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1.
Article in Chinese | WPRIM | ID: wpr-603237

ABSTRACT

Objective To analyze the drug resistance and homology of Acinetobacter baumannii (Ab) isolated from patients with explosive injury ,so as to explore the characteristics of drug resistance and prevalence of infection .Methods A total of 61 strains of AB isolated from clinical specimens of patients with explosive injury were collected .The antimicrobial susceptibility of these iso‐lates was detected by using K‐B test .All the strains were gene typed by using the pulsed field gel electrophoresis .Results The re‐sults of antimicrobial susceptibility test shown that the 61 isolates of Ab had high resistance rate ,and were multi‐drug resistant to common antibacterial agents ,except for tigecycline (the resistante rate was 11 .5% ) and minocycline (the resistante rate was 48 .0% ) .The 61 isolates of Ab were divided into 8 kinds of genotypes ,among which type A was the most prevalent one (25 strains) .Other genotypes were type B(10 strains) ,type C(6 strains) ,type D(4 strains) ,type E(8 strains) ,type F(3 strains) ,type G(4 strains) and type H(1 strain) .The isolates of Ab were with high homology .Conclusion Multi‐drug resistance is observed in strains of Ab isolates from patients with explosive injury .Clonal strains of AB may be disseminates among regions ,which indicates that high attention should be paid to these strains .

2.
Chinese Journal of Neuromedicine ; (12): 1006-1011, 2015.
Article in Chinese | WPRIM | ID: wpr-1034264

ABSTRACT

Objective To establish new experimental models of primary explosive injury to brain in dogs and investigate the effect of early treatment on primary explosive injury in dogs by using two doses of 20% mannitol.Methods Thirty-six mongrel male dogs were randomly divided into three groups: model group, high-dose treatment group and low-dose treatment group (n=12).Models of primary craniocerebral explosive injury were established in all the groups.Dogs in the high-dose treatment group and low-dose treatment group were given 1.0 g/kg and 0.5 g/kg 20% mannitol 6 h after injury, and these treatments were given every 6 h;0, 3, 6, 12, 24 and 48 h after injury, respiratory frequency, heart rate, blood pressure (BP), intracranial pressure (ICP), CT of skull, urea nitrogen (BUN), creatinine (Cr) and survival time were observed and compared.Results The levels of respiratory frequency and heart rate were significantly increased, and the levels of BP and ICP were significantly decreased in the high-dose treatment group and low-dose treatment group as compared with those in the model group 12, 24 and 48 h after injury (P<0.05);24 and 48 h after injury, as compared with those in the model group and high-dose treatment group, the levels of BUN and Cr in the low-dose treatment group were significantly lower (P<0.05).The midline shift in the high-dose treatment group ([3.5±0.41] mm) and low-dose treatment group ([3.3±0.22] mm) was significantly decreased than that in the model group ([6.4±0.50] mm) 48 h after injury (P<0.05).The survival time in both high-dose treatment group (131.6±8.73 h) and low-dose treatment group (133.7±9.31 h) was significantly longer than that in control group (96.0±3.0 h,P<0.05).Conclusion Early proper treatment for primary craniocerebral explosive injury by using mannitol can relieve the indexes of respiratory frequency, heart rate, BP and ICP, and relieve the severities of cerebral edema, prolong the survival time in dogs, but high-dose 20% mannitol might aggravate the kidney damage of the injured dogs.

3.
Chinese Journal of Neuromedicine ; (12): 999-1002, 2014.
Article in Chinese | WPRIM | ID: wpr-1034047

ABSTRACT

Objective To investigate the early physiologic and pathologic changes of primary explosive injury to brain in dogs.Methods Thirty mongrel male dogs were randomly divided into 13 mm detonated injury group (n=10),9 mm detonated injury group (n=10) and 5 mm detonated injury group (n=10); a spherical explosive with explosive energy of 1 g TNT was used to detonate at different distances (13,9 and 5 mm) to dogs' head to cause the severe,moderate and slight degrees of craniocerebral primary explosive injury in these dogs,respectively.Changes of respiratory frequency (RF),heart rate (HR) and mean arterial blood pressure (MABP),survival time and behavior in these dogs were observed; HE staining and electron microscopy were used to observe the pathological and ultrastructural changes of the brain tissues.Results The RF,HR and MABP levels after cerebral explosive injury were decreased in dogs of three groups; the decreased extent was increased following the increase of injury extent,with significant difference among the three groups (13 mm detonated injury group>9 mm detonated injury group>5 mm detonated injury group,P<0.05).The server the injury,the more obvious the changes of dog behaviors (13 mm detonated injury group>9 mm detonated injury group>5 mm detonated injury group,P<0.05).There were different extents of contusion and laceration of the brains,brain hemorrhage,and subdural hematoma in the three groups.Conclusions RF,HR and BP levels are decreased in three groups after cerebral primary explosive injury in dogs; the more obvious the physiologic and pathologic changes,the severer degrees of craniocerebral explosive injury.The severer injury dogs have more obvious behavioral changes.The survival time in dogs with the severer degrees of craniocerebral explosive injury is shorter than that in slight injury one.

4.
Article in Chinese | WPRIM | ID: wpr-543663

ABSTRACT

[Objective]To study therapeutic effect of different medicines on motorneuron of spinal cord after explosive injury of spinal cord.[Method]Thirty-six rabbits were randomly divided into model group(group A,n= 12),the dexamethasone experiment group(group B,n= 12) and the methylprednisolone experiment group(group C,n=12),all rabbits were made explosive wound by 0.9 g cyclotrimethylene trinitramine,group A injection NS after blast, group B injection dexamethasone and group C injection methylprednisolone,6 and 24 hours after specimen had been taken out,then morphological change and quantity of the spinal motorneurons be observed under light microscopes.[Result]The reversible change of the neurons of rabbits happened after six hours,after 24 hours,the died motoneuron increase obviously, some rabbits remedied with dexamethasone and methylprednisolone after explosive injury in group B and C,quantity of the died motorneuron marked significant difference than that in the control group(P0.05).[Conclusion]Glycocotical stdroid can protect spinal cord motoneurons after explosive injury of spinal cord.In the experiment,there is no preponderance in early treatment of explosive injury of spinal cord between methylprednisolone and dexamethasone.

5.
Article in Chinese | WPRIM | ID: wpr-583621

ABSTRACT

Obiective: To observe the changes in corneal tissue after seawater soaking following explosive injury in rabbits and the effects of seawater soaking on the healing of cornea after explosive injury. Methods:Make 20 similar explosive injury models of rabbit's eyeball using 10 adult grey rabbits. For each rabbit, the right eye was in experiment and the left one was for comparison. After the injury, the experimental eyes were soaked in seawater for 30 minutes and the comparable eyes were soaked in 0.9% sodium chloride injection for the same time. All eyes were underwent slit lamp examinations, fluorescein dyeing, and ultrasonic cornea thickness metering on the corneas before the injury and 1,2,3,4,5,7,9,10,15 and 20 days after the injury respectively. At the same time, 2 rabbits were killed and the eyes were examined pathologically. The cornea thickness numbers were compared using self- comparison t test and grouping t test. Results: After seawater soaking following explosive injury, slit lamp microscope examination found that the corneas were edema and turbidity, the experimental eyes were stricter than the control eyes. The corneas of the experimental eye were vascularized 10 days after the injury. Fluorescein dyeing showed that more apparent pigmentations were found on the experimental eyes than that on the control ones.Comparative examination under the optical microscope showed that the corneal tissues of the experiment eyes changed distinctly, their inflammations were patency and healing was delayed and the vascularization degree became high after the injury. Cornea thickness of the experimental eyes became apparently thicker than that of the control eyes. The difference was statistically significant. Conclusion:Scars and vascularization of various degrees will appear in corneal stroma after the explosive injuries. Seawater soaking will have bad effects on the healing of the cornea injured in explosions.

6.
Article in Chinese | WPRIM | ID: wpr-670578

ABSTRACT

Objective: To establish an efficient animal model for the study of explosive injury in maxillofacial region.Methods: The detonator, steel spheres as fragments simulants shot by smooth-bore barrel and a synchronizer were used to define the wound model in the maxillofacial region of 18 dogs. The whole system was triggered when shooting. Wounding parameters and the changes of targets after explosion were observed and recorded. Results: The overpressure of blast wave decreased exponentially according to the distance from explosive. After injury, the local damage of dogs was serious and extensive compounded with the damages in heart, lung and brain. The injury was aggravated with the increasing of over pressure and energy absorption. Conclusion: The new wound model can be used for the study of explosive injury in maxillofacial region that is characterized by serious tissue damage and multi-etiology.

7.
Article in Korean | WPRIM | ID: wpr-161225

ABSTRACT

During the three years from March, 1983 to Feb, 1986, 159 cases of head injury surgically treated in the department of neurosurgery, Capital Armed Forces General Hospital were clinicostatistically analysed and discussed with the review of the literature. The following results were obtained.1) Due to the army distinctiveness, all cases were male and the age incidence was becoming maximal at the third decade. 2) Traffic accidents form by far the largest Group(38.4%), and next are, in order of incidence, accidents due to fall from height, simple fall(19%), exercise(12.6%), gun shot wound or explosive injury(9.4%) and assault(9.4%). 3) Skull fracture were seen in 115 cases(72.3%), and nearly half of those 55 cases, were linear fracture. 4) Of the 133 patients with intracranial hematoma or subdural hygroma, 88 cases(66.7%) were accompanied by skull fracture. 93% of epidural hematomas were associated with skull fracture and the most common wite of hematoma was temporoparietal area. 5) Of all cases of subdural hematoma, acute type was prevalent(59.4%) and its main site involved was temporoparietal area. 6) The associated injuries were found in 22.6% of patients. The frequent ones were facial bone fracture, upper extremity fracture, clavicle fracture, and chest injury, in order. 7) The minor head injury of Glasgow coma scale score(GCS) of 13 to 15 was 68 cases(42.8%). The moderated head injury of 9 to 12 was 28 cases(17.6) and the serve head injury of 3 to 8, 63 cases(39.1%). 8) The operation mortality was 26.8% and the good recovery was achieved 55.4% of patients. The remaining 18.8% resulted in disabled or vegetative state. 9) In the accidents of gun shot wound or explosive injury, operation mortality rate was 60%, but 5 cases(33.3%) were seen good recovery.


Subject(s)
Humans , Male , Accidents, Traffic , Arm , Clavicle , Craniocerebral Trauma , Facial Bones , Glasgow Coma Scale , Head , Hematoma , Hematoma, Subdural, Acute , Hospitals, General , Incidence , Military Personnel , Mortality , Neurosurgery , Persistent Vegetative State , Skull Fractures , Subdural Effusion , Thoracic Injuries , Upper Extremity , Wounds and Injuries
8.
Article in Korean | WPRIM | ID: wpr-161226

ABSTRACT

A series of 24 cases of gun shot and explosive injuried patients of the brain is analyzed according to causes, types, operability, the relation between Glasgow coma scale(GCS) and operative mortality, associated injuries, complications and sequelae. The authors notice that gun shot and explosive injury of the brain are more worse than blunt head trauma because of injury mechanism by itself.


Subject(s)
Humans , Brain , Coma , Craniocerebral Trauma , Mortality
9.
Article in Chinese | WPRIM | ID: wpr-547576

ABSTRACT

Guinea pigs were exposed to 10 impulses of either 157-or 163dB peak SPL.The threshold shift recovery was monitored for 30 d, and tympanometric changes and co-chlear hislochemistry were investigated.The results showed that the 157dB level produced a recovey pattern linear to post-exposure log time and no PTS was found.The 163dB level produced a recovery-stop-recovery pattern, showing 13dB threshold shift on the 30th day after exposure.There are no TM perforation in both groups but most of the cochleas showed loss of outer hair cells or reduced activity of succinic dehydrogenase (SDH).

10.
Article in Chinese | WPRIM | ID: wpr-555941

ABSTRACT

The explosive terror attack is the most frequent in all terror activities in the world. The authors reviewed its current situation and the challenges we are confronted with in China and elsewhere. In the present paper, the types, characteristics and emergency medical support (particularly classifying and emergency treatment, triage, transportation and evacuation, seeking and unearthing for buried victims) of explosive injuries in explosive attack site were systematically expounded.

11.
Article in Chinese | WPRIM | ID: wpr-553728

ABSTRACT

To investigate the mechanism of common carotid artery injury produced by explosion in neck region, and to determine the severity of carotid injury based on the injury of neck and the pressure of blast waves. After the detonation of the blast source at different distances, the injuries to rabbits' neck and carotid artery were examined, and the pressure of the blast waves to both skins and common carotid artery were measured with PVDF(polyvinylidene fluoride)sensors and oscilloscope. The endothelium of the injured carotid artery desquamated and micro thrombus formed on the arterial walls the after injury. Disruptions in the tunica media might account for pseudo aneurysm formation. These results offered experimental evidences pseudo aneurysm and thrombus formation in the carotid artery after an explosion in the neek region.

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