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1.
Article in English | WPRIM | ID: wpr-928580

ABSTRACT

OBJECTIVES@#To study the association of the levels of heavy metals and trace elements during pregnancy with congenital heart defects (CHD) in offspring, and to establish a model for predicting the probability of CHD based on the levels of heavy metals and trace elements during pregnancy.@*METHODS@#Based on the prospective birth cohort study in Gansu Provincial Maternal and Child Health Hospital in 2010-2012, a nested case-control study was conducted for the follow-up observation of 14 359 pregnant women. Among the pregnant women, 97 pregnant women whose offspring were diagnosed with CHD during follow-up were enrolled as the CHD group, and 194 pregnant women whose offspring had no CHD were selected as the control group. Inductively coupled plasma mass spectrometry was used to measure the levels of heavy metals and trace elements in maternal blood samples and fetal umbilical cord blood samples. A multivariate logistic regression analysis was used to evaluate the association between heavy metal and trace elements and CHD in offspring. A nomogram model for predicting the probability of CHD in offspring was established based on the levels of heavy metals and trace elements during pregnancy.@*RESULTS@#Compared with the control group, the CHD group had significantly higher levels of aluminum (Al), natrium (Na), calcium (Ca), titanium (Ti), selenium (Se), strontium (Sr), stannum (Sn), stibium (Sb), barium (Ba), and thorium (Th) in maternal blood samples (P<0.05), as well as significantly higher levels of Al, zinc (Zn), magnesium (Mg), kalium (K), Ca, Ti, chromium (Cr), copper (Cu), arsenic (As), Se, Sr, argentum (Ag), cadmium (Cd), Sn, and plumbum (Pb) in umbilical cord blood (P<0.05). The multivariate logistic regression analysis showed that the increase in the Sb level in maternal blood was associated with the increase in the risk of CHD in offspring [adjusted odds ratio (aOR)=4.81, 95% confidence interval (CI): 1.65-14.07, P=0.004], while in umbilical cord blood, the high levels of Al (aOR=4.22, 95%CI: 1.35-13.16, P=0.013), Mg (aOR=8.00, 95%CI: 1.52-42.08, P=0.014), and Pb (aOR=3.82, 95%CI: 0.96-15.23, P=0.049) were significantly associated with the risk of CHD in offspring. The levels of Al, Th, and Sb in maternal blood and levels of Al, Mg, and Pb in umbilical cord blood were included in the predictive model for CHD in offspring based on the levels of heavy metals and trace elements during pregnancy, and the calibration curve of the nomogram predictive model was close to the ideal curve.@*CONCLUSIONS@#Increases in the levels of Al, Th, Sb, Mg, and Pb during pregnancy may indicate the increase in the risk of CHD in offspring, and the nomogram predictive model based on these indices can be used to predict the probability of CHD in offspring.


Subject(s)
Case-Control Studies , Child , Cohort Studies , Female , Heart Defects, Congenital/etiology , Humans , Metals, Heavy , Pregnancy , Prospective Studies , Trace Elements/analysis
2.
Braz. J. Pharm. Sci. (Online) ; 58: e18674, 2022. graf
Article in English | LILACS-Express | LILACS | ID: biblio-1374556

ABSTRACT

Abstract Fluoride anions are indispensable trace elements required for sustaining life. To investigate the homeostasis and action of fluoride in the body, a new highly sensitive and selective fluorescence detection method was designed for fluoride in aqueous solutions. A fluorescent probe for fluoride (FP-F) was synthesized for imaging F- in living cells. The design strategy for the probe was based on the specific reaction between fluoride and silica to mediate deprotection of this probe to fluorescein. Upon treatment with F-, FP-F, a closed and weakly fluorescent lactone, was transformed into an open and strongly fluorescent product. Under the optimum conditions, the detection limit for fluoride was 0.526 nM. FP-F could detect micromolar changes in F- concentrations in living cells by confocal microscopy.

3.
Article in Chinese | WPRIM | ID: wpr-905819

ABSTRACT

Objective:To investigate the association between serum trace elements and dyslipidemia in Pudong New Area. Methods:A community-based cross-sectional study was carried out. A stratified, cluster sampling approach was used for sampling. In total 1 814 community residents aged above 35 years old were recruited in Pudong New Area, Shanghai. A face-to-face investigation was conducted and blood samples were collected. Serum levels of 16 trace elements, including boron, vanadium, chromium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, selenium, strontium, molybdenum, tin, antimony, and barium were measured by inductively coupled plasma mass spectrometry (ICP-MS). The relationship between serum trace elements and dyslipidemia was analyzed with single and multiple Logistic regression models. Results:Prevalence of dyslipidemia is higher among participants of more than 45 years old with high BMI, hypertension or diabetes.Serum iron leveled the highest, followed by copper, zinc, selenium, strontium, boron and other trace elements. After adjusting for potential confounders, the odds ratios of dyslipidemia associated with the highest quartile of trace elements concentrations were 1.41 (95%CI: 1.12-1.78), 0.77 (95%CI: 0.61-0.96), 1.65 (95%CI: 1.31-2.09), 1.27 (95%CI: 1.02-1.58), and 1.32 (95%CI: 1.06-1.66) for chromium, cobalt, zinc, arsenic, and tin, respectively, compared with that associated with the other three quartiles. Conclusion:Some serum trace elements are potentially associated with dyslipidemia in community residents.

4.
Article in Chinese | WPRIM | ID: wpr-846062

ABSTRACT

Lycium ruthenicum is a kind of medicinal and edible plant with excellent health-care effect, which is a unique medicinal plant in the desert region of northwest China. Phytochemical investigations have identified that the fruit of this herb contains a variety of bioactive ingredients, including anthocyanins, flavonoids, alkaloids, and polysaccharides, as well as of fatty acids, amino acids, and some trace elements (such as manganese, selenium, and zinc, etc). Modern pharmacological researches have demonstrated that both the extract of L. ruthenicum and its constituents exhibit a wide range of pharmacological activities, such as anti-oxidation, anti-fatigue, hypoglycemic and hypolipidemic activity, cardiovascular and liver protection, as well as immune-regulatory activity. The chemical constituents of L. ruthenicum and their pharmacological effects are systematically summarized in this paper, and all information presented here may strongly facilitate further investigations on the pharmacological activities of this herb and the development and applications of the related products of this herb.

5.
J Genet ; 2019 Jul; 98: 1-10
Article | IMSEAR | ID: sea-215427

ABSTRACT

This study aims to analyse the potential relationship between single-nucleotide polymorphism (SNPs) in trace element related metabolic genes GSTM3, GSTP1, GPX1 and NKG2D and the risk of gastric cancer. A case–control study was conducted in the hospital of Xianyou, Fujian, China. In this study, a total of 299 patients with histopathological diagnosis in gastric cancer and 295 healthy control subjects were involved. Association between the SNPs in trace element-related metabolic genes and gastric cancer risk was analysed using the unconditional logistic regression model. No relationship was found between the SNPs of GSTM3 and GPX1 genes and gastric cancer risk. However, the risk of gastric cancer is related to the SNPs of NKG2D gene (rs1049174). Patients who carry the rs1049174 GG genotype have a higher incidence of the gastric cancer and a multivariate odds ratio (OR) of 1.85 (95% confidence intervals (CI): 1.02–3.38). Through haplotype analysis, two haplotypes (i.e. A_rs1746123-T_rs10431294-G_rs1049174 and T_rs1746123-T_rs10431294-C_rs1049174), OR of 0.29 (95% CI: 0.15–0.56) and 0.33, (95% CI: 0.22–0.50), respectively, were found to have lower incidence of gastric cancer. Meanwhile, another two haplotypes (T_rs1746123-C_rs10431294-C_rs1049174 and T_rs1746123-T_rs10431294-G_rs1049174), OR of 1.81 (95% CI: 1.40–2.34) and 3.09 (95% CI: 2.30–4.16), respectively, were found to have a higher incidence of gastric cancer. Further, no influence of the haplotype on the risk of cardia gastric cancer was found. However, the haplotype T_rs1746123-T_rs10431294-C_rs1049174 had lower incidence of noncardia gastric cancer by 46%. Our data showed that polymorphisms of trace element-related metabolic genes are important in gastric cancer pathology.

6.
Article in English | WPRIM | ID: wpr-777605

ABSTRACT

BACKGROUND@#The effects of prenatal exposure to toxic elements on birth outcomes and child development have been an area of concern. This study aimed to assess the profile of prenatal exposure to toxic elements, arsenic (As), bismuth (Bi), cadmium (Cd), mercury (total mercury (THg), methylmercury (MHg), inorganic mercury (IHg)), lead (Pb), antimony (Sb) and tin (Sn), and essential trace elements, copper (Cu), selenium (Se) and zinc (Zn), using the maternal blood, cord blood and placenta in the Tohoku Study of Child Development of Japan (N = 594-650).@*METHODS@#Inductively coupled plasma mass spectrometry was used to determine the concentrations of these elements (except mercury). Levels of THg and MeHg were measured using cold vapour atomic absorption spectrophotometry and a gas chromatograph-electron capture detector, respectively.@*RESULTS@#Median concentrations (25th-75th) of As, Cd, Pb, Sb, Sn and THg in the maternal blood were 4.06 (2.68-6.81), 1.18 (0.74-1.79), 10.8 (8.65-13.5), 0.2 (0.06-0.40) and 0.2 (0.1-0.38) ng mL and 5.42 (3.89-7.59) ng g, respectively. Median concentrations (25th-75th) of As, Cd, Pb, Sb, Sn and THg in the cord blood were 3.68 (2.58-5.25), 0.53 (0.10-1.25), 9.89 (8.02-12.5), 0.39 (0.06-0.92) and 0.2 (0.2-0.38) ng mL and 9.96 (7.05-13.8) ng g, respectively.@*CONCLUSIONS@#THg and Sb levels in the cord blood were twofold higher than those in the maternal blood. Cord blood to maternal blood ratios for As, Cd and Sb widely varied between individuals. To understand the effects of prenatal exposure, further research regarding the variations of placental transfer of elements is necessary.


Subject(s)
Adult , Female , Fetal Blood , Chemistry , Humans , Japan , Maternal Exposure , Maternal-Fetal Exchange , Metals , Blood , Placenta , Chemistry , Pregnancy , Blood , Trace Elements , Blood , Urban Health
7.
Article in Chinese | WPRIM | ID: wpr-744619

ABSTRACT

Objective To analyze the energy supply nutrients (protein,fat and lactose) and mineral elements (calcium,copper,iron,zinc,magnesium,sodium,potassium) supplied in breast milk from the resident of Lanzhou,and investigate the problems of those energy supply nutrients and mineral elements in breast milk of this population so that to provide basis for breast feeding.Methods Breast milk from 1 215 mothers whose babies were fed totally by the breast milk and grew well was collected and assayed for the contents of protein,fat,lactose,calcium,copper,iron,zinc,magnesium,sodium and potassium in Lanzhou region.The optimal range for breast feeding was set by normal distribution method.The results were compared with the breast milk from other internal region in order to clarify the contents difference.Results The prevalence of mother-milk-fed in this region was 48.5%.The normal ranges (unit:g/100 g) of fat,lactose and protein were 1.57-5.11,6.58-7.16 and 0.79-1.35,and the normal ranges of calcium,copper,iron,zinc,magnesium,sodium and potassium were 5.25-7.83 mmol/L,5.66-8.28 mmol/L,0.14-0.3 mmol/L,15-64.48 μmol/L,0.98-1.62 mmol/L,1.92-18.82 mmol/L,7.95~ 17.31 mmol/L in the high quality breast milk.Compared with the other internal region,the normal ranges of the protein,fat and lactose in Lanzhou were lower.The contents of protein,fat,lactose,calories,calcium,copper,zinc and sodium in the breast milk from the whole investigated population were significantly lower compared with breast milk of high quality (P<0.01).Conclusion The quality of breast milk in Lanzhou is not so good.The contents of various nutrients in breast milk should be improved to a proper level by appropriate ways so that to improve the growth and development of the baby.

8.
Article in Chinese | WPRIM | ID: wpr-692692

ABSTRACT

Objective The levels of multi-trace elements in whole blood of pregnant women in Zhejiang province were analyzed to establish the reference range for this population.Methods Routine physical exami-nation data of 21 151 pregnant women during January 2015 to September 2016 from Hangzhou Dian Medical Center were analyzed retrospectively.Three groups including early pregnancy group,middle pregnancy group and late pregnancy group were divided according to the pregnancy period.A total of 1 859 women range from 20 to 40 years old healthy without pregnant were selected as control group.The levels of copper(Cu),zinc (Zn),calcium(Ca),magnesium(Mg)and iron(Fe)in different pregnancy groups were analyzed statistically. The reference interval of each element in the early,middle and late pregnancy group should be established re-spectively if necessary.Results There were significant differences existed in the levels of Cu between early, middle,late pregnancy group and the control group(P<0.05).The levels of whole blood Cu increased gradu-ally with the time of pregnancy.Compared with the control group,the levels of Zn in other group were differ-ent,and the deficiency rates in early,middle,late pregnancy group were 5.6%,9.3% and 5.0% respectively. There was no significant difference in the level of Fe between the control group and the early pregnancy group (P=0.083).But the levels of Fe in middle and late pregnancy group showed significant difference with control group(P< 0.05).The reference ranges published in manufactures′ package inserts could not meet clinical needs.Conclusion The lack of trace elements existed in different stages of pregnancy.It′s important to moni-tor and analyze the levels of trace elements during each stages of pregnancy,and intervention measures should be done as necessary.T he taken of Cu supplement should based on its reference interval in each stage of preg-nancy respectively.T he taken of Fe supplement should based on the reference interval of healthy,reproductive-age w omen.

9.
China Pharmacy ; (12): 3072-3075, 2017.
Article in Chinese | WPRIM | ID: wpr-671262

ABSTRACT

OBJECTIVE:To study the extraction rate and speciation of antivitiligo-related elements in Opercalina turperthum by water extraction and semi-bionic extraction. METHODS:Water extraction and semi-bionic extraction were respectively used. Wa-ter-soluble state and suspension state in extract of O. turperthum were separated by microporous filtering film;organic and inorgan-ic trace elements in water-soluble state were separated by macroporous resin. The contents of Cu,Zn,Fe,Ca,Mg,Mn and Sr were detected by flame atomic adsorption spectrophotometry,and speciation analysis was conducted. RESULTS:After water extrac-tion,extraction rates of 7 trace elements were 40.47%-72.49%;ratio of suspended particles was 3.69%-8.78%;ratio of organic state/inorganic state was 104.36% in water-soluble state of Sr and 3.94%-48.39% in water-soluble state of Cu,Zn,Fe,Ca,Mg, Mn. After semi-bionic extraction,except for Mn,extraction rates of trace elements were higher than water extraction,extraction rates of Cu,Zn,Fe,Ca,Mg,Sr were 77.69%-90.19%;ratio of suspended particles was 0.39%-8.57%;the ratio of organic state/inorganic state was 72.74%-180.79% in water-soluble state of elements. CONCLUSIONS:Cu,Zn,Fe,Ca,Mg,Mn and Sr in O. turperthum are dissolved easily,mainly existing in the form of inorganic state. After semi-bionic extraction,except for Mn,the dis-solution rate of other elements and the proportion of organic trace elements after dissolution increase significantly. Both dissolution and effective utilization rate of trace elements by semi-bionic extraction are higher than water extraction.

10.
Br J Med Med Res ; 2016; 15(2): 1-12
Article in English | IMSEAR | ID: sea-182976

ABSTRACT

Aims: The aim of this exploratory study was to clarify the differences between the prostatic levels of trace elements in patients with benign prostatic hyperplasia (BPH) and healthy male inhabitants. Methodology: We prospectively evaluated the prostatic levels of 43 trace elements in 32 patients with BPH and 32 healthy males. Measurements were performed using instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides combined with inductively coupled plasma mass spectrometry. Results: In the hyperplastic prostates a significant increase in the mean level of Bi, Cr, Hg, Sb, and Se and a significant decrease in the mean level of Ce, Cs, Dy, Er, Gd, Ho, La, Mo, Nd, Pb, Pr, Sm, Sn, Tb, Tm, U, and Y was observed. It was not found any differences in the mean prostatic level of Ag, Al, Au, B, Be, Br, Cd, Co, Fe, Li, Mn, Nb, Ni, Rb, Sc, Th, Ti, Tl, Yb, Zn, and Zr between BPH-patients and healthy males. Conclusion: Present study finding of trace element contents and correlation between pairs of trace element mass fractions indicates that there is a great disturbance of prostatic trace element metabolism in BPH gland. Obtained data did not confirm a critical role of Cd and Pb accumulation in the pathogenesis of BPH. A potential age-related Zn, Fe, and Se deficiency in the prostate has not been found as being involved in the etiology of BPH. This work data cast doubts on a beneficial effect of the Zn, Fe, and Se supplementations on BPH prevention and treatment. Additional studies of other chemical elements in BPH are planned.

11.
Article in Chinese | WPRIM | ID: wpr-497462

ABSTRACT

Objective To establish the normal reference intervals of whole blood trace elements among pregnant women in Han‐gzhou area to provide the clinical diagnostic basis for ensuring the health of pregnant women and their fetuses .Methods A total of 122 whole blood samples in pregnant awaiting delivery in a general hospital of Hangzhou City during 2015 were collected randomly . The levels of lead(Pb) ,cadmium(Cd) ,copper(Cu) ,zinc(Zn) ,nickel(Ni) ,chromium(Cr) ,beryllium(Be) ,manganese(Mn) ,cobalt (Co) ,arsenic(As) ,molybdenum(Mo) ,thallium(Ti) and thallium(Tl) were determined with ICP‐MS .And the results were statisti‐cally analyzed .Results The detection results of whole blood Cu ,Cr ,Mn and Ti showed a normal distribution .The 5% -95% refer‐ence interval was determined according to x ± 1 .96s ,the normal reference intervals for these 4 elements were 255 .37 -668 .23 , 56 .09-151 .93 ,18 .46-54 .60 and 800 .90 -2 632 .02 μg/L respectively .Conclusion Formulating the normal reference values of whole blood microelements levels has an important significance for clinical doctors to provide the nutritional health care guidance and master the heavy metal pollution level .

12.
Article in English | IMSEAR | ID: sea-166418

ABSTRACT

Background: Haemodialysis patients are at risk of developing trace elements imbalance and lipid peroxidation. The present study was aimed to assess plasma levels of copper (Cu), zinc (Zn), selenium (Se) and malondialdehyde (MDA) of haemodialysis patients and to investigate the possible effect of haemodialysis on these trace elements and MDA imbalance. Methods: Blood samples of fifty hemodialysis patients and forty healthy controls subjects were analyzed for determination of hemoglobin, albumin, creatinine, urea and high-sensitivity C-reactive protein (hs-CRP). Cu, Zn and Se were determined in plasma (before and after hemodialysis) and erythrocytes and MDA in plasma before and after hemodialysis. Results: The study showed that, plasma Zn and Se concentrations were lower in haemodialysis patients compared to that of healthy controls, while plasma Cu, MDA and Cu/Zn ratio were higher. Plasma Cu/Zn ratios were positively correlated to MDA and weakly correlated to hs-CRP levels whereas plasma Se concentrations were inversely correlated to MDA. In addition, MDA levels increased after haemodialysis session. Conclusions: Based on the results of the present study regarding the imbalance of trace elements in haemodialysis patients, it seems reasonable to periodically assess the trace elements status and consider possible correctional therapy in case of deficiency.

13.
Article in English | WPRIM | ID: wpr-629029

ABSTRACT

Background: Microwave is the most reliable sample digestion method. However, it requires expensive microwave digester automation and has relatively low productivity. In this study, three non-automated digestion methods, i.e. wet acid digestion using nitric acid (HNO3) and hydrogen peroxide (H2O2), wet acid digestion using HNO3, and dry washing, are compared in order to determine the best approach. Methods: Certified reference material IAEA-086 (International Atomic Energy Agency, Austria) and hair and nail samples from 20 female students of Universiti Kebangsaan Malaysia, aged 19 to 30 years, were collected and analysed using the three digestion methods. Results: For hair samples, analysis of variance of repeated measures showed significant differences in the level of all elements (P < 0.001) between the three methods. For nail samples, only the copper (Cu) level showed no significant difference (P = 0.100) between methods. Wet acid digestion using HNO3 and H2O2 showed the best within- and between-run relative standard deviation (RSD) values, with within-run RSD for all elements, except for selenium (Se), < 5%. The between-run precision ranges from 6.14% to 17.96% for hair and from 3.53% to 11.52% for nail samples. Wet acid digestion using HNO3 and H2O2 showed both good accuracy and precision for manganese (Mn) and magnesium (Mg), with percentage recoveries of 110% and 96.9%, respectively. All elements show higher method detection limit (MDL) values than the previous study: 0.05 μg/g Mg for wet acid digestion using HNO3, 0.02 μg/g Se for wet acid digestion using HNO3 and H2O2, and 0.2 μg/g Mg for dry ash method. Conclusion: Wet acid digestion using HNO3 and H2O2 proved to be the best method in terms of precision, accuracy, recovery, and MDL. However, only Mn and Mg showed adequate precision, accuracy, and percentage of recovery.

14.
Article in Chinese | WPRIM | ID: wpr-479580

ABSTRACT

Objective Accodring to the guideline of Reference Intervals in the Clinical Laboratory(ISO15189) ,to establish the reference range of Cu ,Fe ,Zn ,Ca and Mg in the peripheral blood of preschool children in Suzhou .Methods Using atomic absorp-tion spectrometry to detect the levels of Cu ,Fe ,Zn ,Ca and Mg in peripheral blood of 3 992 Kindergarden children in Suzhou from Apr to May 2014 ,according the age ,the children were divided into three groups ,1 511 cases in 3 to 4 years old group including 750 boys ,761 girls ,1 169 cases in 4 to 5 years old group including 570 boys ,599 girls ,1 312 cases in 5 to 6 years old group inclu-ding 604 boys 708 girls .According to NCCLS's guideline C28 -A2 to define the reference range .Results The concentration of copper ,iron ,zinc ,calcium ,magnesium had no significant differences in different gender and age groups(P>0 .05) ,the reference ranges in peripheral blood of the preschool children in Suzhou were Cu 11 .47-32 .53 umol/L ,Fe 6 .86-9 .80 mmol/L ,Zn 64 .46-133 .02 umol/L ,Ca 1 .47-2 .09 mmol/L ,Mg 1 .21 -1 .75 mmol/L .Conclusion There are regional difference on the levels of Cu ,Fe ,Zn ,Ca ,Mg in children's peripheral blood ,each region should to establish the local reference range follow the guideline .

15.
Article in English | WPRIM | ID: wpr-183198

ABSTRACT

BACKGROUD/OBEJECTIVES: Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found in vegetal dietary sources that has antioxidant and chemopreventive properties, in arsenic trioxide (As2O3)-induced Male Wistar rats. MATERIALS/METHODS: Adult rats received 3 mg/kg As2O3 (intravenous injection, iv.) on alternate days for 4 days. Resveratrol (8 mg/kg) was administered (iv.) 1 h before As2O3 treatment. The plasma and homogenization enzymes associated with oxidative stress of rat kidneys were measured, the kidneys were examined histologically and trace element contents were assessed. RESULTS: Rats treated with As2O3 had significantly higher oxidative stress and kidney arsenic accumulation; however, pretreatment with resveratrol reversed these changes. In addition, prior to treatment with resveratrol resulted in lower blood urea nitrogen, creatinine and insignificant renal tubular epithelial cell necrosis. Furthermore, the presence of resveratrol preserved the selenium content (0.805 +/- 0.059 microg/g) of kidneys in rats treated with As2O3. However, resveratrol had no effect on zinc level in the kidney relative to As2O3-treated groups. CONCLUSIONS: Our data show that supplementation with resveratrol alleviated nephrotoxicity by improving antioxidant capacity and arsenic efflux. These findings suggest that resveratrol has the potential to protect against kidney damage in populations exposed to arsenic.


Subject(s)
Adult , Animals , Arsenic , Blood Urea Nitrogen , Creatinine , Epithelial Cells , Humans , Kidney , Male , Necrosis , Oxidative Stress , Plasma , Rats , Rats, Wistar , Selenium , Zinc
16.
Article in Chinese | WPRIM | ID: wpr-452460

ABSTRACT

Objective To analyze the relationship between anemia and blood levels of lead and trace elements in children,and to provide basis for the prevention and treatment of anemia.Methods 80 children with anemia(case group)and 90 health children (control group)were enrolled in the study.The blood levels of trace elements (iron,zinc,calcium,magnesium,copper)and lead were detected in all subjects,in order to analyze their correlations with anemia.Results Compared with control group,the blood levels of iron,zinc and magnesium in case group were significantly lower(P0.05).With the re-duction of iron,zinc and magnesium and the rise of calcium and lead,the severity of anemia increased significantly(P0.05).The blood level of iron was positive correlated with Hb,RBC and MCH (P<0.05).The blood level of zinc was positive correlated with Hb and MCH(P<0.05).The blood level of lead was negative correlated with Hb,MCV and MCH(P<0.05).Conclusion The blood level changes of trace elements and leas effect the severity of anemia in children.It is necessary to test the blood levels of trace elements and lead.

17.
Article in English | IMSEAR | ID: sea-162223

ABSTRACT

In order to investigate the effect of some of micronutrients application on micronutrient distribution, partitioning, and their ratio in different parts of soybean plant; we conducted an experiment in field conditions at Kermanshah, Iran, 2010 and 2011. Three levels of zinc (0, 20, 40 kg.ha-1 from ZnSo4 source); iron (0, 25, 50 kg.ha-1 from FeSo4 source) and manganese (0, 25, 40 kg.ha-1 from MnSo4 source) were applied. Based on results, it was found that Zn and Mn concentrations increased within the plant with micronutrient fertilizers application. The highest Zn concentration was observed in pod, but Maximum Fe and Mn concentrations recorded in leaves. With increases in soybean old and reach to full maturity stage, the Zn, Fe, and Mn content in tissue plant were decreased. The results indicated that with Zn application [Zn]/[Fe] and [Zn]/[Mn] ratios in seed increased. With Fe fertilizer application [Zn]/[Fe] ratio was decreased, but had no effect on [Zn]/[Mn] ratio.

18.
Neotrop. ichthyol ; 11(1): 211-216, Jan-Mar/2013. graf
Article in English | LILACS | ID: lil-670929

ABSTRACT

This study applies total mercury (THg) concentration and stable isotope signature (δ15N and δ13C) to evaluate the trophic status and feeding ground of Trichiurus lepturus during its ontogeny in northern Rio de Janeiro, south-eastern Brazil. The trophic position of T. lepturus is detected well by THg and δ15N as the sub-adult planktivorous specimens are distinct from the adult carnivorous specimens. The δ13C signatures suggest a feeding ground associated with marine coastal waters that are shared by fish in different ontogenetic phases. The diet tracers indicated that the fish feeding habits do not vary along seasons of the year, probably reflecting the prey availability in the study area. This fish has economic importance and the concentration of THg was compared to World Health Organization limit, showing that the adult specimens of T. lepturus are very close to the tolerable limit for safe regular ingestion. .


Este estudo utilizou a concentração de mercúrio total (THg) e a assinatura isotópica (δ15N e δ13C) para avaliar a posição trófica e a área de alimentação de Trichiurus lepturus durante sua ontogenia no norte do Rio de Janeiro, sudeste do Brasil. A posição trófica de T. lepturus foi bem detectada pelo THg e δ15N com os espécimes sub-adultos planctívoros distintos dos espécimes adultos carnívoros. As assinaturas de δ13C sugerem uma área de alimentação associada a águas marinhas costeiras que são compartilhadas por peixes em diferentes fases ontogenéticas. Os traçadores de dieta indicaram que os hábitos alimentares desse peixe não variam ao longo das estações do ano, refletindo provavelmente a disponibilidade de presas na área de estudo. Esse peixe tem importância econômica e a concentração de THg foi comparada com o limite estabelecido pela Organização Mundial de Saúde, demonstrando que os espécimes adultos de T. lepturus estão bem próximos do limite tolerável para uma ingestão regular segura.


Subject(s)
Animals , Mercury Poisoning/veterinary , Perciformes/physiology , Animal Feed/adverse effects
19.
Article in English | IMSEAR | ID: sea-147729

ABSTRACT

Background & objectives: Relationship of trace elements with obesity and diabetes is complex, alterations in their metabolism can be induced by the diseases and their complications. To study the role of the trace elements in diabetes and obesity, serum trace elements levels (Cr, Se, Fe, Zn, Cu and Mn) were measured in obese women with or without diabetes as well as healthy women. Further, correlation between serum trace elements levels and glucose, insulin, homeostasis model assessment (HOMA-IR), glycated haemoglobin (HbA1c), body mass index (BMI), waist circumferences, waist -to -hip ratio and high-sensitivity C-reactive protein (hsCRP) were also determined in these women. Methods: This study was performed with morbidly obese (BMI >40 kg/m2) women with diabetes (n=41), without diabetes (n=45) and 50 healthly non obese women. Anthropometric measurements were taken and levels of serum Zn, Cr, Fe Cu and Mn were determined. Biochemical parameters included serum glucose, insulin, lipids, haemoglobin, hsCRP and HbA1C. Results: The levels of Zn (P<0.001), Mn (P<0.05), Fe (P<0.05) were significantly lower and the level of Cu (P<0.001) and Cu / Zn ratio (P<0.05) were significantly higher in the diabetic obese women than those of the healthy women. Also, the levels of Zn and Fe were significantly lower and the levels of Cu were significantly higher in the non diabetic obese women than those of the healthy group. Serum Zn levels negatively and serum Cu levels positively correlated with anthropometric values in diabetic and non diabetic obese women. Further, serum Zn, Mn and Cr levels negatively correlated and serum Se levels positively correlated glycaemia control parameters in diabetic obese women. In addition, serum Zn levels negatively correlated with hsCRP in diabetic and nondiabetic obese females. Interpretation & conclusions: Our findings showed significant association between Zn and Fe deficiencies and obesity. Also, obese women with diabetes may be at a greater risk of developing imbalances and deficiencies of trace elements compared with obese women without diabetes.

20.
Chinese Pharmaceutical Journal ; (24): 1484-1488, 2013.
Article in Chinese | WPRIM | ID: wpr-860255

ABSTRACT

OBJECTIVE: To establish an ICP-MS method for simultaneous determination of 19 trace elements, i.e. Na, Mg, Al, Si, K, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Ag, Cd, Sn, Hg, and Pb, in Andrographis Herba. METHODS: After microwave digestion treatment, samples were directly determined by inductively coupled plasma mass spectrometry based in octopole reaction system (ORS). RESULTS: The validated method indicated that the correlative coefficients (r) for all elements were above 0.9990. The limits of detections were in the range of 0.001-0.051 μg · kg-1. The reproducibility and stability were satisfactory with all RSDs below 10%. The spiked recoveries for Andrographis paniculata were between 88.64% and 102.98%. CONCLUSION: The method is simple, rapid and sensitive, which meets the requirement of trace analysis and can be used for the quality control of Andrographis Herba.

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