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1.
Rev. Paul. Pediatr. (Ed. Port., Online) ; 41: e2021145, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1387507

ABSTRACT

Abstract Objective: To determine the prevalence of metabolic syndrome (MS) and its components among Brazilian adolescents. Data source: Databases, such as LILACS, MEDLINE, and SciELO, were searched for original cross-sectional studies published between 2010 and 2021. The inclusion criteria were determined based on the mnemonic CoCoPop — Condition, Context, and Population: studies determining the prevalence of MS and its components (condition) in the general population of Brazilian adolescents, female and male (population), enrolled in public or private schools in rural or urban areas (context). Reviews, editorials, and articles that did not directly relate to the prevalence of MS or that included non-adolescent age groups or groups with specific health conditions (obesity/overweight and others) were excluded. Data synthesis: A total of 15 studies, including 43,227 adolescents, were identified. MS prevalence (95% confidence interval [95%CI]) was 2.9% (2.65-3.18) and 2.4% (1.90-2.90) (p<0.001) in males and females, respectively, by using the International Diabetes Federation (IDF) criteria. There was a significant difference in MS prevalence among Brazilian regions (Q=24.7; p<0.001). The lowest MS prevalence (95%CI) was determined for North Region of Brazil, 1.8% (1.52-2.13), and the highest for Northeast Region of Brazil, 2.9% (2.62-3.23). Regarding MS components, a higher prevalence (95%CI) was found for low high-density lipoprotein (HDL), 22.1% (12.49-36.17), followed by abdominal obesity, 11.0% (8.05-14.94), and arterial hypertension, 10.3% (7.84-13.48). Conclusions: This study allowed the determination of the prevalence of MS and the MS components in Brazilian adolescents, highlighting relevant aspects to be addressed on public health management.


RESUMO Objetivo: Determinar a prevalência da síndrome metabólica (SM) e seus componentes em adolescentes brasileiros. Fontes de dados: Realizaram-se buscas nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs), Medical Literature Analysis and Retrieval System Online (Medline) e Scientific Electronic Library Online (SciELO) por estudos transversais originais publicados entre 2010 e 2021. Os critérios de inclusão foram determinados pelo Mnemônico CoCoPop — Condição, Contexto e População: estudos que determinam a prevalência de SM e seus componentes (condição) na população geral de adolescentes brasileiros, feminino e masculino (população), matriculados em escolas públicas ou privadas em áreas rurais ou urbanas (contexto). Revisões, editoriais, artigos não relacionados com a prevalência de SM ou que incluíssem grupos etários não adolescentes ou com condições de saúde específicas (obesidade/sobrepeso e outros) foram excluídos. Síntese dos dados: Quinze estudos, com 43.227 adolescentes, foram identificados. A prevalência de SM (intervalo de confiança — IC95%) no sexo masculino foi de 2,9% (2,65-3,18) e no feminino foi de 2,4% (1,90-2,90) (p<0,001), pelos critérios da Federação Internacional de Diabetes (IDF). Houve diferença significativa na prevalência de SM entre regiões brasileiras (Q=24,7; p<0,001). A menor prevalência de SM (IC95%) foi encontrada em região Norte, com 1,8% (1,52-2,13), e a maior na região Nordeste, com 2,9% (2,62-3,23). Em relação aos componentes da SM, maior prevalência (IC95%) foi encontrada para lipoproteína de baixa densidade (HDL) baixa (22,1%, 12,49-36,17), seguida de obesidade abdominal (11,0%, 8,05-14,94) e hipertensão arterial (10,3%, 7,84-13,48). Conclusões: Este estudo permitiu determinar a prevalência da SM e seus componentes em adolescentes brasileiros, destacando aspectos relevantes a serem abordados na gestão da saúde pública.

2.
Arch. cardiol. Méx ; 92(3): 305-311, jul.-sep. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1393824

ABSTRACT

Abstract Introduction: Patients with psoriasis have an increased prevalence of cardiovascular risk factors as well as cardiovascular disease. Objective: To determine if patients with psoriasis and metabolic syndrome (MS) have a higher frequency of subclinical atherosclerosis compared with those with psoriasis without MS. Materials and Methods: A cross-sectional study was conducted in patients with psoriasis; MS was defined according to ATP III criteria. Demographic, clinical, and anthropometric data were obtained. Blood chemistry, high sensitive C-reactive protein (hs-CRP), and insulin were measure. Subclinical atherosclerosis was defined as high carotid intima-media thickness (CIMT) by Mode B ultrasound. Results: 92 patients with psoriasis were included, 67 (72.8%) with MS and 25 (27.2%) without MS. Subjects with psoriasis and MS had significantly higher weight, body mass index, waist circumference, systolic blood pressure, glucose, insulin, triglycerides, insulin resistance, hs-CRP, and lower level of high-density lipoprotein cholesterol, compared with subjects without MS. High CIMT was greater in patients with psoriasis and MS than in those without MS. Age and MS were independent predictors of increased CIMT after multiple linear regression analysis. Conclusions: MS is associated with greater inflammation and subclinical atherosclerosis in patients with psoriasis.


Resumen Introducción: Los pacientes con psoriasis tienen prevalencia incrementada de factores de riesgo y enfermedad cardiovascular. Objetivo: Determinar si los pacientes con psoriasis y síndrome metabólico (SM) tienen mayor frecuencia de ateroesclerosis subclínica comparados con pacientes con psoriasis y sin SM. Material y Métodos: Estudio transversal, en pacientes con psoriasis; SM fue definido con base en criterios ATP III. Se obtuvieron datos demográficos, clínicos y antropométricos. Se realizó química sanguínea, proteína C reactiva de alta sensibilidad (PCR-hs) e insulina. Ateroesclerosis subclínica fue definida como grosor de íntima-media carotídeo (GIMC) elevado, medido por ultrasonido tipo B. Resultados: Se incluyeron 92 pacientes con psoriasis, 67 (72.8 %) con SM y 25 (27.2 %) sin SM. Los sujetos con psoriasis y SM tuvieron valores significativamente más elevados de peso, índice de masa corporal, circunferencia de cintura, tensión arterial sistólica, glucosa, insulina, triglicéridos, resistencia a insulina, PCR-hs y menores niveles de colesterol de alta densidad, comparados con sujetos sin SM. El GIMC fue mayor en pacientes con psoriasis y SM. La edad y el SM fueron predictores independientes de mayor GIMC después de realizar múltiples análisis de regresión lineal. Conclusiones: Síndrome metabólico está asociado con mayor inflamación y ateroesclerosis subclínica en pacientes con psoriasis.

3.
An. Fac. Cienc. Méd. (Asunción) ; 55(2): 40-46, 20220801.
Article in Spanish | LILACS | ID: biblio-1380313

ABSTRACT

Introducción: El Síndrome Metabólico es de alta prevalencia en la población adulta y comprende un conjunto de factores de riesgo para el desarrollo de diabetes mellitus tipo 2 y cardiopatía isquémica. Objetivos: Determinar la frecuencia, componentes más frecuentes y la diferencia de las mediciones entre hombres y mujeres de Síndrome metabólico en pacientes jóvenes del ambulatorio de la Primera Cátedra de Clínica Médica del Hospital de Clínicas. Materiales y métodos: Diseño observacional, descriptivo, retrospectivo de corte transversal, que incluyó a pacientes adultos de 18 a 40 años que consultaron en el ambulatorio de la Primera Cátedra de Clínica Médica del Hospital de Clínicas de enero a diciembre de 2019. Se determinaron las variables demográficas (edad, sexo, procedencia), perímetro de cintura, presión arterial, c-HDL, triglicéridos y la glicemia. El Síndrome Metabólico se determinó de acuerdo a las definiciones de la NCEP-ATP III. Resultados: Se incluyeron en el estudio 312 pacientes, la edad media fue de 27,5± 6,2 años, en el sexo masculino fue de 27,4 ± 6,6 años y en sexo femenino de 27,9 ± 6,4 años. El 10,5% de los pacientes cumplieron con los criterios para el diagnóstico de Síndrome Metabólico, de los cuales 60,6% pacientes son del sexo femenino. Los componentes individuales más frecuentes son el perímetro de cintura aumentada y el c-HDL bajo. Conclusión: La frecuencia de Síndrome Metabólico es similar a otro estudio realizado en adultos jóvenes e inferior que, en adultos mayores, más en mujeres que en hombres y los componentes individuales más frecuentes fueron la obesidad y la dislipidemia.


Introduction: Metabolic syndrome is highly prevalent in the adult population and includes a set of risk factors for the development of type 2 diabetes mellitus and ischemic heart disease. Objectives: To determine the frequency, most frequent components and the difference of the measurements between men and women of Metabolic Syndrome in young patients of the ambulatory of the First Chair of Medical Clinic of the Hospital of Clinics. Materials and methods: Observational, descriptive, retrospective cross-sectional design, which included adult patients aged 18 to 40 who consulted in the outpatient clinic of the First Chair of Medical Clinic of the Hospital de Clínicas from January to December 2019. The demographic variables (age, sex, origin), waist circumference, blood pressure, HDL-C, triglycerides and glycemia. Metabolic syndrome was determined according to the NCEP-ATP III definitions. Results: 312 patients were included in the study, the mean age was 27.5 ± 6.2 years, in males it was 27.4 ± 6.6 years and in females 27.9 ± 6.4. years. 10.5% of the patients met the criteria for the diagnosis of metabolic syndrome, of which 60.6% patients are female. The most frequent individual components are increased waist circumference and low HDL-C. Conclusion: Frequency of metabolic syndrome similar to another study carried out in young adults and lower than in older adults, more in women than in men and the most frequent individual components were obesity and dyslipidemia.


Subject(s)
Metabolic Syndrome , Diabetes Mellitus, Type 2 , Dyslipidemias , Clinical Medicine , Risk Factors
4.
Int. j. cardiovasc. sci. (Impr.) ; 35(3): 400-409, May-June 2022. tab, graf
Article in English | LILACS | ID: biblio-1375644

ABSTRACT

Abstract Background: Due to the growing concern about work-related social and health aspects, occupational health and safety has become relevant. Objective: This work aims to develop a model to assist cardiovascular risk management in a team of haul truck operators, who work in rotating shifts at a mining company in Brazil. Methods: This longitudinal study evaluated risk factors for cardiovascular diseases of 191 mineworkers at three times points - 2010, 2012, and 2015. In addition, the risk of developing cardiovascular diseases was calculated, and the risk factors were analyzed using the chi-square test, the U Mann-Whitney test, and binary logistic regression. The significance level was set at 5%. Results: In the study period, body weight, body mass index (BMI), waist-to-height ratio (WHR), systolic (SBP), and diastolic blood pressure (DBP), total cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglycerides levels of the study group increased. In 2015, there was a high prevalence of alcohol intake, overweight or obesity, central obesity, inadequate WHR, high blood pressure, total cholesterol above 190 mg/dL, and triglycerides above 150 mg/dL. An association was identified between increased cardiovascular risk and age, SBP, HDL-C, low-density lipoprotein cholesterol (LDL-C), and elevated glucose levels. Conclusion: Intense interventions for reduction and prevention of elevated alcohol intake, blood pressure levels, WHR, metabolic syndrome, blood glucose, and LDL-C levels, and low HDL-C levels are needed. In addition, a close monitoring of mine workers over 38 years of age who smoke, consume alcoholic beverages, and have altered blood glucose levels is important.


Subject(s)
Humans , Male , Female , Occupational Health , Miners , Heart Disease Risk Factors , Tobacco Use Disorder , Alcohol Drinking , Cardiovascular Diseases/prevention & control , Longitudinal Studies , Metabolic Syndrome , Metabolic Syndrome/complications , Shift Work Schedule , Hypercholesterolemia
5.
Rev. colomb. gastroenterol ; 37(2): 136-143, Jan.-June 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1394942

ABSTRACT

Abstract Introduction: Cirrhosis of the liver is a significant cause of morbidity and mortality in Latin America; the increased prevalence of metabolic syndrome in our population could be changing the epidemiological profile of patients with advanced chronic liver disease. Aim: To characterize a group of patients with cirrhosis of the liver at an outpatient hepatology care center in Cartagena de Indias, Colombia, and determine the contribution of nonalcoholic steatohepatitis (NASH) as an etiological factor in this population. Materials and methods: Retrospective, cross-sectional, analytical study. All patients who attended the hepatology follow-up with a diagnosis of cirrhosis of the liver were in the six-monthly follow-up protocol that included screening for hepatocellular carcinoma (HCC) and esophageal varices. Results: 346 patients were included, most were women (54.3 %). The first and second causes of cirrhosis were cryptogenic (35 %) and NASH (30.9 %), respectively, followed by viral hepatitis (17 %) and autoimmune diseases (9 %). Of these patients, 87.4 % were within categories A and B of the Child-Turcotte-Pugh score, and only 12.5 % (33 patients) were in stage C. Also, 60 % had at least one clinical decompensation, 38 % a history of variceal hemorrhage, and 4 % a diagnosis of HCC; 80.6 % of patients with NASH cirrhosis had diabetes, and 46.7 % were overweight. Conclusion: NASH cirrhosis is an emerging cause of advanced chronic liver disease in Colombia.


Resumen Introducción: la cirrosis hepática es una importante causa de morbimortalidad en América Latina; el incremento de la prevalencia del síndrome metabólico en nuestra población podría estar cambiando el perfil epidemiológico de los pacientes con enfermedad hepática crónica avanzada. Objetivos: caracterizar un grupo de pacientes con cirrosis hepática y determinar la contribución de la esteatohepatitis no alcohólica (NASH) como factor etiológico de esta población en la ciudad de Cartagena de Indias, Colombia, en un centro de atención ambulatoria de hepatología. Métodos: estudio retrospectivo, transversal, analítico. Se incluyeron todos los pacientes que acudieron al seguimiento de hepatología con diagnóstico de cirrosis hepática que se encontraban en el protocolo de seguimiento semestral que incluía el cribado de hepatocarcinoma y várices esofágicas. Resultados: se incluyeron 346 pacientes. La mayoría fueron mujeres (54,3 %). La primera y segunda causa de cirrosis fue la criptogénica (35 %) y la NASH (30,9 %), respectivamente; seguidas de las hepatitis virales (17 %) y enfermedades autoinmunes (9 %). De estos pacientes, el 87,4 % se encontraba dentro de las categorías A y B de la escala pronóstica de Child-Turcotte-Pugh, y solo el 12,5 % (33 pacientes) en estadio C. El 60 % había presentado al menos una descompensación clínica, 38 % tenía antecedentes de hemorragia por várices y 4 %, diagnóstico de hepatocarcinoma. El 80,6 % de los pacientes con cirrosis NASH era diabético y el 46,7 % tenía exceso de peso. Conclusión: La cirrosis NASH es una causa emergente de enfermedad hepática crónica avanzada en Colombia.

6.
Cienc. Salud (St. Domingo) ; 6(2): 77-83, 20220520. ilus
Article in Spanish | LILACS | ID: biblio-1379387

ABSTRACT

Introducción: el síndrome de ovario poliquístico (SOP) es un trastorno endocrino metabólico altamente dominante, el cual es considerado como una de las afecciones más comunes en las mujeres, tanto adolescentes como adultas durante su etapa fértil. Presenta una prevalencia de aproximadamente un 21 % a nivel global. Objetivo: determinar la prevalencia del síndrome de ovario poliquístico en pacientes que acudieron a una consulta de ginecología-obstetricia y endocrinología en la Romana, República Dominicana. Metodología: estudio observacional, retrospectivo, analítico y de corte transversal en el que se analizaron 252 récords médicos de distintas pacientes con y sin SOP para determinar la prevalencia de esta. Como herramienta de estudio se utilizó un formulario creado por el asesor y colaboradores, que se aplicó a los récords médicos empleando los criterios de Rotterdam como determinantes para el diagnóstico del SOP. Resultados: los resultados mostraron que un 67 % de las mujeres no presentaron SOP, correspondiendo a 170 pacientes, mientras que las 82 pacientes restantes presentaron SOP, representando un 33 %. Asimismo, el grupo etario con mayor frecuencia de SOP correspondió al rango de 26 a 35 años con un 52.4 %. Por otra parte, se presentaron más pacientes con SOP no obesas con un 71 %. Con relación a la presencia de ciclos menstruales regulares e irregulares, las pacientes irregulares con SOP indicaron un 47.6 % y las pacientes regulares sin SOP indicaron un 16.7 %, resultando que se acepta la hipótesis nula. Conclusiones: la prevalencia de síndrome de ovario poliquístico fue de un 33 %. El rango de edad más frecuente fue de 26 a 35 años. Predominó la presencia de pacientes con SOP no obesas. La comparación de las pacientes con ciclos menstruales irregulares fue mayor para aquellas que padecen SOP


Introduction: Polycystic ovary syndrome (PCOS) is a highly dominant endocrine metabolic disorder, which is considered one of the most common conditions in women, both adolescents and adults during their fertile stage. It has a prevalence of approximately 21% globally. Objectives: To determine the prevalence of polycystic ovary syndrome in patients who attended a gynecology-obstetrics and endocrinology consultation in la Romana, Dominican Republic. Methodology: An observational, retrospective, analytical and cross-sectional study in which 252 medical records of different patients with and without PCOS were analyzed to determine its prevalence. As a study tool, a form created by the advisor and collaborators was used, which was applied to medical records, the Rotterdam criteria were employed as determinants for the diagnosis of PCOS. Results: The results showed that 67% of the women did not present PCOS corresponding to 170 patients, while the remaining 82 patients presented PCOS representing 33%. Likewise, the age group with the highest frequency of PCOS corresponded to the range of 26 to 35 years with 52.4%. On the other hand, there were more non-obese PCOS patients with 71%. Regarding the presence of regular and irregular menstrual cycles, irregular patients with PCOS indicated 47.6% and regular patients without PCOS indicated 16.7%, resulting in the acceptance of the null hypothesis. Conclusions: The prevalence of polycystic ovary syndrome was 33%. The most frequent age range was 26 to 35 years. The presence of non-obese PCOS patients predominated. The comparison of patients with irregular menstrual cycles was higher for those with PCOS


Subject(s)
Humans , Female , Adult , Polycystic Ovary Syndrome , Physicians' Offices , Endocrinology , Gynecology , Obstetric Nursing
7.
An. bras. dermatol ; 97(2): 166-172, Mar.-Apr. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1374246

ABSTRACT

Abstract Background Androgenetic alopecia in the pediatric population is rarely discussed in the literature. Although the prevalence of the metabolic syndrome is increased in patients with early-onset androgenetic alopecia, the presence of metabolic syndrome risk factors in pediatric androgenetic alopecia is unknown. Objective To evaluate the demographics, medical and family histories, clinical and trichoscopic features, androgenic hormones, and metabolic syndrome risk factors in pediatric androgenetic alopecia. Methods The medical reports of pediatric patients with androgenetic alopecia were reviewed. Results The study included 23 patients (12 females and 11 males) with a mean age of 15,3 ± 2,1 years. Sixteen patients had adolescent androgenetic alopecia and seven, had childhood alopecia. Nine patients reported a family history, all of whom had adolescent androgenetic alopecia. Hyperandrogenism was noted in three patients with adolescent androgenetic alopecia. The most common hair loss pattern was diffuse thinning at the crown with preservation of the frontal hairline which was noted in 10 patients (43.5%), six of whom were males. Fourteen patients (60.9%) had at least one metabolic syndrome risk factor. The most common risk factor was obesity or overweight (47.8%) followed by insulin resistance (21.7%), high fasting blood glucose (13%), high blood pressure (4.4%) and lipid abnormalities (4.4%). Study limitations Retrospective study; lack of a control group. Conclusion Pediatric androgenetic alopecia is often associated with metabolic syndrome risk factors. Therefore, androgenetic alopecia in the pediatric population may indicate a future metabolic syndrome which warrants an accurate and prompt diagnosis for early screening and treatment.

8.
ABCS health sci ; 47: e022212, 06 abr. 2022. tab, graf
Article in English | LILACS | ID: biblio-1372690

ABSTRACT

INTRODUCTION: The anthropometric indicators of obesity may be important in predicting metabolic syndrome (MS). OBJECTIVE: To evaluate the anthropometric indicators as predictors of MS and verify the association of these indicators with MS in older adult individuals of both sexes. METHODS: Cross-sectional epidemiological study was carried out with 222 individuals aged 60 years or older residents in the urban area of Aiquara, Bahia state, Brazil. Older adults were measured for anthropometric indicators: body mass index (BMI), waist-to-height ratio (WHtR), waist circumference, conicity index, the sum of skinfolds; blood pressure; biochemical variables: fasting glucose, triglycerides, total cholesterol, and fractions. For the diagnosis of MS, the definition of the International Diabetes Federation was used. Descriptive and inferential data analysis was tested using correlation, the Poisson regression technique, and the Receiver Operating Characteristic (ROC) curve. RESULTS: The prevalence of MS was 62.3%. There was a correlation of all anthropometric indicators with MS in both sexes. The indicators of visceral fat had a strong association in that these indicators had an area under the ROC curve higher than 0.76 (CI95% 0.66­0.85). Thus, most results showed a weak correlation. CONCLUSION: All anthropometric indicators can be used to predict MS in older adults for both sexes, however, BMI and WHtR showed the best predictions.


INTRODUÇÃO: Os indicadores antropométricos de obesidade podem ser importantes na predição da síndrome metabólica (SM). OBJETIVO: Avaliar os indicadores antropométricos como preditores da SM, bem como verificar a associação desses indicadores com a SM em idosos de ambos os sexos. MÉTODOS: Estudo epidemiológico transversal realizado com 222 indivíduos com 60 anos ou mais residentes na zona urbana de Aiquara-BA, Brasil. Os idosos foram avaliados quanto aos indicadores antropométricos: índice de massa corporal (IMC), razão cintura-estatura (RCEst), circunferência da cintura, índice de conicidade, soma de dobras cutâneas; pressão sanguínea; bioquímicos: glicemia em jejum, triglicérides, colesterol total e frações. Foram classificados quanto à presença de SM de acordo com a Federação Internacional de Diabetes. A análise descritiva e inferencial dos dados foi testada utilizando correlação, a técnica de regressão de Poisson e a curva Receiver Operating Characteristic (ROC). RESULTADOS: A prevalência de SM foi de 62,3%. Houve correlação de todos os indicadores antropométricos com a SM em ambos os sexos. Os indicadores de gordura visceral apresentaram forte associação, pois possuem área abaixo da curva ROC superior a 0,76 (IC95% 0,66-0,85). Assim, a maioria dos resultados apresentou correlação fraca. CONCLUSÃO: Todos os indicadores antropométricos podem ser usados para rastrear a SM em idosos de ambos os sexos, no entanto, o IMC e a RCEst apresentaram as melhores previsões.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Anthropometry , Health of the Elderly , Metabolic Syndrome , Obesity , Cross-Sectional Studies , ROC Curve
9.
Rev. chil. nutr ; 49(2)abr. 2022.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1388593

ABSTRACT

RESUMEN La población universitaria presenta cambios en su estilo de vida, que se refleja en su composición corporal, y alteraciones metabólicas. Los estudiantes del área de la salud son futuros promotores de estilos de vida saludables. El objetivo de este trabajo fue identificar la frecuencia del Síndrome metabólico (SM) y sus componentes en los estudiantes del programa de Nutrición y Dietética. Noventa estudiantes de 18 a 25 años, en quienes se evaluaron los componentes del SM, la actividad física por acelerometría, el consumo de alcohol mediante el cuestionario Audit, tabaquismo y horas de sueño por el método Pittsburgh. Las prevalencias encontradas fueron: SM 1,1%, circunferencia de cintura elevada 4,5%, triglicéridos altos 11%, HDL bajos 32%, presión arterial elevada 1,1%. Se encontró que 73% cumplían con las recomendaciones de actividad física recomendadas por la OMS. Sin embargo, el 100% de los estudiantes pasaron más de 9 horas sedentarias por día, el 6,7% presentaron un consumo de alcohol catalogado como perjudicial, 19% estuvieron expuestos al humo o eran fumadores, y el 63,3% se consideraron como malos dormidores. No hubo asociación entre las variables del estilo de vida con los componentes del SM. En conclusión, los triglicéridos altos y las HDL bajas, el sedentarismo y la baja calidad de sueño son variables importantes para tener en consideración en programas de intervención con la finalidad de ser nutricionistas coherentes con la profesión.


ABSTRACT Changes to body composition and metabolic functions occur in the university population due to lifestyle choices. Students in the health programs are expected to fulfill a fundamental role in promoting healthy lifestyles. The objective of this work was to identify the frequency of Metabolic Syndrome (MS) and its components among students of a Nutrition and Dietetics program. Ninety students between 18 and 21 years old were evaluated for each of the components of the MS, physical activity by accelerometry, alcohol consumption by Audit questionnaire, smoking, and hours of sleep by Pittsburgh method. The prevalence found were: MS 1.1%, high waist circumference 4.5%, high triglycerides 11%, low HDL 32%, high blood pressure 1.1%. Regarding variables related to lifestyle habits, 73% complied with physical activity recommendations recommended by the WHO. However, 100% of the students were sedentary more than 9 hours per day, 6.7% had alcohol consumption classified as harmful, 19% were exposed to smoke or were smokers, and 63.3% were considered bad sleepers. There was no association between lifestyle variables and the MS components. In conclusion, high triglycerides, low HDL, sedentary lifestyle, and low sleep quality are crucial variables to consider in intervention programs aimed at training nutritionist, in keeping with the profession.

10.
Rev. chil. nutr ; 49(2)abr. 2022.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1388596

ABSTRACT

RESUMEN La obesidad es un problema de salud pública a nivel mundial. Existen evidencias sobre la interacción entre la microbiota intestinal, la regulación metabólica y la obesidad. El problema mundial de la obesidad impulsa el estudio de nuevas propuestas preventivas y/o terapéuticas. El trasplante de microbiota fecal (TMF) se proyecta como un posible tratamiento para la obesidad y sus comorbilidades asociadas. El objetivo de este estudio es sintetizar la documentación actual que existe sobre el efecto en parámetros metabólicos y clínicos que produce el TMF en humanos con obesidad, así como evidenciar la metodología empleada en el TMF. En los resultados primarios se señaló la existencia de cambios significativos en la composición de la microbiota intestinal (MI) y mejoría en marcadores metabólicos como disminución de la resistencia a la insulina (RI) y de la hemoglobina glicada (HbA1c), así como aumento de colesterol de alta densidad (HDL). Además, en marcadores clínicos como la disminución del índice de masa corporal y de la circunferencia de cintura. En los resultados secundarios se sustentó la necesidad de estandarizar el diseño experimental del TMF, iniciando con establecer la correcta selección de donantes hasta determinar el seguimiento del TMF a largo plazo. En conclusión, a pesar de que hay un número limitado de estudios y una falta de estandarización de las metodologías para llevar a cabo TMF, se han podido evidenciar algunas asociaciones metabólicas positivas, por lo que el TMF sigue siendo una opción potencialmente prometedora para el tratamiento coadyuvante de la obesidad.


ABSTRACT Obesity is a worldwide health problem. There is evidence of the interaction between the gut microbiota metabolic regulation, and obesity. The global problem of obesity has prompted the study of new preventive and/or therapeutic proposals. Fecal Microbiota Transplantation (FMT) is projected as a possible treatment for obesity and its associated comorbidities. The objective of this study is to synthesize the current documentation that exists on the effect in metabolic and clinical parameters produced by FMT in humans with obesity, as well as to make evident the methodology used in FMT. Primary results indicated the existence of significant changes in the composition of gut microbiota and improvement in some metabolic markers such as a decrease in insulin resistance (IR) and glycated hemoglobin (HbA1c), as well as an increase in high-density cholesterol (HDL). Further changed were noted in clinical markers such as the decrease in body mass index and waist circumference. Secondary results supported the need to standardize the experimental design of FMT, starting with establishing the correct selection of donors to determine the long-term follow-up of FMT. In conclusion, even though there is a limited number of studies and a lack of standardization on the methodology to carry out FMT, some positive metabolic associations have been shown, which is why FMT remains a potentially promising option for treatment adjuvant of obesity.

11.
Rev. Assoc. Med. Bras. (1992) ; 68(3): 323-328, Mar. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1376141

ABSTRACT

SUMMARY OBJECTIVES: This study examined the association between handgrip strength and body composition, physical fitness, and biomarkers in postmenopausal women with metabolic syndrome. METHODS: A total of 75 postmenopausal women were diagnosed with metabolic syndrome participated in this study. Muscle strength was assessed via a hydraulic grip strength dynamometer; physical fitness tests included a timed-up-and-go, arm curl test, and 30-s chair stand. Body composition was assessed via bioelectrical impedance, from which estimates of fat mass, body fat percentage, fat-free mass, and visceral fat area were determined. Fasting plasma glucose and glycated hemoglobin were measured via blood sample analyses. Multiple linear regression analyses were conducted using handgrip strength as the dependent variable and using body composition, physical fitness, and biomarkers as independent variables. RESULTS: The results revealed that 52% of the total sample were classified as obese, 37.3% as overweight, and only 10.7% as normal weight. Significant correlations were present between handgrip strength and fat-free mass (p=0.002; R=0.590), mean blood pressure (p=0.002; R=0.450), and arm curl (p=0.001; R=0.795). CONCLUSION: This study showed that handgrip strength was predictive of fat-free mass, blood pressure, and upper limb strength performance.

12.
Rev. bras. ginecol. obstet ; 44(3): 287-294, Mar. 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1387881

ABSTRACT

Abstract Objective To evaluate the association between polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS), adding liver assessment through elastography and ultrasound, for correlation with non-alcoholic fatty liver disease (NAFLD). Metabolic syndrome occurs in~43% of women with PCOS, and NAFLD is the hepatic expression of MetS. Methods One hundred women, 50 with PCOS and 50 controls, matched by age (18- 35 years) and body mass index (BMI) were included, restricted to patients with overweight and obesity grade 1, at the Assis Chateaubrian Maternity School, Universidade Federal do Ceará, Brazil. For the diagnosis of PCOS, we adopted the Rotterdam criteria, and for the diagnosis of MetS, the criteria of the National Cholesterol Education Program (NCEP/ATP III). Hepatic elastography and ultrasound were performed to assess liver stiffness and echotexture, respectively. Results The average ages were 29.1 (±5.3) and 30.54 (±4.39) years, for the PCOS and the control group, respectively. Patients with PCOS had a risk 4 times higher of having MetS, odds ratio (95% confidence interval)=4.14, than those in the control group. Women with PCOS had higher average of abdominal circumference (100.9±9.08 cm vs 94.96±6.99 cm) and triglycerides (162±54.63 mg/dL vs 137.54±36.91mg/dL) and lower average of HDL cholesterol (45.66±6.88 mg/dL vs 49.78±7.05 mg/dL), with statistically significant difference. Hepatic steatosis was observed on ultrasound in women with PCOS; however, with no statistically significant difference. There was no change to NAFLD at elastography in any group. Conclusion Women with PCOS had 4-fold higher frequency of MetS andmore hepatic steatosis, with no statistically significant difference. There was no change in liver stiffness between the groups at elastography. The results can be extended only to populations of overweight and obesity grade 1, with PCOS or not. They cannot be generalized to other untested groups.


Resumo Objetivo Avaliar a associação entre a síndrome do ovário policístico (SOP) e a síndrome metabólica (SM), agregando avaliação do fígado por elastografia e ultrassonografia, para correlação com doença hepática gordurosa não alcoólica (DHGNA). A SM ocorre em cerca de 43% dasmulheres comSOP, e DHGNA é a expressão hepática da SM. Métodos Foramincluídas 100 mulheres, pareadas por idade (18-35 anos) e índice de massa corporal (IMC), 50 comSOP e 50 controles com sobrepeso e obesidade grau I, na Maternidade-Escola Assis Chateaubriand, Brasil. Para o diagnóstico de SOP, adotamos os critérios de Rotterdam e, para o diagnóstico de SM, os critérios do National Cholesterol Education Program (NCEP/ATP III). Elastografia hepática e ultrassonografia foram realizadas para avaliar a rigidez e a ecotextura do fígado, respectivamente. Resultados As médias de idade foram de 29,1 (±5,3) e 30,54 (±4,39) anos para os grupos SOP e controle, respectivamente. Pacientes com SOP apresentaram risco 4 vezes maior de SM do que aquelas no grupo controle [[razão de chances (intervalo de confiança de 95%) = 4,14]. Mulheres com SOP tiveram maior média de circunferência abdominal (100,9±9,08cm vs 94,96±6,99 cm) e triglicérides (162±54,63 mg/dL vs 137,54±36,91 mg/dL) e menor média de colesterol HDL (45,66±6,88 mg/dL vs 49,78±7,05mg/dL), com diferença estatisticamente significativa. Esteatose hepática foi observada em ultrassonografias de mulheres com SOP, porém sem diferença estatisticamente significativa. Não houve mudança para DHGNA na elastografia em nenhum dos grupos. Conclusão Mulheres com SOP tiveram frequência quatro vezes maior de SM e mais esteatose hepática, sem diferença estatisticamente significativa. Não houve mudança na rigidez do fígado entre os grupos na elastografia. Os resultados podem ser estendidos apenas a populações com sobrepeso e obesidade grau 1, com SOP ou não. Eles não podem ser generalizados para outros grupos não testados.

13.
Rev. peru. med. exp. salud publica ; 39(1): 36-46, ene.-mar. 2022. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1389926

ABSTRACT

RESUMEN Objetivo. Estimar el efecto de una intervención educativa basada en nutrición y estilos de vida saludables para incrementar la proporción de adolescentes libres de componentes del síndrome metabólico. Materiales y métodos. Se realizó un estudio preexperimental en una muestra representativa de adolescentes de dos escuelas de un distrito altoandino del Perú (ciudad de Cajamarca); 388 estudiantes completaron la intervención, así como la medición basal y la posintervención. La intervención tuvo nueve ejes temáticos, cada uno fue desarrollado en una sesión educativa de 45 min cada dos semanas. Se usó los criterios del National Cholesterol Education Program Expert Panel and Adult Treatment Panel III para el síndrome metabólico. Se realizó la comparación de proporciones pareadas (prueba de McNemar) para determinar el impacto de la intervención. Resultados. En la medición basal, el 20,4% (IC95%: 16,2 a 24,5) no tenía componentes de SM, posintervención dicha proporción se incrementó a 32,5% (IC95%: 27,7 a 37,3), la diferencia de proporciones fue 12,1% (IC95%: 7,5 a 16,8; p<0,001). La prevalencia de síndrome metabólico fue 4,6% (IC95%: 2,4 a 6,9) basalmente; posintervención fue 2,3% (IC95%: 0,7 a 3,9). La diferencia de proporciones fue 2,3%, (IC95%: 0,3 a 3,2; p=0,022). Entre los componentes, la mayor reducción fue en la proporción de hipertrigliceridemia (diferencia de proporciones: 21,9%, IC95%: 16,9 a 26,9; p<0,001), también se observó una reducción significativa de la hipertensión arterial (diferencia de proporciones: 3,1%, IC95%: 0,6 a 5,6; p=0,025). En los demás componentes no hubo diferencias significativas. Conclusiones. La intervención educativa incrementó en un 59,3% la proporción de estudiantes libres de algún componente del síndrome metabólico.


ABSTRACT Objective. To estimate the impact of a school-based nutritional and healthy lifestyle intervention to increase the proportions of adolescents free of components of the metabolic syndrome. Materials and methods. We conducted a pre-experimental study in a representative sample of adolescents from two schools in a high Andean district of Peru (Cajamarca city); 388 students completed the intervention and the baseline and post-intervention measurement. The intervention had nine thematic modules; each module was developed in an educational session of 45 minutes every two weeks. We used the National Cholesterol Education Program Expert Panel and Adult Treatment Panel III criteria for metabolic syndrome. We used paired proportions comparison (McNemar test) to determine the impact of the intervention. Results. At baseline, 20.4% (95% CI: 16.2 to 24.5) students had no metabolic syndrome components, post-intervention this proportion increased to 32,5% (95% CI: 27.7 to 37.3), the difference in proportions was 12.1% (95% CI: 7.5 to 16.8; p<0.001). The prevalence of metabolic syndrome was 4.6% (95% CI: 2.4 to 6.9) at baseline, while post-intervention was 2.3% (95%CI: 0.7 to 3.9). During the analysis of components, the greatest reduction was observed in the proportion of hypertriglyceridemia (difference in proportions: 21.9%, 95%CI: 16.9 to 26.9, p <0.001); we also found a significant reduction in arterial hypertension (difference in proportions: 3.1%, 95% CI: 0.6 to 5.6, p=0.025). In the other components, there were no significant differences. Conclusions. The school-based intervention increased in 59.3% the proportion of students free of any component of the metabolic syndrome.

15.
J. pediatr. (Rio J.) ; 98(1): 53-59, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1360559

ABSTRACT

Abstract Objective: To investigate the association between oral contraceptive use and cardiovascular risks, including metabolic syndrome and their components in Brazilian adolescents. Method: This study used data from the Study of Cardiovascular Risks in Adolescents (Estudo de Riscos Cardiovasculares em Adolescentes - ERICA), a nationwide, cross-sectional, school-based study with individuals aged 12-17 years. Sociodemographic variables and OC use were assessed by a self-administered questionnaire. International Diabetes Federation criteria were used to define metabolic syndrome. Descriptive statistics were reported as prevalence and their respective confidence interval of 95% of oral contraceptives according to variables. Logistic regression was performed. Crude and adjusted odds ratios were calculated. Results: This subsample was composed of 22,682 female adolescents, of which 12.65% reported using oral contraceptives and their use was associated with hypertension and hypertriglyceridemia. These associations remained statistically significant after adjusting for age, school region, race, and tobacco use with an increase of 2.68 (1.66 - 4.32) and 3.45 (2.56 - 4.65) times, respectively. Conclusion: The present study was the first to examine the association between the use of oral contraceptives and cardiovascular risk factors among the largest number of female Brazilian adolescents. This method was significantly associated with hypertension, hypertriglyceridemia. Teenagers using oral contraceptives should be monitored for side effects, including blood pressure measurements and advised to avoid smoking.


Subject(s)
Humans , Female , Child , Adolescent , Cardiovascular Diseases/chemically induced , Cardiovascular Diseases/epidemiology , Brazil/epidemiology , Cross-Sectional Studies , Risk Factors , Contraceptives, Oral/adverse effects , Heart Disease Risk Factors
16.
An. bras. dermatol ; 97(1): 28-36, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1360088

ABSTRACT

Abstract Background: Vitiligo is an acquired and progressive mucocutaneous disease resulting from the loss of active epidermal melanocytes. Metabolic syndrome (MetS) affects about 25% of the world's population and is linked to inflammatory skin diseases including vitiligo. Fatty AcidBinding Protein 4 (FABP4) is an intracellular lipid chaperone. FABP4 is closely associated with MetS. Objectives: To evaluate the serum level of FABP4 in vitiligo patients and its relation to MetS in the investigated cases. Methods: This case control study was conducted on 45 patients having non segmental vitiligo and 45 matched controls. Their lipid profile, blood glucose and serum FABP4 levels were measured. Results: There were significant elevations in FABP4 (p < 0.001), cholesterol (p < 0.001), triglycerides (p = 0.005), and glucose (fasting [p = 0.001] and 2 hours post prandial [p < 0.001]) levels in patients in comparison with controls. MetS was significantly more prevalent among vitiligo patients (p < 0.001) and associated with high FABP4 serum levels (p = 0.037). In vitiligo patients, there were significant positive correlations between FABP4 serum levels and triglycerides (p = 0.047), cholesterol (p = 0.001) and LDL (p = 0.001) levels and negative correlation regarding HDL level (p = 0.009). FABP4 level was a significantly good diagnostic test for early detection of vitiligo (p < 0.001). Study limitations: The small number of studied subjects. Conclusions: FABP4 may play an active role in the disease process of vitiligo that could be mediated through associated dyslipidemia and hyperglycemia. FABP4 may be a marker of vitiligo helping in its early diagnosis, but it does not appear to be useful for determining vitiligo severity, activity or associated MetS.


Subject(s)
Humans , Metabolic Syndrome , Fatty Acid-Binding Proteins/blood , Triglycerides , Vitiligo , Case-Control Studies
17.
Rev. Assoc. Med. Bras. (1992) ; 68(2): 250-255, Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1365337

ABSTRACT

SUMMARY OBJECTIVE: The metabolic syndrome involves both metabolic and cardiovascular risk factors and is associated with cardiovascular mortality. Epicardial fat tissue plays a crucial role in deleterious effects of metabolic syndrome on the heart, including myocardial fibrosis. The fragmented QRS reflects heterogeneous depolarization of the myocardium and occurs as a result of fibrosis. Thus, we aimed to investigate whether there is an association between fragmented QRS and epicardial fat tissue in patients with metabolic syndrome. METHODS: This study enrolled 140 metabolic syndrome patients, of whom 35 patients with fragmented QRS (+) and 105 patients with fragmented QRS (−). The two groups were compared with respect to clinical, laboratory, electrocardiographic, and echocardiographic indexes. RESULTS: Fragmented QRS (+) patients had higher waist circumference, red cell distribution width, creatinine, left ventricular end-systolic diameter, left atrium diameter, septal a velocity, QRS duration, and epicardial fat tissue compared with fragmented QRS (−) patients. Waist circumference, red cell distribution width, QRS duration, left ventricular end-systolic diameter, left atrium diameter, septal a velocity, and epicardial fat tissue were significantly associated with the presence of fragmented QRS. The QRS duration and epicardial fat tissue were independently associated with the presence of fragmented QRS on surface electrocardiographic in metabolic syndrome patients. CONCLUSIONS: Epicardial fat tissue and QRS duration were independently associated with the presence of fragmented QRS. Basic echocardiographic and electrocardiographic parameters might be used for the risk stratification in metabolic syndrome patients.


Subject(s)
Humans , Metabolic Syndrome/complications , Echocardiography , Adipose Tissue/diagnostic imaging , Electrocardiography/methods , Waist Circumference
18.
Rev. chil. nutr ; 49(1)feb. 2022.
Article in English | LILACS-Express | LILACS | ID: biblio-1388582

ABSTRACT

ABSTRACT Metabolic syndrome (MS) is a global health problem. Dietary factors, especially fatty acids, may affect MS pathology. However, the associations between omega-3 polyunsaturated fatty acids (n-3 PUFAs) and MS risk demonstrate inconsistent results. To clarify the relationship between dietary n-3 PUFA and endothelial function on MS, we carried out a systematic review. An electronic literature search based on controlled clinical trials (CCTs) between 2004 and 2020 was conducted. A total of 28 articles were included in the systematic review. Studies were analyzed according intervention type: dietary interventions (12 CCTs), dietary supplementation interventions (9 CCTs) and mixed interventions (7 CCTs). Studies with dietary interventions characterized by n-3 PUFAs increased by food source, such as Mediterranean and Nordic-style diets, reported significant reduction in systolic and diastolic blood pressure, and also in inflammatory endothelial biomarkers. The same effect was also observed in mixed interventions and in CCTs with n-3 PUFAs supplementation. Dietary interventions with n-3 PUFAs contributes to improved endothelial and cardiovascular health in SM and associated risk factors.


RESUMEN El síndrome metabólico (SM) es un problema sanitario global. Los factores dietéticos, especialmente los ácidos grasos, pueden afectar la patología del SM. Sin embargo, las asociaciones entre los ácidos grasos poliinsaturados omega-3 (AGPI n-3) y el riesgo de SM pueden ser inconsistentes. Para aclarar esta relación entre AGPI n-3 dietarios y la función endotelial en el SM, realizamos una revisión sistemática. Se realizó una búsqueda bibliográfica en fuentes electrónicas de ensayos clínicos controlados (ECC) entre 2004 y 2020. Se incluyeron un total de 28 artículos en la revisión. Los estudios fueron analizados según intervención realizada: intervención dietaria (12 ECC), intervención con suplementación dietética (9 ECC) e intervenciones mixtas (7 ECC). Los estudios que utilizaron intervenciones dietéticas con aumento de AGPI n-3 a través de alimentos, como las dietas mediterráneas y nórdicas, reportaron una reducción significativa de la presión arterial sistólica (PAS), diastólica (PAD) y de biomarcadores endoteliales inflamatorios. El mismo efecto se observó en intervenciones mixtas y ECC con suplementación de AGPI n-3. Las intervenciones dietéticas con AGPI n-3 contribuyen a mejorar la salud endotelial y cardiovascular y sus factores de riesgo asociados.

19.
Arq. bras. cardiol ; 118(1): 33-40, jan. 2022. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1360114

ABSTRACT

Resumo Fundamento A ação do peptídeo natriurético atrial (ANP) na natriurese, diurese e vasodilatação, resistência à insulina, fígado, rim e tecido adiposo pode contribuir para o desenvolvimento metabólico e cardiovascular saudável. Embora o nível circulante de ANP seja reduzido em pacientes com obesidade, sua resposta à perda de peso ainda é pouco explorada em populações pediátricas. Objetivo Avaliar os efeitos das variações do ANP em resposta à intervenção interdisciplinar para perda de peso na Síndrome Metabólica (SMet) e nos riscos cardiometabólicos em adolescentes com obesidade. Métodos 73 adolescentes com obesidade participaram de uma terapia interdisciplinar para perda de peso de 20 semanas, incluindo uma abordagem clínica, nutricional, psicológica e de exercícios físicos. A composição corporal, análises bioquímicas e pressão sanguínea foram avaliadas. A SMet foi classificada de acordo com a Federação Internacional de Diabetes (IDF) (2007). Após o tratamento, os voluntários foram divididos de acordo com os níveis de plasma do ANP aumento (n=31) ou ANP redução (n=19). Resultados Ambos os grupos apresentaram redução significativa de peso corporal, índice de massa corporal (IMC) e circunferências de cintura, pescoço e quadril (CC, CP e CQ, respectivamente), e aumento da massa livre de gordura (MLG). É interessante observar que houve uma redução significativa na gordura corporal, na razão de TG/HDL-c e na prevalência de SMet (de 23% para 6%) somente no grupo com ANP aumento. Conclusão Este estudo sugere que o aumento nos níveis séricos de ANP após a terapia para perda de peso pode estar associado a melhorias nos riscos cardiometabólicos e na prevalência reduzida de SMet em adolescentes com obesidade.


Abstract Background The action of atrial natriuretic peptide (ANP) on natriuresis, diuresis and vasodilatation, insulin resistance, liver, kidney, and adipose tissue may contribute to the healthy metabolic and cardiovascular development. Even though the circulating level of ANP is reduced in patients with obesity, its response to weight loss remains poorly explored in pediatric populations. Objective To evaluate the effects of ANP variations in response to interdisciplinary weight loss intervention on metabolic syndrome (MetS) and cardiometabolic risks in adolescents with obesity. Methods 73 adolescents with obesity attended a 20-week clinical interdisciplinary weight loss therapy including clinical, nutritional, psychological and exercise training approach. Body composition, biochemical analyses and blood pressure were evaluated. MetS was classified according to the International Diabetes Federation (IDF) (2007). After the treatment, volunteers were divided according to Increasing (n=31) or Decreasing (n=19) ANP plasma levels. Results Both groups present significant reduction of body weight, Body Mass Index (BMI), waist, neck and hip circumferences (WC, NC and HC, respectively) and increasing fat-free mass (FFM). Interestingly, a significant reduction in body fat, TG/HDL-c ratio and MetS prevalence (from 23% to 6%) was observed in the Increased ANP group only. Conclusion This study suggests that an increase in ANP serum levels after weight loss therapy could be associated with improvements in cardiometabolic risks and the reduced prevalence of MetS in adolescents with obesity.


Subject(s)
Humans , Child , Adolescent , Cardiovascular Diseases/etiology , Cardiovascular Diseases/prevention & control , Metabolic Syndrome/epidemiology , Pediatric Obesity/therapy , Body Composition , Weight Loss/physiology , Body Mass Index , Atrial Natriuretic Factor/metabolism
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