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Article in English | WPRIM | ID: wpr-713446


PURPOSE: Predicted adult height (PAH) is often crucial to decision-making about treatment with human growth hormone (GH) or gonadotropin-releasing hormone agonist in children with short stature. This study compares final adult height (FAH) with different methods used to determine PAH and assesses the clinical utility and analytical validity of height prediction for children not treated with GH. METHODS: Clinical findings were retrospectively analyzed, and the heights of 44 children (22 males and 22 females) who visited our clinic between August 2006 and June 2017 and reached near final adult height (NFAH) were evaluated. Children treated with GH were excluded. We compared measured NFAH to PAH using the Bayley-Pinneau (BP), Tanner-Whitehouse Mark 2, and Roche-Wainer-Thissen (RWT) methods. RESULTS: Pearson correlation between all 3 prediction methods and NFAH showed high positive correlations in males and females (P < 0.05). The average difference between PAH and NFAH for the BP method (0.4±3.9 cm) was significantly lower than those for the RWT and TW 2 methods in females (P=0.000, analysis of variance). Furthermore, only PAH by the BP method in females was very close to measured NFAH (paired t-test). A Bland-Altman plot verified that 95% of the differences between the PAH and NFAH exist between limits of agreement (mean±1.96 standard deviation). CONCLUSIONS: The BP method is more useful to predict NFAH in females than other methods. Careful attention is still required when using such tools because PAH can be inaccurate. Therefore, a more accurate FAH prediction model for Korean children is needed.

Adult , Child , Female , Gonadotropin-Releasing Hormone , Human Growth Hormone , Humans , Male , Methods , Retrospective Studies
Chinese Pharmaceutical Journal ; (24): 1381-1386, 2017.
Article in Chinese | WPRIM | ID: wpr-858602


Heterogeneous liquid preparations are widely used in clinic, and played an important role in pharmaceutical preparations. But at the same time, since the instability of the physical and chemical properties of the heterogeneous liquid preparation, the dispersed particles have a large specific surface energy and form a thermodynamic unstable system. Especially when in the traditional Chinese medicine liquid preparation, which has a large number of unknown non quantitative components, can easily appear the phenomenon of subsidence, coalescence, stratification and phase inversion during the storage process. Therefore, it is of great significance to study the stability observation and prediction of heterogeneous liquid preparation for its prescription design, production process screening, quality evaluation, storage and transportation. However, only in the fields of food, beverage, cosmetics and other related fields have some research at home and abroad for the moment, and we fond there are few reports on heterogeneous liquid formulations. This paper attempts to study the methods of stability prediction in the fields mentioned above, and then we expect to provide a reference for the establishment of rapid, accurate, economic, scientific and objective prediction methods of the heterogeneous liquid preparation.

Article in Korean | WPRIM | ID: wpr-647063


There is are d for more accurate prediction in surgical orthodontic treatment. Video imaging is an important technology in planning orthognathic surgery and educating Patients about the esthetic results after treatment. Preoperative and postoperative lateral cephalogram of 30 patients who had one piece Le Fort I osteotomy advancement and mandibular set back by bilateral intraoral vertical ramal osteotomy with or without genioplasty were used in this study. The computer generated soft tissue line drawing prediction were compared with the actual postoperative cephalograms. The results are as follows. 1. 14 variables showed Statistically significant differences from 24 variables between computer predicted profile and post operative profile 2. Most of the differences were found in the maxilla-related soft tissue landmarks. 3. The predicted results were more accurate in the groups who had small amount of mandibular set back. 4. The predicted results were more accurate in the groups who had no genioplasty. Most of these differences were within 2mm ranges. Therefore profile change prediction by video imaging could be considered clinically acceptable.

Genioplasty , Humans , Jaw , Orthognathic Surgery , Osteotomy
Article in Korean | WPRIM | ID: wpr-656135


This paper aimed to study what the influences of orthodontic treatment of pronunciation are. We compared the duration and the acoustic wave patterns of Korean consonants pronounced by a control group with those of a patient who had his four premolars extracted and had been given orthodontic treatment The results were as follows : 1. Compared to the control group, the treatment group had a longer duration time of consonant pronunciation for all consonants but "s " and "th" in CV(consonant-vowel) pairs. Especially in the case of "dz", "phih" for CV-pairs, and "d" in VCV(vowel-consonant-vowel) clusters, the duration of consonant sound showed a sharp contrast between the control group and the treatment group. 2. There were clear differences in the acoustic wave patterns of "ts", "phih" and "ch", all of which were in VCV-clusters. The acoustic wave pattern of "ts", when pronounced by the treatment group, was stronger than the control group's. This phenomenon was most remarkable in the transitive section where the "ts" sound flowed into the following vowel. When a preceding vowel shifted to the consonant "phih", the attack property of the appeared clearly in the acoustic waves of the t,reament group, while in the control group the starting point of consonart was indistinctive. Consonant duration for the treatment group was longer, and the appearance of a zero crossing point in the acoustic wave was more frequent. In the case of "ch", the treatment group produced a strong acoustic wave, and the property of aspiration was obvious in it 3. When the treatment group pronounced "d" and "dz" in CV-pairs, the acoustic-wave was similar to that of aspirated "th" and "ch". 4. The aspirated "th" and "ch" pronounced by the treatment group showed the stronger airstream and acoustic wave form.

Bicuspid , Humans , Sound