Exposición a temperaturas extremas y su efecto en la gestación en un departamento de Colombia / Exposure to extreme temperatures and its effect on pregnancy in a department of Colombia

Introducción: Diversas investigaciones han establecido la relación entre temperatura y duración del embarazo, la exposición a temperaturas altas durante el embarazo plantea interrogantes en especial el papel que esta juega frente a los partos prematuros y partos de bajo peso, es indispensable determinar si las temperaturas altas o bajas tienen un comportamiento protector o de riesgo sobre el feto durante la gestación en regiones tropicales. Objetivo: describir la relación entre la exposición a temperaturas altas y bajas durante el embarazo y su efecto en la edad gestacional y peso al momento del parto en los recién nacidos del departamento del Guaviare-Colombia. Metodología: Estudio tipo observacional, analítico, retrospectivo de corte transversal que busco determinar la relación entre exposición a temperaturas altas y bajas durante el embarazo y su efecto en la edad gestacional y peso al momento del parto en los recién nacidos, el universo estuvo conformado por 10.137 nacidos vivos, de los cuales 9.932 cumplieron los criterios de inclusión. Se determinó Odds Ratio para estimar la asociación entre las variables. Resultados: Dentro de la semana de retraso 3 el estar expuesto a temperaturas máximas percentil 90 es un factor protector para la ganancia ponderal de peso OR < 1, la exposición a temperaturas mínimas percentil 10 se asoció como factor protector para el parto prematuro en la semana de retraso 1 y 2 OR < 1.Conclusión: A pesar del beneficio de las altas y bajas temperaturas durante el embarazo en la ganancia ponderal de peso y disminución del parto prematuro, es recomendable prevenir la exposición a temperaturas extremas durante el periodo de gestación[AU]

Introduction: Various investigations have established the relationship between temperature and duration of pregnancy. Exposure to high temperatures during pregnancy raises questions, especially the role it plays in premature births and low-weight births. It is essential to determine whether high temperatures or low have a protective or risky behavior on the fetus during pregnancy in tropical regions.Objective: to describe the relationship between exposure to high and low temperatures during pregnancy and its effect on gestational age and weight at the time of delivery in newborns in the department of Guaviare-Colombia.Methodology:Observational, analytical, retrospective cross-sectional study that sought to determine the relationship between exposure to high and low temperatures during pregnancy and its effect on gestational age and weight at the time of delivery in newborns. The universe was made up of 10,137 births. alive, of which 9,932 met the inclusion criteria. Odds Ratio was determined to estimate the association between the variables.Results:Within the 3rd week of delay, being exposed to maximum temperatures at the 90th percentile is a protective factor for weight gain OR < 1, exposure to minimum temperatures at the 10th percentile was associated as a protective factor for premature birth in the week. of delay 1 and 2 OR < 1. Conclusion: Despite the benefit of high and low temperatures during pregnancy in weight gain and reduction in premature birth, it is advisable to prevent exposure to extreme temperatures during the gestation period[AU]

Introdução: Várias investigações estabeleceram a relação entre temperatura e duração da gravidez. A exposição a altas temperaturas durante a gravidez levanta questões, especialmente o papel que desempenha nos partos prematuros e nos nascimentos de baixo peso. É essencial determinar se as temperaturas altas ou baixas têm um comportamento protetor ou de risco para o feto durante a gravidez em regiões tropicais. Objetivo:descrever a relação entre a exposição a altas e baixas temperaturas durante a gravidez e seu efeito na idade gestacional e no peso no momento do parto em recém-nascidos no departamento de Guaviare-Colômbia. Metodologia: Estudo observacional, analítico, retrospectivo e transversal que buscou determinar a relação entre a exposição a altas e baixas temperaturas durante a gravidez e seu efeito na idade gestacional e no peso no momento do parto em recém-nascidos. O universo foi composto por 10.137 nascimentos. vivos, dos quais 9.932 preencheram os critérios de inclusão. O Odds Ratio foi determinado para estimar a associação entre as variáveis. Resultados:Na 3ª semana de atraso, a exposição a temperaturas máximas no percentil 90 é fator de proteção para ganho de peso OR < 1, a exposição a temperaturas mínimas no percentil 10 foi associada como fator de proteção para parto prematuro na semana. de atraso 1 e 2 OR < 1.Conclusão:Apesar do benefício das altas e baixas temperaturas durante a gravidez no ganho de peso e redução do parto prematuro, é aconselhável evitar a exposição a temperaturas extremas durante o período de gestação[AU]

Association of birth and periodontal disease in Bolivia, Chile and Colombia / Asociación de parto prematuro y enfermedad periodontal en Bolivia, Chile y Colombia

Introduction. Preterm birth is a major medical, social, and economic problem that causes a large proportion of neonatal mortality and morbidity, has a high impact on the healthcare system, and affects family quality of life. The weight of newborns with mothers with periodontal disease is significantly lower compared to mothers not affected by this oral disease. This adverse outcome is considered a global public health problem based on epidemiological data. Objective. To determine the association between the prevalence of preterm births and periodontal disease in Bolivia, Chile, and Colombia from 2000 to 2020. Materials and methods. This ecological study considered the population of women in Bolivia, Chile, and Colombia, according to the prevalence of preterm births and periodontal disease discriminated by age. The study covered the period between 2000 and 2020. The search strategy within the Institute for Health Metrics and Evaluation investigative tool included prevalence, age groups, causes of preterm births and periodontal disease, context and locations, women, and rates. Statistical analysis included a simple linear regression between preterm births and periodontal disease for each age group within each country. Results. Preterm birth rates were higher in the 15-19 years age group (Bolivia: 697,563; Chile: 844,864; Colombia: 804,126). The periodontal disease prevalence increased with age, as we observed in the 45-49 years group (Bolivia: 22,077,854; Chile: 34,297,901, Colombia: 32,032.830). According to age groups, the linear regression was statistically significant (p < 0.001) in all age groups for the Bolivian population over 30 years for the Colombian, and only in the 15-19 years group for the Chilean women. Conclusion. An association was found between preterm births and periodontal disease in all age groups in Bolivia, only in the group of 15 to 19 years in Chile, and 30 years and up in Colombia over the 20-year period.

Introducción. El parto prematuro es un problema médico, social y económico importante, causa gran mortalidad y morbilidad neonatal, tiene un impacto importante en el sistema de salud y afecta la calidad de vida de las familias. El peso de los recién nacidos de madres con enfermedad periodontal es significativamente menor en comparación con los de madres no afectadas por esta enfermedad bucal. Este resultado adverso se considera un problema de salud pública global según los datos epidemiológicos. Objetivo. Determinar la asociación entre la prevalencia de parto prematuro y la enfermedad periodontal en Bolivia, Chile y Colombia entre el 2000 y el 2020. Materiales y métodos. Este estudio ecológico consideró las poblaciones de mujeres de Bolivia, Chile y Colombia, y la prevalencia de partos prematuros y enfermedad periodontal, discriminadas por grupos de edad. El estudio abarcó el período entre el 2000 y el 2020. La estrategia de búsqueda con la herramienta de investigación del Institute for Health Metrics and Evaluation incluyó prevalencia, grupos de edad, años entre 2000 y 2020, causas de parto prematuro y enfermedad periodontal, contexto y ubicaciones, mujeres y tasas. El análisis estadístico incluyó una regresión lineal simple entre parto prematuro y enfermedad periodontal para cada grupo de edad dentro de cada país. Resultados. Las tasas de partos prematuros fueron mayores en el grupo de 15 a 19 años (Bolivia: 697.563, Chile: 844.864, Colombia: 804.126). La prevalencia de la enfermedad periodontal aumentó con la edad, particularmente en el grupo de 45 a 49 años (Bolivia: 22'077.854, Chile: 34'297.901, Colombia: 32'032,830). Según los grupos de edad, la regresión lineal fue estadísticamente significativa (p < 0,001) para todos los grupos evaluados de la población boliviana, en los grupos mayores de 30 años para las colombianas y solo en el grupo de 15 a 19 años para las mujeres chilenas. Conclusión. Se encontró asociación entre el parto prematuro y la enfermedad periodontal en todos los grupos de edad en Bolivia, solo en el grupo de 15 a 19 años en Chile, y de 30 años y más en Colombia en el período evaluado de 20 años.

Role of isoxsuprine as a tocolytic agent in the management of preterm labor in Indian clinical practice

Preterm labor (PTL) is one of the prime etiological factors responsible for neonatal disease burden and fatality. Despite recent advances in neonatal care and obstetrics, the occurrence of PTL is increasing, and women who have previously experienced spontaneous PTL are more susceptible to PTL in the future. Currently, PTL is diagnosed based on regular uterine contractions, their frequency, and associated cervical changes. Antenatal corticosteroids and magnesium sulfate interventions can improve neonatal outcomes. Tocolytic medications can temporarily delay delivery to facilitate the administration of corticosteroids. Isoxsuprine is a preferred tocolytic agent because it significantly increases the average latency period, delays delivery by >48 hours, and is associated with improved perinatal outcomes. This review examines recommendations from expert gynecologists for the management of PTL in the Indian clinical setting. The experts opined that intravenous administration with Isoxsuprine provides the advantage of dose titration, thereby minimizing potential side effects. Moreover, continuation of oral isoxsuprine till 37 weeks as maintenance therapy was advised as per literature evidence and experts’ clinical experience. Furthermore, concomitant administration of nifedipine and magnesium sulfate was not recommended as this can lead to neuromuscular blockade and fatal respiratory arrest, due to the action of both molecules on the blockage of calcium channels. The experts also emphasized the significance of considering individual experiences with various treatment options and identified specific obstacles and difficulties related to the utilization of isoxsuprine as a tocolytic agent, thereby offering valuable insights into potential approaches to overcome these challenges.

Examining maternal influences on low birth weight of baby: a study in Washim district

Background: This research investigated low birth weight (LBW) in Washim district, Maharashtra, India, recognizing its profound impact on infant health. With a prevalence of 13.3%, lower than state and national averages, the study focuses on maternal factors such as anemia, premature deliveries, and inadequate weight gain during pregnancy as contributors to LBW. Methods: A cross-sectional study involving LBW infants and mothers was conducted in Washim district. The census approach (universal sampling) was employed in this study, encompassing the entire population of low birth weight babies born across all blocks in the Washim district and could be tracked by healthcare workers. This involved every eligible individual, eliminating the need for traditional sampling techniques. Data were collected from 6 Blocks, 153 Health sub-centers, and 25 primary health centers between April 1, 2022, and March 31, 2023, using a standardized questionnaire administered by healthcare workers. The study included 876 babies and mothers. Results: Washim district reported a 13.3% LBW rate, lower than the state (20.1%) and national (17.8%) averages. High LBW incidence was noted among mothers with anemia (91.4%), premature deliveries (78.18%), and inadequate weight gain during pregnancy (average gain: 7.9 kg). Conclusions: The study identified anemia during pregnancy, premature deliveries, and inadequate weight gain as primary contributors to LBW in the district.

Research progress on cervical cerclage for preventing preterm birth in twin pregnancies / 中华围产医学杂志

Preterm birth is the most common maternal complication in twin pregnancies. In recent years, cervical cerclage has been of long-standing interest in the prevention of preterm birth in twin pregnancies. However, its clinical application in the treatment of cervical insufficiency of twin pregnancies remains a controversial subject. In addition, infection or inflammation conditions are considered to be closely related to the perinatal outcomes of twin pregnancies after cervical cerclage. This paper reviews the research progress on cervical cerclage in twin pregnancies, recommending cervical cerclage for twin pregnancies with cervical length≤15 mm or cervical dilatation, while it is not suggested for those with cervical length of 15-25 mm or history-indicated cervical cerclage. The clinical significance of preoperative evaluation of intraamniotic infection or inflammation of twin pregnancies needs to be further explored, but it is necessary to avoid the effect of antibiotic use on the evaluation of surgical effects.

Factors affecting spontaneous premature birth in singleton pregnancy / 预防医学

Objective@#To investigate the factors affecting spontaneous preterm birth in singleton pregnancy, so as to provide insights into reducing the risk of preterm birth.@*Methods@#A total of 230 lying-in women with spontaneous preterm birth in singleton pregnancies admitted to the Hangzhou Obstetrics and Gynecology Hospital were selected as the case group, and lying-in women with full-term birth in singleton pregnancies in the hospital during the study period were selected as controls. Basic information and pregnancy status were collected through the hospital information system, and factors affecting spontaneous preterm birth in singleton pregnancies were analyzed using a multivariable logistic regression model.@*Results@#The lying-in women in the case group had a mean age of (33.40±3.16) years and a mean gestational weeks at delivery of (34.72±2.15) weeks. The lying-in women in the control group had a mean age of (28.30±3.92) years and a mean gestational weeks at delivery of (39.84±2.09) weeks. Multivariable logistic regression analysis identified age of 35 years and older (OR=1.280, 95%CI: 1.022-1.603), induced abortion three times and above (OR=3.122, 95%CI: 1.368-7.121), history of preterm birth (OR=3.769, 95%CI: 1.725-8.240), premature rupture of membranes (OR=12.708, 95%CI: 4.836-33.391), gestational hypertension (OR=2.934, 95%CI: 1.313-6.550), gestational diabetes (OR=2.510, 95%CI: 1.249-5.038) and cervical canal length ≤25 mm (OR=5.832, 95%CI: 2.380-14.279) as factors affecting spontaneous preterm birth in singleton pregnancies.@*Conclusion@#Spontaneous preterm birth in singleton pregnancy may be associated with age, number of induced abortions, premature rupture of membranes, complications in pregnancy and cervical canal length.

Incidence and factors associated with bronchopulmonary dysplasia in discharges from Neonatal Intensive Care Units in Northern Minas Gerais / Incidência e fatores associados à displasia broncopulmonar em egressos de Unidades de Terapia Intensiva Neonatal no norte de Minas Gerais

Abstract Objectives: to evaluate the incidence and factors associated with bronchopulmonary dysplasia (BPD) in premature infantsdischarged from Neonatal Intensive Care Units (NICU). Methods: retrospective cohort study with premature infants discharged from the NICU. The sampling process was random, considering premature infants being followed up at a high-risk outpatient clinic registered in a NICU from 2014 to 2018. The collection was carried out from medical records and interviews with mothers or guardians, with information regarding complications during pregnancy, conditions of birth, care and morbidities in the NICU. BPD was measured for premature neonates using oxygen therapy for a period equal to or greater than 28 days or 36 weeks of corrected gestational age. After bivariate analyses, binary logistic regression analysis was followed. For the final model, a significance level of 5% (p<0.05) was defined, with registration of the respective Odds Ratio and 95% confidence intervals. Results: data from 293 preterm infants, predominantly male (55.6%) with gestational age from 32 to 36 weeks, were evaluated. BPD was recorded for 63 children (21.5%). The variables that remained statistically associated with BPD were: birth weight, gestational age and late sepsis. Conclusions: there was a high incidence of BPD. Associated factors highlight the need for improving preand postnatal care.

Resumo Objetivos: avaliar a incidência e fatores associados à displasia broncopulmonar (DBP) em egressos de Unidades de Terapia Intensiva Neonatal (UTIN). Métodos: estudo de coorte retrospectivo com prematuros egressos de UTIN. O processo amostral foi aleatório, considerando crianças em seguimento em ambulatório de alto risco com registro em UTIN no período de 2014 a 2018. A coleta foi realizada a partir de prontuários e entrevistas com as mães ou responsáveis, com informações referentes às intercorrências durante a gestação, condições de nascimento, cuidados e morbidades na UTIN. A DBP foi aferida para neonatos com utilização de oxigenioterapia por períodoigual ou superior a 28 dias ou 36 semanas de idade gestacional corrigida. Após análises bivariadas, seguiu-se análise de regressão logística binária. Para o modelo final definiu-se nível de significância de 5% (p<0,05), com registro das respectivas Odds Ratio e intervalos de confiança de 95%. Resultados: foram avaliados dados de 293 prematuros, predominantemente do sexo masculino (55,6%) e idade gestacional de 32 a 36 semanas. A DBP foi registrada para 63 crianças (21,5%). As variáveis que permaneceram estatisticamente associadas à DBP foram: peso de nascimento, idade gestacional e registro de sepse tardia. Conclusões: registrou-se elevada incidência de DBP. Os fatores associados destacam a necessidade de melhoria dos cuidados pré e pós-natais

Evaluation of the kangaroo method during the Covid-19 pandemic in two reference maternity hospitals in Pernambuco / Avaliação do método canguru durante pandemia de Covid-19 em duas maternidades de referência em Pernambuco

Abstract Objectives: to evaluate the second stage of the Kangaroo Mother Care (KMC) and its integration with the third stage in maternity hospitals in Recife in the context of the coronavirus pandemic. Methods: normative assessment carried out at the Kangaroo Neonatal Intermediate Care Unit (KNICU) in two public reference maternity hospitals for KMC between November/2021 and May/2022. The logical model and matrix of KMC indicators were developed and validated using the Delphi Method: semi-structured interviews were carried out with professionals from the KNICU team and the municipal child health coordination. It was considered implemented when the criteria were met (from 100.0 to 80.0%); partially implemented (79.9 to 60.0%); incipient (59.9 to 40.0%) and not implemented (<or=39.9%). Results: the MC was partially implemented in both KNICU (79.0% both). The Structure dimension was implemented (84.0 and 97.0%) and the Process dimension, in the Education (70.0% both) and Management components, were partially implemented (61.0% and 78.0%), although the units claim that they do not share clinical objectives, exams and treatments and do not have an effective referral/counter-referral system. While Assistance was implemented in one unit (90.0%) and partially implemented in the other (75.0%). Conclusion: KNICU was partially implemented during the coronavirus pandemic in the two reference maternity hospitals, but with obstacles to integration with the third stage of the method.

Resumo Objetivos: avaliar a segunda etapa do Método Canguru (MC) e a sua integração com a terceira etapa em maternidades do Recife no contexto da pandemia de coronavírus. Métodos: avaliação normativa realizada na Unidade de Cuidados Intermediários Neonatais Canguru (UCINCa) em duas maternidades públicas de referência para o MC entre novembro/2021 e maio/2022. Elaborou-se o modelo lógico e a matriz de indicadores do MC, validada através do Método Delphi. Realizaram-se entrevistas semiestruturadas com profissionais da equipe das UCINCa e a coordenação municipal de saúde da criança. Considerou-se implantado quando os critérios alcançaram (de 100,0 a 80,0%); parcialmente implantado (79,9 a 60,0%); incipiente (59,9 a 40,0%) e não implantado (<ou=39,9%). Resultados: o MC estava parcialmente implantado nas duas UCINCa (79,0% ambas). A dimensão Estrutura encontrava-se implantada (84,0 e 97,0%) e a de Processo, nos componentes Educação (70,0% ambas) e Gestão encontravam-se parcialmente implantados (61,0% e 78,0%), embora as unidades afirmem não compartilhar os objetivos clínicos, exames e tratamentos e não ter um sistema de referência/contrarreferência efetivo. Ao passo que o componente Assistencial estava implantado em uma unidade (90,0%) e parcialmente implantado na outra (75,0%). Conclusão: a UCINCa encontrava-se parcialmente implantada durante a pandemia de coronavírus nas duas maternidades de referências, mas com obstáculos para a integração com a terceira etapa do método.

Infección del tracto urinario asociada al parto prematuro en un hospital de Apurímac, Perú

Introducción: El parto prematuro es una de las principales causas de muerte en niños menores de 5 años, con repercusiones negativas para la sociedad, generando un gasto económico. Objetivo: Determinar la asociación entre la infección del tracto urinario y el parto prematuro. Métodos: Estudio retrospectivo, analítico, de casos y controles. Se seleccionaron como casos 30 embarazadas con diagnóstico de parto prematuro, y para comparación, 60 embarazadas como control. Se evaluó como factor de riesgo, la presencia de infección del tracto urinario; además, se incluyeron otros factores de confusión. Para el análisis bivariado, se usó la prueba de chi-cuadrado. Cada exposición se evaluó por separado, para determinar su asociación con la variable dependiente. Las variables independientes significativas se incluyeron en una regresión logística multivariada, con el fin de corregir los factores de confusión. La asociación se analizó mediante odds ratio, con intervalos de confianza del 95 %; los valores de p se calcularon con un nivel de significancia <0,05. Se utilizó el programa SPSS versión 25 para procesar los datos. Resultados: Se encontró que 27 (90 %) gestantes en el grupo de casos, y 33 (55 %) en el grupo control, tenían infección urinaria; siendo significativamente (p < 0,00) mayor en el grupo de casos. Además, en el análisis multivariado, la infección urinaria se asoció significativamente con el parto prematuro (p < 0,00), aumentando su riesgo (ORA = 15,5). Conclusiones: La infección del tracto urinario está asociada al parto prematuro.

Introduction: Premature birth is one of the main causes of death in children under 5 years of age, with negative repercussions for society, generating an economic expense. Objective: To determine the association between urinary tract infection and premature birth. Methods: Retrospective, analytical, case-control study. 30 pregnant women with a diagnosis of premature birth were selected as cases, and 60 pregnant women as controls were selected for comparison. The presence of urinary tract infection was evaluated as a risk factor; other confounding factors were also included. For the bivariate analysis, the chi-square test was used. Each exposure was evaluated separately to determine its association with the dependent variable. Significant independent variables were included in a multivariate logistic regression in order to correct the confounding factors. The association was analyzed using odds ratios, with 95 % confidence intervals; p values were calculated with a significance level <0.05. The SPSS version 25 program was used to process the data. Results: It was found that 27 (90%) pregnant women in the case group, and 33 (55%) pregnant women in the control group, had urinary infection; being significantly (p<0.00) higher in the case group. Furthermore, in the multivariate analysis, urinary infection was significantly associated with premature birth (p<0.00) increasing its risk (AOR=15.5). Conclusions: Urinary tract infection is associated with premature birth.

Gestações e nascimentos em tempos de COVID-19 / Embarazos y nacimientos en tiempos de COVID-19 / Pregnancies and births in times of COVID-19

Resumo Objetivo Identificar o perfil de nascimentos das gestações de mulheres com acesso à internet que cursaram com a infecção pelo SARS-CoV-2 e seus desfechos. Métodos Estudo transversal integrado a uma coorte prospectiva, com coleta entre agosto de 2021 e fevereiro de 2022, baseado nas respostas de 304 mulheres que tiveram gestações e/ou partos durante o período pandêmico. Resultados Do total, 25,7% das entrevistadas tiveram COVID-19, com predomínio de diagnósticos no terceiro trimestre. Queixas de anosmia, fadiga e cefaleia prevaleceram como relacionados à infecção. As variáveis: utilizar o Sistema Único de Saúde para atendimento (p = 0,084); diabetes gestacional (p = 0,141); baixo peso de nascimento (p = 0,117); necessidade de internação em unidade neonatal (p = 0,120) foram inseridas no modelo de regressão por terem valores de p inferiores a 0,20. A variável referente ao tipo de parto (p=1,000) foi inserida no modelo por se tratar de uma variável de interesse e com descrição de relevância na literatura. A prematuridade foi a única variável que apresentou associação estatística com a infecção pelo SARS-CoV-2 durante a gestação (p = 0,008) na análise bivariada, explicando o desfecho da infecção na gestação (<0,001), comprovado no modelo de Regressão Robusta de Poisson. Conclusão Observou-se alta prevalência de COVID-19 na amostra, com variação de sintomas e predomínio de partos operatórios. No entanto, a infecção pelo SARS-CoV-2 explicou apenas a maior ocorrência de nascimentos prematuros.

Resumen Objetivo Identificar el perfil de nacimientos de los embarazos de mujeres con acceso a internet que lo cursaron con la infección por SARS-CoV-2 y sus desenlaces. Métodos Estudio transversal integrado a una cohorte prospectiva, con recopilación entre agosto de 2021 y febrero de 2022, basado en las respuestas de 304 mujeres que tuvieron embarazos o partos durante el período pandémico. Resultados Del total, el 25,7 % de las entrevistadas tuvieron COVID-19, con predominio de diagnósticos en el tercer trimestre. Prevalecieron quejas de anosmia, fatiga y cefalea como relacionadas a la infección. Las variables utilización del Sistema Único de Salud para atención (p = 0,084), diabetes gestacional (p = 0,141), bajo peso de nacimiento (p = 0,117), necesidad de internación en unidad neonatal (p = 0,120) se introdujeron en el modelo de regresión por tener valores de p inferiores a 0,20. Se introdujo la variable relacionada al tipo de parto (p = 1,000) en el modelo por tratarse de una variable de interés y con descripción de relevancia en la literatura. La prematuridad fue la única variable que presentó asociación estadística con la infección por SARS-CoV-2 durante el embarazo (p = 0,008) en el análisis bivariado, lo que explica el desenlace de la infección en el embarazo (>0,001), comprobado en el modelo de regresión robusta de Poisson. Conclusión Se observó alta prevalencia de COVID-19 en la muestra, con variación de síntomas y predominio de partos operatorios. Sin embargo, la infección por SARS-CoV-2 explicó solamente la mayor incidencia de nacimientos prematuros.

Abstract Objective Identify the profile of births of pregnancies of women with internet access who were infected with SARS-CoV-2 and their outcomes. Methods Cross-sectional study integrated into a prospective cohort, with collection between August 2021 and February 2022, based on the responses of 304 women who had pregnancies and/or deliveries during the pandemic period. Results Of the total, 25.7% of the interviewees had COVID-19, with a predominance of diagnoses in the third quarter. Complaints of anosmia, fatigue and headache prevailed as related to the infection. The variables using the Unified Health System for care (p = 0.084); gestational diabetes (p = 0.141); low birth weight (p = 0.117); need for admission to a neonatal unit (p = 0.120) were included in the regression model because they had p values lower than 0.20. The variable referring to the type of delivery (p=1.000) was inserted in the model because it is a variable of interest and with a description of relevance in the literature. Prematurity was the only variable that was statistically associated with SARS-CoV-2 infection during pregnancy (p = 0.008) in the bivariate analysis, explaining the outcome of infection during pregnancy (<0.001), confirmed in the Poisson Robust Regression model. Conclusion There was a high prevalence of COVID-19 in the sample, with varying symptoms and a predominance of operative deliveries. However, SARS-CoV-2 infection only explained the higher occurrence of premature births.

Incidence of prematurity and associated risk factors among users of a health insurance company / Incidência de prematuridade e fatores de risco associados entre usuárias de uma operadora de planos de saúde

Abstract Objectives: to analyze the incidence ofprematurity in users of a health insurance plan; to analyze the associated risk factors. Methods: a retrospective study was conducted in five maternity hospitals with puerperal women who were users of health insurance plans by telephone interviews guided by a semi-structured questionnaire. The variables studied were related to sociodemographic, clinical and outcome conditions. Univariate and multivariate analysis with Backward logistic regression was performed. Results: 1,193 participants were evaluated and 116 premature births were identified. It was found that preterm birth (p<0.001; OR=4.596; CI95%=2.544-8.305), oligohydramnios (p=0.019; OR=2.697; CI95% =1.140-6.380), diabetes mellitus prior to pregnancy (p<0.001; OR=4.897; CI95%=2.147-11.169), twin pregnancy (p<0.001; OR=7.115; CI95%=3.578-14.148), autoimmune disease (p<0.001; OR=3.799; CI95%=1.987-7.260), stress during pregnancy (p=0.026; OR=1.568; CI95%=1.053-2.335), urinary infection (p=0.008; OR=1.825; CI95%=1.161-2.867), placenta previa (p=0.001; OR=3.180; CI95%=1.517-6.667), pre-eclampsia (p<0.001; OR=4.833; CI95%=2.860-8.169), gestational bleeding (p=0.001; OR=2.185; CI95%=1.340-3.564), interval between pregnancies less than six months (p=0.001; OR=3.502; CI95%=1.594-7.698), pregnancy resulting from in vitro fertilization (p<0.001; OR=2.874; CI95%=1.466-5.637) were statistically relevant as risk factors for prematurity. Conclusion: knowledge of these factors may be important in developing strategies to improve the assistance offered to pregnant women by the health insurance providers.

Resumo Objetivos: analisar a incidência de prematuridade em usuárias de uma operadora de planos de saúde; analisar os fatores de risco associados. Métodos: estudo retrospectivo, realizado em cinco maternidades com puérperas usuárias de planos de saúde por meio de entrevistas telefônicas guiadas por questionário semiestruturado. As variáveis estudadas foram relativas às condições sociodemográficas, clínicas e de desfecho. Realizou-se análise uni e multivariada com regressão logística Backward. Resultados: foram avaliadas 1193 participantes e identificados 116 nascimentos prematuros. Verificou-se que prematuro prévio (p<0,001; OR=4,596; IC95%=2,544-8,305), oligodrâmnio (p=0,019; OR=2,697; IC95%=1,140-6,380), diabetes mellitus anterior a gestação (p<0,001; OR=4,897; IC95%=2,147-11,169), gestação de gemelares (p<0,001; OR=7,115; IC95%=3,578-14,148), doença autoimune (p<0,001; OR=3,799; C95%=1,987-7,260), estresse durante a gestação (p=0,026; OR=1,568; IC95%=1,053-2,335), infecção urinária (p=0,008; OR=1,825; IC95%=1,161-2,867), placenta prévia (p=0,001; OR=3,180; IC95%=1,517-6,667), pré-eclâmpsia (p<0,001; OR=4,833; IC95%=2,860-8,169), sangramento gestacional (p=0,001; OR=2,185; IC95%=1,340-3,564), intervalo entre gestações menor que seis meses (p=0,001; OR=3,502; IC95%=1,594-7,698), gestação proveniente de fertilização in vitro (p<0,001; OR=2,874; IC95%=1,466-5,637) foram estatisticamente relevantes como fatores de risco para prematuridade. Conclusão: o conhecimento desses fatores pode ser importante na elaboração de estratégias para melhorar a assistência ofertada às gestantes por operadoras de planos de saúde.

Spatial patterns of prematurity and its determinants in the metropolitan region of São Paulo, Brazil, 2010-2019 / Padrões espaciais da prematuridade e seus determinantes na região metropolitana de São Paulo, Brasil, 2010-2019

ABSTRACT Objective: To analyze spatial distribution of preterm births and their association with maternal, social, and health services indicators in the metropolitan region of São Paulo, Brazil, 2010-2019. Methods: Ecological study using data on preterm newborns from 39 municipalities in the metropolitan region of São Paulo. Univariate global Moran's index (Im) was used to evaluate spatial association of prematurity, and univariate local Moran's index by using the cluster map (LISA) to identify spatial patterns and clusters. Bivariate global Moran's index was also used to analyze spatial autocorrelation with maternal, social, and health services indicators. Results: A total of 3,103,898 live births were registered in period 2010-2019, of which 331,174 (10.7%) were preterm. The global Moran's index showed spatial independence (Im=0.05; p-value=0.233) of the proportion of preterm births between municipalities. However, in the local spatial analysis it was possible to identify a statistically significant spatial cluster between the municipalities of Biritiba Mirim, Guararema and Salesópolis, with high proportions of preterm births. In the bivariate analysis, a significant positive spatial association was identified with proportions of mothers under 20 years old (Im=0.17; p-value=0.024) and mothers with low schooling (Im=0.17; p-value=0.020), and a significant negative spatial association with HDI (Im=-0.14; p-value=0.039). Conclusions: The local spatial approach identified a spatial cluster located in the far east of the metropolitan region of São Paulo, where actions by health managers are needed to minimize occurrence of preterm births.

RESUMO Objetivo: Analisar a distribuição espacial dos nascimentos prematuros e sua associação com indicadores maternos, sociais e de serviços de saúde na região metropolitana de São Paulo, Brasil, 2010-2019. Métodos: Estudo ecológico utilizando dados sobre recém-nascidos pré-termo dos 39 municípios da região metropolitana de São Paulo. Utilizou-se o índice de Moran (Im) global univariado para avaliar a associação espacial da prematuridade, e o índice de Moran local univariado por meio do mapa de clusters (LISA) para a identificação de padrões e aglomerados espaciais. Também foi utilizado o índice de Moran global bivariado para analisar a autocorrelação espacial com os indicadores maternos, sociais e de serviços de saúde. Resultados: Foram registrados 3.103.898 nascidos vivos no período 2010-2019, dos quais 331.174 (10,7%) foram prematuros. O índice de Moran global mostrou independência espacial (Im=0,05; p-valor=0,233) da proporção dos nascimentos prematuros entre municípios. No entanto, na análise espacial local foi possível identificar aglomerado espacial estatisticamente significativo entre os municípios de Biritiba Mirim, Guararema e Salesópolis, com proporções altas de nascimentos pré-termo. Na análise bivariada, identificou-se associação espacial significativa positiva com proporções de mães menores de 20 anos (Im=0,17; p-valor=0,024) e mães com baixa escolaridade (Im=0,17; p-valor=0,020), e associação espacial significativa negativa com IDH (Im=-0,14; p-valor=0,039). Conclusão: A abordagem espacial local identificou agrupamento espacial situado no extremo leste da região metropolitana de São Paulo, onde ações dos gestores de saúde são necessárias para minimizar a ocorrência de partos prematuros.

Hypertensive disorders during pregnancy as a major cause of preterm birth and adverse perinatal outcomes: findings from a Brazilian National Survey

ABSTRACT Objective This study aimed to evaluate the prevalence of hypertensive disorders during pregnancy among Brazilian women with preterm births and to compare the epidemiological characteristics and perinatal outcomes among preterm births of women with and without hypertension. Methods This was a secondary cross-sectional analysis of the Brazilian Multicenter Study on Preterm Birth. During the study period, all women with preterm births were included and further split into two groups according to the occurrence of any hypertensive disorder during pregnancy. Prevalence ratios were calculated for each variable. Maternal characteristics, prenatal care, and gestational and perinatal outcomes were compared between the two groups using χ2 and t-tests. Results A total of 4,150 women with preterm births were included, and 1,169 (28.2%) were identified as having hypertensive disorders. Advanced maternal age (prevalence ratio (PR) 2.49) and obesity (PR= 2.64) were more common in the hypertensive group. The gestational outcomes were worse in women with hypertension. Early preterm births were also more frequent in women with hypertension. Conclusion Hypertensive disorders of pregnancy were frequent among women with preterm births, and provider-initiated preterm births were the leading causes of premature births in this group. The factors significantly associated with hypertensive disorders among women with preterm births were obesity, excessive weight gain, and higher maternal age.

Relação entre a condição bucal de gestantes internadas e desfechos adversos na gestação / Relationship between the oral condition of hospitalized pregnant women and adverse pregnancy outcomes

Objetivo: avaliar se a condição bucal favoreceu a presença de desfechos adversos da gestação (DAG) em mulheres internadas e acompanhadas em um hospital escola. Métodos: um estudo de coorte retrospectiva com mulheres grávidas que foram internadas entre setembro de 2019 e início de março de 2020 e que continuaram o acompanhamento obstétrico. Resultados: Das 65 gestantes que seguiram acompanhamento, 27 (41,5%) dos bebês nasceram pré-termo e 20 (30,8%) com baixo peso, sendo que as duas condições estavam presentes em 15 crianças (23,1%), sendo significantemente relacionadas com a menor semana gestacional na internação. Ao relacionar diferentes fatores com o desfecho pré-termo, houve diferença significante em gestantes com a ocupação "do lar" e com o tempo de internação igual ou maior que 10 dias e com a presença de baixo peso ao nascer. Não foi observada relação dos dados avaliados da condição bucal das gestantes na internação com o parto pré-termo. Conclusões: Gestantes que necessitam de internação hospitalar durante a gravidez, independente da condição bucal, aumentam a possibilidade de apresentarem DAG, sendo fundamental a realização do correto acompanhamento pré-natal.(AU)

Objective: to assess whether the oral condition favored the presence of adverse effects during pregnancy in pregnant women hospitalized and followed up at a teaching hospital. Methods: a retrospective cohort study with mothers who were hospitalized during pregnancy between September 2019 and early March 2020 and who continued obstetric follow-up. Results: 83 pregnant women were interviewed and 65 were followed up Of the 65 pregnant women who followed up, 27 (41.5%) of the babies were born preterm and 20 (30.8%) with low birth weight, and both conditions were present in 15 children (23.1%), being significantly related to the shortest gestational week at admission. When relating different factors with the preterm outcome, there was a significant difference in pregnant women with the occupation "housewife" and with the length of hospital stay equal to or greater than 10 days and with the presence of low birth weight. There was no relationship between the evaluated data on the oral condition of pregnant women during hospitalization and preterm delivery. Conclusions: Pregnant women who require hospitalization during pregnancy, regardless of oral condition, increase the possibility of having negative pregnancy outcomes, and correct prenatal care is essential. (AU)

A internação da gestante pode afetar a condição bucal do filho no terceiro ano de vida? / Can a pregnant woman's hospitalization affect the child's oral condition in the third year of life?

Objetivo: Avaliar se a hospitalização na gestação pode influenciar na condição bucal do filho no terceiro ano de vida. Métodos: Estudo longitudinal com bebês de gestantes internadas e acompanhadas no setor da Obstetrícia de um Hospital Escola em Pelotas, RS, Brasil. Os dados referentes a hospitalização e ao parto foram coletados do prontuário hospitalar e no terceiro de vida do filho (a) de um questionário aplicado a mãe e do exame bucal da criança. Cada agravo bucal foi avaliado com critérios específicos, por uma examinadora calibrada e analisado no programa IBM SPSS Statistics com 5% de nível de significância. Resultados: Participaram 20 díades mãe-filho (a). Alterações da oclusão acometeram 95% das crianças, sendo a mordida aberta anterior (MAA) a principal. Ainda, 25% das crianças apresentaram opacidades demarcas e/ou hipoplasia do esmalte, sendo significativamente maior em filhos de mães mais jovens e 20% tinham cárie da primeira infância (CPI), estando relacionada à ausência de creme dental fluoretado e à qualidade da higiene bucal. Conclusão: O reflexo mais evidente da hospitalização na gestação na saúde bucal no terceiro ano de vida do filho (a) foi a oclusão alterada, especialmente a MAA.(AU)

Objective: To assess whether hospitalization during pregnancy can influence the child's oral condition in the third year of life. Methods: Longitudinal study with babies of pregnant women hospitalized and followed up in the Obstetrics sector of a Teaching Hospital in Pelotas, RS, Brazil. Data referring to hospitalization and childbirth were collected from the hospital records and in the child's third of life through a questionnaire applied to the mother and the child's oral examination. Each oral condition was evaluated with specific criteria, by a calibrated examiner and analyzed in the IBM SPSS Statistics program with a 5% minimum significance level. Results: 20 mother-child participated. Occlusion alterations affected 95% of the children, with anterior open bite (AOB) being the main. Still, 25% of the children had opacities and/or enamel hypoplasia, which was significantly higher in children of younger mothers, and 20% had early childhood caries, which is related to the absence of fluoride toothpaste and the quality of oral hygiene. Conclusion: The clearest reflection of hospitalization during pregnancy on oral health in the third year of the child's life was altered occlusion, especially the AOB.(AU)

Desarrollo psicomotor según características sociodemográficas y clínicas en niños de hasta 36 meses, con parálisis cerebral

Introducción: Es importante conocer el desarrollo psicomotor de los niños con parálisis cerebral de acuerdo con sus características sociodemográficas y clínicas para realizar un mejor tratamiento en este tipo de pacientes. Objetivo: Describir el desarrollo psicomotor según las características sociodemográficas y clínicas de niños hasta 36 meses con parálisis cerebral. Métodos: Estudio observacional, descriptivo, de corte transversal con datos retrospectivos. Se revisaron 177 historias clínicas de pacientes con diagnóstico de parálisis cerebral de 0 a 36 meses, atendidos del 1 de enero de 2015 al 31 de diciembre de 2016 en un instituto nacional de rehabilitación de Lima, Perú. Resultados: La edad promedio fue 25,1 ± 7,16 meses, el 58,19 % fue del sexo masculino, el grupo etario de 25-36 meses representó el 67,89 %, predominó la parálisis cerebral espástica cuadripléjica con 28,25 %, el 14,12 % tenía alteración en la audición y el 19,21 % convulsiones. El promedio de porcentajes de desarrollo psicomotor global fue de 62,66 %; los menores promedios fueron para el comportamiento motor grueso (57,15 %), el grupo etario de 0 a 12 meses (51,49 %), las niñas (57,72 %), la parálisis cerebral espástica cuadriplejia (42,55 %), niños con alteración auditiva y visual (36,92 %), con convulsiones (46,17 %) y prematuros (58,26 %). Conclusiones: Los niños hasta 36 meses con parálisis cerebral tienen un retraso global del desarrollo psicomotor de aproximadamente el 35 %, con mayor afectación los de menor edad, las niñas, los que tienen parálisis cerebral espástica cuadripléjica, alteración auditiva y visual, convulsiones y son prematuros.

Introduction: It is important to know the psychomotor development of children with cerebral palsy according to their sociodemographic and clinical characteristics to carry out a better approach in this type of patients. Objective: To describe the psychomotor development according to sociodemographic and clinical characteristics of children up to 36 months with cerebral palsy. Methods: Observational, descriptive, cross-sectional study with retrospective data. 177 medical records of patients with a diagnosis of cerebral palsy from 0 to 36 months were reviewed, treated from January 1, 2015 to December 31, 2016 at a national rehabilitation institute in Lima, Peru. Results: The average age was 25.1 ± 7.16 months, the 58.19% were male, the age group of 25-36 months represented 67.89%, quadriplegic spastic cerebral palsy predominated with 28.25%, 14.12% had alteration in hearing and 19.21% seizures. The average percentage of global psychomotor development was 62.66%; the lowest averages were for gross motor behavior (57.15%), the age group from 0 to 12 months (51.49%), girls (57.72%), spastic cerebral palsy quadriplegia (42.55%), children with hearing and visual impairment (36.92%), with seizures (46.17%) and premature (58.26%). Conclusions: Children up to 36 months with cerebral palsy have a global delay in psychomotor development of approximately 35%, with greater affectation in younger children, girls, those with spastic quadriplegic cerebral palsy, hearing and visual disorders, seizures and are premature.

COVID-19 and pregnancy outcomes: a retrospective study from a tertiary health care center of Uttarakhand, India

Background: Information regarding the effects of COVID-19 on pregnancy outcomes evolved rapidly in the recent years. This study aims to present the outcomes in COVID-19 positive pregnant women.Methods: This retrospective cohort study was conducted in a tertiary health care center of Uttarakhand, India from April 2021 to June 2021. The maternal and neonatal data for the included cases were extracted from hospital records and appropriately analysed.Results: The positivity rate of COVID-19 among obstetric population was 7.9% by universal screening protocol. 55.2% participants were in the age group of 25-30 years. Gestation age at presentation ranged from 6 weeks to 41 weeks. 47.3% participants had pre-existing comorbidities. 26.4% study subjects had pregnancy related comorbidities, the most common being gestational diabetes mellitus (14.7%), followed by pre-eclampsia (8.8%). Only 21.1% participants were symptomatic at presentation. Most common presenting symptom was fever (87.5%) followed by breathlessness (62.5%). 7.5% required invasive ventilation and 10.5% cases required intensive care unit (ICU) admission and 76.5% participants underwent caesarean section which was done for obstetric indications only. 3.9% participants died due to COVID-related complications. Nearly 35% neonates were preterm, 29.4% had low birth weight and 24.1% needed neonatal intensive care unit (NICU) admission. Nasopharyngeal swab for COVID reverse transcriptase-polymerase chain reaction (RT-PCR) after 24 hours of birth was negative in all neonates. There were 10 (14.7%) stillbirths.Conclusions: COVID-19 in pregnancy was associated with higher risks of gestational diabetes mellitus, preeclampsia and higher rates of invasive ventilation, ICU admission, caesarean sections, maternal mortality specially in women with pre-existing comorbidities, stillbirths, preterm births and NICU admission.

Narrativas de mulheres mães: vivências e ressignificações diante da prematuridade extrema / Narratives of women mothers: experiences and resignifications in the face of extreme prematurity / Narrativas de mujeres madres: vivencias y resignificaciones frente a la prematuridad extrema

OBJETIVO: A partir do nascimento pré-termo, a maternidade é convocada prematuramente, pois o tempo final da gestação não pode ser vivido e o que foi idealizado não se concretiza. Dessa forma, a mulher mãe precisa ressignificar seu papel e a própria maternidade, reestruturando seu sistema cuidador para dar conta da situação real que se apresenta. O nascimento prematuro insere muitas dificuldades para a mulher, influenciando em momentos estressantes e deflagrando sentimentos de frustação, culpa, ansiedade, tristeza, medo, entre outros. OBJETIVO: Compreender as dificuldades, emoções e sentimentos presentes durante o nascimento e hospitalização dos recém-nascidos pré-termos extremos e como a(s) maternidade(s) puderam ir se construindo nesse contexto. MÉTODO: Estudo qualitativo, com coleta de narrativas de mulheres que compartilharam suas experiências em um site especializado na internet. A análise foi realizada a partir da Análise de Conteúdo, utilizando como embasamento teórico a teoria do apego. RESULTADOS: As narrativas retratam uma alta expectativa em relação ao nascimento dos bebês, bem como a frustração e angústia geradas a partir da necessidade de uma separação brusca e literal. Ainda, os momentos foram marcados por uma rotina exaustiva e pelo medo do bebê vir a óbito, além da necessidade de aprenderem a reconhecer os sinais sutis dos bebês e construir modos de cuidados possíveis. As narrativas trabalhadas foram/são uma maneira que elas encontraram para relatar suas histórias e de ressignificar o vivido. CONSIDERAÇÕES FINAIS: Destaca-se a importância de haver o reconhecimento das vivências maternas nesse contexto para que melhorias no acolhimento prestado e construção de políticas públicas sejam possíveis de serem realizadas.

OBJECTIVE: From preterm birth, motherhood is called prematurely, as the final period of pregnancy cannot be lived and what was idealized does not come true. Thus, the mother-woman needs to reformulate her role and her own motherhood, restructuring her care system to account for the real situation that is presented. Premature birth entails many difficulties for women, influencing stressful moments and triggering feelings of frustration, guilt, anxiety, sadness, and fear, among others. OBJECTIVE: Understand the difficulties, emotions, and feelings present during the birth and hospitalization of extreme preterm newborns and how motherhood could be built in this context. METHODS: Qualitative study, collecting narratives from women who shared their experiences on a specialized website on the internet. The analysis was carried out from the Content Analysis, using the attachment theory as the theoretical basis. RESULTS: The results point to a high expectation in relation to the birth of babies, as well as the frustration and anguish generated by the need for a sudden and literal separation. The moments were marked by an exhaustive routine and by the fear of the baby dying, in addition to the need to learn to recognize the subtle signs of the babies and build possible care modes. The narratives worked on were a way they found to report their stories and redefine what they had lived. CLOSING REMARKS: The importance of recognizing maternal experiences in this context is highlighted so that improvements in the reception provided and the construction of public policies are possible to be carried out.

OBJETIVO: Desde el parto prematuro, la maternidad es convocada prematuramente, ya que el período final del embarazo no se puede vivir y lo idealizado no se hace realidad. Por lo tanto, la madre necesita replantear su rol y maternidad, reestructurar su sistema de cuidado para dar cuenta de la situación real que se presenta. El parto prematuro conlleva muchas dificultades para la mujer, influyendo en momentos estresantes y desencadenando sentimientos de frustración, culpa, ansiedad, tristeza, miedo, entre otros. OBJETIVO: Comprender las dificultades, emociones y sentimientos presentes durante el parto y la hospitalización de recién nacidos prematuros extremos y cómo la(s) maternidad(es) podría(n) ser construida(s) en ese contexto. MÉTODO: Estudio cualitativo, con la recopilación de relatos de mujeres que compartieron sus experiencias en un sitio web especializado en internet. El análisis se realizó con base en el Análisis de Contenido, utilizando como base teórica la teoría del apego. RESULTADOS: Apuntaron a una alta expectativa en relación al nacimiento de bebés, así como a la frustración y angustia que genera la necesidad de una separación repentina y literal. Aún así, los momentos estuvieron marcados por una rutina exhaustiva y por el miedo a la muerte del bebé, además de la necesidad de aprender a reconocer los signos sutiles de los bebés y construir posibles modos de cuidado. Las narrativas trabajadas fueron/son una forma que apoyan para relatar sus historias y para resignificar la experiencia. CONSIDERACIONES FINALES: Se resalta la importancia de reconocer las experiencias maternas en este contexto, para que se puedan llevar a cabo mejoras en la atención brindada y la construcción de políticas públicas.

The clinical value of lung ultrasound in premature infants with bronchopulmonary dysplasia

SUMMARY OBJECTIVE: This study aimed to explore the risk factors of bronchopulmonary dysplasia in premature infants and the clinical application value of lung ultrasound in the diagnosis of bronchopulmonary dysplasia. METHODS: A total of 80 premature infants with a gestational age of <32 weeks or a birth weight of <1,500 g who were treated in our hospital from January to August 2021 were randomly divided into a bronchopulmonary dysplasia group (n=12) and a non-bronchopulmonary dysplasia group (n=62). The clinical data, lung ultrasound, and X-ray image characteristics of the two groups were compared. RESULTS: Among the 74 preterm infants, 12 preterm infants were diagnosed with bronchopulmonary dysplasia, and 62 preterm infants were determined not to have bronchopulmonary dysplasia. There were significant differences in sex, severe asphyxia, invasive mechanical ventilation, premature membrane ruptures, and intrauterine infection between the two groups (p<0.05). Lung ultrasound showed abnormal pleural lines and alveolar-interstitial syndrome in all 12 patients with bronchopulmonary dysplasia and vesicle inflatable signs in 3 patients. Before clinical diagnosis, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of lung ultrasound in the diagnosis of bronchopulmonary dysplasia were 98.65, 100, 98.39, 92.31, and 100%, respectively. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of X-rays in the diagnosis of bronchopulmonary dysplasia were 85.14, 75.00, 87.10, 52.94, and 94.74%, respectively. CONCLUSION: The diagnostic efficiency of lung ultrasound for premature bronchopulmonary dysplasia is better than that of X-rays. The application of lung ultrasound can screen patients with bronchopulmonary dysplasia early for timely intervention.

Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort: comparison with INTERGROWTH

Abstract Objective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Methods: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92-2.31)/1.60 (1.27-2.02) for SGA; 0.90 (0.55-1.47)/1.05 (0.55-1.99) for LGA; 1.65 (1.08-2.51)/1.58 (1.28-1.96) for stunting; and 1.48 (1.02-2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.