El Cuidado de Sí desde una Perspectiva Relacional / Self-Care from a Relational Perspective

Resumen El cuidado de sí no es una capacidad que el individuo adquiere de manera ais lada o con el simple paso de una edad a otra, sino que se origina en un contexto relacional temprano y, como tarea del desarrollo, constituye un hito importante de cara al establecimiento de relaciones maduras en la adultez.

Abstract Self-care is not a capacity that the individual acquires in isolation or with the simple passage from one age to another, but it originates in an early relational context and, as a developmental task, it constitutes an important milestone toward the establishment of mature relationships in adulthood.

Efectos del entrenamiento en marcos relacionales de condicionalidad sobre el responder relacional deíctico / Effects of Training in Conditional Relational Framing on the Deictic Relational Responding

Resumen Desde la Teoría de los Marcos Relacionales, la toma de perspectiva se concibe como un patrón de responder relacional arbitrariamente aplicable bajo control de claves contextuales deícticas personales, espaciales y temporales. Además, se asume necesaria la capacidad para responder relacionalmente bajo el control de claves contextuales condicionales. Sin embargo, no se ha reportado evidencia empírica que permita identificar la relación existente entre los marcos de condicionalidad y la precisión en el responder relacional deíctico. El objetivo del estudio fue analizar si el entrenamiento en marco de condicionalidad podría facilitar el desempeño sobre el responder deíctico. Participaron cuatro niños con desarrollo normalizado que fueron divididos en dos condiciones experimentales (C1 y C2). Los participantes de ambas condiciones se expusieron a un protocolo de evaluación y entrenamiento en marcos deícticos. A su vez, solo los participantes de la C2 se expusieron a una fase de evaluación y entrenamiento en marcos de condicionalidad previo al entrenamiento en marcos deícticos. Los resultados mostraron que todos los participantes exhibieron mejoras en sus ejecuciones post-test en las relaciones deícticas y que los participantes de C2 obtuvieron mejores resultados con respecto a su pre-test en los niveles de mayor complejidad deíctica tras el entrenamiento en marcos condicionales. Se discute la necesidad de protocolos de toma de perspectiva más naturalistas que posibiliten indagar en cómo se desarrollan los términos relacionales y se abstrae la función de las claves contextuales que permiten interpretar, atribuir y predecir el comportamiento de otro.

Abstract According to Relational Frame Theory, perspective taking is conceived as an arbitrarily applicable relational pattern of relational responding under the control of personal, spatial, and temporal deictic contextual cues. Furthermore, the ability to respond relationally under the control of conditional contextual cues is assumed to be necessary. However, no empirical evidence has been reported to identify the relationship between conditionality frames and accuracy in deictic relational responding. The study aimed to analyze whether training in conditionality frames could facilitate performance on deictic responding. Four children with normalized development participated and were divided into two experimental conditions (C1 and C2). Participants in both conditions were exposed to an evaluation protocol and training on deictic frames. In turn, only C2 participants were exposed to an evaluation and training phase in conditionality frames before the training in deictic frames. Results showed that all the participants exhibited improvements in their post-test performances on deictic relations and that the C2 participants performed better with respect to their pre-test on the levels of greater deictic complexity after training in conditional frames. We discuss the need for more naturalistic perspective-taking protocols that allow us to investigate how relational terms are developed and abstract the role of contextual cues that allow us to interpret, attribute, and predict another's behavior.

Modified Simiao Yong'an Decoction combined with conventional western medicine on lower limb hemodynamics in patients with low-risk diabetes foot / 国际中医中药杂志

Objective:To explore the effect of modified Simiao Yong'an Decoction combined with conventional western medicine on lower limb hemodynamics in patients with low-risk diabetes foot (DF).Methods:This retrospective cohort study included 70 patients with infectious diabetic foot, between January 2015 and May 2019, and they were divided into control group and study group, with 35 in each group. The control group was treated with conventional western medicine, while the study group was treated with modified Simiao Yong'an Decoction on the basis of the control group. Both groups were treated for 4 weeks and followed up for 1 year. The levels of basic fibroblast growth factor (bFGF) and VEGF were detected by ELISA, the levels of blood viscosity, fibrinogen and HbAlc were detected by automatic hemorheological analyzer, the dorsal artery of foot was detected by color Doppler ultrasound, the diameter and blood flow velocity of dorsal artery of foot were recorded, and the conduction velocity of sural nerve and common peroneal nerve were detected by electromyography for recurrence rate calculation. And the clinical response rates were evaluated.Results:The total clinical response rate was 94.3% (33/35) in the study group and 77.1% (27/35) in the control group, and there was significant difference between the two groups ( χ2=4.20, P=0.040). After treatment, the bFGF [(177.15±7.96)ng/L vs. (158.87±7.21)ng/L, t=10.00], VEGF[(53.77±4.15)ng/L vs. (45.44±4.92)ng/L, t=7.66] levels in the study group were significantly higher than those in the control group ( P<0.01). After treatment, the whole blood viscosity [(3.84±0.86)mPa?s vs. (4.56±0.99)mPa?s, t=3.25], fibrinogen [(3.59±0.78) g/L vs.(4.23±0.97)g/L, t=3.04]and HbAlc[(9.61±1.31)% vs. (10.85±1.82)%, t=3.27] levels in the study group were significantly lower than those in the control group ( P<0.01). After treatment, the sural nerve conduction velocity [(39.42±5.11)m/s vs. (34.22±4.52)m/s, t=4.51], common peroneal nerve conduction velocity [(40.94±4.22)m/s vs. (35.52±3.72)m/s, t=5.70], blood vessel diameter [(2.21±0.60)mm vs. (1.92±0.52)mm, t=2.16], while the blood flow velocity [(55.89±5.84)cm/s vs. (52.95±5.85)cm/s, t=2.10] in the study group were significantly higher than those in the control group ( P<0.05). During the follow-up, the recurrence rate was 21.21% (7/33) in the study group and 29.63% (8/27) in the control group. with out statistical significance between the two groups ( χ2=0.20, P=0.653). Conclusion:Modified Simiao Yong'an Decoction combined with conventional western medicine can improve lower limb blood circulation and nerve conduction velocity of low-risk DF patients, promote rehabilitation and reduce recurrence.

Foucault: subjetividade e verdade à luz do cuidado de si / Foucault: subjetividad y verdad a la luz del cuidado de sí / Foucault: subjectivity and truth in the light of care of self

RESUMO. Buscamos, no presente artigo, situar o conjunto nocional da relação consigo (rapport à soi) na construção da categoria de subjetividade do pensamento tardio de Michel Foucault. Atrelamos a ele a questão da relação com o Outro e propomos a possibilidade de inscrever a psicanálise na história do cuidado de si. Nosso material primário é a transcrição das aulas ministradas pelo filósofo no começo de 1982 e o livro L'herméneutique du sujet (Foucault, 2001); e nosso suporte principal para análise são as conferências de 1980, L'origine de l'herméneutique de soi, e o livro Foucault, de Deleuze (2005). Como resultado, apresentamos a capacidade de afecção de si por si proporcionada pela relação consigo, demonstramos o modo como a posição do Outro influencia a produção da verdade do sujeito, e reforçamos a necessidade de se pensar práticas como a da psicanálise a partir do arranjo deixado pela história das técnicas de si.

RESUMEN. En el artículo, buscamos identificar el conjunto nocional de la relación con usted (rapport à soi) en la construcción de la categoría de subjetividad del pensamiento posterior de Michel Foucault. Le atribuimos la cuestión de la relación con el Otro y proponemos la posibilidad de inscribir el psicoanálisis en la historia del cuidado de sí. Nuestro material principal es la transcripción de las clases impartidas por el filósofo a principios del 1982, el libro L'herméneutique du sujet (Foucault, 2001) y nuestro principal apoyo para el análisis son las conferencias del 1980, L'origine de l'herméneutique de soi y el libro Foucault, de Deleuze (2005). Como resultado, presentamos la capacidad de autoafecto (de ti para ti) proporcionada por la relación con usted, demostramos lá manera en que la posición del Otro influye en la producción de la verdad del sujeto, y reforzamos la necesidad de pensar sobre las prácticas como de la psicoanálisis desde del arreglo dejado por la historia de las técnicas de sí.

ABSTRACT. In this article, we situate the notional set of the relation with oneself (rapport à soi) in the construction of the category of subjectivity in Michel Foucault's later thought. We show how that relation is attached to the relation with the Other, and we propose the possibility of inscribing psychoanalysis in the history of the care of the self. Our primary material is the transcription of the lectures the philosopher gave in early 1982, the book L'herméneutique du sujet (Foucault, 2001), and our main basis for analysis is the 1980 conferences, L'origine de l'herméneutique de soi, and the book Foucault, by Deleuze (2005). As a result, we present the capacity for self-affection afforded by the relation with oneself, we demonstrate the way in which the Other's position influences the production of the subject's truth, and we concur with the need to think about practices such as psychoanalysis from the perspective of the arrangement left by the history of techniques of the self.

Mechanism study of Si Miao Formula on alleviating insulin resistance by increasing the abundance of Akkermansia muciniphila in mice / 药学学报

In our previous study, we found that Si Miao Formula (SMF) had the effect of improving the disorder of glucose metabolism caused by high fat and high sucrose diet, and significantly altered the composition of gut microbiota, especially increasing the level of Akkermansia muciniphila (A. muciniphila). However, it is unclear that the role of intestinal flora and A. muciniphila play in SMF improving blood glucose homeostasis, and the mechanism of how SMF increases the level of A. muciniphila. Therefore, this study will explore the correlation between SMF improving the insulin resistance and increasing the level of A. muciniphila, as well as the mechanism of SMF-induced growth of A. muciniphila using the in vitro and in vivo experiments. We explored the effect of intestinal flora and A. muciniphila on SMF-improved insulin resistance through fecal microbiota transplantation (FMT) and antibiotic intervention. In order to study the mechanisms underlying SMF on elevating A. muciniphila, we disassembled SMF to find the key component which can particularly elevate the number of A. muciniphila. Using the in vitro anaerobic culture system combined with cell and animal experiments, we explored the mechanism of the key component in elevating A. muciniphila. The research was approved by the Animal Ethical and Welfare Committee of Shanghai University of Traditional Chinese Medicine. Our results showed that the gut microbiota altered by SMF can improve high fat and sucrose diet induced insulin resistance in recipient mice, and the improvement was closely related to the abundance of A. muciniphila. Cortex Phellodendri played the most important role in regulating the composition of intestinal flora and increasing the number of A. muciniphila, of which, berberine was the key component of Cortex Phellodendri which up regulated A. muciniphila. We have found that berberine cannot directly promote the growth of A. muciniphila in vitro, but it can stimulate the expression of mucin, which, in turn, promote the growth of A. muciniphila. The above results show that the improved insulin sensitiviy by SMF depends on the increased level of A. muciniphila. The effect of SMF on elevating the amount of A. muciniphila might be correlated with the increased expression of mucin stimulated by berberine.

Comparison of the da Vinci Si and Xi surgical systems in robot-assisted laparoscopic adrenalectomy / 中华泌尿外科杂志

Objective:To compare the clinical efficacy and cost of robot-assisted laparoscopic adrenalectomy with da Vinci Xi and Si surgical system in the treatment of adrenal tumors.Methods:The clinical data of 99 patients performing robotic-assisted laparoscopic adrenalectomy in our hospital between June 2019 and December 2020 were retrospective analyzed. Among them, 57 cases were Si system robot assisted laparoscopic adrenalectomy (group Si), 35 male, 22 female; age (45.6±14.0)years; BMI(21.0±1.2); 6 with diabetes, 10 hypertension, 14 with abdominal surgery; 28 left, 29 right; 9 ASA score ≥3; tumor diameter (3.9±1.2)cm. There were 42 cases of Xi system robot-assisted laparoscopic adrenalectomy (group Xi), 21 male, 21 female; age(44.8±14.5)years; BMI(21.4±1.8); 2 with diabetes, 12 hypertension, 11 with abdominal surgery; 15 left, 27 right; 7 with ASA score ≥3; tumor diameter (3.7±1.1) cm. Sex, age, BMI, comorbidities, history of abdominal surgery, lateral division, ASA score, and tumor diameter were not significantly different between the two groups ( P>0.05). Operation method: except for the different docking procedures, the same surgical procedures were roughly performed in the two groups. The docking method of the Si group was the doctor holding the attractor as the guide. The operating room nurse introduced the robot cart under the guidance of the attractor, and then completed the docking.Group Xi docking adoptd the own laser positioning system of the robot system, without manual positioning and guidance; the mechanical arm of the Xi system was also more flexible. Complications were graded according to the Clavien-Dindo grading system. Comparing the treatment effect, safety, and cost of the two groups were compared. Results:The anesthesia times in the Si and Xi groups were (140.0±24.3) min and (125.6±26.4) min ( P=0.006), respectively. The surgical times in the Si and Xi groups were (109.0±18.8) min and (98.8±20.7) min (P=0.013), respectively. The docking times between the Si and Xi groups were (7.8±1.4) min and (5.0±0.9) min ( P<0.001), respectively. The estimated intraoperative blood loss in the Si and Xi groups was (121.5±70.8) ml and (124.7±68.9) ml ( P=0.824), respectively. The postoperative indwelling times of the drainage tube in the Si and Xi groups were (3.4±1.2) d and (3.4±1.3) d ( P=0.892), respectively. Postoperative bed times in the Si and Xi groups were (2.3±1.0) d and (2.5±1.2) d ( P=0.419), respectively. Postoperative hospitalization times in the Si and Xi groups were (6.4±1.5) d and (6.2±1.5) d ( P=0.484), respectively. Post Clavien ≥ grade 3 complications were four and two in groups Si and Xi, respectively ( P=0.642). The total cost during hospitalization in the Si and Xi groups was (51 975.2±7 320.8) Yuan and (56 830.9±8 392.5) Yuan, respectively ( P=0.003). The surgery and consumables costs for the Si and Xi groups were (23 785.3±4 063.1) Yuan and (28 021.2±6 066.8) Yuan ( P<0.001), respectively. Conclusions:Compared with the Si system, the Xi system robot-assisted laparoscopic adrenalectomy can provide similar perioperative results and safety, and shorten the time of anesthesia and surgery, but the total cost of hospitalization is increased.

Network pharmacology-based mechanism of Sijunzi Decoction in treatment of colorectal cancer / 国际中医中药杂志

Objective:To explore the potential target and signaling pathway of Sijunzi Decoction in treating Colorectal Cancer (CRC) with network pharmacology.Methods:The Traditional Chinese Medicine System Platform (TCMSP) and Swiss Target Prediction database were adopted to establish the database of Sijunzi Decoction effective ingredients and targets. Therapeutic Target Database (TTD), Online Mendelian Inheritance in Man, Drugbank and GeneCards were used to build the CRC target database. The common gene names of target proteins were checked in Uniprot database. The STRING database was applied to analyze the interactions between the targets and the DAVID was used for the enrichment analysis on gene ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. The network topology results were analyzed by Cytoscape 3.7.1 software.Results:134 active compounds of Sijunzi Decoction were gained, and PPI includes 125 targets protein (TP53,AKT1,IL-6,et al.). The 516 cellular biological processes, 53 cellular component and 98 molecular function were obtained through GO biological process enrichment analysis. The result of KEGG pathway enrichment showed that PI3K-Akt signaling pathway, TNF signaling pathway and FoxO signaling pathway were the main pathways.Conclusion:Sijunzi Decoction is mainly used to treat CRC by regulating key proteins such as TP53,AKT1, IL-6 and interfering with signal pathways such as PI3K-Akt, TNF and FoxO, reflecting the characteristics of Sijunzi Decoction in the treatment of CRC with multi-component,multi-target and multi-pathway characters.

Application and effect of virtual-reality surgery simulation system in minimally invasive cataract surgery training for ophthalmology residents / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To investigate the application and effect of virtual-reality surgery exercise in minimally invasive cataract surgery training for ophthalmology residents.<p>METHODS:Twenty ophthalmology residents with equal seniority who had completed 3a standardized residency training in the Affiliated Eye Hospital of Nanjing Medical University from 2019 to 2021 were prospectively enrolled. After passing the theoretical examination, residents were randomly divided into virtual surgery exercise(Dry-lab)group(<i>n</i>=10)and real animal surgery exercise(Wet-lab)group(<i>n</i>=10). Dry-lab and Wet-lab group residents performed training using the Eye SI surgical simulator and pig eye respectively. At the end of the training, the overall training effects of the residents in both groups were rated using the Eye SI surgical simulator and the real pig eye operation, and the module training effects of the residents in both groups were rated using the virtual surgical simulator. Furthermore, a questionnaire survey was used to objectively evaluate the two training methods.<p>RESULTS:Residents in Dry-lab group had significantly higher total scores on both operation assessments,simulator assessment and real pig eye operation assessment than Wet-lab group(88.03±1.34 <i>vs</i> 80.35±2.87, 87.50±3.03 <i>vs</i> 77.60±5.62, 88.57±1.89 <i>vs</i> 83.10±3.22, all <i>P</i><0.01). The simulator module assessment results showed that the residents in Dry-lab group scored significantly better than Wet-lab group in terms of scores and completion time on each module(<i>P</i><0.01). The questionnaire results showed that Dry-lab group rated better than Wet-lab group in terms of the novelty of training, the proximity to the real surgical experience, the degree of help to the improvement of microsurgery skills, the confidence to perform real surgery, and the overall satisfaction of surgical training(<i>P</i><0.05). <p>CONCLUSION:Applying virtual-reality surgery exercise to cataract surgery skills training for ophthalmology residents can significantly improve the cataract skills, increase overall training satisfaction, and help residents enhance their confidence, psychological quality, decision-making, and processing ability during real surgery at the initial stage of practice. This provides a new standard and model for establishing a formal and standardized cataract surgery training system for ophthalmology residents.

Si Junzitang Regulates NKG2A Expression to Improve Anti-colon Cancer Function of NK Cells / 中国实验方剂学杂志

ObjectiveTo explore the mechanism of Si Junzitang in regulating the expression of NKG2A to affect the anti-colon cancer function of natural killer （NK） cells. MethodNK cells isolated from healthy honors were cultured and used to construct the three incubation models of NK cells， human colon cancer HCT116 cells， and NK cells + HCT116 cells （co-incubation）. real-time fluorescence quantitative polymerase chain reaction （Real-time PCR） was conducted to determine the mRNA levels of natural killer group 2 member A （NKG2A） and interleukin （IL）-15 in NK cells， as well as the mRNA level of histocompatibility leucocyte antigen E （HLA-E） in HCT116 cells. The secretion of IL-15 was detected by enzyme-linked immunosorbent assay （ELISA）. Methyl thiazolyl tetrazolium （MTT） assay was employed to determine the applicable concentration of IL-15 and test the effects of Si Junzitang and IL-15 on the activities of NK cells and the HCT116 cells in the co-incubation model. The effects of Si Junzitang and IL-15 on the mRNA levels of NKG2A in NK cells and HLA-E in HCT116 cells were detected by Real-time PCR. Monalizumab （M， anti-NKG2A mab） was used to block the NKG2A-HLA-E pathway in co-incubation model， and then the proliferation of HCT116 cells was detected by MTT assay. ResultThe interaction of NK cells and HCT116 cells up-regulated the mRNA levels of NKG2A in NK cells and HLA-E in HCT116 cells （P<0.05）， as well as the expression level and secretion of IL-15 （P<0.05）. Compared with the blank group， Si Junzitang and Si Junzitang + IL-15 promoted the proliferation and improved the anti-colon cancer function of NK cells （P<0.01）. Furthermore， they down-regulated the mRNA levels of NKG2A in NK cells and HLA-E in the HCT116 cells co-incubated with NK cells （P<0.01）. M and IL-15 + M inhibited the proliferation of HCT116 cells compared with the groups without M （P<0.01）. ConclusionThe interaction of NK cells and HCT116 cells can induce activation of NKG2A-HLA-E pathway to impair NK cell function. Si Junzitang can inhibit the activation of NKG2A-HLA-E pathway to restore the anti-colon cancer function of NK cells.

The self-confidence of dental students in oral surgery / La autoconfianza de los estudiantes de odontología en cirugía oral

ABSTRACT: The aim of this study is to evaluate the self-confidence of undergraduate students and thus to highlight the strengths and weaknesses of oral surgery education from the students' perspectives. A survey was conducted by preparing a questionnaire to assess the the self-confidence of students in performing oral surgery. Survey questions have been imported to Google Forms®. It was then electronically delivered to the students through the Turkish Dental Association. Regarding the data, besides the frequency and percentage distributions, the relationship between the variables was analyzed using the Chi-Square test. A total of 615 students, including 386 female and 229 male students, participated in this study. Of the students, 62.4% were 5th year and 37.56% were 4th year students. According to the survey, it was observed that male students and 5th year students were in general more confident in themselves. Students had low self-confidence in differentiating between odontogenic and non- odontogenic pain and recognizing malignant lesions or lesions with high malignant potential. In the oral surgery curriculum, subjects in which the students have issues should be identified and more emphasis should be placed on them. Oral pathology as well as head and neck anatomy courses should be emphasized further, priority should be given to case-based courses, and reminder presentations should be made at certain intervals. In addition, considering that practice is important for gaining self- confidence, students must practice more under the supervision of instructors in the areas in which they feel inadequate.

RESUMEN: El objetivo de este estudio es evaluar la autoconfianza de los estudiantes de pregrado y así resaltar las fortalezas y debilidades de la educación en cirugía oral desde la perspectiva de los estudiantes. Se realizó una encuesta mediante la elaboración de un cuestionario para evaluar la autoconfianza de los estudiantes en la realización de cirugía oral. Las preguntas de la encuesta se importaron a Google Forms®. Luego se les entregó electrónicamente a los estudiantes a través de la Asociación Dental Turca. En cuanto los datos, además de las distribuciones de frecuencia y porcentaje, se analizó tambien la relación entre las variables mediante la prueba Chi-Cuadrado. Se participaron 386 estudiantes femininas y 229 estudiantes masculinos en este estudio, un total de 615 personas. El 62,4% de los estudiantes eran del 5º año y el 37,56% eran estudiantes del 4º año. Según la encuesta, se observó que los estudiantes masculinos y los estudiantes del 5º año tenían en general más confianza en sí mismos. Los estudiantes tenían poca confianza en sí mismos para diferenciar entre dolor odontogénico y no odontogénico y reconocer lesiones malignas o lesiones malignas con alto potencial. En el plan de estudios de cirugía oral, se deben identificar las materias en las que los estudiantes tienen problemas y se debe poner más énfasis en ellas. Se debe enfatizar aún más los cursos de patología oral, así como de anatomía de cabeza y cuello. Se debe dar prioridad a los cursos basados en casos, y se deben hacer presentaciones recordatorias a ciertos intervalos. Además, considerando que la práctica es importante para aumentar la autoconfianza, los estudiantes deben practicar más bajo la supervisión de instructores en las áreas en las que se sienten inadecuados.

Identidad personal en niños y adolescentes: estudio cualitativo / Personal identity in children and adolescents: a qualitative study / Identidade pessoal em crianças e adolescentes: estudo qualitative

Resumen (analítico) La construcción de identidad personal es un proceso evolutivo. Escasas investigaciones estudian este proceso en la infancia. El objetivo de esta investigación es describir la construcción de identidad personal de niños y adolescentes entre 6 y 18 años, desde un enfoque constructivista evolutivo. Se realiza un análisis temático de narrativas autobiográficas escritas por 119 niños y adolescentes. Los resultados se organizaron en torno a tres dimensiones de la identidad personal: unidad de identidad, integración de identidad, integración con otros; observándose que desde la infancia hay un reconocimiento personal, luego se integran diferentes eventos vitales significativos y en la adolescencia se complejiza su construcción, incorporando mayor reflexión y aspectos ideológicos. Se discuten implicancias para favorecer un desarrollo adaptativo de la identidad en todas las edades, validando diversidad de opciones.

Abstract (analytical) Construction of personal identity is a developmental process. Few research investigates this process in children. The research objective is to describe the personal identity construction of children and adolescents between 6 and 18 years old, from a developmental constructivist approach. Thematic analysis of autobiographical narratives written by 119 children and adolescents is performed. Results were organized around the three personal identity dimensions: unity of self, integration of self and integration with others. Results show from childhood there is a personal recognition, then different significant life events are integrated, and in adolescense this construction becomes more complex, integrating more reflection and ideological aspects. Implications are discussed to promote an adaptive development of identity through lifespam, validating a diversity of options.

Resumo (analítico) A construção da identidade pessoal é um processo evolutivo. Poucas pesquisas investigam esse processo na infância. O objetivo desta pesquisa é descrever a construção da identidade pessoal de crianças e adolescentes entre 6 e 18 anos, a partir de uma abordagem construtivista evolutiva. É realizada uma análise temática das narrativas autobiográficas escritas por 119 crianças e adolescentes. Os resultados foram organizados em torno de três dimensões da identidade pessoal: unidade de identidade, integração de identidade, integração com os outros; e mostram que desde a infância há um reconhecimento pessoal, logo diversos acontecimentos significativos da vida são integrados, e na adolescência sua construção torna-se mais complexa, incorporando mais reflexão e aspectos ideológicos. As implicações para promover o desenvolvimento adaptativo da identidade em todas as idades são discutidas, validando a diversidade de opções.

El sujeto según Sartre y Lacan. Encuentros y desencuentros entre fenomenología y psicoanálisis / The subject according to Sartre and Lacan. Encounters and disagreements between phenomenology and psychoanalysis

Este trabajo consiste en comparar el concepto de sujeto propuesto por Jacques Lacan al psicoanálisis con la concepción de subjetividad que puede deducirse de la obra de Jean-Paul Sartre que da lugar a su propuesta de un psicoanálisis existencial

This work consists of comparing the concept of subject proposed by Jacques Lacan to psychoanalysis with the conception of subjectivity that can be deduced from the work of Jean-Paul Sartre that gives rise to his proposal of an existential psychoanalysis

Mechanism study of Sijunzi Decoction intervening colorectal cancer based on network pharmacology / 国际中医中药杂志

Objective:Based on the network pharmacology, this study preliminarily aims to explore the mechanism of Sijunzi Decoction in the intervention of colorectal cancer. Methods:The active components and targets of Sijunzi Decoction were gained by Traditional Chinese Medicine Pharmacology Database Systems (TCMSP); and the targets were standardized with the help of Uniprot database. The related targets of colorectal cancer were obtained by GeneCards database and Disgenet database, and the intersection targets of berbal medicine and diseases were screened by R language. The visual regulation network of "active ingredient-disease target" of Sijunzi Decoction was constructed by Cytoscape software, and the protein interaction network was constructed by STRING database. The functional enrichment analysis of gene ontology (GO) and the pathway enrichment analysis of Kyoto Encyclopedia of Gene and Genome (KEGG) were carried out by Bioconductor platform. Results:A total of 135 active components and 68 intersection targets of Sijunzi Decoction were obtained. The core target proteins included IL6, VEGFA, CASP3, EGFR and so on. GO functional enrichment analysis involved 91 items, which mainly affected transcription factor activity, enzyme activity, receptor activity and biochemical process regulation. KEGG pathway enrichment analysis contained 126 items, concerning infection, cancer, apoptosis, inflammation and other pathways. Conclusion:The active components of Sijunzi Decoction mainly regulate biological processes such as transcription factor activity and enzyme activity of colorectal cancer cells through cancer signal pathway and inflammatory signal pathway, so as to play a role of interventing of colorectal cancer.

Effects of ethanol extract of Si Miao Wan on hepatic lipid accumulation / 中国药科大学学报

@#This study aimed to investigate the ameliorative effects of 60% ethanol elution fraction (ESMW) from Si Miao Wan on the hepatic lipid accumulation and its mechanism.TG kit, BODIPY fluorescence staining, QPCR, WB, oil red O staining, and AMPKα knockdown were used to detect the ability of ESMW to improve lipid accumulation in hepatocytes stimulated with free fatty acid.Furthermore, the effects of ESMW on the oral glucose tolerance, serum biochemical indexes, TG content in liver tissue, the expressions of mRNA and protein related to lipid metabolism in liver tissue were studied in mice fed with high fat diet to verify the mechanism of ESMW fraction on hepatic lipid accumulation.The results showed that ESMW inhibited lipid accumulation induced by free fatty acids by regulating AMPK signaling pathway, and that ESMW significantly improved the lipid metabolism of mice fed with high fat diet, with relation to AMPK signaling pathway.

Explore Mechanism of Modified Si Junzitang in Improving Acidic Microenvironment and Reversing Gastric Precancerous Lesions Based on MCT4/CD147 / 中国实验方剂学杂志

Objective:To observe the effect of modified Si Junzitang on the level of lactic acid in gastric mucosa and the expression of Carboxylic acid transporter 1（MCT1）， monocarboxylic acid transporter 4（MCT4）， and extracellular matrix metalloproteinase inducer （CD147）in rats with gastric precancerous lesions（GPL）. Method:Seventy-four SD male rats were randomly divided into normal group （12 rats） and model group （62 rats）. <italic>N</italic>-methyl-<italic>N'</italic>-nitro-<italic>N</italic>-nitrosoguanidine（MNNG）-ammonia compound method was used to establish GPL rat models， and at the 9^th week， the model rats were randomly divided into model group， folic acid group（2.7 mg·kg^-1）， modified Si Junzitang high， medium and low dose groups（12.6， 6.3， 3.15 g·kg^-1）， with 12 rats in each group. After intragastric administration for 12 weeks， the general conditions of the rats were observed. Hematoxylin-eosin（HE）staining was used to observe the histopathological changes of gastric mucosa in rats， chemical colorimetry was used to detect the content of lactic acid in gastric mucosa； immunohistochemistry and real-time polymerase chain reaction（Real-time PCR）were used to detect MCT1， MCT4， CD147 protein and mRNA expression in gastric mucosal tissues. Result:Modified Si Junzitang significantly improved the pathological manifestations in GPL rats such as gastric mucosal epithelial gland structure， disorder of arrangement and cell atypia. Compared with the normal group， the lactic acid content of the gastric mucosa tissue in the model group increased significantly（<italic>P</italic><0.01）， and the protein and mRNA expressions of MCT1， MCT4， CD147 significantly increased（<italic>P</italic><0.05， <italic>P</italic><0.01）. Compared with the model group， the lactic acid content in each dose group of modified Si Junzitang was significantly reduced（<italic>P</italic><0.05， <italic>P</italic><0.01）， and the protein expression levels of MCT4 and CD147 were also significantly reduced in each dose group of modified Si Junzitang（<italic>P</italic><0.05， <italic>P</italic><0.01）. The mRNA expression of MCT4 was significantly reduced in the middle and high dose groups（<italic>P</italic><0.05， <italic>P</italic><0.01）， and the mRNA expression of CD147 was significantly reduced in the high dose group（<italic>P</italic><0.05）. Modified Si Junzitang showed no significant regulatory effect on MCT1. Conclusion:Modified Si Junzitang can significantly improve the abnormal histopathology of gastric mucosal epithelium in GPL model rats. Its mechanism may be related to down-regulating the overexpression of MCT4 and CD147， inhibiting lactic acid outflow， and improving the acidic microenvironment of gastric mucosal epithelium.

Efficacy of Pinggan Yuyin Qingre Recipe for Treatment of Hyperevaporative Dry Eye Disease Caused by Meibomian Gland Dysfunction / 中国实验方剂学杂志

Objective:To observe the therapeutical effect and the safety of Pinggan Yuyin Qingre recipe on the hyperevaporative dry eye disease （Yin deficiency and Yang hyperactivity type） caused by the meibomian gland dysfunction（MGD）. Method:The 120 Consecutive outpatients who met the criteria were included in the trial and divided into three layers （mild， moderate and severe） according to the meibomian gland function classification （grade 1-3）. The patients in each layer were randomly assigned to the experiment group and the control group at a ratio of 1∶1. Both groups were treated with sodium hyaluronate eye drops， 1 drop/eye/time， 3 times a day. In the experiment group， Pinggan Yuyin Qingre recipe was additionally prescribed two times a day. The treatment course was 8 weeks in both groups. All patients were evaluated at the beginning and end of the study mainly for noninvasive tear breakup time （NITBUT），corneal lesions score，meibomian gland exclusion score，meibomian gland structure，eye symptom score，the ocular surface disease index（OSDI） score，and the traditional Chinese medicine（TCM） syndrome scores at both overall and layered levels. Result:A total of 116 cases completed the study，with 1 drop-out case and 3 eliminated cases. Both before and after treatment，NITBUT，the corneal lesions score，the symptom score，and the OSDI score in the experiment group were significantly superior to the control group， but there was no significant difference in meibomian gland exclusion score between two groups，only with a superior tendency in experiment group. There were significant differences in the scores of the related TCM syndrome scores between two groups after treatment. There were no adverse reactions， no abnormal changes in electro cardiogram （ECG） or liver and kidney functions in all patients. Conclusion:Pinggan Yuyin Qingre recipe can effectively improve the hyperevaporative dry eye disease caused by meibomian gland dysfunction， the tear film stability，eye dryness， burning，itching，foreign body sensation and TCM symptoms of patients with dry eye syndrome of Yin deficiency and Yang hyperactivity. The improvement effect is more obvious in moderate and severe patients. It is an effective，safe，and well-tolerated treatment for the hyperevaporative dry eye.

Mechanism of Modified Si Junzitang on Neuronal Anti-anoikis of Cells in Rats with Cerebral Ischemia Through Fibulin-5 and p-Akt / 中国实验方剂学杂志

Objective:To investigate the effect of modified Si Junzitang on the expression of fibrous protein-5（Fibulin-5）， phosphorylated protein kinase B（p-Akt ）in hippocampus of rats after cerebral ischemia-reperfusion （I/R） injury and the anoikis of nerve cells. Method:The 60 male SD rats of SPF grade were randomly divided into sham operation group， model group， Edaravone group （3.2 mg·kg-1）and modified Si Junzitang high， medium and low-dose groups（19.08，9.54，4.77 g·kg-1）.The middle cerebral artery occlusion （MCAO） model was established by suture method，the rats were killed 7 days later，neurological deficit score was evaluated before the death，histopathological observation was performed by hematoxylin eosin staining， apoptosis index of nerve cells was detected by TdT-mediated dUTP nick end labeling（TUNEL）staining， the expression of Fibulin-5， p-Akt and protein in ischemic hippocampus were detected by immunohistochemistry and Western blot. Result:The neurological deficit score showed that，compared with the sham operation group， the neurological deficit score of the model group was significantly increased （P<0.01）， compared with model group， the neurological deficit score of Edaravone group，the high， medium， low dose groups of modified Si Junzitang were decreased （P<0.05，P<0.01）. Immunohistochemical results showed that，compared with the sham operation group， the expression of Fibulin-5， p-Akt protein and the apoptosis index of nerve cells in the model group were significantly increased （P<0.05，P<0.01）， compared with model group， the protein expressions of Fibulin-5 and p-Akt in Edaravone group， high， medium and low-dose groups of modified Si Junzitang were significantly increased （P<0.05，P<0.01）， and the apoptosis index of nerve cells was obvious，there was a significant decrease （P<0.05，P<0.01）. Western blot results showed that，compared with the sham operation group， the relative expression of Fibulin-5 and p-Akt protein in the model group was significantly down-regulated （P<0.01）， compared with model group， the protein expressions of Fibulin-5 and p-Akt in the Edaravone group， the high， medium and low-dose groups of modified Si Junzitang were significantly up-regulated （P<0.05，P<0.01）. Conclusion:The modified Si Junzitang may stabilize the extracellular matrix （ECM） Fibulin-5， increase the adhesion of ECM to cells and promote the expression of p-Akt protein， thus inhibiting neuronal apoptosis and protecting cerebral ischemia injury.

Reconfiguración del sentido de enfermedad crónica: la emergencia de bienestar / Reconfiguration of the Meaning of Chronic Disease: The Emergence of Wellbeing

Resumen Esta investigación pretende comprender cómo se configuran y reconfiguran en el relato los órdenes de sentido y acción para la emergencia del bienestar. Esto, mediante diálogos generativos en la relación que establecen pacientes con enfermedades crónicas en diferentes etapas de ciclo vital, su familia y profesionales de la salud. Se realizó esta investigación cualitativa, con diseño narrativo-conversacional. La experiencia de enfermedad crónica se organiza en historias centradas en problemas, con cristalización del sí mismo en la relación cuidador-paciente. Esto implica la construcción de identidad centrada en la imposibilidad de cuidar en un sentido totalizante que desdibuja la diversidad del sí mismo. En el contexto conversacional surgen nuevos sentidos de la enfermedad crónica, emergente en las diferentes formas de acción y de relación; lo que implica coevolución hacia formas de organización y afrontamiento generativo con nuevos posicionamientos del sí mismo centrado en la recuperación del poder que tienen las personas y las familias para decidir dentro de opciones posibles.

Abstract This research intends to gain insight into the pathways on which people narratives are configured and reconfigured to obtain the emergence of wellbeing. This is done through generative dialogues established by patients with chronic diseases at different stages of the life cycle, their families and health professionals. A qualitative research was carried out with a narrative-conversational design. Chronic disease experience is organized in problem-based stories and depicts a scenario where the self is crystallized in the relationship carer-patient, which implies the construction of an identity centered on the impossibility of taking care in a widespread sense that, in turn, fades the diversity of self. New insights on chronic disease experience have emerged during the conversational process, providing different meanings and relations. Therefore, it comprises a co-evolution towards novel ways of organization and generative coping, which enables new strategies to empower the patient and involve their relatives in a process of shared responsibilities aimed at improving the health status of people with chronic diseases.

Maternidade versus sacrifício: uma análise do efeito moral dos discursos e práticas sobre a maternidade comumente engendrados nos corpos das mulheres / Maternity versus sacrifice: an analysis of the moral effect of the discourses and practices about maternity commonly engendered in the womens bodies / Maternidad versus sacrificio: un análisis del efecto moral de los discursos y prácticas sobre la maternidad comúnmente engendrados en los cuerpos de las mujeres

O presente trabalho parte da análise de uma hashtag disseminado em redes sociais de apoio mútuo entre mães, denominado #menasmain, para refletir sobre alguns lugares-comuns (porém não únicos) na experiência feminina materna: culpa, dívida, fracasso, sacrifício, despotencialização. O artigo pretende demonstrar como se disseminam discursos SOBRE a maternidade e não COM as mulheres-mães, elucidando certo efeito moral dos discursos e práticas sobre a maternidade comumente engendrado nos corpos das mulheres. Com esta narrativa, pretendemos forjar novas políticas acerca de nós mesmas na direção do cuidado de si e entender se as mulheres estão podendo construir, na experiência de se tornarem mães, uma ética que dialogue com o efeito moral dos discursos e práticas em seus corpos, possibilitando-lhes se subjetivarem diferentemente das formas hegemônicas.

The present paper is based on the analysis of a hashtag disseminated through social media used for mutual support by mothers, called #menasmain (something like #badmon), to think about some commonplaces (though not exclusive) in the feminine mother experience: self-blame, debt, failure, sacrifice, depotentialization. The article aims to demonstrate how the discourses disseminated are ABOUT maternity and not WITH female - mothers, elucidating a certain moral effect of the discourses and practices about maternity commonly engendered in the women's bodies. Through this narrative, we intend to forge new politics regarding ourselves towards self-care and understand if women are being able to create, in the experience of becoming a mother, an ethic that communicates with the moral effect of the discourses and practices in their bodies, allowing them different subjetifications from the hegemonic forms.

Este documento se basa en el análisis de un hashtag diseminado en redes sociales de apoyo mutuo entre madres, llamado #menasmain, para reflexionar sobre algunos lugares comunes (pero no únicos) en la experiencia femenina materna: culpa, deuda, fracaso, sacrificio, despotencialización. El artículo tiene como objetivo demostrar cómo se difunden los discursos SOBRE la maternidad y no CON las mujeres-madres, aclarando un cierto efecto moral de los discursos y prácticas sobre la maternidad comúnmente engendrados en los cuerpos de las mujeres. Con esta narrativa, pretendemos forjar nuevas políticas sobre nosotras mismas hacia el cuidado de sí y comprender si las mujeres pueden construir, en la experiencia de convertirse en madres, una ética que dialoga con el efecto moral de los discursos y prácticas en sus cuerpos, permitiéndoles subjetivarse de manera diferente a las formas hegemónicas.

As Dimensões do Self na Terapia Cognitiva PósRacionalista / The Dimensions of 'Self' in Post-Rationalist Cognitive Therapy

O presente artigo tem como objetivo analisar as dimensões do self na perspectiva da terapia cognitiva pós-Racionalista de Vittorio Guidano. Trata-se de um estudo qualitativo, exploratório e teórico, que teve como fonte a literatura especializada na área. Apresenta os principais conceitos e formulações da terapia cognitivo pós-racionalista, descrevendo o self como um processo emocional, afetivo e cognitivo, que se estabelece nos níveis tácito e explícito. Analisa também a dimensão autopoética e ortogenética, situando o self como um sistema complexo, que se autoproduz e se complexifica a partir de transformações internas. Conclui que os vínculos afetivos possuem um papel fundamental para a estruturação de tonalidades emotivas, que atuam como unidades organizadoras do autoconhecimento. Essas unidades possibilitam conhecer a forma específica que assume a auto-organização no desenvolvimento da identidade.(AU)

This article aims to analyze the dimensions of the Self in the perspective of Vittorio Guidanos Post-Rationalist Cognitive Therapy. This is a qualitative, exploratory and theoretical study, based on specialized literature in the area. It presents the main concepts and formulations of Post-Rationalist Cognitive Therapy, describing the Self as an emotional, affective and cognitive process, which is established on the tacit and explicit levels. It also analyzes the auto-poetic and orthogenetic dimension, placing the Self as a complex system, which self-produces and becomes more complex based on internal transformations. It concludes that affective bonds play a fundamental role in structuring emotional tones, which act as organizing units for the sense of itself. These units make it possible to know the specific form that self-organization takes in the development of the identity.(AU)

Este artículo tiene como objetivo analizar las dimensiones del "sí mismo" en la perspectiva de la Terapia Cognitiva Posracionalista de Vittorio Guidano. Este es un estudio cualitativo, exploratorio y teórico, basado en literatura especializada en el área. Presenta los principales conceptos y formulaciones de la Terapia Cognitiva PostRacionalista, describiendo el "sí mismo" como un proceso emocional, afectivo y cognitivo, que se establece en los niveles tácito y explícito. También analiza la dimensión autopoética y ortogenética, colocando el "sí mismo" como un sistema complejo, que se auto-produce y se vuelve más complejo en función de las transformaciones internas. Concluye que los vínculos afectivos tienen un papel fundamental en la estructuración de los matices emocionales, que actúan como unidades organizadoras para el sentido de uno mismo. Estas unidades permiten conocer la forma específica que toma la autoorganización en el desarrollo del "sí mismo".(AU)