cortical de emojis en personas con alta y baja empatía afectiva. Método. El estudio se llevó a cabo con 69 participantes, distribuidos en dos grupos -baja y alta empatía afectiva-, según su puntaje en el Índice de Reactividad Interpersonal. Cada participante observó emojis con expresiones de alegría, ira y neutros. Se registraron los potenciales relacionados a eventos (PRE) P100, N170 y LPP. Resultados. Se encontró una mayor amplitud del N170 en el grupo de personas con alta empatía afectiva y, en general, mayor magnitud del LPP ante emojis de ira. Conclusión. Los resultados sugieren que los emojis son procesados corticalmente de forma similar al rostro humano y que la empatía afectiva modula la codificación del emoji, pero no la atención temprana y el enganche atencional hacia estos estímulos.


Abstract Objective. The objective of this research was to identify the differences in the cortical processing of emojis in people with high and low affective empathy. Method. The study was carried out with 69 participants divided into two groups, low and high affective empathy, according to their score in the Interpersonal Reactivity Index. Each participant observed emojis with happy, neutral and angry expressions. Events related potential (ERP) P100, N170 and LPP were recorded. Results. An amplitude greater than N170 in the high affective empathy group, and a generally greater magnitude of the LPP in response to angry emoji were found. Conclusion. The results suggest that the emojis are processed cortically in a similar way to the human face and that affective empathy modulates the coding of the emoji but not the early attention and the attentional attachment to these stimuli.


Resumo Escopo. Identificar as diferencias no processamento cortical de emojis em pessoas com alta e baixa empatia afetiva. Metodologia. O estudo foi feito com 69 participantes, distribuídos em dois grupos, baixa e alta empatia afetiva, segundo sua pontuação no Índice de Reatividade Interpessoal. Cada participante observou emojis com expressões de alegria, neutrais e ira. Foram registrados os potenciais relacionados a eventos (PREs) P100, N170 e LPP. Resultados. Foi achada uma maior amplitude do N170 em um grupo de pessoas com alta empatia afetiva e, em geral, maior magnitude do LPP frente a de emoji com ira. Conclusão. Os resultados sugerem que os emojis são processados corticalmente de forma similar ao rosto humano e que a empatia afetiva modula a codificação do emoji mas não a atenção precoce e o engajamento atencional para estes estímulos.


Subject(s)
Humans , Empathy , Attention , Face , Social Media
10.
Article in English | WPRIM | ID: wpr-739469

ABSTRACT

OBJECTIVE: This study investigated error-monitoring deficits in female college students with binge drinking (BD) using event-related potentials (ERPs) and the modified Flanker task. METHODS: Participants were categorized into BD (n=25) and non-BD (n=25) groups based on the scores of the Korean-version of the Alcohol Use Disorder Identification Test (AUDIT-K) and the Alcohol Use Questionnaire (AUQ). The modified Flanker task, consisting of congruent (target and flanker stimuli are the same) and incongruent (target and flanker stimuli are different) conditions, was used to evaluate error-monitoring abilities. RESULTS: The BD group exhibited significantly shorter response times and more error rates on the Flanker task, as well as reduced error-related negativity (ERN) amplitudes compared with the non-BD group. Additionally, ERN amplitudes measured at FCz and Cz were significantly correlated with scores on the AUDIT-K and AUQ in the whole participants. The BD and non-BD groups did not show any significant differences in error positivity amplitudes. CONCLUSION: The present results indicate that college students with BD have deficits in error-monitoring, and that reduced ERN amplitudes may serve as a biological marker or risk factor of alcohol use disorder.


Subject(s)
Alcohol Drinking , Binge Drinking , Biomarkers , Evoked Potentials , Female , Humans , Reaction Time , Risk Factors , Young Adult
11.
Article in Chinese | WPRIM | ID: wpr-754189

ABSTRACT

Objective To explore the influencing factors of cognitive dysfunction in patients with temporal lobe epilepsy using event-related potential detection methods and to evaluate the correlation between them. Methods Sixty patients with temporal lobe epilepsy were enrolled according to the inclusion and ex-clusion criteria. Clinical data ( including age of onset,duration of disease,type of seizure,frequency of epi-sodes and anti-epileptic drugs) were collected. The determination of event-related potentials was improved for all patients enrolled. The latency of the N1,P2,N2,and P3 waves and the amplitude of the P3 wave are com-prehensively analyzed. Results Patients with temporal lobe epilepsy:the average latency of N1,P2,N2 and P3 and the average amplitude of P3 wave were ( 108. 47± 24. 58) ms,( 181. 70 ± 29. 63) ms,( 255. 63 ± 32. 66) ms,(367. 03±40. 43) ms and (6. 45± 5. 84) μV,respectively. ERPs (latency of P3 wave) of the age of onset ≤14 years old and the age of onset >14 years old group were statistically significant (P<0. 05). ERPs (latency of N2 wave and P3 wave) of course>5 years group and disease course≤5 years group were statistically significant (P<0. 05). There was significant difference in ERPs (P3 wave amplitude) between the general seizure group and the partial seizure group (P<0. 05). ERPs (latency of P3 wave) frequency of seizures >4 times/month group and≤4 times/month group were statistically significant (P<0. 05); ERPs (latency of N2 wave) of combination group and monotherapy group was statistically significant (P<0. 05). The course of the temporal lobe epilepsy and medicine therapy of combination were impact factors of the la-tency of N2 wave (P<0. 05). Temporal seizure frequency,age of onset and course of disease were impact fac- tors of P3 wave (P<0. 05). Conclusion Age of onset,the course of the temporal lobe epilepsy,the type of seizures,the frequency of seizures and the anti-epileptic drugs are important influencing factors of cognitive dysfunction in patients. In event-related potentials,they have different effects on different stages of cognition.

12.
Article in Chinese | WPRIM | ID: wpr-753902

ABSTRACT

Objective To explore the cognitive process of cognitive flexibility in obsessive-compulsive disorder patients. Methods Thirty-two patients with obsessive-compulsive disorder (OCD) and thirty-two healthy controls were included. The Task Switch paradigm and event-related potentials were used to assess cognitive flexibility. Results The accuracy rate was lower in the OCD than in control group in both repeat and switch trials (P<0.05). Reaction time analysis revealed significant differences in both repeat and switch between the OCD and controls ( P<0.05). ERPs revealed significant differences in N2 and P3 amplitudes between OCD and controls (P<0.05). There was no significant correlation between cognitive flexibility (accuracy rate and reaction time of repeat and switch, and N1, N2 and P3 amplitudes) and clinical forced symptoms in OCD (P>0.05). Conclusion Obsessive-compulsive disorder of cognitive flexibility by injured.

13.
Article in Chinese | WPRIM | ID: wpr-753628

ABSTRACT

Objective To investigate the effect of upper limb rehabilitation robot assisted training on the event-related potential P300, upper limb function and quality of life in stroke patients. Methods A total of 90 stroke patients admitted to Yuyao People's Hospital from May 2017 to January 2018 were randomly divided into control group(45 cases) and observation group(45 cases) according to the digital table.The control group received conventional rehabilitation exercise, and the observation group was supplemented by Motorika ReoGo upper limb rehabilitation robot on the basis of the control group. The P300 latency, P300 amplitude, upper limb function and quality of life of the two groups were compared before and after treatment.Results Before training,the latency of P300,amplitude of P300, upper limb function and quality of life score had no statistically significant differences between the two groups(all P>0.05).After training,the latency of P300,amplitude of P300 in the control group were (389.54 ± 28.19)ms,(2.79 ± 0.23) μV,respectively,which in the observation group were (356.25 ± 24.54)ms, (3.06 ± 0.19) μV,respectively.The latency of P300 in both two groups was significantly shorter than those before training(t=4.490,12.342,all P <0.05),and the amplitude of P300 were significantly higher than those before training(t= -3.476,-10.061,all P<0.05),which of the observation group were significantly better than those of the control group(t= -5.975,6.071,all P<0.05).After training,the Fugl-Meyer scale(FMA) and Barthel scale (MBI) scores of the control group were (35.62 ± 9.72) points,(81.35 ± 10.96) points,respectively,which of the observation group were (44.65 ± 11.23) points,(89.63 ± 11.59) points,respectively.The FMA and MBI scores in the two groups were significantly higher than those before training(t= -5.107,-8.595,-9.039,-11.417,all P<0.05),which of the observation group were significantly higher than those of the control group(t=4.078,3.482, all P<0.05).Conclusion Motorika ReoGo assisted upper limb rehabilitation robot can significantly improve P300 latency,amplitude,upper limb function and quality of life in stroke patients.

14.
Article in Korean | WPRIM | ID: wpr-765199

ABSTRACT

Electroencephalography (EEG) and event-related potentials (ERPs) are useful measures of information processing that are believed to reflect the cognitive processing of the brain. Recently, these electrophysiological markers have been studied repeatedly to examine patients with schizophrenia. Among the ERPs components, P50, P300, mismatch negativity, loudness dependence of auditory evoked potentials, and 40 Hz auditory steady state response are meaningful neurophysiological markers of schizophrenia. The employment of novel ERP paradigms designed to carefully characterize the early spectrum of perceptual and cognitive information processing allows investigators to identify the neurophysiological basis of cognitive dysfunction in schizophrenia and examine the associated clinical and functional impairments. Lately, functional neural networks using resting state EEG have been studied extensively in patients with schizophrenia. In this article, qEEG, several ERP components, and functional neural networks that were considered useful neurophysiological markers of schizophrenia are reviewed and their clinical implications are discussed.


Subject(s)
Electronic Data Processing , Brain , Electroencephalography , Employment , Evoked Potentials , Evoked Potentials, Auditory , Humans , Research Personnel , Schizophrenia
15.
Chinese Medical Journal ; (24): 1063-1070, 2019.
Article in English | WPRIM | ID: wpr-797476

ABSTRACT

Background:@#Visual-spatial neglect (VSN) is a neuropsychological syndrome, and right-hemisphere stroke is the most common cause. The pathogenetic mechanism of VSN remains unclear. This study aimed to investigate the behavioral and event-related potential (ERP) changes in patients with or without VSN after right-hemisphere stroke.@*Methods:@#Eleven patients with VSN with right-hemisphere stroke (VSN group) and 11 patients with non-VSN with righthemisphere stroke (non-VSN group) were recruited along with one control group of 11 age- and gender-matched healthy participants. The visual-spatial function was evaluated using behavioral tests, and ERP examinations were performed.@*Results:@#The response times in the VSN and non-VSN groups were both prolonged compared with those of normal controls (P < 0.001). In response to either valid or invalid cues in the left side, the accuracy in the VSN group was lower than that in the non-VSN group (P < 0.001), and the accuracy in the non-VSN group was lower than that in controls (P < 0.05). The P1 latency in the VSN group was significantly longer than that in the control group (F[2, 30] = 5.494, P = 0.009), and the N1 amplitude in the VSN group was significantly lower than that in the control group (F[2, 30] = 4.343, P = 0.022). When responding to right targets, the lefthemisphere P300 amplitude in the VSN group was significantly lower than that in the control group (F[2, 30] = 4.255, P = 0.025). With either left or right stimuli, the bilateral-hemisphere P300 latencies in the VSN and non-VSN groups were both significantly prolonged (all P < 0.05), while the P300 latency did not differ significantly between the VSN and non-VSN groups (all P > 0.05).@*Conclusions:@#Visual-spatial attention function is impaired after right-hemisphere stroke, and clinicians should be aware of the subclinical VSN. Our findings provide neuroelectrophysiological evidence for the lateralization of VSN.

16.
Article in Chinese | WPRIM | ID: wpr-746028

ABSTRACT

Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the negative symptoms of chronic schizophrenia and on the P300 component of schizophrenics' event-related potentials (ERPs).Methods Ninety convalescing schizophrenia patients were randomly divided into a 5 Hz group,a 10 Hz group and a 15 Hz group,each of 30.The three groups were treated with the corresponding 5 Hz,10 Hz or 15 Hz rTMS once a day,five times a week for five consecutive weeks.The P300 ERPs of all three groups were tested before and after the treatment.Any curative effect was evaluated using the scale for the assessment of negative symptoms (SANS).Results After the treatment,the average SANS score of the 10 Hz group was significantly different from that before the treatment and also from those of the other two groups after the treatment.After the treatment,significant improvement was also observed in the amplitude of P300 in the 10 Hz group.The treatment's effectiveness was negatively correlated with age and longer course of the disease.Conelusion rTMS at 10 Hz is the most effective of the protocols tested for improving the negative symptoms of schizophrenia and improving cognitive functioning.

17.
Chinese Journal of Neurology ; (12): 184-189, 2019.
Article in Chinese | WPRIM | ID: wpr-745911

ABSTRACT

Objective To explore the characteristics of emotional memory in patients with earlystage Parkinson's disease (PD).Methods The methods of emotional memory neuro-cognitive test and event-related evoked potentials (ERPs) test were set.The emotional memory was detected in 30 early-stage PD patients without treatment (PD group) and 30 matched (including education level,etc) healthy controls (control group),who were recruited in the Department of Neurology,Anqing Municipal Hospital from June 2016 to June 2018.Results Compared with the control group (55.83%±4.17%),the negative valence picture recognition rate in the PD group (50.30%±4.04%) showed statistically significant difference (t=4.85,P<0.05).The ERPs-P300 latency was (337.47 ± 7.87) ms,the amplitude was (6.34 ± 0.62) μV,and the reaction time was (3 729.21±226.85) ms in the control group,showing statistically significant difference (t=-3.30,4.04,2.76,P<0.05) compared with that in the PD group ((344.20±7.94) ms,(5.75±0.52) μV,(3 935.33±222.24) ms,respectively).There was no statistically significant difference in positive and neutral stimuli recognition between the two groups (P>0.05).In the PD group,the correct recognition in positive,neutral and negative valence pictures (57.97% ±4.44%,49.77% ±4.49%,50.30% ±4.04%,respectively)showed statistically significant difference (F=39.17,P<0.05),also seen in the reaction time ((3 725.87 ±210.10) ms,(4 085.80±231.67) ms and (3 935.33±222.24) ms,respectively;F=9.58,P<0.05),P300 latency ((328.07±6,07) ms,(347.37±7.49) ms and (344.20±7.94) ms,respectively;F=60.32,P<0.05),and amplitude ((6.55±0.66) μV,(5.57 ± 0.63) μV and (5.75 ± 0.52) μV,respectively;F=22.44,P<0.05).But there was no statistically significant difference between negative and neutral stimuli recognition in the PD group (P>0.05).In the control group,the correct recognition in positive,neutral and negative valence pictures (59.47% ±4.61%,50.63%±4.96%,55.83%±4.17%,respectively) also showed statistically significant difference (F=25.85,P<0.05),also seen in the reaction time ((3 657.13±218.85) ms,(4 026.81±221.23) ms and (3 729.21±226.85) ms,respectively;F=8.57,P<0.05),P300 latency ((326.13±5.96) ms,(345.10±7.95) ms and (337.47±7.87) ms,respectively;F=51.04,P<0.05),and amplitude ((6.69±0.68) μV,(5.59±0.67) μV and (6.34±0.62)μV,respectively;F=22.15,P<0.05).There was no statistically significant difference in the rating of valence of emotional pictures between the PD and the control groups (P>0.05).However,there was statistically significant difference in the latency and amplitude of P300 in the rating of negative valence of emotional pictures between the two groups (t=-5.63,4.16,P<0.05).Conclusions The results suggest that there is emotional memory impairment in early stage of PD,which is mainly based on selective negative emotional valence.Testing the emotional memory of patients with PD is helpful for early identification and intervention.

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Article in Chinese | WPRIM | ID: wpr-800603

ABSTRACT

Objective@#To investigate the effect of upper limb rehabilitation robot assisted training on the event-related potential P300, upper limb function and quality of life in stroke patients.@*Methods@#A total of 90 stroke patients admitted to Yuyao People's Hospital from May 2017 to January 2018 were randomly divided into control group(45 cases) and observation group(45 cases) according to the digital table.The control group received conventional rehabilitation exercise, and the observation group was supplemented by Motorika ReoGo upper limb rehabilitation robot on the basis of the control group.The P300 latency, P300 amplitude, upper limb function and quality of life of the two groups were compared before and after treatment.@*Results@#Before training, the latency of P300, amplitude of P300, upper limb function and quality of life score had no statistically significant differences between the two groups(all P>0.05). After training, the latency of P300, amplitude of P300 in the control group were (389.54±28.19)ms, (2.79±0.23)μV, respectively, which in the observation group were (356.25±24.54)ms, (3.06±0.19)μV, respectively.The latency of P300 in both two groups was significantly shorter than those before training(t=4.490, 12.342, all P<0.05), and the amplitude of P300 were significantly higher than those before training(t=-3.476, -10.061, all P<0.05), which of the observation group were significantly better than those of the control group(t=-5.975, 6.071, all P<0.05). After training, the Fugl-Meyer scale(FMA) and Barthel scale(MBI) scores of the control group were (35.62±9.72)points, (81.35±10.96)points, respectively, which of the observation group were (44.65±11.23)points, (89.63±11.59)points, respectively.The FMA and MBI scores in the two groups were significantly higher than those before training(t=-5.107, -8.595, -9.039, -11.417, all P<0.05), which of the observation group were significantly higher than those of the control group(t=4.078, 3.482, all P<0.05).@*Conclusion@#Motorika ReoGo assisted upper limb rehabilitation robot can significantly improve P300 latency, amplitude, upper limb function and quality of life in stroke patients.

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Article in Chinese | WPRIM | ID: wpr-744573

ABSTRACT

Objective To observe the role of working memory in the process of language, and provide an objective evaluation for Chinese language rehabilitation.Methods From December, 2017 to June, 2018, 20 healthy subjects accepted word-picture matching tasks as the word and picture showed on the different (task 1) or same (task 2) screens, and their event-related potential of N400 were compared in matched and mismatched conditions.Results Forteen subjects were included finally. Task 1 induced N400 appeared earlier with higher amplitude and more activation in central parietal occipital region, followed larger N170 and P1 wave. There were significant differences in most cerebral regions between the two tasks in N400 amplitude difference of matched and mismatched conditions (t> 2.319, P < 0.05).Conclusion Word-picture matching tasks may involve more language-related brain regions with the intervention of working memory, that might work better in process of vocabulary. The tasks simulating the scene of Chinese language rehabilitation can be used as an objective evaluation for clinical activities.

20.
Int. arch. otorhinolaryngol. (Impr.) ; 22(4): 408-414, Oct.-Dec. 2018. tab
Article in English | LILACS | ID: biblio-975611

ABSTRACT

Abstract Introduction The P3 cognitive evoked potential is recorded when a subject correctly identifies, evaluates and processes two different auditory stimuli. Objective to evaluate the latency and amplitude of the P3 evoked potential in 26 cochlear implant users with post-lingual deafness with good or poor speech recognition scores as compared with normal hearing subjects matched for age and educational level. Methods In this prospective cohort study, auditory cortical responses were recorded from 26 post-lingual deaf adult cochlear implant users (19 with good and 7 with poor speech recognition scores) and 26 control subjects. Results There was a significant difference in the P3 latency between cochlear implant users with poor speech recognition scores (G-) and their control group (CG) (p= 0.04), and between G- and cochlear implant users with good speech discrimination (G+) (p= 0.01). We found no significant difference in the P3 latency between the CG and G+. In this study, all G- patients had deafness due to meningitis, which suggests that higher auditory function was impaired too. Conclusion Post-lingual deaf adult cochlear implant users in the G- group had prolonged P3 latencies as compared with the CG and the cochlear implant users in the G+ group. The amplitudes were similar between patients and controls. All G- subjects were deaf due to meningitis. These findings suggest that meningitis may have deleterious effects not only on the peripheral auditory system but on the central auditory processing as well.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Cochlear Implants , Event-Related Potentials, P300/physiology , Deafness/physiopathology , Speech Perception/physiology , Prospective Studies , Meningitis/complications
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