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Chinese Pharmaceutical Journal ; (24): 1381-1386, 2017.
Article in Chinese | WPRIM | ID: wpr-858602


Heterogeneous liquid preparations are widely used in clinic, and played an important role in pharmaceutical preparations. But at the same time, since the instability of the physical and chemical properties of the heterogeneous liquid preparation, the dispersed particles have a large specific surface energy and form a thermodynamic unstable system. Especially when in the traditional Chinese medicine liquid preparation, which has a large number of unknown non quantitative components, can easily appear the phenomenon of subsidence, coalescence, stratification and phase inversion during the storage process. Therefore, it is of great significance to study the stability observation and prediction of heterogeneous liquid preparation for its prescription design, production process screening, quality evaluation, storage and transportation. However, only in the fields of food, beverage, cosmetics and other related fields have some research at home and abroad for the moment, and we fond there are few reports on heterogeneous liquid formulations. This paper attempts to study the methods of stability prediction in the fields mentioned above, and then we expect to provide a reference for the establishment of rapid, accurate, economic, scientific and objective prediction methods of the heterogeneous liquid preparation.