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1.
Article in Chinese | WPRIM | ID: wpr-907873

ABSTRACT

Objective:To investigate the therapeutic effects of Omalizumab in children suffering from multiple allergic diseases.Methods:All children who developed with multiple allergic diseases and were treated with Omalizumab in Department of Pediatrics, Peking University Third Hospital from September 2018 to December 2020 were retrospectively analyzed.Their gender, age, type of allergic disease, serum total IgE (TIgE) and serum allergen-specific IgE (sIgE) levels before treatment, Omalizumab dosage, therapeutic effect and adverse drug reactions were analyzed.Results:In terms of the 28 children who were treated with Omalizumab, the male/female ratio was 17/11, and the age was (9.6±2.7)years.There were 24 cases of asthma (85.7%), 24 cases of allergic rhinitis (85.7%), 9 cases of food allergy (32.1%), 7 cases of atopic dermatitis (25.0%), and 2 cases of chronic urticaria (7.1%), with 26 cases (92.8%) having more than two kinds of allergic diseases, and 28 children having elevated TIgE or sIgE.TIgE was between 39.5 to 3 826.0 kU/L, and the median was 611 kU/L.After treatment, the frequency of wheezing attacks in 24 children with asthma was reduced, the nasal symptoms in 24 children with allergic rhinitis were alleviated, the skin it-ching in 6 children with atopic dermatitis was alleviated, and 1 case had poor improvement, the symptoms in 2 cases with chronic urticaria were alleviated, 9 children had food allergy and 3 cases reached tolerance.Conclusions:The treatment of allergic diseases in children, apart from asthma, Omalizumab is suitable for allergic rhinitis, atopic dermatitis and chronic urticaria.In the treatment of food allergy, it also has the function of increasing the threshold of food allergen tolerance.There are significant therapeutic benefits in children with multiple allergic diseases or being allergic to multiple allergens.

2.
Article in Chinese | WPRIM | ID: wpr-907300

ABSTRACT

Allergic diseases which affect children′s health and quality of life are common diseases.Many pediatric patients′ symptoms are uncontroled after routine treatments.Omalizumab, a highly specific and binding humanized monoclonal anti-IgE antibody, has been approved as an additional treatment for moderate to severe persistent asthma and chronic spontaneous urticaria now.At the same time, there are also data confirming its efficacy and safety in other allergic diseases.This review mainly summarizes the application of omalizumab in children with allergic diseases, and focuses on the evaluation system of clinical efficacy in various diseases.Meanwhile, it discusses how the potential biomarkers predict and evaluate clinical reactions.

3.
Article in Chinese | WPRIM | ID: wpr-877552

ABSTRACT

According to the etiology, allergic diseases are related to wind and heat; according to the pathogenesis, most of allergic diseases are


Subject(s)
Acupuncture Points , Acupuncture Therapy , Hot Temperature , Humans , Hypersensitivity/therapy , Meridians
4.
Article in Chinese | WPRIM | ID: wpr-876487

ABSTRACT

Objective To understand the distribution of allergens in children with common allergic diseases in Guangzhou, and to provide evidence for the prevention and treatment of environmental allergens in children with different allergic diseases. Methods This study enrolled a total of 6 869 children with allergic diseases, including wheezing diseases and asthma (1 013 cases), allergic rhinitis (660 cases), allergic conjunctivitis (422 cases), eczema (2 762 cases), atopic dermatitis (831 cases) and urticaria (1 181 cases). Western blotting was used to detect the serum allergen type E specific antibodies (sIgE) of the patients. The results were statistically analyzed. Results The total positive rate of sIgE in 6 869 children was 74.01%. The positive rate of male children (75.02%) was higher than that of female children (72.25%). The positive rate of inhalation allergens (53.47%) was higher than that of food allergens (57.39%). House dust mites and milk were the most common inhalation allergens and food allergens, respectively. Eczema was the most common allergic disease in infants and toddlers. Allergic rhinitis and urticaria were common in school-age children. Conclusion The main allergens causing allergic diseases in children in Guangzhou were dust mites and milk. Different allergic diseases had its specific allergens. It is necessary to take targeted prevention measures accordingly.

5.
Article in Chinese | WPRIM | ID: wpr-793028

ABSTRACT

The academic thought of professor - on "no allergy without any deficiency" was explored. Theory and the clinical application were elaborated on allergic diseases treated with heat-sensitive moxibustion. It is believed that the critical pathogenesis of allergic diseases is deficiency, particularly the deficiency of the lung, the spleen and the kidney. The invasion of exogenous factors or the disturbance of the retained pathogens in the body may induce allergy. Regarding the therapeutic method, the warming method is applicable for the deficiency and the heat-sensitization counteracts allergy. The sensitized points are detected in accordance with the two-step location method and they are stimulated with the suspended moxibustion. The feeling of heat-sensitive moxibustion is a sign of activation of endogenous regulatory function in the human body. It is a kind of external therapy for the internal disorders, directly acting on the pathogenesis, strengthening the antipathogenic and removing the allergic factors. This therapy is a new endogenous anti-allergic approach.

6.
Article in Chinese | WPRIM | ID: wpr-849743

ABSTRACT

Recent studies have revealed that the interactions of nervous and immune system play a role in the advancement of allergy diseases. Allergy diseases are the consequence of an aberrant response from the immune system to foreign substances and harmful stimuli, have high incidence and the related allergic symptoms seriously affect the patient's quality of life. Specific immune mediator receptors [such as type 1 histamine receptors (H1R), protease activating receptor 2 (PAR-2), tropomyosin receptor kinase A (TrkA)] may be expressed on the surface of neurons and nerve fibers of the nervous system, while neuropeptide receptors [such as neurokinin receptor-1 (NK-1R), vasoactive intestinal peptide receptor (VPAC)] and neurotransmitter receptors [such as α7 acetylcholine nicotinoid-like receptor (α7nAChR), Beta 2 adrenergic receptor (β2AR)] may also be expressed on the immune cell membrane in the immune system. Therefore, esthesioneure can be activated by inflammatory mediators secreted by immune cells to conduct sensation and release neuropeptides and neurotransmitters, while the function of immune cells can be regulated by neuropeptides and neurotransmitters from the nervous system. Further understanding the role of neuroimmune in allergic diseases may provide guidance for the treatment of allergic diseases.

7.
Article | IMSEAR | ID: sea-205396

ABSTRACT

Background: Globally, inhalant allergen sensitization (IAS) in allergic diseases (ADs) is commonly associated with indoor allergens, mainly house dust mites (HDMs). Objective: The objective of this study was to determine the association between HDM sensitization (HDM-SN) and ADs. Materials and Methods: A retrospective study was conducted which included all patients with allergies, >15 years of age, and seen over a 1-year period at the Allergy Center, Lalune clinics, Jeddah, Saudi Arabia. Results of serum specific immunoglobulin E (sIgE) to 30 common inhalant allergens (INHs) were collected by medical students. Severity of sensitization was classified as 1–6 (1–2 being mild, 3–4 being moderate, and 5–6 being severe). Medical records of patients with HDM-SN were reviewed to determine any clinical diagnosis of ADs and other associated IAS. Results: A total of 55 adults with HDM-SN, 34 males (62%) and 21 females (38%), with an age range of 15>56 years were studied. ADs associated with HDM-SN were allergic rhinitis (AR) (27%), asthma (22%), allergic conjunctivitis (AC) (18%), atopic dermatitis (ATD) (16%), allergic sinusitis (9%), and chronic urticaria (8%). The average severity class of HDM-SN in our sample was moderate (Dermatophagoides pteronyssinus [2.3] and Dermatophagoides farinae [2.2]). Other IAS found to be associated with HDM-SN were cockroaches (13.86%), Alternaria (12.4%), cats (12.4%), Bermuda (11.67%), and mesquite (10.21%). Conclusion: Average HDM-SN severity class was moderate in the studied group of patients (early to middle adult ages). HDM-SN is always associated with other IAS (INH-SNs) which explains the importance of obtaining an all-INH panel in patients with HDM-SN. IAS which most frequently had an association with HDM-SN was cockroaches, Alternaria, and cats with two outdoor allergens Bermuda, and mesquite, following closely. HDM-SN is usually associated with multiple ADs mainly involving INHs including AR, asthma, and AC, and less commonly ATD, sinusitis, and chronic urticaria.

8.
Article in English | WPRIM | ID: wpr-760239

ABSTRACT

Allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, are common heterogeneous diseases that encompass diverse phenotypes and different pathogeneses. Phenotype studies of allergic diseases can facilitate the identification of risk factors and their underlying pathophysiology, resulting in the application of more effective treatment, selection of better treatment responses, and prediction of prognosis for each phenotype. In the early phase of phenotype studies in allergic diseases, artificial classifications were usually performed based on clinical features, such as triggering factors or the presence of atopy, which can result in the biased classification of phenotypes and limit the characterization of heterogeneous allergic diseases. Subsequent phenotype studies have suggested more diverse phenotypes for each allergic disease using relatively unbiased statistical methods, such as cluster analysis or latent class analysis. The classifications of phenotypes in allergic diseases may overlap or be unstable over time due to their complex interactions with genetic and encountered environmental factors during the illness, which may affect the disease course and pathophysiology. In this review, diverse phenotype classifications of allergic diseases, including atopic dermatitis, asthma, and wheezing in children, allergic rhinitis, and atopy, are described. The review also discusses the applications of the results obtained from phenotype studies performed in other countries to Korean children. Consideration of changes in the characteristics of each phenotype over time in an individual’s lifespan is needed in future studies.


Subject(s)
Asthma , Bias , Child , Classification , Dermatitis, Atopic , Humans , Phenotype , Prognosis , Respiratory Sounds , Rhinitis, Allergic , Risk Factors
9.
Chinese Pharmacological Bulletin ; (12): 607-611, 2019.
Article in Chinese | WPRIM | ID: wpr-857248

ABSTRACT

A20 (also known as TNFAIP3 ) is a zinc finger which can be activated by a variety of inflammatory factors such protein with both ubiquitination and deubiquitination functions, as LPS, IL-1 and TNF-α. To date, A20 has been considered a negative regulator of NF-kB with immunomodulatory effects. And the latest researches have shown the involvement of A20 in the occurrence and development of various allergic diseases. This article reviews the origin, structure, and biological functions of A20 and its role in allergic asthma, through which new methods and ideas might be enlightened for the treatment and prevention of allergic asthma.

10.
Article in Korean | WPRIM | ID: wpr-716871

ABSTRACT

In order to overcome a certain disease, it is necessary to confirm the prevalence, natural course and risk factors of the disease. The Korean Academy of Pediatric Allergy and Respiratory Disease has become the mainstream and has been paying a great deal of attention to the epidemiologic research of allergic diseases in Korean children since 1995. In this review, we would like to summarize the International Study of Asthma and Allergies in Childhood epidemiology study in Korea, the cohort study for allergic diseases, and the national medical big data. New epidemiological studies are needed to clarify the relationships between allergic diseases and factors such as air pollution, climate changes, microbiome, and diet, which are likely to be new risk factors for allergic diseases. Based on these epidemiological studies, we hope to find ways to overcome pediatric allergic diseases in Korea and also to share epidemiologic techniques and manpower.


Subject(s)
Air Pollution , Asthma , Child , Climate Change , Cohort Studies , Diet , Epidemiologic Studies , Epidemiology , Hope , Humans , Hypersensitivity , Korea , Microbiota , Prevalence , Risk Factors
11.
Chinese Journal of Immunology ; (12): 786-789, 2018.
Article in Chinese | WPRIM | ID: wpr-702818

ABSTRACT

Allergic diseases is a major worldwide health problem.The abnormal structure of intestinal microbiota is closely related to the occurrence and development of allergic diseases.The formation of intestinal microbiota in early life is influenced by many factors,such as the mode of delivery,feeding methods,the addition of probiotics or prebiotics,heredity and so on.The abnormal structure of intestinal microbiota in early life is an important factor influencing the occurrence of allergic diseases in the later life.In this paper, we will discuss the relationship between the abnormal structure of intestinal microbiota in early life and allergic diseases with the latest literature.

12.
Article in Chinese | WPRIM | ID: wpr-692460

ABSTRACT

With the change of environment and life-style,the incidence of allergic diseases in children is increasing,but its pathogenesis is not entirely elucidated.It is shown that tryptophan catabolism mediated by indoleamine 2,3-dioxygenase plays a significant role in the pathophysiology of allergic diseases of children such as asthma and allergic rhinitis.These roles include inducing Treg cell,inhibiting Th2 cell response,mediating immune tolerance and so forth.Therefore,it is a new target for the prevention and treatment of allergic diseases by stimulating the immune cells and changing the diet structure to regulate tryptophan catabolism.This article reviews the role of tryptophan decomposition in children allergic diseases.

13.
Asia Pacific Allergy ; (4): e8-2018.
Article in English | WPRIM | ID: wpr-750125

ABSTRACT

The prevalence of allergic diseases has increased dramatically in recent decades, and are now considered major chronic diseases at the global level. The increasing burden of allergic diseases has led to numerous worldwide and local researchers to investigate the time trends in its prevalence and identify its driving factors. Environmental changes such as urbanization and industrialization have been suggested to explain the increasing prevalence, but recent reports from Western countries suggest that this prevalence has reached a plateau or even possibly, started to decrease. However, such environmental changes are still occurring in many Asia-Pacific countries, including Korea, and it is speculated that the peak in allergy epidemics has yet to come. The present systematic literature review aimed to explore the time trends in the prevalence of allergic diseases in Korea and to identify the unmet needs for facilitating further studies.


Subject(s)
Chronic Disease , Epidemiology , Hypersensitivity , Incidence , Korea , Prevalence , Urbanization
14.
Article in Korean | WPRIM | ID: wpr-221134

ABSTRACT

Recent studies reported increased risks for the development of allergic diseases in children after prenatal exposure to drugs. The mechanisms by which drug exposure may actually cause allergic diseases are not known. It has been suggested that these drugs promote transplacental allergen transfer to the fetus, resulting in the preservation of allergens. If transferred to the fetus, these allergens could induce a Th2-dominant immune response and allergic sensitization of the fetus. The development of the fetal immune system is influenced by the allergic state of the mother. Maternal IgE can cross fetal membranes, and a Th2-dominant phenotype in the mother can promote an allergy-prone phenotype in the fetus. The fetal immune system starts early in development but mainly matures in later trimesters. Maternal use of antibiotics during pregnancy may prove to be a risk factor for persistent wheezing and allergy development in early infancy. Paracetamol exposure during pregnancy was associated with allergic rhinitis, its use until 6 months of age was associated with allergic sensitization and a history of asthma in girls. Exposure to proton pump inhibitors (PPIs) and Histamine 2-antagonists (H2As) has been associated with an increased risk for the development of atopic dermatitis, asthma, allergic rhinitis, and especially with the development of multiple allergic diseases. Our reviews showed it is necessary to prescribe such drugs under the consultation of an expert physician and to try and reduce exposure as much as possible to prevent offspring allergies in the case of mothers with a history of allergic diseases.


Subject(s)
Acetaminophen , Allergens , Anti-Bacterial Agents , Asthma , Child , Dermatitis, Atopic , Extraembryonic Membranes , Female , Fetus , Histamine , Humans , Hypersensitivity , Immune System , Immunoglobulin E , Mothers , Phenotype , Pregnancy , Proton Pump Inhibitors , Respiratory Sounds , Rhinitis, Allergic , Risk Factors
15.
Article in English | WPRIM | ID: wpr-179288

ABSTRACT

Recent studies have suggested a close association between prenatal maternal distress and allergic diseases in the offspring. We selected relevant birth-cohort or national registry studies using a keyword search of the PubMed database and summarized current evidence on the impact of prenatal maternal distress on the development of offspring's allergic diseases. Moreover, we postulated possible pathways linking prenatal distress and allergic diseases based on relevant human and animal studies. Both dysregulated hypothalamic-pituitary-adrenal axis and increased oxidative stress may cause structural (altered brain/lung development) and functional (skewed immune development) changes, which may predispose the fetus to developing allergic diseases during childhood. Although many facts are yet to be discovered, changes in the placental response and epigenetic modification are presumed to mediate the whole process from maternal distress to allergic diseases. Maternal prenatal distress can also interact with other physical or environmental factors, including familial or physical factors, indoor and outdoor pollutants, and early childhood psychological distress. The gut-microbiome-brain axis and the role of the microbiome as an immune modulator should be considered when investigating the stress-allergy relationship and exploring potential intervention modalities. Further research is needed, and particular attention should be given to defining the most vulnerable subjects and critical time periods. To this end, studies exploring relevant biomarkers are warranted, which can enable us to explore adequate intervention strategies.


Subject(s)
Animals , Asthma , Biomarkers , Epigenomics , Fetus , Humans , Microbiota , Oxidative Stress , Placenta
16.
Article in English | WPRIM | ID: wpr-627271

ABSTRACT

Interleukin 31 (IL-31)is one of the cytokines which appears to be an important regulator of Th2 responses. Previous study has been done to determine IL-31 serums levels in atopic dermatitis (AD). However, the serum levels of IL-31 in allergic rhinitis (AR) and atopic asthma (AA) is not many reported and still unclear. The objective of this cross sectional study is to determine an association between IL-31 and other predisposing factors with allergic diseases in HRPZ II (Hospital Raja PerempuanZainab II) and HUSM (Hospital UniversitiSains), Kelantan, Malaysia. This study involved 70 patients of AD, 70 patients of AR, 70 patients of AA and 70 healthy controls from staffs and people in HUSM.Five milliliters of blood were withdrawn and centrifuged for 5 minutes at 2000 rpm to obtain the serum and analyzed for IL-31 levels by using enzyme-linked immunosorbent (ELISA) kits (Human IL 31 Duoset, R&D System). Simple and multiple logistic regressions were used to analyze the association between IL-31 levels and predisposing factors among allergic diseases. The levels of IL-31 and other predisposing factors showed significant associations in smoking status, occupational exposure and area of living for AD and AR, however in AA, the significant association only found in smoking status and occupational exposure. In conclusion, we found that there were associations between IL-31 serum levels and other predisposing factors with AD, AR and AA. The findings can be the pilot study to determine IL-31 levels in allergic diseases in Malaysia.

17.
Article in English | WPRIM | ID: wpr-751137

ABSTRACT

@#Interleukin 31 (IL-31)is one of the cytokines which appears to be an important regulator of Th2 responses. Previous study has been done to determine IL-31 serums levels in atopic dermatitis (AD). However, the serum levels of IL-31 in allergic rhinitis (AR) and atopic asthma (AA) is not many reported and still unclear. The objective of this cross sectional study is to determine an association between IL-31 and other predisposing factors with allergic diseases in HRPZ II (Hospital Raja PerempuanZainab II) and HUSM (Hospital UniversitiSains), Kelantan, Malaysia. This study involved 70 patients of AD, 70 patients of AR, 70 patients of AA and 70 healthy controls from staffs and people in HUSM.Five milliliters of blood were withdrawn and centrifuged for 5 minutes at 2000 rpm to obtain the serum and analyzed for IL-31 levels by using enzymelinked immunosorbent (ELISA) kits (Human IL 31 Duoset, R&D System). Simple and multiple logistic regressions were used to analyze the association between IL-31 levels and predisposing factors among allergic diseases. The levels of IL-31 and other predisposing factors showed significant associations in smoking status, occupational exposure and area of living for AD and AR, however in AA, the significant association only found in smoking status and occupational exposure. In conclusion, we found that there were associations between IL-31 serum levels and other predisposing factors with AD, AR and AA. The findings can be the pilot study to determine IL-31 levels in allergic diseases in Malaysia.


Subject(s)
Causality
18.
Article in English | WPRIM | ID: wpr-219829

ABSTRACT

PURPOSE: The gut microbiota can influence several diseases through immune modulation; however, the exact role of microbes such as Clostridium difficileand the relationship between microbiota colonization and allergic diseases are not well known. This study aimed to determine the relationship between C. difficilecolonization and/or infection (CDCI) during infancy and allergic diseases during early childhood. METHODS: Infants 1–12 months of age presenting changes in bowel habits for more than 2 weeks were enrolled in this study. After dividing them into 2 groups according to the presence and absence of C. difficile, the risk of allergic disease development during childhood was identified and compared. RESULTS: Sixty-five patients were included in this study; 22 (33.8%) were diagnosed with CDCI. No significant differences were observed in baseline characteristics between the C. difficile-positive and -negative groups except for antibiotic exposure (22.7% vs. 60.5%, P=0.004). Compared to the C. difficile-negative group, the risk of developing at least one allergic disease was higher in the C. difficile-positive group after adjusting other variables (adjusted odds ratios, 5.61; 95% confidence interval, 1.52–20.74; P=0.007). Furthermore, food allergies were more prevalent in the C. difficile-positive group (P=0.03). CONCLUSION: CDCI during infancy were associated with a higher risk of developing allergic diseases during early childhood. These results suggest that CDCI during infancy might reflect the reduced diversity of the intestinal microbiota, which is associated with an increased risk of allergic sensitization. To identify the underlying mechanism, further investigation and a larger cohort study will be needed.


Subject(s)
Clostridioides difficile , Clostridium , Cohort Studies , Colon , Food Hypersensitivity , Gastrointestinal Microbiome , Humans , Hypersensitivity , Infant , Microbiota , Odds Ratio
19.
Rev. chil. pediatr ; 87(2): 88-95, abr. 2016. ilus
Article in Spanish | LILACS | ID: lil-783489

ABSTRACT

Las enfermedades alérgicas y el asma son el resultado de complejas interacciones entre la predisposición genética y factores ambientales. El asma es una de las enfermedades crónicas más prevalentes en niños. En este artículo se revisan algunos factores ambientales como la exposición a alérgenos, tabaco, bacterias, componentes microbianos, dieta, obesidad y estrés, que intervienen durante la vida intrauterina y la infancia en la regulación epigenética de las enfermedades alérgicas y el asma. La revisión se realiza en tres tipos de modelos: in-vitro, animales y humanos.


Allergic diseases and asthma are the result of complex interactions between genetic predisposition and environmental factors. Asthma is one of the most prevalent chronic disease among children. In this article we review some environmental factors like: allergen exposition, tobacco, bacteria, microbial components, diet, obesity and stress, which influences during intrauterine and infancy life in the epigenetic regulation of asthma and allergic diseases. The review has been done in three models: in-vitro, animal and human.


Subject(s)
Humans , Animals , Child , Asthma/etiology , Epigenesis, Genetic , Hypersensitivity/etiology , Asthma/genetics , Risk Factors , Genetic Predisposition to Disease , Environment , Hypersensitivity/genetics
20.
Chinese Pharmacological Bulletin ; (12): 616-619, 2016.
Article in Chinese | WPRIM | ID: wpr-492459

ABSTRACT

Allergic diseases such as allergic asthma, allergic der-matitis, allergic rhinitis, are polygenic diseases, involving the interaction between the environment, genes and immunity. In the past few decades, the incidence rate of allergic diseases in-creased predominantly and influenced the quality of people's lives seriously, so looking for new targets for the prevention and treat-ment of allergic diseases and drugs with less adverse reaction be-comes a hot topic for researchers. MicroRNAs(miRNAs)are a class of endogenous non-coding small RNAs that mediate nega-tively posttranscriptional regulation of gene expression by targe-ting specific mRNA sequences to inhibit the translation of mR-NAs. They are widely involved in the biological processes of cell differentiation, immune response and tumor development. The study shows that miRNAs can control the occurrence and devel-opment of allergic diseases. Studying the regulatory role of miR-NAs in allergic diseases has important implications for exploring the immunopathological mechanisms and discovering new thera-peutic targets of drugs.

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