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1.
Article | IMSEAR | ID: sea-227750

ABSTRACT

Procalcitonin (PCT), a key hormone regulating calcium homeostasis, has previously shown the potential to differentiate between bacterial and viral infections. However, when we move further into the field of COVID-19 pandemic, an unprecedented question was raised: Can PCT levels increase without bacterial co-infection in SARS-CoV-2 infection? This review systematically searched PubMed, Scopus, and Google Scholar for articles on procalcitonin (PCT) in the context of COVID-19 published from 2019 to 2023. Inclusion criteria focused on relevant articles, excluding non-English publications. Increasing PCT levels were observed in COVID-19 patients, especially in severe cases, often interpreted as evidence of bacterial co-infection. However, the role of PCT in the immune response to SARS-CoV-2 remains unclear. The proposed mechanisms suggest that SARS-CoV-2 can stimulate the production of PCT even in the absence of bacterial co-infection by modulating the interferon (IFN) pathway and reducing the regulation of monocyte function. Furthermore, PCT has implications in antibiotic management, with guidelines recommended to avoid antibiotics in patients with low serum PCT levels. Increased PCT values show associations with the severity of disease, including increased mortality, which further underlines the need for a detailed understanding of the dynamics of the PCT in COVID-19. This review emphasizes the evolving significance of PCT in COVID-19, with elevated PCT levels emerging as a valuable prognostic indicator, aiding in disease severity assessment and management. However, the intricate dynamics of PCT in COVID-19 demand further investigation, particularly in distinguishing viral infection from bacterial co-infection.

2.
Article in Chinese | WPRIM | ID: wpr-1019916

ABSTRACT

Objective To explore the value of cytokines,procalcitonin(PCT)and neutrophil-lymphocyte ratio(NLR)in the early diagnosis and prognosis evaluation in the patients with sepsis.Methods 98 patients with sepsis admitted to the First Affiliated Hospital of Air Force Medical University from January 2020 to January 2023 were selected as research objects,including 82 patients in the sepsis non-shock group and 16 patients in the sepsis shock group.According to the death within 28 days,the patients was divided into survival group(n=82)and death group(n=16).Meantime,95 cases of non-septic infection group were included as control.The expression of interleukin(IL)-1β,IL-2,IL-4,IL-5,IL-6,IL-8,IL-10,IL-12p70,IL-17,tumor necrosis factor(TNF)-α,interferon(IFN)-γ,IFN-α,PCT,and NLR were detected within 24h after admission,and their relationship with sepsis was analyzed by ROC curve.Results ①The IL-2,IL-4,IL-5,IL-6,IL-8,IL-10,IL-12p70,IL-17,TNF-α,IFN-α,NLR and PCT in patients with sepsis were significantly higher than those in healthy subjects(Z=0.43~30.54,all P<0.05)except IL-1β,IFN-γ.Further analysis of ROC showed that IL-8,NLR,PCT and IL-17 had strong predictive ability,with area under curve(AUC)of 0.78(95%CI:0.71~0.84),0.81(95%CI:0.75~0.87),0.83(95%CI:0.78~0.88),0.86(95%CI:0.81~0.92),respectively.Combined detection of the four indicators can effectively improve the diagnostic efficiency of sepsis,with the AUC of 0.90(95%CI:0.85~0.93).② There were no significant differences in cytokines,PCT and NLR concentration between positive and negative blood culture groups(P>0.05),suggesting that these indexes were not affected by blood culture detection results.③Among the patients in the shock group,IL-6[122.10(10.77~10 000.00)ng/L]was significantly higher than that in non-shock group[25.56(1.02~9 096.74)ng/L],the difference was statistically significant(Z=74.55,P=0.01),with the AUC of 0.73(95%CI:0.59~0.87).The levels of IL-10[10.69(1.12~1 338.00)ng/L],IL-2[12.52(0.86~280.42)ng/L]and IL-5[9.55(0.93~259.57)ng/L]in sepsis death group were higher than those[2.55(0.34~695.13)ng/L,4.46(0.13~625.43)ng/L,2.75(0.01~117.88)ng/L]in survival group,the differences were statistically significant(Z=3.64,6.37,4.74,all P<0.05),and the AUC were 0.69(95%CI:0.53~0.85),0.71(95%CI:0.56~0.85)and 0.72(95%CI:0.58~0.87),respectively.Conclusion The combined detection of IL-8,NLR,PCT and IL-17 is helpful for the early diagnosis of sepsis.The increase of IL-6 level can effectively predict the occurrence of septic shock,and the high expression of IL-10,IL-2 and IL-5 has a good predictive value for the death of sepsis patients.

3.
Article | IMSEAR | ID: sea-234460

ABSTRACT

Background: COVID-19 is a systemic disease that affects a broad spectrum of tissues and cells. Infected patients experience a wide variety of clinical signs, ranging from mild clinical signs to bilateral interstitial pneumonia. COVID-19 patients who also experience acute respiratory distress syndrome can result in multi-organ failure without comorbidities. Procalcitonin (PCT) also indicates severity and prognosis to reduce mortality. Method: The research method is descriptive with a cross-sectional approach. The research was conducted at the Siti Fatimah hospital in South Sumatra province in February to May 2022. The sample for this research was the results of a PCT examination in 2021 totaling 66 people. The method for examining PCT levels uses the enzyme-linked method with serum or plasma samples. Results: Obtained PCT levels showed that there was a low risk of PCT levels (?0.05-<0.5) in 26 patients (39.4%), severe risk of PCT levels (?0.5-<2) in 15 patients (22 .7%) and high risk of PCT levels (?2) in 25 patients (37.9%). Based on mortality status, high levels were obtained in 43 patients with a low-risk living category in 21 patients. Based on the history of the disease, high levels were obtained in 41 patients with a history of high-risk disease in 18 patients. Based on the category of treatment in the inpatient room, high levels were obtained in 37 patients treated in the non-ICU room, resulting in low-risk PCT levels in 17 patients. Conclusions: There is a 39.4% PCT level (?0.05-<0.5) which indicates low risk is more common in COVID-19 patients than severe risk and high risk.

4.
Article | IMSEAR | ID: sea-228238

ABSTRACT

Background: Serum procalcitonin (PCT) is already known predictive marker in serious bacterial infection and it is emphasized that these biomarkers can be used as a marker of increased mortality in critically ill patients. The aim of the study was to evaluate the serial PCT level and find out whether these biomarkers can be used to predict mortality. Methods: This was a prospective observational study. Primary objective was to study the serum PCT as a prognostic marker in critically ill children (2 months to 12 years) admitted in PICU while secondary objective was to find out the association of level of serum procalcitonin with different organ system disease involvement and to compare the results of the serum procalcitonin with the PRISM-3 score in diagnosing the severity of illness in the patient. Patient outcome was assessed at hospital discharge, and the patients were divided into non-survivors and survivors. A p value of <0.05 will be considered statistically significant.Results: A total of 185 patients were enrolled, the median age was 5 years (2 months to 12 years) with 56.76% being males. Majority (34.59%) of patients the primary diagnosis was of respiratory system. The median of serum PCT on day 1, day 3 and day 7 with outcome (p<0.05) in dead was significantly higher as compared to alive. The median PRISM score in dead was 21(13-33) which was significantly higher as compared to alive 11 (8-12.7). Serum PCT and PRISM score had significant discriminatory power to predict mortality. Conclusions: In the present study serum PCT found to be a good prognostic marker for all cause mortality in critically ill patients admitted in PICU.

5.
Article in Chinese | WPRIM | ID: wpr-965199

ABSTRACT

Objective To analyze the prognosis of children with severe mycoplasma pneumonia (MPP) and its correlation with serum SAA, PCT and SF levels, so as to provide a basis for evaluating the prognosis of children with MPP. Methods A total of 273 children with MPP admitted to our hospital from January 2020 to December 2020 were divided into mild MPP children (n=187) and severe MPP children (n=86) according to the severity of their disease. According to the prognosis, children with severe MPP were divided into survival group (n=65) and death group (n=21). Serum SAA, PCT and SF levels were determined. Pearson correlation analysis was used to analyze the correlation between serum SAA, PCT and SF levels and APACHE ⅱ score. ROC curve was used to analyze the predictive value of serum SAA, PCT and SF levels for poor prognosis of children with severe MPP. Results The levels of serum SAA, PCT and SF and APACHE II score in children with severe MPP were significantly higher than those in children with mild MPP (P<0.05). Serum SAA, PCT and SF levels and APACHE II score in death group were significantly higher than those in survival group (P<0.05). Pearson correlation analysis showed that APACHE II score was positively correlated with serum SAA, PCT and SF levels (r =0.474,0.519,0.446,P<0.05). The AUC, sensitivity and specificity of combined ROC curve analysis to predict the prognosis of severe MPP were 0.871, 85.9% and 93.6% respectively, which were higher than those of SAA, PCT and SF alone. Conclusion SAA, PCT and SF are closely related to the prognosis of severe MPP, and can be used as potential markers to predict poor prognosis of severe MPP children.

6.
Article in Chinese | WPRIM | ID: wpr-998533

ABSTRACT

Objective The changes and risk factors of FeNO, CRP and PCT in patients with bronchial asthma complicated with sleep apnea syndrome (SAS) in Shanghai area were analyzed to provide theoretical basis for the prevention and treatment of SAS in patients with bronchial asthma. Methods A total of 436 patients with bronchial asthma admitted to our hospital from January 2019 to June 2022 were selected and divided into control group and experimental group according to whether SAS occurred during hospitalization. The experimental group was divided into three subgroups according to the apnea hypopnea index (AHI) values: mild group (AHI>15 times /h or 15 times /h or 28 kg/m2(OR=5.629),allergic rhinitis(OR=6.166)and neck circumference>40 cm(OR=5.265)were independent risk factors for SAS in patients with bronchial asthma(P<0.05);Pearson correlation analysis showed that AHI was positively correlated with serum FeNO,CRP and PCT levels in patients with bronchial asthma and SAS(r=0.471,0.436,0.502,P<0.05). Conclusions Patients with old bronchial asthma in Shanghai area have a higher risk of SAS, and the severity of the disease is positively correlated with the levels of FeNO, CRP and PCT. In particular, obese patients with allergic rhinitis should be given early intervention to reduce the risk of SAS.

7.
Article in Chinese | WPRIM | ID: wpr-1004877

ABSTRACT

【Objective】 To compare the bioactive ingredients in activated platelet-rich plasma (PRP) from cord blood and adult blood, explore its reasonable indicators reflecting the inflammatory regulation ability, in order to guide the preparation. 【Methods】 PRP was prepared and activated from 63 healthy adults (31 males, 32 females) and 61 neonates (30 males, 31 females), and 20 cytokines were measured using Luminex technology for assessing the age- and sex-based bioactive differences of PRP. High-sensitivity C-reactive protein(hs-CRP), procalcitonin and MMPs/TIMPs from each sample were measured for their correlations with the 10 inflammation-related cytokines. 【Results】 The activated cord blood PRP released 10 growth factors and chemokines more than the adult blood PRP, whereas IGF-1, HGF and 8 pro-inflammatory cytokines lower than the latter. Most cytokines of adult PRP were more in females than in males (P<0.05), except for IGF-1 and HGF, which showed no difference by gender. Compared with hs-CRP and PCT, MMPs/TIMPs ratio was more closely related with the inflammation-related cytokines, which can reflect the inflammatory regulation of PRP. 【Conclusion】 Due to the lower immunocompetence and no age or gender disturbance, cord blood PRP has the rational MMPs/TIMPs ratio and more cytokines which promote the inflammation and wound healing.

8.
Article | IMSEAR | ID: sea-217123

ABSTRACT

Introduction: Sepsis has a death rate of ?25% globally and its clinical treatment presents an important clinical challenge. The Acute Physiology and Chronic Health Evaluation II (APACHE II) is the standard method for assessing sepsis. Serum PCT level can be increase in case of sepsis. With this background, the present research is aimed to study the survival among the sepsis cases and correlate them with serum procalcitonin levels, APACHE II Score and other risk factors. Methodology: The study was conducted among 75 cases diagnosed having sepsis admitted in medical ICU. APACHE II score, serum procalcitonin (PCT) and other investigation were carried out along with clinical history and examination. Data were analysed using epi-info software. Results: The cases fatality rate of sepsis cases in medical intensive care unit in our hospital was 37.3%. The mortality rate was significantly higher patients with comorbidities, especially cases with respiratory or CNS involvement. The serum PCT levels were significantly higher in the group of non survivors as compared to group of survivors. Higher APACHE II score associated with higher mortality. Serum PCT levels go on increasing along the spectrum of sepsis. A PCT level was significantly hire in culture positive cases compare to sterile cases. Conclusion: From this study we conclude that serum PCT level is useful investigation in sepsis cases to predict mortality

9.
Article in Chinese | WPRIM | ID: wpr-907715

ABSTRACT

Objective:To explore the early warning of blood growth differentiation factor-15 (GDF15) as a new stress indicator.Methods:A total of 53 armed police soldiers selected to participate in high-intensity training, measuring the soldiers' serum GDF15, high-sensitivity C-reactive protein (S-CRP), and C-reactive protein (CRP) before and after the high-intensity training , Interleukin-6 (IL-6), Procalcitonin (PCT) levels, compare the coefficient of variation of each index; use SPSS 24 software for statistical analysis, measurement data are expressed as mean ± standard deviation (Mean±SD), The comparison of measurement data adopts group t test. Results:The GDF15 level of fighters after high-intensity training was (176.28±97.45) pg/mL, which was higher than (120.35±69.87) pg/mL before high-intensity training. The difference was very significant ( P <0.001). After high-intensity training, IL-6 and CRP levels were lower than before high-intensity training, the difference was statistically significant ( P<0.05); there was no statistically significant difference in S-CRP and PCT before and after high-intensity training ( P>0.05). The coefficient of variation of GDF15 index is smaller than S-CRP, CRP, IL-6, PCT. Conclusion:Blood growth differentiation factor-15 (GDF15) is of great significance in warning the stress state after high-intensity training. It has higher sensitivity than other conventional stress indicators like S-CRP, CRP, IL-6 and PCT.

10.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;54(11): e11295, 2021. tab, graf
Article in English | LILACS | ID: biblio-1339451

ABSTRACT

This study aimed to investigate the diagnostic value of heparin-binding protein (HBP) in the cerebrospinal fluid of children with purulent meningitis (PM). This study included 118 children with PM diagnosed at our hospital from January 2018 to January 2020, 110 children with viral meningitis (VM) and 80 children with suspected meningitis who were ruled out by cerebrospinal fluid (CSF) analysis during the same period. HBP and white blood cell (WBC) count in the CSF, and inflammatory factors, including C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and procalcitonin (PCT), were measured. Receiver-operator characteristic curves were used to analyze the predictive value of HBP, CRP, PCT, and TNF-α levels in the diagnosis of PM by CSF analysis. HBP levels in the CSF of children with PM were higher, while the CRP and serum PCT and TNF-α levels were elevated in all groups (P<0.05). In addition, HBP levels in the CSF were more accurate for the diagnosis of PM than traditional diagnostic indexes. HBP levels in the CSF can be used as an important reference for early diagnosis of PM.


Subject(s)
Humans , Child , Meningitis, Bacterial/diagnosis , Meningitis, Viral , C-Reactive Protein , Blood Proteins , Antimicrobial Cationic Peptides , Procalcitonin
11.
Article | IMSEAR | ID: sea-214740

ABSTRACT

Fluid Attenuated Inversion Recovery (FLAIR) MRI of brain is sensitive in detecting parenchymal lesions, extra axial lesions such as meningoencephalitis, and leptomeningeal tumoural disease. We wanted to compare gadolinium enhanced T2W FLAIR with PC-T1W (post contrast T1 weighted) MRI sequence in detection and evaluation of meningeal and parenchymal lesions. We also wanted to compare gadolinium enhanced T1W FLAIR with PC-T1W MRI sequence in detection and evaluation of meningeal and parenchymal lesions.METHODS65 patients with clinical diagnosis of cerebral meningitis or intracranial tumoural disease were scanned on 1.5 T 16 channel MRI scanner. A standard brain protocol was used, followed by PC-T1W and post contrast FLAIR, with PC-T1W MR preceding post contrast FLAIR. Images were assessed independently by 2 radiologists who marked the technique they thought had made the meningeal and parenchymal disease more conspicuous. In case of disagreement the radiologists made a consensus determination.RESULTSPC-T2 FLAIR showed better enhancement in 100% of the intra axial lesions compared to PC-T1W images. However, PC-T1 FLAIR showed better enhancement than PC-T1W images in only 81% of the same. PC-T2 FLAIR showed better enhancement in 100% of the extra-axial lesions compared to PC-T1W images. However, PC-T1 FLAIR showed less enhancement in all the extra axial lesions.CONCLUSIONSContrast enhanced T2 FLAIR MRI showed better enhancement of parenchymal and meningeal lesions. PC-T2 FLAIR detected more number of lesions when compared to PC-T1W, aided better delineation of extra-axial mass lesions due to superior enhancement, and had a better demarcated dural tail. Post-contrast T2 FLAIR images should be included in routine protocol for contrast MRI brain study.

12.
Electron. j. biotechnol ; Electron. j. biotechnol;37: 41-46, Jan. 2019. tab, graf
Article in English | LILACS | ID: biblio-1051228

ABSTRACT

Background: Science and technology are two desirable elements for the economic and social development of a country. Biotechnology has a particularly important potential for economic development. Nevertheless, patent production in Latin America remains underdeveloped, which creates the need to analyze its trend and the efforts made to promote patent production. Therefore, the purpose of this study was, on the one hand, to determine trends in biotechnology-related PCT (Patent Cooperation Treaty) applications in Chile, Mexico, Argentina, Brazil, and Cuba from 1999 to 2015, and, on the other hand, to determine whether there is a relationship between the gross domestic expenditure on research and experimental development as a percentage of gross domestic product (GERD/GDP) and PCT applications for biotechnological inventions from 2007 to 2015 (in this case, the period under study was limited from 2007 to 2015, due to data availability for GERD/GDP in the five selected countries). Results: The first part of this study shows that the growth in biotechnology PCT applications has been moderate and gradual and the trend was fitted to a linear model. The second set of results shows that GERD/GDP is associated with biotechnology-related PCT applications issued during the study period with a significance level of α = 0.01. Conclusions: Even though results indicate a gradual and modest progress, it is necessary that these five representative Latin American nations continue acting toward the protection of intellectual property in the area of biotechnology, especially by configuring strategies for further progress based on investments on research and development.


Subject(s)
Biotechnology/trends , Biotechnology/statistics & numerical data , Patents as Topic/statistics & numerical data , Argentina , Research , Brazil , Technological Development , Technological Development/statistics & numerical data , Chile , Cuba , International Cooperation , Latin America , Mexico
13.
Article | IMSEAR | ID: sea-185509

ABSTRACT

Penetrating injuries to the “cardiac box“ are amongst the most lethal traumatic injuries with an estimated 6% of the patients arriving to the hospital 1 alive . We report the benign presentation of a 79 year-old female with penetrating injury to the cardiac box. Post-operative course was unremarkable. In this report, we discuss the surgical implications of penetrating injury to the cardiac box

14.
China Modern Doctor ; (36): 5-8, 2019.
Article in Chinese | WPRIM | ID: wpr-1037976

ABSTRACT

Objective To analyze the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) in the detection of incision infection after breast cancer surgery. Methods A total of 152 breast cancer patients admitted to our hospital from June 2016 to April 2018 were enrolled. All patients were given surgery.According to whether the wound infection occurred after operation, the patients were divided into control group (not infected, n=114) and observation group (infected, n=38). The serum levels of PCT, CRP and IL-6 were measured in the two groups on the 2 nd postoperative day. Results The average operation time and hospital stay in the observation group were longer than those in the control group (P<0.05). The serum levels of PCT, CRP and IL-6 in the observation group were higher than those in the control group (P<0.05). The positive rate of the observation group was higher than that of the control group (P<0.05). Conclusion In patients with breast cancer surgery, serum PCT, CRP and IL-6 detection can provide a good reference for the prediction of postoperative incision infection.

15.
Article in Chinese | WPRIM | ID: wpr-753823

ABSTRACT

Objective To investigate the clinical significance of plasma amino -terminal pro -brain natriuretic peptide(NT-proBNP) in children with bacterial meningitis.Methods From April 2013 to March 2017, 32 children with bacterial meningitis in PICU of the Second People′s Hospital of Liaocheng Affiliated to Taishan Medical College were selected.The patients were evaluated the severity of the disease by Glasgow coma scale (GCS).Thirty-five cases who admitted to the hospital in the same period were selected as the control group ,excluding congenital heart disease,chronic cardiac dysfunction ,cardiomyopathy,myocarditis,heart failure,chronic renal insufficiency.The blood samples were collected from the hospital in 24h, and the levels of the plasma NT -proBNP, procalcitonin (PCT),C-reactive protein(CRP) and Na ions were determined.Results Compared with the control group ,the levels of the plasma NT-proBNP was significantly increased [(7 123.97 ±6 901.60)ng/L vs.(39.29 ±19.41)ng/L,t=5.839,P<0.01],the level of PCT was significantly increased [(25.14 ±2.35) ng/dL vs.(0.63 ±0.15ng/dL,t =10.820,P<0.01],the level of CRP was significantly increased [(97.89 ±4.63mg/dL vs.(5.23 ±1.22mg/dL,t=21.130,P<0.01],and the GCS was significantly decreased (t=18.132,P<0.01) in children with bacterial meningitis group.The plasma NT -proBNP level of children with GCS <8points [( 13 328.08 ±7 938.85 ) ng/L ] was significantly higher than that in children with GCS 8~14points[(3 401.50 ±1 526.75)ng/L](t=5.816,P<0.01) and GCS≥15points [(39.74 ±18.64) ng/L] ( t =5.816,P<0.01).There was a significant positive correlation between the level of plasma NT -proBNP and PCT ( r =0.969, P <0.01), also a significant positive correlation between the level of plasma NT -proBNP and CRP (r=0.961,P<0.01),while a significant negative correlation between the level of plasma NT-proBNP and sodium ions(r=0.886,P<0.01) in children with bacterial meningitis by Pearson correlation test.Conclusion Detection of the plasma NT-proBNP has significant clinical significance for early diagnosis and assessment of the severity of the illness of children with bacterial meningitis .

16.
Article in Chinese | WPRIM | ID: wpr-803125

ABSTRACT

Objective@#To investigate the clinical significance of plasma amino-terminal pro-brain natriuretic peptide(NT-proBNP) in children with bacterial meningitis.@*Methods@#From April 2013 to March 2017, 32 children with bacterial meningitis in PICU of the Second People′s Hospital of Liaocheng Affiliated to Taishan Medical College were selected.The patients were evaluated the severity of the disease by Glasgow coma scale(GCS). Thirty-five cases who admitted to the hospital in the same period were selected as the control group, excluding congenital heart disease, chronic cardiac dysfunction, cardiomyopathy, myocarditis, heart failure, chronic renal insufficiency.The blood samples were collected from the hospital in 24h, and the levels of the plasma NT-proBNP, procalcitonin(PCT), C-reactive protein(CRP) and Na ions were determined.@*Results@#Compared with the control group, the levels of the plasma NT-proBNP was significantly increased[(7 123.97±6 901.60)ng/L vs.(39.29±19.41)ng/L, t=5.839, P<0.01], the level of PCT was significantly increased[(25.14±2.35)ng/dL vs.(0.63±0.15ng/dL, t=10.820, P<0.01], the level of CRP was significantly increased[(97.89±4.63mg/dL vs.(5.23±1.22mg/dL, t=21.130, P<0.01], and the GCS was significantly decreased(t=18.132, P<0.01) in children with bacterial meningitis group.The plasma NT-proBNP level of children with GCS<8points[(13 328.08±7 938.85)ng/L]was significantly higher than that in children with GCS 8~14points[(3 401.50±1 526.75)ng/L](t=5.816, P<0.01) and GCS≥15points[(39.74±18.64)ng/L](t=5.816, P<0.01). There was a significant positive correlation between the level of plasma NT-proBNP and PCT(r=0.969, P<0.01), also a significant positive correlation between the level of plasma NT-proBNP and CRP(r=0.961, P<0.01), while a significant negative correlation between the level of plasma NT-proBNP and sodium ions(r=0.886, P<0.01) in children with bacterial meningitis by Pearson correlation test.@*Conclusion@#Detection of the plasma NT-proBNP has significant clinical significance for early diagnosis and assessment of the severity of the illness of children with bacterial meningitis.

17.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;51(7): e6783, 2018. tab, graf
Article in English | LILACS | ID: biblio-951732

ABSTRACT

To avoid the abuse and misuse of antibiotics, procalcitonin (PCT) and C-reactive protein (CRP) have been used as new approaches to identify different types of infection. Multiple databases were adopted to search relevant studies, and the articles that satisfied the inclusion criteria were included. Meta-analyses were conducted with Review Manager 5.0, and to estimate the quality of each article, risk of bias was assessed. Eight articles satisfied the inclusion criteria. The concentrations of both PCT and CRP in patients with bacterial infection were higher than those with non-bacterial infection. Both PCT and CRP levels in patients with G− bacterial infection were higher than in those with G+ bacterial infection and fungus infection. In the G+ bacterial infection group, a higher concentration of CRP was observed compared with fungus infection group, while the difference of PCT between G+ bacterial infection and fungus infection was not significant. Our study suggested that both PCT and CRP are helpful to a certain extent in detecting pneumonia caused by different types of infection.


Subject(s)
Humans , C-Reactive Protein/analysis , Calcitonin/blood , Pneumonia, Bacterial/microbiology , Lung Diseases, Fungal/microbiology , Biomarkers/blood , Sensitivity and Specificity
18.
Article in Chinese | WPRIM | ID: wpr-696188

ABSTRACT

Objective To study the relationship between the serum levels of procalcitonin (PCT) and pulmonary function in patients with chronic obstructive pulmonary disease (COPD).Methods From January 2016 to May 2107,88 cases of patients with COPD and 100 cases of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) were chosen as the object of study,pulmonary function was measured in all patients,grouped according to the standard of pulmonary function classification,and detected the serum levels of PCT by immunoturbidimetry.Results The serum levels of PCT were not statistically different among the COPD patients (F=1.401,P>0.05).But among the AECOPD patients,the serum levels of PCT in the Ⅳ class of pulmonary function were significantly higher than that in the Ⅰ,Ⅱ class and Ⅲ class and this difference was statistically significant (F=9.128,P<0.05).Conclusion The serum levels of PCT had significant reference value for the judgement of the severity of pulmonary function impairment in AECOPD patients.

19.
China Medical Equipment ; (12): 97-101, 2018.
Article in Chinese | WPRIM | ID: wpr-706542

ABSTRACT

Objective: To investigate the value of joint detection of soluble triggering receptor expresses on myeloid cells-1(sTREM-1) and procalcitonin (PCT) in the early diagnosis of children with sepsis. Methods: 78 children with sepsis were selected into the sepsis group, 23 children with common infection were selected into the normal infection group. In addition, 25 healthy children selected into the health control group. The levels of sTREM-1, PCT, and C reactive protein (CRP) among the three groups were compared, respectively. And then, the sepsis group were further divided into general sepsis subgroup (32 cases), severe sepsis subgroup (26 cases) and septic shock subgroup (20 cases) according to the degree of sepsis. The levels of sTREM-1, PCT and CRP among the three sepsis subgroups were compared. And the receiver operating characteristic (ROC) curve was adopted to analyze the value that diagnosed children with sepsis by using the three indicators. Results: The levels of sTREM-1, PCT and CRP of sepsis group were significantly higher than those of common infection group and health control group (t=22.071, t=21.508, t=17.870, t=55.167, t=52.070, t=30.359, P<0.05). The differences of sTREM-1 and PCT among various sepsis subgroups were significant (H=22.082, H=39.449, P<0.05), but the difference of CRP level between septic shock subgroup and severe sepsis subgroup was no significant. As the compared result of AUC of ROC of diagnosing sepsis, the AUC of sTREM-1 was maximum (0.88), and its 95% confidence interval (CI) was 0.78-0.98. At the optimum cutoff value of sTREM-1, the sensitivity and specificity were 83.33% and 68%, respectively, and they were higher than those of PCT and CRP, respectively. Besides, the cutoff values of sTREM-1 and PCT were used as standard to carry out joint diagnosis for children with sepsis, and the sensitivity and specificity were 91.03% and 64%, respectively, at this joint diagnosis. Conclusion: The joint detection of sTREM-1 and PCT has higher sensitivity in the early diagnosis of children with sepsis and it has a certain clinical application value.

20.
Article in Chinese | WPRIM | ID: wpr-506098

ABSTRACT

Objective To investigate the predictive value of serum lactate combined with PIRO (Predisposition,Infection,Response and Organ dysfunction) score in the development of multiple organs dysfunction syndrome (MODS) in septic patients and to study procalcitonin (PCT),in order to provide guidelines for clinical care.Methods From April 2015 to July 2016,a total of 752 sepsis patients were enrolled and divided into MODS group (n =488) and non-MODS group (n =264) according to the criteria of MODS.At 28 d after admission,these patients were divided into survival group (n =477) and death group (n =275).PCT and lactate levels in serum were measured,and PIRO score of these patients was calculated.Then the differences in levels of PCT and lactate in serum were compared among patients at different PIRO score categories.ROC was constructed to observe the clinical values of the biomarkers,PIRO score and lactate combined with PIRO score in predicting prognosis.Result PCT,lactate levels in serum and PIRO score were significantly higher in MODS group and death group,showing significant positive correlation.The areas under ROC curves (AUCs) of serum lactate combined with PIRO score for predicting MODS were 0.906,which was significantly higher than that of serum PCT (0.716),serum lactate (0.851) and PIRO score (0.840) alone (all P < 0.05).Serum PCT,serum lactate and PIRO score were the independent predictors of MODS.Conclusions Serum lactate in combination with PIRO score was a valuable indicator in predicting development of MODS in septic patients.

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