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1.
Kampo Medicine ; : 1-8, 2021.
Article in Japanese | WPRIM | ID: wpr-924609

ABSTRACT

Kampo medicine is widely used in Japan for neuro-otologic disease (e.g. tinnitus, dizziness, hearing loss). Some patients with these diseases suffer from comorbidity of other non-otologic symptoms. We reviewed typical Kampo medicine formulations for neuro-otologic disease. Kampo extracts have indications not only the neuro-otologic but also other systemic diseases. Kampo medicine would facilitate the care of patients with both neuro-otologic diseases and comorbid symptoms.

2.
Kampo Medicine ; : 284-295, 2020.
Article in Japanese | WPRIM | ID: wpr-887342

ABSTRACT

We are planning a study focused on the gathering of clinical data for the purpose of formalizing diagnostic logic at 6 institutions specialized in Kampo-based medical examinations. However, during the planning stage, it has been recognized that there are a large number of Kampo formulas to be studied, and differences among faculties and individuals exist regarding how to identify each Kampo formula, methods of gathering findings, and the evaluation of efficacy. Here we report the solution proposal reached after building consensus among all participating faculties on these issues. After raising the issues, conferences were held for each of them, until a unanimous consensus was obtained. As a result, the following conclusions were reached. Thirty-three Kampo formulas were selected as targets for the formalization of diagnostic logic. In addition, the range of dosage forms, crude drug ingredients, and permissible dosages for each Kampo formula were determined. Regarding clinical findings for these Kampo medicines, the items to be collected and evaluation criteria were also established. The criteria for evaluating the validity and safety of each Kampo medicine were decided, together with the grading and timing of evaluation. We hope that our solution proposal reached after building consensus becomes the basis for Kampo research in the future.

3.
Kampo Medicine ; : 272-283, 2020.
Article in Japanese | WPRIM | ID: wpr-887341

ABSTRACT

Various measures are being undertaken all over the world to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Artificial respirators and extracorporeal membrane oxygenators (ECMO) have been introduced for severely ill patients, and antiviral pharmacotherapy has been attempted. However, in the current situation, it is not feasible to wait for evidence-based effective treatments, and it is imperative to deal with daily situations. It would be very helpful to retrospectively evaluate the doctors who worked during the Spanish flu pandemic without access to medical devices such as ventilators, or drugs including antibacterial and antiviral agents. Based on the fact that Kampo medicine was used to treat patients with the Spanish flu, this article demonstrates the high pathogenicity of the Spanish flu virus, the mechanism of action of antiviral drugs, and clinical evidence. As one of the measures against the COVID-19 pandemic, we propose the role of Kampo medicine, which has relative clinical safety with few side effects, and can be expected to induce antiviral action by autoimmune activation.

4.
Kampo Medicine ; : 262-267, 2020.
Article in Japanese | WPRIM | ID: wpr-887339

ABSTRACT

The Japan society of oriental medicine created a committee of medical safety in 2017. The first activity was to summarize the representative side effects of Kampo medicine and to enlighten members of our society about them. In this report, we documented the knowledge to keep in mind at present on pseudoaldosteronism, drug-induced liver injury, and drug-induced lung injury. Since these three major side effects may cause clinically severe conditions, it is very important to detect them early and take appropriate measures. Therefore, proper examinations at the right time are necessary while taking Kampo medicine.

5.
Kampo Medicine ; : 204-212, 2020.
Article in Japanese | WPRIM | ID: wpr-887330

ABSTRACT

We administered Kampo medicine to 40 patients whose lower urinary tract symptoms worsened in winter and examined the changes in their lower urinary tract symptoms and coldness symptoms. The effectiveness was evaluated by International Prostate Symptom Score (IPSS), Overactive Bladder Symptom score (OABSS),and the interview of coldness symptom. IPSS scores were significantly improved in 30 cases (75.0%), and OABSS scores were significantly improved in 26 cases (65.0%). The number of the night-time frequency of urination significantly decreased from 2.5 times to 2.0. The symptoms of coldness were improved in 21 of 29 cases (72.5%). Moreover, in the group of 21 cases whose coldness symptoms were improved total OABSS were significantly improved compared to the group of 8 cases with no change of coldness symptoms. Appropriate administration of Kampo medicine was considered to be one of the effective measures that could improve lower urinary tract symptoms due to cold stress as well as coldness symptoms.

6.
Kampo Medicine ; : 185-192, 2020.
Article in Japanese | WPRIM | ID: wpr-887327

ABSTRACT

We conducted a fact­finding survey about the difficulties of handling the telephone consultations at a Kampo medicine outpatient clinic. We extracted the details of consultations that could not be handled by an outpatient nurse alone from the descriptive data of the telephone responses described by the nurses in the sur­vey. We, then, identified the factors that were involved in the difficulties encountered in these consultations, and countermeasures were established and implemented. One year later, we compared and examined the status of telephone consultations between before and after the fact-­finding survey. We classified the telephone con­sultations that were difficult for the outpatient nurses to handle alone into four categories : (1) consultation about a physical disorder, (2) questions about prescribed Kampo medicines, (3) reports and questions based on the patient's own judgment, and (4) questions about treatment and hospitalization. Some of the questions about Kampo medicines included the continued use of the medicine and drug interactions, and the main topics of the survey's nurse self-­judgment reports were dose reductions and changes in Kampo medicine regimens. As a re­sult of the introduction of guidelines prepared by the nurses together with physicians at the clinics, the outpa­tient nurses became able to handle telephone consultations about frequently asked questions (FAQs). At 1 year after the survey, the number of cases of difficulties in handling telephone consultations decreased to less than half the original value, and no telephone consultations were made within 1 week after the patients' first visits to the outpatient clinic.

7.
Kampo Medicine ; : 143-153, 2020.
Article in Japanese | WPRIM | ID: wpr-843009

ABSTRACT

Diabetic foot lesions are internationally defined as infections, ulcers, or destructive lesions of the tissue of the lower extremities in patients with diabetes associated with neuropathy and peripheral artery disease. Early treatment is necessary for the three main causes of diabetic foot disease : neuropathy, peripheral artery disease, and infection. In this study, based on these associated factors, Kampo medicine was found to be effective for foot lesions in 50 to 100% of the 13 outpatients and 4 inpatients with diabetes. Kampo medicine treatment was effective for 50% or more patients with diabetes and neuropathy. In peripheral artery disease, Kampo medicine improved the circulation ; in particular, tokishigyakukagoshuyushokyoto improved the ankle-­brachial pressure index. In patients with diabetes and infection, hozai improved the general condition in combination with antibiotics of Western medicine.

8.
Article in Japanese | WPRIM | ID: wpr-826065

ABSTRACT

[Objective] We report a successfully treated case by a combined therapy of acupuncture and Kampo medicine for a patient with lower limb pain associated with Guillain-Barre syndrome (GBS).[Case] The patient was a 74-year-old man whose chief complaints were severe lower limb pain, gait difficulty, and hyposthenia. Clinical history: In late September in X year, the patient had a cold infection. On October 14, he became aware of weakness in his lower limbs on both sides, difficulty in walking, and severe pain in his lower limbs. He visited our hospital's general internal medicine department and was diagnosed with GBS. The patient was hospitalized and started to receive intravenous immunoglobulin therapy for GBS. Since pain in the lower limbs continued after treatment, he received analgesics, which was not effective. Therefore, acupuncture treatment was started on October 30 aiming to alleviate lower limb pain. Evaluation: Pain and burning sensation were evaluated using a numerical rating scale (NRS), and Hughes' function grade scale (FG) as an objective evaluation. [Acupuncture treatment] The acupuncture treatment was based on Chinese medicine. The basic combination of meridian points for treatment of the case were LR3 (Taichong), LI4 (Hegu), KI6 (Zhaohai), KI3 (Taixi), ST36 (Zusanli), PC6 (Neiguan), and SI8 (Xiaohai). The patient received acupuncture treatments once a day for 12 weeks.[Progress] The first evaluation of the patient's pain in his lower limbs on both sides was 10 points in NRS and 4 units in FG. Pain was alleviated immediately after acupuncture treatment was started, and a significant improvement in pain was observed by the seventh acupuncture treatment. However, the patient started to complain of burning sensation on his soles. Therefore, the combined use of Kampo medicine (Choutousan, Rokumijiougan) were introduced in addition to the acupuncture treatment, and his burning sensation disappeared. Since then, rehabilitation was enhanced, and after three months from the start of acupuncture treatment, he was discharged since the FG was improved to 2 units. [Discussion] Lower limb pain and burning sensation in this case were considered to be neuropathic pain associated with GBS, and conventional analgesics were only temporarily effective. In contrast, the combined use of acupuncture and Kampo medicine alleviated the pain and burning sensation, and ADL was improved. Acupuncture and Kampo medicine were effective for lower limb pain and burning sensation from GBS.

9.
Article in Chinese | WPRIM | ID: wpr-850968

ABSTRACT

Classical prescription is long-lasting which is characterized by simple composition and obvious curative effect. It is popular over China and welcomed by many people. Japanese Kampo medicine and traditional Chinese medicine originated from the same resource but flowed into two branches. Some classical prescription experts are mostly influenced by Japanese Kampo medicine, emphasizing the correspondence between prescriptions and syndromes, physical identification and abdominal diagnosis, which have become the research direction of most classical prescription scholars. Traditional Chinese medicine and Japanese Kampo medicine differ in the dialectical system, application form, dose and dosage form of classical prescription. It is important to have a clear insight of the development status of classical prescription in Chinese medicine and that of Japanese Kampo medicine, understand the differences between them and make full use of advantages and avoid disadvantages. It can provide ideas for the correct development path of classical prescription and reference for the research of preparation of classical prescription in China.

10.
Kampo Medicine ; : 283-289, 2019.
Article in Japanese | WPRIM | ID: wpr-781963

ABSTRACT

Questionnaire survey was conducted to know awareness of female nursing students about state of self-health condition and the effect of Kampo education on the interest degree in Kampo. It was shown that 20% of students felt that they were not healthy and 40% of students felt that they were not confident in their health. It was also shown that many students took a painkiller to cure menstrual pain and headache. In addition, it was shown that 55% of students experienced internal use of Kampo medicine. This tendency was more prominent in students who were interested in Kampo medicine. And, there were many students who wanted to take Kampo medicine, which was effective to dysmenorrhea, headache, menstrural irregular, premenstrual syndrome, and menopausal disorders. The demand on Kampo medicine of students who were not interested in Kampo medicine were prominently increased after Kampo education used slides (papers) reading about Kampo. Those results indicate that Kampo education is also important for students who are not interested in Kampo medicine.

11.
Kampo Medicine ; : 254-259, 2019.
Article in Japanese | WPRIM | ID: wpr-781958

ABSTRACT

We added Kampo medicine (Japanese traditional herbal medicine) to disease-­modifying anti-­rheumatic drugs (DMARDs) to treat rheumatoid arthritis (RA) in 41 patients. After 1 year, disease activity assessments showed improvement in the number of tender joints and DAS 28-­CRP, and Boolean remission increased from 3 cases to 6 cases. However, 16 of 41 patients had an insufficient therapeutic effect with Kampo medicine ; therefore, their DMARD treatment was strengthened. Disease activity in the 16 patients with strengthened DMARD therapy (Western group) was compared with that in the 25 patients who did not require strengthened DMARD therapy (Kampo group). The Western group had high disease activity at the beginning of Kampo medicine, and a year later CRP and DAS 28­-CRP improved. In the Kampo group, disease activity was relatively good at the beginning of Kampo medicine, and patient global assessment (PGA) improved. We believe that combination therapy, with DMARDs controlling synovitis and Kampo medicine improving PGA, is an effective way to achieve Boolean remission.

12.
Kampo Medicine ; : 181-182, 2019.
Article in Japanese | WPRIM | ID: wpr-781935

ABSTRACT

Shinshin-ichinyo is the concept derived from Zen Buddhism in Japan in which mind and body connect with and negate each other at the same time. Western medicine has been dealing with “organs and diseases” based on mind-­body dualism, but Oriental medicine has been dealing with “patients with disease” based on this con­cept. Psychosomatic medicine was established as holistic medicine by using this concept, and becomes popular in the field of general medicine, but it is still unclear who introduced this concept to the field of Kampo or tra­ditional Japanese medicine. Here I explored one possibility by investigating some literature.

13.
Kampo Medicine ; : 167-174, 2019.
Article in Japanese | WPRIM | ID: wpr-781933

ABSTRACT

According to the World Health Organization (WHO), mortality by age, sex, and cause of death is the foun­dation of public health both globally and domestically. Comparable mortality statistics over time and investi­gations of mortality were used to develop the International Statistical Classification of Diseases and Related Health Problems (ICD). In the ICD, the WHO states that morbidity statistics are also an essential foundation of public health, but they are much less widely applied. The 10th revision of the ICD (ICD-10) is now in use, but further revisions must be made in the development of the 11th revision (ICD-11) to capture advances in health science and medical practice, to make better use of the digital revolution, and to evaluate traditional medicine (TM). Revision of ICD-10 began in 2007, and an ICD-11 version for preparing implementation was released on July 18, 2018. ICD-11 features a new TM chapter on Japanese traditional medicine, known as Kampo medicine, traditional Chinese medicine, and Korean medicine. ICD-11 will be approved at the next World Health Assembly in May 2019 and will come into effect. This means that the WHO does not currently recognize the effects of TM, but that we as well as the WHO will have hard time to prepare and study the effects of TM on morbidity statistics. It is very important to the study of Kampo medicine that we will be able to properly evaluate the terms and classifications contained in ICD-11.

14.
Kampo Medicine ; : 162-166, 2019.
Article in Japanese | WPRIM | ID: wpr-781932

ABSTRACT

Kampo medicine is well known to play an important role in cancer therapy, especially as a supportive therapy. We literally investigated the significance of Kampo medicine on antitumor effect including our data in the era that cancer immunotherapy using immune checkpoint inhibitors is a main stream. Up to now, many reports have been published regarding the mechanism of Kampo medicine on augmentation of immunity, particularly innate immunity. Regarding the effect of Kampo medicine on cancel of immune suppression by cancer, a few reports have been published including our data that juzentaihoto reduced regulatory T cell ratio in advanced pancreas cancer patients. Interestingly, a certain kind of Kampo medicine has possibility to induce immune tolerance in murine cardiac transplant model through increased regulatory T cells, and to suppress intestinal inflammation by anticancer drug by functioning immune checkpoint (PD-1). We hope that Kampo medicine would be proved to possibly regulate immune function from the viewpoint of immune checkpoint in the near future.

15.
Kampo Medicine ; : 65-71, 2019.
Article in Japanese | WPRIM | ID: wpr-758220

ABSTRACT

Vertigo and dizziness are common symptoms encountered in clinical settings. We had examined 40 cases with a chief complaint of vertigo and dizziness that were effectively treated with Kampo medicines for 5 years. Here, we present 4 typical cases and report on the outcomes of these cases. A majority of the patients reported here had dizziness as the main complaint and were female. About 35% of the cases improved in no more than 7 days, and 50% of the cases were cured within 14 days. Ryokeijutsukanto (45%) and shinbuto (55%) are the most commonly prescribed Kampo medicines. We had to treat the patients with not only a single, but also multiple Kampo medicines because of tangled yin and yang. Cases of dizziness without any specific neuro­logical abnormality were difficult to treat with modern medicine ;however, Kampo medicine could treat such cases promptly.

16.
Kampo Medicine ; : 18-24, 2019.
Article in Japanese | WPRIM | ID: wpr-758212

ABSTRACT

The background and course of Kampo treatment in 39 patients with uncontrollable otolaryngeal symptoms treated between April 2013 and March 2016, in the Department of Kampo Medicine at Tohoku University Hospital, were analyzed retrospectively. An improvement in overall symptoms was noted with Kampo treatment in 28 of 39 cases (71%). The commonly reported subjective symptoms included glossodynia (7 cases), postnasal drip (4 cases), oral discomfort (4 cases), dizziness (3 cases), and taste disorder (3 cases). Analysis using the classification of qi, blood, and fluid revealed that cases with qi stagnation pattern (15 of 18 cases) were effectively treated with Kampo treatment. Prior reports support our finding that smoothing qi with Kampo medicine is effective in alleviating some chronic symptoms. The symptoms improved within 6 weeks after the treatment was initiated. Therefore, a 6-week period can be considered sufficient to determine the effectiveness of Kampo medicine. Many of the patients for whom Kampo treatment was not effective had depression and domestic stress. In conclusion, Kampo treatment may be effectively used to treat uncontrollable, chronic otolaryngeal symptoms in selected cases that are unresponsive to Western medicine.

17.
Palliative Care Research ; : 193-196, 2019.
Article in Japanese | WPRIM | ID: wpr-758192

ABSTRACT

We report a patient, who had neuropathic pain after radiation, called “chronic post-radiation pain syndrome,” who was successfully treated by Shimbuto. The patient was a 83-year-old man, diagnosed with Stage IB non-small cell lung cancer of the left upper lobe. Although the lesion had a surgical indication, he selected radiotherapy, and stereotactic body radiotherapy was performed. A few months later, he experienced neuropathic pain in his anterolateral chest wall. Loxoprofen and acetaminophen had little effect; moreover, tramadol hydrochloride/acetaminophen combination tablets and pregabalin induced drowsiness and dizziness. He then wanted to take Kampo medicine (Japanese traditional medicine) and was observed to have susceptibility to gastrointestinal disorders and cold intolerance by Kampo diagnosis. We prescribed Shimbuto 5 g per day, along with pregabalin. After 2 months, the pain had almost disappeared and he could stop taking pregabalin. Shimbuto is usually prescribed to patients at a risk of gastrointestinal disorders, pain, numbness, and other symptoms induced by cold intolerance. Shimbuto includes the extract of processed aconite root, which is effective for pain and numbness; therefore, it might be a good option for treating neuropathic pain when we have difficulties with Western medicine.

18.
Kampo Medicine ; : 72-81, 2018.
Article in Japanese | WPRIM | ID: wpr-689004

ABSTRACT

Berberine-containing goldenseal root has been classified into Group 2B (possibly carcinogenic to humans) by International Agency for Research on Cancer based on evidence of carcinogenicity in experimental animals. It was also confirmed that ultrahigh concentration berberine can induce DNA damage in cultured cells. Thus, two articles in Journal of Japan Medical Association advocated carcinogenicity and reproductive toxicity of oren, obaku, and daio considering that ingredients of daio and berberine contained in oren and obaku can cause DNA damage. However, many fallacies and arbitrary descriptions are observed in the two articles. The concentration of berberine that caused toxicity in the experiments is extremely higher than the possible concentration in humans taking Kampo medicine. Although no studies have shown carcinogenicity and reproductive toxicity of oren or obaku, the advocates in the articles were played up by a weekly magazine causing unreasonable anxiety to patients. Here, we present scientific counterarguments against the fallacies of the articles.

19.
Kampo Medicine ; : 178-183, 2018.
Article in Japanese | WPRIM | ID: wpr-688532

ABSTRACT

An eight-year-old girl was referred and admitted to our hospital with the chief complaint of purpura on her lower legs. Blood tests revealed pancytopenia, and bone marrow findings showed marrow hypoplasia. Refractory cytopenia of childhood (RCC) was diagnosed based on the central diagnostic system of the Myelodysplastic Syndrome Committee of the Japanese Society of Pediatric Hematology. Immunosuppressive therapy was performed with the administration of rabbit antithymocyte globulin, methylprednisolone and cyclosporin A,but it was not effective. Eight months after admission to our hospital, Kampo treatment was started based on traditional Kampo diagnosis. After treatment with oral administration of kamikihito and kyukikyogaito, her pancytopenia gradually improved. Erythrocyte transfusion was discontinued after 2 months, and concentrated platelet transfusion also became unnecessary after 3 months. As a result of improvement in pancytopenia, her white blood cell count, hemoglobin value, and platelet count reached almost normal levels after 16 months. The scheduled bone marrow transplantation was canceled. The action mechanisms of kamikihito and kyukikyogaito for RCC are not clear, and their effective rates are also unknown. However, Kampo treatments are less invasive, inexpensive, and have few side effects. We believe that Kampo medicine is a therapeutic method that should be actively attempted in cases of RCC with poor response to standard treatment.

20.
Kampo Medicine ; : 396-401, 2018.
Article in Japanese | WPRIM | ID: wpr-758208

ABSTRACT

The education of Kampo medicine is performed in a very small portion of the field of nursing education. The questionnaire survey which related to Kampo medicine was carried out for the female nursing student who received the training of motherly nursing. As a result, 86% of the students did not know about the fellow of the Japan Society for Oriental Medicine. However, 70% of the students thought that a lecture of Kampo medicine was necessary for nursing student, and 78% of them thought that Kampo medicine was necessary for medical treatment. Furthermore, after reading a collection of slides about Kampo medicine, the number of student who thought that a lecture of Kampo medicine was necessary for nursing students and that Kampo medicine was necessary for medical treatments, was increased.

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