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1.
Chinese Journal of Digestion ; (12): 522-527, 2021.
Article in Chinese | WPRIM | ID: wpr-912206

ABSTRACT

Objective:To investigate the overlapping prevalence and risk factors of gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) among rural adults in Shaanxi Province.Methods:From February 1 to October 31 in 2019, 12 villages in Shaanxi Province were randomly selected for household questionnaire survey through multistage stratified cluster sampling. A total of 2 423 subjects were enrolled, including 1 037 males and 1 386 females, with age of (45.3±16.9) years old. GERD was diagnosed according to the Montreal criteria, FD and IBS were diagnosed according to the Rome Ⅳ criteria. The overlapping prevalence of the three diseases were calculated. The risk factors for the overlapping of GERD, FD and IBS were analyzed. Multivariate logistic regression was used for statistical analysis.Results:Among the 2 423 subjects, 624 cases had GERD (302 cases), FD (377 cases) or IBS (167 cases), of which 30.77% (192/624) patients had overlap of ≥two diseases. The overlap rates of GERD and FD, GERD and IBS, FD and IBS, GERD, FD and IBS were 2.56% (62/2 423), 1.61% (39/2 423), 2.52% (61/2 423) and 1.24% (30/2 423), respectively. The results of Multivariate analysis showed that female and migraine without aura were positively correlated with the overlap of GERD and FD, FD and IBS, and GERD and IBS (odds ratio ( OR)=3.08, 2.68, 3.66, 7.37, 5.91 and 4.46, 95% confidence interval ( CI) 1.35 to 7.01, 1.35 to 5.30, 1.52 to 8.83, 3.97 to 13.69, 1.78 to 19.60 and 2.01 to 9.92; all P<0.05). Heavy drinking (alcohol intake≥50 g/d (male) or≥30 g/d (female)) was positively correlated with the overlap of FD and IBS, GERD and IBS, and GERD, FD and IBS ( OR=3.69, 4.20 and 4.91, 95% CI 1.19 to 11.48, 1.01 to 17.50 and 1.23 to 19.52; all P<0.05). Heavy smoking (smoking≥20 cigarettes per day) was positively correlated with the overlap of GERD and FD, FD and IBS, GERD and IBS, and GERD, FD and IBS ( OR=3.44, 6.25, 8.27 and 7.04, 95% CI 1.07 to 11.01, 1.60 to 24.44, 1.80 to 38.07 and 1.76 to 28.12; all P<0.05). The educational level of junior or senior high school and age≥60 years old were negatively correlated with the overlap of GERD and FD, FD and IBS, GERD and IBS, and GERD, FD and IBS ( OR=0.47, 0.29, 0.20, 0.05, 0.23, 0.10, 0.37 and 0.16, 95% CI 0.23 to 0.93, 0.09 to 0.95, 0.09 to 0.42, 0.01 to 0.19, 0.09 to 0.60, 0.02 to 0.65, 0.15 to 0.87 and 0.03 to 0.81; all P<0.05). Conclusions:The overlap of GERD, FD and IBS is common and affected by many factors. Female, age≥60 years old, heavy smoking, heavy drinking, low education level and history of migraine without aura are associated with multiple overlaps of GERD, FD and IBS.

2.
Article in Chinese | WPRIM | ID: wpr-905934

ABSTRACT

Objective:To explore the clinical efficacy and safety of modified Heweitang in the treatment of functional dyspepsia (FD) due to liver-stomach disharmony and its regulation of gastrointestinal hormones and brain-gut peptides. Method:One hundred and twenty-six eligible patients were randomized into a control group (62 cases) and an observation group (64 cases). Patients in the observation group took the modified Heweitang granules with warm water 30 min after meals, 10 g/time, 3 times/day, while those in the control group took the corresponding placebo granules at the same dose in the same manner. The treatment in both groups lasted for four weeks. Before and after treatment, the four main symptoms including postprandial satiety, early satiety, upper abdominal pain, and upper abdominal burning sensation were scored, followed by the examination of gastric emptying (GE) and the scoring of the functional digestive disorders quality of life questionnaire (FDDQL), 7-point global overall symptom scale (GOSS), and liver-stomach disharmony syndrome. The cholecystokinin (CCK), motilin (MTL), gastrin (GAS), serotonin (5-HT), vasoactive intestinal peptide (VIP), and substance P (SP) levels before and after treatment were detected, and then the safety was evaluated. Result:After treatment, the scores of the four main symptoms, GOSS, and liver-stomach disharmony syndrome in the observation group were lower than those in the control group (<italic>P</italic><0.01), while the GE rate and FDDQL scores in the observation group were higher (<italic>P</italic><0.01). The CCK, GAS, 5-HT, and VIP levels of the observation group declined as compared with those of the control group (<italic>P</italic><0.01), whereas the MTL and SP levels were elevated (<italic>P</italic><0.01). After treatment, the overall response rate in the observation group was (51/57)89.47%, higher than (15/56)26.79% in the control group (<italic>χ</italic><sup>2</sup>=45.696, <italic>P</italic><0.01). No drug-related adverse reactions were found during the trial. Conclusion:The modified Heweitang is efficient and safe in relieving the main and related symptoms and traditional Chinese medicine (TCM) syndrome, regulating the secretion of gastrointestinal hormones and brain-gut peptides, promoting GE rate, and improving the quality of life of patients with FD due to liver-stomach disharmony.

3.
Article in Chinese | WPRIM | ID: wpr-905859

ABSTRACT

Objective:To observe the effects of Chaihu Shugansan on gastric motility and mitochondrial function and mitophagy in rats with functional dyspepsia (FD) and to preliminarily reveal its mechanism in preventing and treating FD. Method:Thirty-two SD rats of SPF grade were randomly divided into the normal group, model group, Chaihu Shugansan (4.8 g·kg<sup>-1</sup>) group, and domperidone group (4.5 mg·kg<sup>-1</sup>) after one week of adaptive feeding, with eight rats in each group. Rats in all groups except for the normal group were exposed to modified tail-clamping stimulation for inducing FD. Four weeks later, the semi-solid nutritive medium was used to observe the gastric emptying rate of FD rats, and the serum citrate synthase (CS), motilin (MTL), and gastrin (GAS) were detected by enzyme-linked immunosorbent assay (ELISA). The pathological changes in gastric tissue were observed by hematoxylin-eosin (HE) staining, the mitochondrial characteristics by transmission electron microscopy, and the expression of microtubule-associated protein light chain 3 (LC3) and voltage-dependent anion-selective channel 1 (VDAC1) by immunofluorescence co-localization. The mitochondria were extracted from fresh gastric tissue for measuring the reactive oxygen species (ROS), malondialdehyde (MDA), and superoxide dismutase (SOD) levels using the biochemical kits. The mitochondrial LC3, yeast Atg6 homologous(Beclin1), and p62 protein expression was assayed by Western blot. Result:Compared with the normal group, the model group exhibited significantly reduced gastric emptying rate (<italic>P</italic><0.01) and serum CS, MTL, and GAS levels (<italic>P</italic><0.01). HE staining showed no pathological changes like erosion or ulcer in the gastric tissue of rats in each group. However, the mitochondria in the gastric tissue were observed swollen and dilated under the transmission electron microscope, and vacuolar lesions appeared. The co-expression of LC3 with VDAC1 increased significantly (<italic>P</italic><0.01). The mitochondrial ROS and MDA levels were elevated significantly (<italic>P</italic><0.01), while SOD content was significantly reduced (<italic>P</italic><0.01). The protein expression levels of LC3 and Beclin1 were significantly up-regulated (<italic>P</italic><0.05, <italic>P</italic><0.01), whereas p62 protein expression was down-regulated significantly (<italic>P</italic><0.01). Compared with the model group, Chaihu Shugansan and domperidone elevated the gastric emptying rate (<italic>P</italic><0.05) and serum CS, MTL, and GAS levels (<italic>P</italic><0.05, <italic>P</italic><0.01). It was observed under the transmission electron microscope that the mitochondrial nuclear membrane of the gastric tissue was intact, with clear structure and high density of mitochondrial cristae, and mitochondrial fission and fusion were observed in some parts. The co-localization area of LC3 and VDAC1 was significantly reduced (<italic>P</italic><0.01). The mitochondrial ROS and MDA levels declined significantly (<italic>P</italic><0.05, <italic>P</italic><0.01), whereas SOD level rose (<italic>P</italic><0.05). The protein expression levels of LC3 and Beclin1 were significantly down-regulated (<italic>P</italic><0.05, <italic>P</italic><0.01), while that of p62 was obviously up-regulated (<italic>P</italic><0.01). Conclusion:The mechanism of Chaihu Shugansan in preventing and treating FD may be related to the improvement of mitochondrial function and the inhibition of mitophagy in gastric tissue.

4.
Article in Chinese | WPRIM | ID: wpr-888085

ABSTRACT

This study aimed to explore the mechanism of Xiaoyao San(XYS) in the treatment of three diseases of liver depression and spleen deficiency, ie, depression, breast hyperplasia, and functional dyspepsia, and to provide a theoretical basis for the interpretation of the scientific connotation of "treating different diseases with the same method" of traditional Chinese medicines. Traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP) was used to screen the active components of XYS which underwent principal component analysis(PCA) with the available drugs for these three diseases to determine the corresponding biological activities. The targets of XYS on depression, breast hyperplasia, and functional dyspepsia were obtained from GeneCards, TTD, CTD, and DrugBank databases. Cytoscape was used to plot the "individual herbal medicine-active components-potential targets" network. The resulting key targets were subjected to Kyoto encyclopedia of genes and genomes(KEGG) pathway analysis and gene ontology(GO) enrichment analysis. A total of 121 active components of XYS and 38 common targets in the treatment of depression, breast hyperplasia, and functional dyspepsia were collected. The key biological pathways were identified, including advanced glycation and products(AGEs)-receptor for advanced glycation and products(RAGE) signaling pathway in diabetic complications, HIF-1 signaling pathway, and cancer-related pathways. The key targets of XYS in the treatment of depression, breast hyperplasia, and functional dyspepsia included IL6, IL4, and TNF, and the key components were kaempferol, quercetin, aloe-emodin, etc. As revealed by the molecular docking, a strong affinity was observed between the key components and the key targets, which confirmed the results. The therapeutic efficacy of XYS in the treatment of diseases of liver depression and spleen deficiency was presumedly achieved by reducing the inflammatory reactions. The current findings are expected to provide novel research ideas and approaches to classify the scientific connotation of "treating different diseases with the same method" of Chinese medicines, as well as a theoretical basis for understanding the mechanism of XYS and exploring its clinical applications.


Subject(s)
Depression/drug therapy , Drugs, Chinese Herbal/pharmacology , Dyspepsia/drug therapy , Humans , Hyperplasia/drug therapy , Medicine, Chinese Traditional , Molecular Docking Simulation
5.
Article in Chinese | WPRIM | ID: wpr-877663

ABSTRACT

OBJECTIVE@#To evaluate the clinical effect of acupuncture for the improvements in various dyspeptic symptoms of postprandial distress syndrome.@*METHODS@#The secondary analysis on the data of a multi-center randomized controlled trial (RCT) was conducted. 278 patients with postprandial distress syndrome were randomized into an acupuncture group (138 cases) and a sham-acupuncture group (140 cases). In the acupuncture group, acupuncture was applied to Baihui (GV 20), Danzhong (CV 17), Zhongwan (CV 12), Qihai (CV 6), Neiguan (PC 6), Zusanli (ST 36), etc. In the sham-acupuncture group, 6 sites, neither located on meridians nor belonged to meridian acupoints, were selected and punctured shallowly. The duration of treatment was 20 min each time, 3 times a week, for 4 weeks totally in the two groups. The follow-up visit lasted for 12 weeks. The scores of dyspeptic symptoms were compared between the two groups before treatment, during treatment (in week 1, 2, 3 and 4) and during follow-up (in week 8, 12 and 16) separately.@*RESULTS@#Besides the scores of early satiety and vomiting in the sham-acupuncture group in week 1, the scores of the other dyspepsia symptoms during treatment and follow-up were all reduced in the two groups as compared with those before treatment (@*CONCLUSION@#Acupuncture remarkably relieves postprandial fullness, early satiety, upper abdominal bloating and belching in patients with postprandial distress syndrome.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Dyspepsia/therapy , Humans , Meridians , Treatment Outcome
6.
Article in Chinese | WPRIM | ID: wpr-826363

ABSTRACT

To investigate the effects of ()infection on autonomic nervous function and calcitonin gene-related peptide in patients with functional dyspepsia(FD). Thirty-one patients with FD matching Rome Ⅳ criteria were included and divided into -positive group and -negative group.All patients were evaluated by Symptom Index of Dyspepsia(SID),Nepean Dyspepsia Index(NDI),and Hospital Anxiety and Depression Scale(HADS).Their heart rate variability(HRV)and calcitonin gene-related peptide(CGRP)level were also measured. There were no significant differences in SID(=-0.858, =0.858),NDI(=-1.464, =0.143),and Hospital Depression Scale score(=0.699, =0.485).However,the Hospital Anxiety Scale score was significantly higher in -positive group than the -negative group(=-2.470, =0.014).The level of CGRP in -positive group[(0.999±0.274)ng/ml]was significantly higher than that in the -negative group[(0.812±0.172)ng/ml;=2.238, =0.033].HRV data showed no significant difference between these two groups at very low frequency(=-1.210, =0.236),low frequency(LF)(=0.419, =0.678),high frequency(HF)(=0.612, =0.546),LF/HF(=-0.882, =0.399),and total power(=-0.963, =0.344). In FD patients,patients with -positive FD patients have higher depression and CGRP levels than those without infection,although their dyspepsia symptoms and HRV show no notable changes.


Subject(s)
Anxiety , Calcitonin , Calcitonin Gene-Related Peptide , Dyspepsia , Helicobacter Infections , Helicobacter pylori , Humans
7.
Kampo Medicine ; : 246-250, 2020.
Article in Japanese | WPRIM | ID: wpr-887337

ABSTRACT

Case 1 was a 28-year-old female who had epigastric discomfort and epigastralgia for three months. These symptoms were accompanied with dizziness, faintness and hot flush. Right after taking ryokeijutsukanto, her dizziness, faintness and chillness of foot disappeared with improvement of gastrointestinal symptoms after two weeks. Case 2 was a 40-year-old female who presented prolonged nausea and epigastralgia for eight months. She also complained of dizziness and strong globus sensation when taking meals. After taking ryokeijutsukanto, her appetite improved in a week and gastrointestinal symptoms improved in 3 weeks. Case 3 was a 15-year-old female whose complaints were nausea, epigastric discomfort, palpitation, dizziness and globus sensation consequent to swaying feeling after riding a roller coaster. These symptoms including nausea improved after taking ryokeijutsukanto with 3g of magnolia bark for a week. Case 4 was a 28-year-old male who presented severe appetite loss and epigastric discomfort when he got tired. He also complained of faintness. His faintness disappeared after taking ryokeijutsukanto for 2 weeks. His appetite also improved after four weeks. Clinical courses of these cases suggest that ryokeijutsukanto may be useful for the treatment of upper gastrointestinal symptoms including functional dyspepsia, i.e. fluid retention with qi-counterflow.

8.
Chinese Acupuncture & Moxibustion ; (12): 1169-1171, 2020.
Article in Chinese | WPRIM | ID: wpr-877581

ABSTRACT

OBJECTIVE@#To verify the clinical effect of acupuncture at "experienced ten acupoints" for functional dyspepsia (FD) of liver stagnation and spleen deficiency.@*METHODS@#A total of 96 patients with FD of liver stagnation and spleen deficiency were randomly divided into an observation group and a control group, 48 cases in each group. In the observation group, "experienced ten acupoint" prescription was applied,acupoints included Shangwan (CV 13), Zhongwan (CV 12), Xiawan (CV 10), Qihai (CV 6), Tianshu (ST 25), Zusanli (ST 36) and Neiguan (PC 6). In the control group, irrelevant acupoint prescription was applied, acupoints included Feiyang (BL 58), Heding (EX@*RESULTS@#Compared before treatment, the symptom score after treatment was decreased in the observation group (@*CONCLUSION@#Acupuncture at "experienced ten acupoints" can improve symptoms in patients with FD of liver stagnation and spleen deficiency, has the better clinical effect.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Dyspepsia/therapy , Humans , Liver , Spleen
9.
Article in Chinese | WPRIM | ID: wpr-873359

ABSTRACT

Objective:To explore the clinical efficacy of Chaihu Shugansan combined with saccharomyces boulardii in treating functional dyspepsia (FD) in children and the effect on serum cytokines and gastrointestinal hormones expression. Method:Totally 120 cases were divided into control group (60 cases) and observation group (60 cases).The control group was treated with Duopanlitong Pian 0.3 mg·kg-1, po, tid, and Saccharomyces boulardii 0.25 g,po,bid. The observation group was treated with Chaihu Shugansan, po,qd, and saccharomyces boulardii 0.25 g,po,bid. Four weeks was a course of treatment.The changes of serum Gastric Hunger Hormone and cytokines, Hamilton depression scale (HAMD) score, symptoms improvement time and clinical effect in the two groups were observed. And the recurrence rate was observed after 6 months follow-up. Result:The total effective rate was compared between control group (76.67%,46/60) and observation group (96.15%,57/60),with significant differences (P<0.01). After treatment, serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in both groups were decreased, while serum levels of ghrelin of both group were increased. However,the decreasing range and the increasing range of observation group were statistically obvious than those of control group (P<0.01). HAMD score and disappearance time of clinical symptoms in observation group was significantly different from those in control group (P<0.01). In adverse reactions during treatment, the control group was inferior to the observation group (P<0.05). After the 6-month follow-up, the recurrence rate in observation group was lower than that in control group (P<0.01). Conclusion:Chaihu Shugansan combined with Saccharomyces boulardii was effective in treatment of FD in children, with a low recurrence rate and good compliance. The mechanism may be related to the effective regulation of brain-intestinal axis, balance of intestinal flora, inhibition of inflammatory reaction, regulation of cytokines and gastrointestinal hormone levels.

10.
Article in Chinese | WPRIM | ID: wpr-872910

ABSTRACT

Based on the clinical characteristics of functional dyspepsia (FD), this paper analyzes and evaluates the consistency between the existing FD animal models and the clinical standards, so as to provide ideas and references for improving the FD animal model. By listing the clinical manifestations and diagnostic criteria of dyspepsia in traditional Chinese and western medicine, this paper assessed the existing animal models of functional dyspepsia, which conformed to 11.7% of the main symptoms and 5% of the secondary symptoms in clinical diagnosis criteria in western medicine, and 15% of the main symptoms and 5% of the secondary symptoms in traditional Chinese medicine(TCM). The results showed that the high degree of anastomose was affected by "high fat feed + senna leaf decoction gavage + restraint + swimming". This method basically conformed with the clinical characteristics of FD in Chinese and western medicine. The deficiency lay in the large number of modeling factors and the lack of control, which might lead to FD model deviation. The average degree of conformity involved "gavage iodoacetamide combined with small platform station", "binding" and "tail clamping stimulation", and the low degree of conformity involved "gavage iodoacetamide" and "stomach implanted electrode". The above methods simulated the characteristics of FD, but the single factor lacked the manifestation of TCM symptoms, which needed further improvement. Therefore, multiple single factor modeling methods were combined, with focus on the development and use of TCM purgative as modeling drug, so as to control the modeling process. An attempt shall be made to develop a set of time schedule of various interference factors during the modeling period of animals, in order to constantly optimize the evaluation criteria of animal models, which is the future study direction of improving FD models.

11.
China Pharmacy ; (12): 1429-1429, 2020.
Article in Chinese | WPRIM | ID: wpr-822360

ABSTRACT

OBJECTIVE:To explo re the dose-effect relationship and mechanism of protective effects of total asiaticoside (TA) on gastrointestinal motility and enteric nervous system (ENS)in aged functional dyspepsia (FD)model rats. METHODS :Aged male SD rats of 16 months old were randomly divided into blank control group ,model group ,TA low dose ,medium dose and high dose groups (15,30,60 mg/kg),with 8 rats in each group. FD model was established by tail-stimulation combined with irregular diet for 4 weeks. The next day after modeling ,administration groups were given relevant doses of TA solution intragastrically ; control group and model group were given constant volume of normal saline intragastrically ,once a day ,for consecutive 15 d. Gastric emptying rate and small intestinal propulsion rate of rats were examined. ELISA were used to detect serum contents of MTL and VIP. Immunofluorescence and immunohistochemistry were proposed to measure the expression of ENS marker (S100β and GDNF)in gastric antrum tissue. The protein expression of S 100β,GFAP,PGP9.5,GDNF,p-MEK and p-ERK 1/2 in gastric antrum tissue were measured by Western blotting assay. RESULTS :Compared with blank control group ,gastric emptying rate and small intestinal propulsion rate ,serum MTL content and protein expression of PGP 9.5 in gastric antrum tissue of model and TA low,medium dose group were decreased significantly ,while serum VIP content ,protein expressions of S 100β,GFAP,GDNF, p-MEK and p-ERK 1/2 in gastric tissue were increased significantly (P<0.05). Compared with model group ,gastric emptying rate and small intestinal propulsion rate of TA groups were increased significantly (P<0.05);except for GFAP protein in TA low dose group(P>0.05),the serum MTL content and the expression of PGP 9.5 protein in gastric antrum tissue of rats in TA groups were increased significantly ,while serum VIP content ,protein expression of S 100β,GFAP,GDNF,p-MEK and p-ERK 1/2 in gastric antrum tissue were decreased significantly (P<0.05). Some or most of the content of gastrointestinal motility indexes and related factor protein expression were significantly different among TA groups (P<0.05),and the indexes in TA high dose group could recover to the levels which were not significantly different with blank control group (P>0.05). CONCLUSIONS :TA can dose-dependently improve the gastrointestinal motility deficiency and ENS dysfunction in aged FD model rats ,especially in high dose(60 mg/kg)of TA group. Its mechanism may be related with promoting the release of endogenous MTL ,inhibiting the secretion of VIP ,expression of GDNF and the activation of downstream signaling pathway ,and promoting the repair of ENS and intestinal neurons.

12.
Article in Chinese | WPRIM | ID: wpr-802217

ABSTRACT

Integrated pharmacological approach was used to predict the target genes and signal pathways of Xiaoer Fupi granules in the treatment of functional dyspepsia(FD), and the possible mechanism was discussed. The disease target information was collected by the DISEASES and UniProt databases, integrated pharmacological platform of traditional Chinese medicine(TCM-IP) was used to predict chemical composition, target, protein gene ontology(GO) function and Kyoto encyclopedia of genes and genomes(KEGG) pathway, and the networks of candidate target and TCMs-chemical components-core targets-key pathways were constructed. A total of 2 882 potential targets and 96 candidate target pathways were predicted, and β-1,4-galactosyltransferase(β-1,4-GalT) subtypes(B4GALT4, B4GALT2, B4GALT1) and phosphorylated protein kinase C subtype D(PRKCD), adenylate cyclase 2(ADCY2) and other targets were predicted. Some pathways were enriched, such as nervous system, endocrine system, thyroid hormone signaling pathway, long-term depression and other pathways related to FD. It was predicted that Xiaoer Fupi granules for treating FD by regulating gastrointestinal hormones, anti-depression, and regulating nerves and endocrine system. This study provides a basis for the precise clinical application and positioning of Xiaoer Fupi granules, and helps to clarify the mechanism of this drug.

13.
Article in Chinese | WPRIM | ID: wpr-800501

ABSTRACT

Objective@#To evaluate the efficacy of cognitive-behavioral therapy (CBT) combined with mirtazapine for patients with functional dyspepsia (FD).@*Methods@#Totally 121 patients with FD who met Rome Ⅳ diagnostic criteria in clinic of clinical psychiatry of a general hospital were collected.They were randomly divided into combined treatment group(n=61) and single drug group(n=60). The treatment period was 8 weeks.All patients with FD were given mirtazapine.The combined treatment group received 8 times systemic CBT treatments at the same time.Symptom checklist-90 (SCL-90) and gastrointestinal integral scale (GIS) were evaluated in all patients before and after 8-week intervention.@*Results@#After 8 weeks of intervention, the total score of SCL-90 scale, somatization, compulsion, depression, paranoia and other factors in the combined treatment group were lower than those in the single group(130.26±36.18 vs 147.95±45.55, 1.34±0.44 vs 1.51±0.5, 1.66±0.50 vs 1.90±0.66, 1.47±0.52 vs 1.69±0.63, 1.48±0.49 vs 1.70±0.61, 1.47±0.50 vs 1.73±0.68, respectively)(all P<0.05). After 8 weeks of intervention, the total score of the GIS scale in the combined treatment group (6.77±5.05 vs 9.49±5.24), vomiting (0.57±0.77 vs 0.88±0.91), spastic upper abdominal pain (0.43±0.74 vs 0.90±1.08) and post-sternal discomfort (0.57±0.89 vs 1.05±1.19) were significantly lower than that of the simple drug group after intervention(6.77±5.05 vs 9.49±5.24, 0.57±0.77 vs 0.88 ±0.91, 0.43±0.74 vs 0.90±1.08 and 0.57±0.89 vs 1.05±1.19, respectively), and the differences were statistically significant (all P<0.05).@*Conclusion@#CBT combined with mirtazapine in the treatment of FD is superior to drug therapy alone.CBT combined with mirtazapine can improve the emotional problems in the treatment of FD and further improving the digestive function.

14.
Article in Chinese | WPRIM | ID: wpr-798362

ABSTRACT

Objective: To discuss the clinical efficacy of modified Sinisan (Qizhi Weitong granule) and saccharomyces boulardi in treating functional dyspepsia (FD) in children, and its effect on changes in serum cytokine and gastrointestinal hormones.Method: Totally 156 cases were divided into control group (78 cases) and observation group (78 cases). The control group was treated with saccharomyces boulardi, 0.25 g, po, bid, after meal. In addition to the therapy of control group, the observation group was also given modified Sinisan (Qizhi Weitong granule), 2.5 g, po, tid, 30 minutes before meal. Four weeks was a course of treatment. Then the clinical efficacy, the time of symptom improvement and the change of serum cytokine and gastrointestinal hormones were observed.Result: The total effective rate of observation group (96.15%) was higher than that of control group (82.05%), with statistical difference (Pγ(IFN-γ), tumor necrosis factor-α(TNF-α), plasma motilin(MTL) and Leptin of both groups had no statistical difference before treatment. After treatment, the serum levels of IL-10, MTL of both group were increased, while the serum levels of IFN-γ, TNF-α, Leptin of both group were decreased. However, the decreasing range and the increasing range of observation group were statistically obvious than those of control group (PConclusion: Modified Sinisan(Qizhi Weitong granule) combined with saccharomyces boulardi have an obvious clinical efficacy in treating child's FD, with a low recurrence. The mechanism may be correlated with the effect of integrated Chinese and Western medicines in regulating serum cytokine and gastrointestinal hormones levels.

15.
Article in Chinese | WPRIM | ID: wpr-861832

ABSTRACT

Background: Patients with functional dyspepsia (FD) often complicated with anxiety. Recognizing effectively the risk factors of anxiety is helpful for the precise treatment with anti-anxiety drug, which can improve the prognosis of patients. Aims: To explore the clinical characteristics and risk factors of FD patients with anxiety. Methods: A total of 295 FD patients from June 2014 to September 2014 at the Second Xiangya Hospital of Central South University were enrolled. Hamilton Anxiety Rating Scale was used to evaluate the anxiety in FD patients. Risk factors of anxiety in FD patients were analyzed. Results: In this study, the incidence of anxiety was 8.1% (24/295) in FD patients. Univariate analysis showed that age, disease duration, marriage status, psychosis history and history of administration of psychotropic drugs were related to the anxiety in FD patients (P<0.05). Multivariate analysis showed that disease duration, marriage status and psychosis history were the risk factors for anxiety in FD patients (P<0.05). Conclusions: Long disease duration, incomplete marriage, and psychosis history are the risk factors for anxiety in FD patients, routine anxiety screening should be carried out in these patients.

16.
Acupuncture Research ; (6): 486-491, 2019.
Article in Chinese | WPRIM | ID: wpr-844284

ABSTRACT

OBJECTIVE: To explore the effect of electroacupuncture (EA) at "Zusanli" (ST36) on gastrointestinal motility and expression of autophagy marker LC3 and autophagy signaling pathway molecule AMP-activated protein kinase (AMPK) in rats with functional dyspepsia (FD), so as to explore its mechanisms underlying improvement of FD. METHODS: A total of 40 male SD rats were randomly divided into blank control, model, EA, AMPK inhibitor and EA+AMPK inhibitor groups, with 8 rats in each group. The FD model was established by tail-clip (30 min/time, twice daily) + single day feeding, and gavage of normal saline (2 mL/time, twice a day) for 2 successive weeks. For rats of EA and EA+AMPK inhibitor groups, EA (4 Hz, 1.0 mA) was applied to bilateral ST36 for 20 min, once daily for 7 successive days. For rats of the AMPK-inhibitor and EA+AMPK inhibitor groups, Compound C (20 mg/kg) solution was administered by intraperitoneal injection before every EA administration. The gastric residual rate and small intestinal transit rate were calculated based on the weight of stomach and length of ink propelling and total small intestine, respectively. The expression levels of c-kit, microtubule-associated protein 1 light chain 3, Beclin 1, phosphorylated (p)-AMPK and p-unc-51 like autophagy activating kinase 1(ULK1) in the gastric antrum tissue were detected by using Western blot. RESULTS: Compared with the blank control group, the gastric residual rate and the expression levels of LC3-Ⅱ/LC3Ⅰ, Beclin 1, p-AMPK and p-ULK1 proteins were significantly increased, and the small intestinal transit rate and the expression of c-kit protein obviously decreased in the model group (P0.05). CONCLUSION: EA at ST36 can promote gastrointestinal motility in FD rats, which is possibly mediated by inhibiting excessive autophagy of interstitial cells of Cajal via down-regulating AMPK/ULK1 signaling.

17.
China Pharmacy ; (12): 473-477, 2019.
Article in Chinese | WPRIM | ID: wpr-817090

ABSTRACT

OBJECTIVE: To study improvement effects of Fuling gancao decoction on functional dyspepsia (FD) model rats. METHODS: Sixty SD rats were randomly divided into normal group, model group, Fuling gancao decoction high-dose group (20 g/kg), Fuling gancao decoction low-dose group (10 g/kg), drug combination group (Fuling gancao decoction 10 g/kg+domperidone 0.004 g/kg), domperidone group (0.004 g/kg), with 10 rats in each group. Except for normal group, other groups were givenicy dilute hydrochloric acid intragastrically to establish FD model.  After modeling, normal group and model group were given constant volume of distilled water at room temperature intragastrically, and other groups were given relevant drug solution (1 mL/100 g) intragastrically, once a day, for consecutive 7 d. The amount of gastric residue was measured to evaluate the gastric emptying function. Immunohistochemistry SP method was used to detect the protein expression of AQP3, Ghrelin and Substance P in gastric mucosa tissue. The protein expression of Claudin-1, Occludin and VIP were detected by Western blot assay. RESULTS: Compared with normal group, the amount of gastric residue was increased significantly in model group (P<0.01); positive expression of AQP3 and Ghrelin protein in gastric mucosa tissue was decreased significantly, while the positive expression of Substance P protein tended to increase; the protein expression levels of AQP3, Ghrelin, Claudin-1 and Occludin were decreased significantly, while those of Substance P and VIP were increased significantly (P<0.05 or P<0.01). Compared with model group, the amount of gastric residue was decreased significantly in administration groups (P<0.05 or P<0.01); the positive expression of AQP3 and Ghrelin protein tended to increase, while less positive expression of Substance P was found; the protein expression levels of AQP3 and Occludin in gastric mucosa tissue were increased significantly in administration groups, while those of VIP were decreased significantly  (P<0.05 or P<0.01); the protein expression levels of Ghrelin and Claudin-1 in gastric mucosa tissue were increased significantly in Fuling gancao decoction high-dose group, Fuling gancao decoction low-dose group and drug combination group, while those of Substance P were decreased significantly (P<0.05). CONCLUSIONS: Fuling gancao decoction may improve the symptom of fluid retention in FD model rats by up-regulating the protein expression of AQP3, Ghrelin, Claudin-1 and Occludin and down-regulating the protein expression of Substance P and VIP in gastric mucosa tissue of rats.

18.
China Pharmacy ; (12): 684-688, 2019.
Article in Chinese | WPRIM | ID: wpr-817075

ABSTRACT

OBJECTIVE: To investigate the effects of Lindera aggregate of stir-baking with vinegar-Aucklandia lappa on gastric emptying and gastrointestinal hormones in functional dyspepsia liver depression and qi stagnation (FDLDQS) model rats. METHODS: Totally 60 SD rats were randomly divided into blank group (n=10) and modeling group (n=50); FDLDQS model was induced by chronic stress restraint or food deprivation or excessive fatigue in modeling group. After modeling, model rats were randomly divided into model group (normal saline), L. aggregate of stir-baking with vinegar group (1.62 g/kg, calculated by crude drug), A. lappa group (1.62 g/kg, calculated by crude drug), L. aggregate of stir-baking with vinegar-A. lappa group (1 ∶ 1, m/m,1.62 g/kg, calculated by crude drug) and mosapride group (positive control, 1.35 mg/kg), with 10 rats in each group. Administration groups were given relevant medicine intragastrically once a day; blank group and model group were given constant volume of normal saline intragastrically, for consecutive 14 d. 2 h after last medication, gastric emptying rate and small intestinal propulsion rate of rats in each group were measured by phenol red content method. After HE staining, the morphological changes of antrum tissue were observed under microscope. The contents of motilin (MTL), gastrin (GAS) and cholecystokinin (CCK) in serum were determined by ELISA method. RESULTS: Compared with blank group, gastric emptying rate and small intestinal propulsion rate of rats were decreased significantly in model group (P<0.01); the serum contents of MTL and GAS were decreased significantly (P<0.01), while the content of CCK was increased significantly (P<0.01). No organic damage was found in all model groups. Compared with model group, L. aggregate stir-baking with vinegar group and A. lappa group, gastric emptying rate and small intestinal propulsion rate of rats were increased significantly in L. aggregate of stir-baking with vinegar-A. lappa group and mosapride group (P<0.05 or P<0.01); serum contents of MTL and GAS were increased significantly (P<0.01), while the content of CCK was decreased significantly (P<0.01). CONCLUSIONS: L. aggregate of stir-baking with vinegar-A. lappa can accelerate gastric emptying and small intestinal propulsion rate of FDLDQS rats, increase serum contents of MTL and GAS but decrease the content of CCK; its effects are better than that of them alone.

19.
Article in English | WPRIM | ID: wpr-776624

ABSTRACT

OBJECTIVE@#To evaluate the effect of Zhizhu Kuanzhong Capsules (, ZKC) for functional dyspepsia (FD) through meta-analysis.@*METHODS@#Online databases, including PubMed, EM base, China National Knowledge Infrastructure, Wanfang Data, VIP database and Cochrane Library, were searched for randomized controlled trials (RCTs) of ZKC for FD from the inception to April, 2016. Trials were selected according to inclusion criteria and were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions and Jadad scale. RevMan 5.3 and GRADEprofiler 3.6 were used for statistical analysis and evidence quality assessment.@*RESULTS@#Twenty-three trials with 2,496 patients were included and most of them were of poor methodological quality. ZKC alone or ZKC combined with routine Western medicine (WM) showed a better clinical effect rate compared with the control group of WM [odds ratio (OR)=3.32, 95% confidence interval (2.66, 4.15), P<0.00001]. No serious adverse reactions were reported.@*CONCLUSIONS@#ZKC alone or ZKC combined with routine WM could significantly improve the clinical effective rate in the treatment of FD. The quality of the evidence is low, so it is necessary to design multicenter, strictly randomized and double-blind controlled trials with large samples to validate the conclusions.

20.
Chinese Acupuncture & Moxibustion ; (12): 1089-1091, 2019.
Article in Chinese | WPRIM | ID: wpr-776208

ABSTRACT

Professor -'s clinical experience of acupuncture and Chinese herbal medicine on functional dyspepsia is introduced. Inview of the treatment based on syndrome differentiation, professor uses acupuncture with Chinese herbal medicine, psychological counseling and regular diet, etc. to treat functional dyspepsia comprehensively. In terms of syndrome differentiation, six-meridian and visceral syndrome differentiation are selected;methods such as soothing liver and regulating , invigorating spleen and stomach are adopted as the treatment principle; meridians are mainly the conception vessel, stomach meridian of foot- and spleen meridian of foot-; acupoints are mainly selected with "new ten needles" and both internal and external treatment are advocated; needling method is fast twisting needle insertion; manipulation is adopted with directional supplementation and draining method; and the combination of acupuncture and Chinese herbs is adopted on the treatment. Regular diet, standardized work and rest, five elements music therapy for psychological intervention, give patients positive psychological hints, to achieve the effect of both body and mind.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Drugs, Chinese Herbal , Dyspepsia , Therapeutics , Humans , Meridians , Treatment Outcome
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