Validación de contenido y fiabilidad del instrumento "Conocimiento, actitud y comportamiento sobre hidratación y reposición de líquidos", en deportistas chilenos

Introducción: Existen estrategias direccionadas a mejorar el rendimiento de los deportistas, algunas estableciendo recomendaciones respecto a la hidratación y reposición de líquidos, con el propósito de asegurar un balance hídrico adecuado en todas las etapas de la práctica deportiva. Sin embargo, existe una carencia de instrumentos adecuados y confiables que permitan explorar esta temática. Objetivo: La presente investigación tiene como objetivo validar por contenido y evaluar la fiabilidad del instrumento "Conocimiento, actitud y comportamiento respecto a la hidratación y reposición de líquidos" en deportistas adolescentes y adultos jóvenes en Chile. Métodos: La adaptación cultural se realizó a través del método Delphi con un panel de expertos en el área, para la evaluación de la fiabilidad se aplicó el cuestionario de manera online a una muestra de 384 deportistas de diferentes disciplinas en dos oportunidades para determinar la estabilidad temporal. Resultados: Todos los ítems lograron porcentajes de acuerdo superior al 80% según el estadístico V de Aiken, en relación con la fiabilidad se obtuvo un Alfa de Cronbach de 0,78 lo que evidencia una consistencia interna aceptable, adicionalmente se obtuvo un Coeficiente de Correlación intraclase de 0,64 entre las dos aplicaciones del cuestionario presentando una fiabilidad regular a buena. Conclusión: Este cuestionario puede ser empleado como una herramienta confiable para ser utilizada en futuras investigaciones en el área de la nutrición deportiva, además como un instrumento que aporta al quehacer de distintos profesionales para apoyar a planificar y evaluar estrategias que propendan al mejoramiento del rendimiento deportivo.

Introduction: There are strategies aimed at improving the performance of athletes, some of which establish recommendations regarding hydration and fluid replacement, with the purpose of ensuring an adequate water balance at all stages of sports practice. However, there is a lack of adequate and reliable instruments to explore this issue. Objective: The present research aims to validate the content and evaluate the reliability of the instrument "Knowledge, attitude and behavior regarding hydration and fluid replacement" among adolescent and young adult athletes in Chile. Methods: The cultural adaptation was carried out through the Delphi method with a panel of experts in the area. For the evaluation of reliability, the questionnaire was applied online to a sample of 384 athletes from different disciplines on two occasions to determine temporal stability. Results: All items achieved percentages of agreement higher than 80% according to Aiken's V statistic, in relation to reliability a Cronbach's Alpha of 0.78 was obtained, which shows an acceptable internal consistency, additionally an intraclass Correlation Coefficient of 0.64 was obtained between the two applications of the questionnaire presenting a regular to good reliability. Conclusion: This questionnaire can be used as a reliable tool for future research around sports nutrition, as well as an instrument that contributes to the work of different professionals to support the planning and evaluation of strategies aimed at improving sports performance.

Effects of water drinking on corneal biomechanics: The association with intraocular pressure changes

Purpose: We aimed to assess the impact of drinking water (500 and 1000 mL) on corneal biomechanics and determine the level of association between changes in intraocular pressure and variations in the different biomechanical properties of the cornea. Methods: A total of 39 healthy young adults ingested either 1000 mL (n = 21) or 500 mL (n = 18) of tap water in 5 min. The CorVis ST system was used to assess corneal biomechanics at baseline and at 15, 30, and 45 min after water ingestion. Results: Water drinking induced statistically significant changes in the deformation amplitude (P < 0.001, ?� = 0.166), highest concavity time (P = 0.012, ?� = 0.093), peak distance (P < 0.001, ?� = 0.171), time and velocity of the first applanation (P < 0.001, ?� = 0.288 and P = 0.016, ?� = 0.087, respectively), and time and velocity of the second applanation (P = 0.030, ?� = 0.074 and P = 0.001, ?� = 0.132, respectively), being independent of the amount of water ingested (P > 0.05 in all cases). There were significant associations between changes in intraocular pressure and some parameters of corneal biomechanics. Conclusion: Small variations in whole?body hydration status alter different biomechanical properties of the cornea, with these changes being associated with intraocular pressure levels. These findings indicate that whole?body hydration status can be considered for the diagnosis and management of different ocular conditions.

Fluid intake, hydration status and body mass changes in U-15 judo athletes during a training day

Despite numerous studies related to dehydration there is still a lack of scientific literature presenting hydration status and fluid intake of judo athletes during different periods. Therefore, the aim of this study was to investigate, fluid intake, hydration status and body weight changes of young judo athletes during a typical day of training in preparation period. Twenty-two young judo athletes (age: 12 ± 0.7 y, experience: 3.5 ± 1.1) voluntarily participated in this study. Hydration status and weight were examined in the morning, before and immediately after the training. All athletes trained 90 min and they consumed fluids ad libitum during the exercise. According to morning urine specific gravity (USG) values, 81.2% of the athletes were dehydrated while only 18.8% of the athletes were euhydrated. Pre-training urine measurements showed that 63.64% of the athletes presented dehydration and 77.27% of the athletes completed the training in dehydrated condition despite fluid availability during the training. Mean body weight loss during training was -0.64 ± 0.66%. It can be concluded that young judo athletes presented high prevalence of dehydration as indicated by USG values. Most of the athletes were dehydrated during a typical training day and completed the training in more dehydrated conditions compared to pre training values despite ad libitum fluid intake. It is of great importance to evaluate hydration status of the athletes before training to refrain from common practice of fluid restriction for weight loss and adverse effects of a persistent state of fluid deficit on physical and health related state.

Does dry skin indicate defective epidermal permeability barrier? / 中华皮肤科杂志

It has been speculated that dry skin results from dysfunction of epidermal permeability barrier. But so far, there is no sufficient evidence to support this speculation. In fact, dry skin indicates low levels of stratum corneum hydration. Stratum corneum hydration levels are primarily determined by the content of natural moisturizers in the skin, while epidermal permeability barrier is mainly regulated by intercellular lipids and structural proteins in the stratum corneum. If dry skin is due to a defective permeability barrier, stratum corneum hydration levels should be inversely correlated with transepidermal water loss (TEWL) , an indicator of epidermal permeability barrier function. But no negative correlation has been demonstrated between stratum corneum hydration levels and TEWL in either normal human skin, ichthyoses lesions of patients, or sebaceous gland-deficient mice in a number of studies. In contrast, a positive correlation between stratum corneum hydration levels and TEWL was observed in normal human skin. Taken together, a line of evidence suggests that dry skin unlikely indicates epidermal permeability barrier dysfunction.

Quantificação de substâncias do fator de hidratação natural (NMF) do estrato córneo ex vivo em função do fototipo e idade / Ex vivo quantification of natural hydration factor (NMF) substances in the stratum corneum as a function of phototype and age

A hidratação cutânea ocorre, em parte, pelos componentes do Fator de Hidratação Natural (NMF), originados da degradação da filagrina, sendo alguns exemplos o ácido pirrolidona-carboxílico (PCA), o ácido urocânico (UCA) e a histidina (His). Estes estão presentes no estrato córneo (EC). O objetivo deste projeto de pesquisa foi determinar, por cromatografia líquida de alta eficiência (CLAE), o PCA, o UCA e a His no estrato córneo de participantes obtido por tape stripping em função do fototipo e idade do participante da pesquisa. Participantes foram selecionados em função da idade acima de 18 anos, ambos os gêneros e fototipo da pele entre I a VI, de acordo com a classificação de Fitzpatrick. As amostras do EC foram obtidas do antebraço volar por tape stripping e irradiadas artificialmente. A cromatografia líquida de alta eficiência (CLAE) foi eficaz para separação e quantificação adequada das substâncias químicas His, PCA e os isômeros de UCA (trans-UCA e cis-UCA) no estrato córneo dos participantes. O método apresentou-se seletivo e ausente de interferentes, ademais, possuiu linearidade e limites de detecção e quantificação compatíveis com os objetivos dessa investigação. No fototipo I, os níveis de His foram menores em comparação aos demais grupos. Ademais, os níveis dessa mesma substância não apresentaram diferença entre as faixas etárias. Em função da irradiação das amostras, o montante de His aumentou em todos os fototipos. Os níveis de PCA apresentaram-se menores após a irradiação em todos os fototipos de pele. Ainda, as concentrações do PCA foram mais elevadas na faixa etária de 46 a 55 anos de idade. Os níveis de concentração do isômero cis-UCA foram maiores nos participantes com fototipo III, após a irradiação UV. Os níveis de concentração do isômero trans-UCA diminuíram após a irradiação, de forma proporcional à formação de cis-UCA em todos os fototipos. A faixa etária de 46-55 anos de idade obteve níveis significativamente menores de trans-UCA e cis-UCA

Cutaneous hydration occurs, in part, by the components of the Natural Hydration Factor (MFN), originating from the degradation of filagrina, some examples being pyrrolidone-carboxylic acid (PCA), urocanic acid (UCA) and histidine (His). These are present in the stratum corneum (SC). The objective of this research project was to determine, by high efficiency liquid chromatography (HPLC), the PCA, UCA and His in the stratum corneum of participants obtained by tape stripping due to the phototype and age of the research participant. Participants were selected according to age above 18 years, both genders and skin phototype between I and VI, according to Fitzpatrick's classification. The SC samples were obtained from the volar forearm by tape stripping and artificially irradiated. High efficiency liquid chromatography (HPLC) was effective for the separation and proper quantification of the chemicals His, PCA and UCA isomers (trans-UCA and cis-UCA) in the stratum corneum of the participants. The method was selective and absent from interfering, in addition, it had linearity and limits of detection and quantification compatible with the objectives of this investigation. In phototype I, His levels were lower compared to the other groups. Moreover, the levels of this same substance showed no difference between age groups. Due to the irradiation of the samples, the amount of His increased in all phototypes. PCA levels were lower after irradiation in all skin phototypes. Furthermore, PCA concentrations were higher in the age group from 46 to 55 years of age. The concentration levels of the cis-UCA isomer were higher in participants with phototype III after UV irradiation. The concentration levels of the trans-UCA isomer decreased after irradiation, proportionally to the formation of cis-UCA in all phototypes. The age group 46-55 years of age obtained significantly lower levels of trans-UCA and cis-UCA

Perfil de composición corporal en militares élite chilenos / Body composition profile of elite Chilean military

RESUMEN: La Bioimpedancia Eléctrica (BIA), al ser una técnica no invasiva pero de elevada precisión, se ha convertido en la actualidad en una herramienta valiosa para determinar la composición corporal en militares, facilitado el control de las distintas variables que se asocian a cada especialidad. El objetivo del presente estudio fue describir el perfil de composición corporal en militares de elite al momento de finalizar un curso de especialización. Participaron 11 militares con un rango de edad entre 22 y 29 años. Se evalúo la composición corporal a través de BIA, inmediatamente después de finalizado un curso de especialización para militares de élite. Las evaluaciones en los militares sobre las variables de la composición corporal a través de BIA mostraron: peso corporal de 84,3 ± 4,52 kg, talla 1,78 ± 0,06 m, índice de masa corporal (IMC) 26,5 ± 1,09, tejido adiposo de 13,7 ± 3,65 %, tejido muscular 49,5 ± 2,34 %, masa libre de grasa 72,7 ± 5,23 kg y 53,2 ± 3,78 l de agua corporal total. Conclusiones: Los militares de elite presentaron elevados niveles de masa libre de grasa, tejido muscular y bajos niveles de tejido adiposo lo que favorece el desarrollo de las actividades militares especializadas y disminuye el riesgo de lesiones. Los datos aquí recogidos sirven como marco de referencia para futuros estudios.

SUMMARY: Electrical bioimpedance (BIA), being a non- invasive technique but with high precision, has become a valuable tool for determining body composition in the military, facilitating the control of the different variables associated with each specialty. The aim of the present study was to describe the body composition profile of elite military personnel at the end of a specialization course. Eleven military personnel between 22 and 29 years of age participated in the study. Body composition was assessed by BIA immediately after completion of a specialization course for elite military personnel. Assessments in the military on body composition variables through BIA showed: body weight of 84.3 ± 4.52 kg, height 1.78 ± 0.06 m, body mass index (BMI) 26.5 ± 1.09, adipose tissue of 13.7 ± 3.65 %, muscle tissue 49.5 ± 2.34 %, fat free mass 72.7 ± 5.23 kg and 53.2 ± 3.78 l of total body water. Conclusions: Elite military personnel presented high levels of fat free mass, muscle tissue and low levels of adipose tissue which favors the development of specialized military activities and decreases the risk of injury. The data collected here serve as a frame of reference for future studies.

Study on the effect of small alcohol on lipid hydration and liposome formation / 生物医学工程学杂志

Liposomes with precisely controlled composition are usually used as membrane model systems to investigate the fundamental interactions of membrane components under well-defined conditions. Hydration method is the most common method for liposome formation which is found to be influenced by composition of the medium. In this paper, the effects of small alcohol (ethanol) on the hydration of lipid molecules and the formation of liposomes were investigated, as well as its coexistence with sodium chloride. It was found that ethanol showed the opposite effect to that of sodium chloride on the hydration of lipid molecules and the formation of liposomes. The presence of ethanol promoted the formation of liposomes within a certain range of ethanol content, but that of sodium chloride suppressed the liposome formation. By investigating the fluorescence intensity and continuity of the swelled membranes as a function of contents of ethanol and sodium chloride, it was found that sodium chloride and ethanol showed the additive effect on the hydration of lipid molecules when they coexisted in the medium. The results may provide some reference for the efficient preparation of liposomes.

Interpretation of ESPEN practical guideline: clinical nutrition and hydration in geriatrics / 中华消化外科杂志

Malnutrition and dehydration are prevalent in the elderly poplulation, and obesity is also a growing problem, which pose a serious challenge to the nutritional management in geriatrics. In order to better guide clinical practice, the European Society for Clinical Nutrition and Metabolism (ESPEN) published the practical guideline on clinical nutrition and hydration in geria-trics on March 5, 2022. This guideline provides 82 recommendations on clinical nutrition and hydration in geriatrics based on clinical practicability, covering basic problems and general prin-ciples, prevention and treatment of malnutrition/nutri-tional risk, prevention and treatment of specific diseases, as well as prevention and treatment of obesity, along with flow-charts, hoping to be convenient for doctors, nutritionists and nurses to use in clinical practice.

Female nurses have a higher prevalence of urinary tract symptoms and infection than other occupations in dialysis units / Técnicas de enfermagem têm uma prevalência maior de sintomas e infecções do trato urinário do que outras ocupações em unidades de diálise

Abstract Introduction: Urinary tract symptoms and infection have been associated with occupational factors that impact hydration habits particularly in women. We compared self-reported urinary symptoms and infection and hydration habits between nurses and other occupations in dialysis units. Methods: Cross-sectional study. Participants worked in five nephrology centers in Brazil and answered an online questionnaire comprising questions regarding urinary tract symptoms and infection episodes in the preceding year; data on usual daily beverage intake, urine frequency, and urine color according to a urine color chart were also collected, as well as perceptions of water access and toilet adequacy at work. Results: We included 133 women (age=36.9±9.5 years). The self-reported usual daily beverage intake was 6.6±2.9 cups/day (~1320 mL), daily urine frequency was 5.4±2.1, and urine color chart score: 3.0±1.2. Nurses (N=66/49.6%) reported higher prevalence of burning sensation (50 versus 27%; P<0.001), urinary urgency (42 versus 21%; P<0.001), and infection (42% versus 25%; P=0.04) as well as lower liquid intake (6.0±2.6 versus 7.3±3.0 cups/day; P=0.01) than controls. Forty four percent of nurses reported being able to drink when thirsty "always" and "most of the time" versus 93% of the control group. Conclusion: Dialysis female nurses reported lower beverage intake and higher prevalence of symptoms and infection than other occupations in the same environment. Interventions to improve hydration can potentially decrease urinary problems in this population.

Resumo Introdução: Sintomas e infecções do trato urinário têm sido associados a fatores ocupacionais que afetam hábitos de hidratação, particularmente em mulheres. Comparamos sintomas e infecções urinárias autorrelatados e hábitos de hidratação entre técnicas de enfermagem e outras ocupações em unidades de diálise. Métodos: Estudo transversal. As participantes trabalhavam em cinco centros de nefrologia no Brasil e responderam um questionário online contendo perguntas sobre sintomas do trato urinário e episódios de infecção no ano anterior; também foram coletados dados sobre a ingestão diária habitual de bebidas, frequência e cor da urina de acordo com uma tabela de cores da urina, assim como percepções sobre o acesso à água e adequação das instalações sanitárias no trabalho. Resultados: Incluímos 133 mulheres (idade=36,9±9,5 anos). Em média, as participantes relataram ingestão de bebidas de 6,6±2,9 copos/dia (~1320 mL), frequência urinária de 5,4±2,1 vezes/dia e escore da tabela de cores da urina de 3,0±1,2. Técnicas de enfremagem (N=66/49,6%) relataram maior prevalência de sensação de ardor (50 versus 27%; P<0,001), urgência urinária (42 versus 21%; P<0,001), e infecção (42% versus 25%; P=0,04), bem como menor ingestão de líquidos (6,0±2,6 versus 7,3±3,0 copos/dia; P=0,01) do que controles. Quarenta e quatro por cento das técnicas de enfermagem relataram poder beber quando têm sede "sempre" e "na maioria das vezes" contra 93% do grupo controle. Conclusão: Técnicas de enfermagem de unidades de diálise relataram menor ingestão de bebidas e maior prevalência de sintomas e infecção do que outras ocupações no mesmo ambiente de trabalho. Intervenções para melhorar a hidratação podem diminuir problemas urinários nesta população.

The Hydration Status of Female Collegiate Soccer Players Over Consecutive Training and Match Days / Estado de Hidratación de Jugadoras de Fútbol Universitarias Durante Días de Entrenamiento y Partidos Consecutivos

Abstract Purpose: Hydration has been shown to play a pivotal role in sport. Soccer is a team sport in which the integrity of all players is vital for team performance; thus, individual player hydration status is important. The primary aim of this study was to investigate the hydration status of female collegiate soccer players during regular season. Methods: Sixteen collegiate female soccer players (age: 20.4 ± 0.8 years; height: 163.6 ± 6.9 cm; weight: 65.3 ± 12 kg) provided urine over 9 days to monitor their hydration status. Hydration was determined by urine specific gravity (Usg). Usg was analyzed in the morning (AM) and in the afternoon before practice/game (PM). Results: All 16 players were at least minimally hypohydrated (Usg > 1.010) in the AM on 5 of the 9 days tested. Players had significantly higher Usg values in the AM as compared to PM (F(1,250) = 23.09; p < 0.0001); however, there was no significant time*day interaction (F(1,250) = 1.98; p = 0.16). Conclusion: Data show a high prevalence of hypohydration occurring in this specific population. This sub-optimal hydration status could be a cause for concern in terms of overall performance. Efforts should be made to integrate hydration interventions and daily monitoring to minimize hypohydration in players.

Resumen Propósito: Se ha demostrado que la hidratación juega un papel fundamental en el deporte. El fútbol es un deporte de equipo en el que la integridad de todos los jugadores es vital para su rendimiento; por lo tanto, el estado de hidratación de cada jugador es importante. El objetivo principal de este estudio fue investigar el estado de hidratación de las jugadoras universitarias de fútbol durante la temporada regular. Métodos: Dieciséis jugadoras universitarias de fútbol (edad: 20.4 ± 0.8 años; estatura: 163.6 ± 6.9 cm; peso: 65.3 ± 12 kg) proporcionaron muestras de orina durante 9 días para controlar su estado de hidratación, la cual se determinó por la gravedad específica de la orina (Usg). La Usg se analizó en la mañana (AM) y en la tarde antes del entrenamiento o el juego (PM). Resultados: Las 16 jugadoras estaban al menos mínimamente hipohidratadas (Usg > 1.010) en la AM en 5 de los 9 días medidos. Las jugadoras tuvieron valores Usg significativamente más altos en AM en comparación con PM (F (1,250) = 23.09; p < 0.0001); sin embargo, no hubo interacción significativa de tiempo * día (F(1,250) = 1.98; p = 0.16). Conclusión: los datos muestran una alta prevalencia de hipohidratación en esta población específica. Este estado de hidratación subóptimo podría ser motivo de preocupación en términos de rendimiento general. Se deberían hacer esfuerzos para integrar las intervenciones de hidratación y el monitoreo diario para reducir al mínimo la hipohidratación en las jugadoras.

Resumo Objetivo: Foi demonstrado que a hidratação desempenha um papel fundamental no esporte. O futebol é um esporte coletivo no qual a integridade de todos os jogadores é vital para o desempenho da equipe; portanto, o estado de hidratação de cada jogador é importante. O objetivo principal deste estudo foi investigar o estado de hidratação de universitárias jogadoras de futebol do sexo feminino durante a temporada regular. Métodos: Dezesseis universitárias jogadoras de futebol (idade: 20,4 ± 0,8 anos; altura: 163,6 ± 6,9 cm; peso: 65,3 ± 12 kg) forneceram amostras de urina por 9 dias para monitorar seu estado de hidratação. A hidratação foi determinada pela gravidade específica da urina Usg. Sua Usg foi analisado pela manhã (matutino) e à tarde (vespertino) antes do treino ou jogo. Resultados: As 16 jogadoras estavam minimamente hipohidratadas (Usg > 1.010) no período matutino em 5 dos 9 dias medidos. As jogadoras apresentaram valores de Usg significativamente maiores no período matutino em comparação ao vespertino (F (1.250) = 23,09; p <0,0001); no entanto, não houve interação tempo * dia significativa (F (1.250) = 1,98; p = 0,16). Conclusão: os dados mostram uma alta prevalência de hipohidratação nesta população específica. Este estado de hidratação abaixo do ideal pode ser uma preocupação em termos de desempenho geral. Devem ser feitos esforços para integrar intervenções de hidratação e monitoramento diário para minimizar a hipohidratação em jogadoras.

Elite Croatian junior taekwondo competitors: morphological characteristics and body composition reference values / Competidores croatas de taekwondo junior de élite: características morfológicas y valores de referencia de composición corporal

SUMMARY: The main purpose of this study was to determine the body composition and anthropometric reference values of male and female junior Croatian taekwondo competitors according to official weight category. Additional aim of the study was to identify possible differences in variables between the weight categories. The sample comprised 247 junior participants of the national taekwondo championships divided into male (N=121) and female (N=126). The variable sample was defined by a set of 8 measurements: Body height (cm), Body mass (kg), Body mass index, Body fat (%), Body fat (kg), Muscle mass (kg), Lean body mass (kg) and Total body water (%). Results confirm previous studies proving that younger taekwondo practitioners have higher levels of body fat than their more experienced peers (seniors). Significant differences were only found between lean and heavy categories. Male junior taekwondo athletes show total body water percentages from 57.4 to 74.8 %, with significantly lower percentages in higher weight categories, while female athletes in heigher categories demonstrate a worrying level of hydration status, therefore endangering their performance and overall health. As the first paper that investigates the reference values of junior taekwondo athletes but based on official weight categories it is especially important as each weight category warrant different body composition requirements, as seen from significant differences across different variables. Future studies should include motor abilities inspection throughout the weight categories and possible use of calculation of metabolic age.

RESUMEN: El objetivo principal de este estudio fue determinar la composición corporal y los valores de referencia antropométricos de los competidores croatas masculinos y femeninos de taekwondo junior según la categoría oficial de peso. Además, se analizó identificar las posibles diferencias en las variables entre las categorías de peso. La muestra estuvo compuesta por 247 participantes junior de los campeonatos nacionales de taekwondo divididos en hombres (N = 121) y mujeres (N = 126). La muestra variable se definió mediante un conjunto de 8 medidas: altura corporal (cm), masa corporal (kg), índice de masa corporal, grasa corporal (%), grasa corporal (kg), masa muscular (kg), masa corporal magra (kg) y agua corporal total (%). Los resultados confirmaron estudios previos que demuestran que los practicantes de taekwondo más jóvenes tienen niveles más altos de grasa corporal que sus pares más experimentados (personas mayores). Solo se encontraron diferencias significativas entre las categorías magra y pesada. Los atletas masculinos de taekwondo junior muestran porcentajes de agua corporal total del 57,4 al 74,8 %, con porcentajes significativamente más bajos en las categorías de peso más alto, mientras que las atletas femeninas en las categorías más altas, demuestran un nivel preocupante de estado de hidratación, poniendo en peligro su rendimiento y salud en general. Como el primer artículo que investiga los valores de referencia de los atletas de taekwondo junior, pero basado en categorías de peso oficiales, es especialmente importante ya que cada categoría de peso garantiza diferentes requisitos de composición corporal, como se puede observar en las diferencias significativas entre las diversas variables. Los estudios futuros deberían incluir un análisis de las habilidades motoras en todas las categorías de peso y el posible uso del cálculo de la edad metabólica.

Prospective Study Of Efficacy And Perinatal Outcome Of Hydrotherapy In Oligohydroamnios Patients

Background:Oligohydramniosmeans a low level of amniotic fluid during pregnancy. It is defined by an amniotic fluid index that is below 5th percentile for the gestational age. It may cause IUGR, fetal anomalies, malpresentations and fetal distress in labour. Oral or intravenous fluid therapy may increase the amount of amniotic fluid and may improve perinatal outcome. Aims And Objectives:To study efficacy and perinatal outcome of hydrotherapy in patients with oligohydamnios. Material & Methods:A prospective observational study wascarried out at tertiary care centre for 6 months. 30 cases of oligohydramnios were enrolled in this study. Results:In present study, maximum (50%) patients admitted for oligohydramnios were between 28 –32 weeks gestational age and 66% were having severeoligohydramnios. After giving hydration therapy, difference in AFI, was 2.57±0.13, which was statistically significant. 83.3% patients were delivered after 36 weeks and 80% were delivered by normal vaginal delivery. 53.3% babies were live healthy, whereasothers needed resuscitation and admitted to NICU. Conclusion:Oligohydramnios has higher impact on perinalal outcome due to antenatal and intrapartum complication. Because of early diagnosis by ultrasonography or clinical analysis, fluid therapy is an option to increase amniotic fluid volume and so perinatal outcome may be improved.

Safety of a rapid outpatient hydration protocol for patients with renal impairment requiring intravenous iodinated contrast media for computed tomography

INTRODUCTION@#Patients receiving intravenous iodinated contrast media for computed tomography (CT) are predisposed to contrast-induced nephropathy. Chronic kidney disease is an important risk factor, and hydration is the mainstay of prevention. While inpatients can undergo intravenous hydration, limited knowledge exists regarding regimens for outpatients. We employed a rapid outpatient hydration protocol to reduce postponement of imaging appointments for patients with suboptimal estimated glomerular filtration rate (eGFR).@*METHODS@#From June 2015, we amended our CT preparation protocol to mandate rapid hydration (oral, intravenous or both) for patients with an eGFR of 30-60 mL/min/1.73 m@*RESULTS@#226 outpatients received the hydration protocol, which correlated with a 95% reduction in postponement of imaging appointments. No complications of fluid overload from hydration were encountered. A significant association was observed between age and decrease in eGFR, but this was not significant when stratified by drop in eGFR category. No statistical significance was found between decrease in eGFR and gender or race. Higher baseline eGFR was less likely to be associated with decrease in eGFR after imaging. Type of hydration was not related to a drop in eGFR category for patients with an eGFR of 45-59 mL/min/1.73 m@*CONCLUSION@#We defined a shorter hydration regimen that is safe to use in the outpatient setting.

Efeito imediato da hidratação laríngea de superfície associada à técnica de vibração sonorizada de língua em cantores amadores / Immediate effect of surface laryngeal hydration associated with tongue trill technique in amateur singers

RESUMO Objetivo Analisar o efeito imediato da hidratação de superfície laríngea associado à técnica de vibração sonorizada de língua (TVSL) em cantores. Método Participaram 30 cantores, sem queixas vocais ou alterações laríngeas, divididos em grupo controle (GC) e experimental (GE). O GC realizou a TVSL por cinco minutos. O GE foi submetido à nebulização de 3 ml de solução salina seguido da TVSL por cinco minutos. Foram realizadas autoavaliação vocal, análise acústica e avaliação perceptivoauditiva nos momentos pré (PréTVSL) e pós (PTVSL) no GC e no momento pré (PréHTVSL), pós hidratação (PH) e pós hidratação+TVSL (PHTVSL) no GE. Na autoavaliação foram avaliados: qualidade, estabilidade, rouquidão e intensidade vocal. Os parâmetros acústicos analisados foram Frequência Fundamental; Jitter%; Shimmer%, Noise-to-harmonic Ratio e Cepstral Peak Prominence-Smoothed (CPPs). A avaliação perceptivoauditiva foi realizada por uma fonoaudióloga experiente. Resultados Na comparação dos resultados da autoavaliação, entre os grupos, observou-se melhora da percepção de estabilidade e intensidade vocal no PTVSL (GC) em relação ao PH (GE). Na comparação entre os momentos do GE houve diferença estatística na sensação de intensidade vocal, apontando melhor resultado para PHTVSL. Não houve diferença estatística entre os grupos investigados na avaliação perceptivoauditiva e na análise acústica. Conclusão A hidratação laríngea de superfície não potencializa o efeito da TVSL em cantores em condição natural de hidratação com uso de 3ml de nebulização. Para os profissionais da voz com grande demanda vocal, a hidratação de superfície pode ser introduzida durante a utilização da voz, para manutenção da qualidade vocal, sem perda de sua qualidade.

ABSTRACT Purpose To analyze the immediate effect of laryngeal surface hydration associated with the performance of Tongue Trills (TT) on singers. Methods Thirty singers without vocal complaints or laryngeal alterations divided into control (CG) and experimental (EG) groups. The CG performed the TT for five minutes. The EG was submitted a nebulization with 3 ml of saline solution followed by TT for five minutes. Voice self-assessment, acoustic analysis and perceptual assessment were performed at Pre (Pre TT) and post (PTT) moments in CG and pre (Pre TT), post hydration (PH) and post hydration + TT (PHTT) in GE. In the self-assessment were evaluated quality, stability, vocal intensity and hoarseness. There were extract the values of the Fundamental frequency; Jitter%; Shimmer%, Noise-to-harmonic Ratio e Cepstral Peak Prominence-Smoothed (CPPs) in the acoustic analyze. The perceptual evaluation was performed by an experienced speech therapist. Results Comparing the results of self-assessment between groups showed improvement in the perception of stability and vocal intensity in the PTT (CG) in relation to PH (EG). Comparison between the EG moments showed a statistical difference in the vocal intensity perception, indicating a better results for PHTT. There was no statistical difference between the groups investigated in the perceptual assessments and acoustic analysis. Conclusion Surface laryngeal hydration does not potentiate the effect of TT on naturally hydrated singers with 3ml nebulization. For voice professionals with high vocal demand, surface hydration can be introduced during voice use to maintain vocal quality.

Enfermedad renal crónica y COVID-19: la importancia de la hidratación / Chronic kidney disease and COVID-19: the importance of hydration

Resumen Como es bien sabido, desde el mes de diciembre se encendieron las alarmas por la aparición de la enfermedad COVID-19 (Coronavirus 2019) en China, la cual es causada por el virus SARS-CoV-2 y se ha expandido a nivel mundial. Entre los síntomas frecuentes encontramos fiebre, fatiga, mialgias, tos seca, anorexia, disnea y producción de esputo y síntomas menos comunes como cefalea, odinofagia, rinorrea y otra sintomatología diferente a la respiratoria, como síntomas gastrointestinales dados por náuseas y diarrea. La proteinuria en cualquier grado, la hematuria de cualquier grado, el aumento de la elevación de la creatinina en pacientes con creatinina basal elevada y la generación de AKI 2 y 3 son los directamente relacionados con la mortalidad intrahospitalaria desde el punto de vista renal, lo que hace que debamos estudiar más aun la enfermedad renal crónica, para poder tomar las medidas necesaria de prevención. En cuanto a la hidratación, se considera, por lo tanto, que si el paciente presenta buena diuresis, los 2 litros de excreción serían necesarios para eliminar los solutos no necesarios del cuerpo, considerando que esta cantidad se logra sumando también las pérdidas extrarrenales; entonces, si el paciente mantiene una función urinaria adecuada a pesar de su grado de insuficiencia renal, una ingesta de líquidos entre 2,5 y 3,5 litros logra las metas. Los pacientes con enfermedad renal crónica deben tomar las medidas de prevención, aún más por ser población de riesgo, recordando por lo tanto algunas, las cuales son la mejor estrategia para evitar la transmisión viral: lavado frecuente de manos, distanciamiento social, evitar contacto con personas infectadas o con sospecha de infección por el virus SARS-CoV-2, usar tapabocas, mantener higiene en su domicilio, lavar superficies o limpiarlas con sustancias a base de alcohol, y algo que no se puede olvidar: estamos aprendiendo del virus, y debemos mantenernos informados del comportamiento del mismo y de los cambios que este pueda generar en la población y en el comportamiento de la enfermedad, para así mismo tomar las medidas.

Abstract As is well known since December, alarms went off for the appearance of the COVID-19 disease (Coronavirus 2019) in China, which is caused by the SARS-CoV-2 virus and has spread worldwide. Frequent symptoms include fever, fatigue, myalgia, dry cough, anorexia, dyspnea and sputum production, and less common symptoms such as headache, odynophagia, rhinorrhea, and other symptoms other than breathing, such as gastrointestinal symptoms due to nausea and diarrhea. Proteinuria in any degree, hematuria of any degree, increased creatinine variation in a patient with elevated baseline creatinine, and the generation of AKI 2 and 3 are those directly related to in-hospital mortality from the renal point of view, which means that we must study chronic kidney disease even more, in order to take the necessary preventive measures. Regarding hydration, it is considered, therefore, that if the patient presents good diuresis, the 2 liters of excretion would be necessary to eliminate the unnecessary solutes from the body, considering that this amount is achieved by also adding extrarenal losses. Therefore, if the patient maintains adequate urinary function despite his degree of kidney failure, a fluid intake of between 2.5 and 3.5 liters achieves the goals, also taking into account. Patients with chronic kidney disease should take preventive measures, even more so as they are a risk population, therefore remembering some, which are the best strategy to avoid viral transmission: frequent hand washing, social distancing, avoiding contact with people infected or suspected of infection with the SARS-CoV-2 virus, wearing face masks, maintaining hygiene at home, washing surfaces or cleaning them with alcohol-based substances and something that cannot be forgotten, remember that we are learning from the virus and that we must keep us informed of the behavior of the same and of the changes that it may generate in the population and in the behavior of the disease, so as to take the measures.

Oral versus intravenous maternal hydration in isolated third trimester oligohydramnios

Background: To study the effect of oral and intravenous maternal hydration in patients with isolated oligohydramnios in terms of mean change in amniotic fluid.Methods: A total number of 38 patients included in the study which fulfill the selection criteria.  Patients were randomly divided in two groups. Amniotic fluid index (AFI) of all patients was measured before the hydration therapy according to the method of Phelan et al.  In maternal oral hydration (Group A), every patient was instructed to drink two liters of water over two hours daily for 1 week. In intravenous hydration (Group B), every woman infused two liters of 0.9% normal saline in two hour daily for 1 week. After 48 hours and 1 week of oral and intravenous hydration, the AFI was reassessed by the same observer. Patients were monitored closely for sign and symptoms of fluid overload. Data was stratified for mean difference in improvement in amniotic fluid index.Results: After oral hydration therapy AFI was 5.926±0.4593 after 48 hours and 8.286±0.6000 after 7 days in Group A. In Group B AFI was 5.784±0.4622 after 48 hours and 7.868±0.2810 after 7 days of intravenous hydration. P value after 48 hours is 0.348 and p=0.014 after 7 days means oral hydration therapy significantly increase amniotic fluid index.Conclusions: Oral maternal hydration significantly increase the amniotic fluid index in patients with isolated oligohydramnios. It is simple, safe and non-invasive method.

Effects of different hydration treatments on technological, physical, nutritional, and bioactive parameters of lentils / Efectos de diferentes tratamientos de hidratación sobre los parámetros tecnológicos, físicos, nutricionales y bioactivos de las lentejas

ABSTRACT Regular lentil consumption may improve health and prevent certain chronic diseases. Lentils have high antioxidant activity and contain proteins, essential amino acids, fiber, minerals, and bioactive compounds. However, few studies have investigated the physicochemical characteristics of lentils when subjected to various soaking and cooking methods. We aimed to evaluate the effects of different hydration and cooking practices on the hydration coefficient, cooking time, primary metabolism compounds (lipids, proteins, fibers, carbohydrates), energy value, soluble protein, color and texture characteristics, amino acid and mineral profiles, bioactive compounds, antioxidant activity, and antinutritional factors (phytates and tannins) in lentils. Hydration water was preheated to initial temperatures of 25°C or 90°C. Lentils pre-hydrated with water at 90°C needed less cooking time, obtained greater softness, and had less decreases in amino acids, minerals, bioactive compounds, and antioxidant activity.

RESUMEN El consumo regular de lentejas puede mejorar la salud y prevenir ciertas enfermedades crónicas. Las lentejas tienen una alta actividad antioxidante y contienen proteínas, aminoácidos esenciales, fibra, minerales y compuestos bioactivos. Sin embargo, pocos estudios han investigado las características fisicoquímicas de las lentejas sometidas a varios métodos de remojo y cocción. El objetivo de este estudio fue evaluar los efectos de diferentes procesos de cocción e hidratación sobre el coeficiente de hidratación, el tiempo de cocción, los metabolitos primarios (lípidos, proteínas, fibras, carbohidratos), el valor energético, la proteína soluble, color y textura, los perfiles de aminoácidos y minerales, los compuestos bioactivos, la actividad antioxidante y los factores antinutricionales (fitatos y taninos) en la lenteja. El agua de hidratación se precalentó a temperaturas iniciales de 25°C o 90°C. Las lentejas prehidratadas con agua a 90°C necesitaban menos tiempo de cocción y obtuvieron una mayor suavidad, disminuyendo también la pérdida de aminoácidos, minerales, compuestos bioactivos y actividad antioxidante.

Formulation Development, Characterization and In-vitro Evaluation of Tamoxifen Loaded Liposomes

Background: The study was aimed to prepare and evaluate tamoxifen loaded controlled release liposomes to reduce the side effects of tamoxifen during cancer treatment. Methods: Different tamoxifen loaded liposomes were prepared by modified ether injection (MEIM) and thin film hydration method (TFHM) under prescribed conditions. The prepared liposomes were characterized by using optical microscopy, evaluating encapsulation efficiency, in-vitro and ex-vivo diffusion studies by using dialysis membrane and chicken intestinal sac respectively.Results: The data revealed that all of the liposomes were spherical in shape and stable under three physical conditions i.e. 4, 25 and 37 ± 2°C temperatures and 60 ±5% relative humidity. Additionally most of the liposomes followed zero order and class II release kinetics. It was also observed that with the increase of phospholipids and cholesterol, entrapment efficiency of liposome vesicles increased thus giving a controlled release drug delivery system but further increase reduced this efficiency at a certain level.Conclusion: The formulated control release liposomes might be a good drug delivery system for target oriented drug delivery with minimum side effects of tamoxifen during cancer treatment

Comparative study of the efficacy of oral and intravenous maternal hydration in the management of third trimester oligohydramnios and it’s effect on maternal and foetal outcome

Background: Amniotic fluid is derived from maternal plasma in very early pregnancy by the 10th week of pregnancy. It forms an aquatic pond inside the amniotic cavity surrounding the fetus. It helps in fetal development. Aim of this study was to determine the impact of hydration therapy in patients complicated by oligohydramnios.Methods: This was a prospective randomized clinical trial conducted on 200 women.Results: Mean AFI in Group I was 4.47±0.90 cm before hydration therapy and 7.16±1.57 cm after hydration therapy with elevation by 60.18%, similarly mean AFI in Group II was 4.52±0.83 cm before hydration therapy and 7.48±1.56 cm after hydration therapy with elevation by 65.48%. However, on comparing the two groups elevations in mean AFI was found statistically insignificant (p >0.05).Conclusions: Oral hydration is non-invasive, low costing, does not exhaust the resource, convenient to the women with minimum side effects and can be done at home.

Optimization of prescription process of curcumin-piperine polymeric micelles by central composite design-response surface method / 中草药

Objective: To optimize the prescription process of curcumin-piperine polymeric compound micelles (Cur/Pip F127/P123-PM) by central composite design-response surface method. Methods: The content of curcumin and piperine was determined by UPLC. The Cur/Pip F127/P123-PM was prepared by thin film hydration method. Based on the single factor test, the dosage, the mass ratio of F127 and the volume of water were used as independent variables, and the drug loading and entrapment efficiency of curcumin, entrapment efficiency of piperine and the micelle size were dependent variables, and next central composite design-response surface method of three factors and five levels was carried out. The analysis results showed and verified the optimal prescription. Finally, the optimal lyophilization conditions of the micelle preparation were initially screened. Results: The optimal preparation process was as follow: the dosage of curcumin and piperine was 12.96 mg and 0.69 mg, respectively; The mass ratio of F127 was 0.46, and the volume of water was 8.85 mL. The compound curcumin micelles prepared by the optimum formulation had the loading capacity of 5.63%, solubility of 1.27 mg/mL and entrapment rate of curcumin was 86.86%. The entrapment rate of piperine was 77.54%; The micelle size was 66.79 nm and the Zeta potential was close to zero. The lyophilized products prepared by using 8% mannitol as a protective agent had a good redispersion. Conclusion: The model established by central composite design-response surface method can be used to optimize the prescription of compound curcumin micelles, and the method had a high accuracy and good predictability advantage.