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1.
Braz. j. biol ; 84: e252952, 2024. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1355913

ABSTRACT

Abstract The main purpose of this study was to find out a possible association between ABO blood groups or Rh and diabetes mellitus (DM) in the local population of eight (8) different towns of Karachi, Pakistan. For this purpose a survey was carried out in Karachi to have a practical observation of these towns during the period of 9 months from June 2019 to Feb. 2020. Out of eighteen (18) towns of Karachi, samples (N= 584) were collected from only eight (8) Towns of Karachi and gave a code-number to each town. Diabetic group sample was (n1=432) & pre-diabetes sample was (n2 =152). A standard Abbot Company Glucometer for Random Blood Sugar (RBS) and Fasting Blood Sugar (FBS) tests, standard blood anti sera were used for ABO/Rh blood type. Health assessment techniques were performed ethically by taking informed consent from all registered subjects. Finally data was analyzed by SPSS version 20.0. In our current study, the comparison of ABO blood groups frequencies between diabetic and pre-diabetic individuals were carried out. The percentage values of blood Group-B as given as: (32% in DM vs. 31% in pre-diabetics), followed by blood Group-O as: (18% in DM vs. 11% in pre-diabetics). Contrary to Group-"B" & "O", blood Group-A and Group-AB were distribution percentage higher pre-diabetic as compared to DM patients, as given as: Group-A (32% in pre-diabetics vs. 26% in DM) & Group-AB (26% in pre-diabetics vs. 24% in diabetic's patients). In addition, percentage distribution of Rh system was also calculated, in which Rh+ve Group was high and more common in DM patients as compared to pre-diabetics; numerically given as: Rh+ve Group (80% in DM vs. 72% in pre-diabetics). Different views and dimensions of the research topic were studied through literature support, some have found no any association and some established a positive association still some were not clear in making a solid conclusion. It is concluded that DM has a positive correlation with ABO blood groups, and people with Group-B have increased susceptibility to DM disease.


Resumo O objetivo principal deste estudo foi descobrir uma possível associação entre grupos sanguíneos ABO ou Rh e diabetes mellitus (DM) na população local de oito (8) diferentes cidades de Karachi, Paquistão. Para tanto, foi realizado um levantamento em Karachi para observação prática dessas cidades durante o período de 9 meses de junho de 2019 a fevereiro de 2020.De dezoito (18) cidades de Karachi, as amostras (N = 584) foram coletadas de apenas oito (8) cidades de Karachi e deram um número-código para cada cidade. A amostra do grupo de diabéticos foi (n1 = 432) e a amostra de pré-diabetes foi (n2 = 152). Um glicômetro padrão da Abbot Company para testes de açúcar no sangue aleatório (RBS) e açúcar no sangue em jejum (FBS), antissoros de sangue padrão foram usados ​​para o tipo de sangue ABO / Rh. As técnicas de avaliação de saúde foram realizadas de forma ética, tomando o consentimento informado de todos os indivíduos registrados. Finalmente, os dados foram analisados ​​pelo SPSS versão 20.0.No presente estudo, foi realizada a comparação das frequências dos grupos sanguíneos ABO entre diabéticos e pré-diabéticos. Os valores percentuais do sangue do Grupo-B são dados como: (32% em DM vs. 31% em pré-diabéticos), seguido pelo sangue do Grupo-O como: (18% em DM vs. 11% em pré-diabéticos). Ao contrário dos Grupos "B" e "O", sangue do Grupo-A e Grupo-AB tiveram distribuição percentual maior de pré-diabéticos em comparação com pacientes com DM, dado como: Grupo-A (32% em pré-diabéticos vs. 26% em DM) e Grupo AB (26% em pré-diabéticos vs. 24% em pacientes diabéticos). Além disso, também foi calculada a distribuição percentual do sistema Rh, no qual o Grupo Rh + ve foi elevado e mais comum em pacientes com DM em comparação aos pré-diabéticos; dados numericamente como: Grupo Rh + ve (80% em DM vs. 72% em pré-diabéticos). Diferentes visões e dimensões do tema de pesquisa foram estudadas com o suporte da literatura, alguns não encontraram nenhuma associação e alguns estabeleceram uma associação positiva, embora alguns não estivessem claros em fazer uma conclusão sólida. Conclui-se que o DM tem correlação positiva com os grupos sanguíneos ABO, e as pessoas com o Grupo B têm maior suscetibilidade à doença DM.


Subject(s)
Humans , Rh-Hr Blood-Group System , Diabetes Mellitus/epidemiology , Pakistan/epidemiology , ABO Blood-Group System , Cities
2.
Braz. j. biol ; 83: e250179, 2023. graf
Article in English | LILACS, VETINDEX | ID: biblio-1339372

ABSTRACT

Abstract Diabetes mellitus (DM) is a non-communicable disease throughout the world in which there is persistently high blood glucose level from the normal range. The diabetes and insulin resistance are mainly responsible for the morbidities and mortalities of humans in the world. This disease is mainly regulated by various enzymes and hormones among which Glycogen synthase kinase-3 (GSK-3) is a principle enzyme and insulin is the key hormone regulating it. The GSK-3, that is the key enzyme is normally showing its actions by various mechanisms that include its phosphorylation, formation of protein complexes, and other cellular distribution and thus it control and directly affects cellular morphology, its growth, mobility and apoptosis of the cell. Disturbances in the action of GSK-3 enzyme may leads to various disease conditions that include insulin resistance leading to diabetes, neurological disease like Alzheimer's disease and cancer. Fluoroquinolones are the most common class of drugs that shows dysglycemic effects via interacting with GSK-3 enzyme. Therefore, it is the need of the day to properly understand functions and mechanisms of GSK-3, especially its role in glucose homeostasis via effects on glycogen synthase.


Resumo O diabetes mellitus (DM) é uma doença não transmissível em todo o mundo, na qual existe nível glicêmico persistentemente alto em relação à normalidade. O diabetes e a resistência à insulina são os principais responsáveis ​​pelas morbidades e mortalidades de humanos no mundo. Essa doença é regulada principalmente por várias enzimas e hormônios, entre os quais a glicogênio sintase quinase-3 (GSK-3) é uma enzima principal e a insulina é o principal hormônio que a regula. A GSK-3, que é a enzima-chave, normalmente mostra suas ações por vários mecanismos que incluem sua fosforilação, formação de complexos de proteínas e outras distribuições celulares e, portanto, controla e afeta diretamente a morfologia celular, seu crescimento, mobilidade e apoptose do célula. Perturbações na ação da enzima GSK-3 podem levar a várias condições de doença que incluem resistência à insulina que leva ao diabetes, doenças neurológicas como a doença de Alzheimer e câncer. As fluoroquinolonas são a classe mais comum de drogas que apresentam efeitos disglicêmicos por meio da interação com a enzima GSK-3. Portanto, é necessário hoje em dia compreender adequadamente as funções e mecanismos da GSK-3, principalmente seu papel na homeostase da glicose via efeitos na glicogênio sintase.


Subject(s)
Humans , Insulin Resistance , Diabetes Mellitus , Glycogen Synthase Kinase 3 , Glucose , Homeostasis
3.
Braz. j. oral sci ; 21: e225337, jan.-dez. 2022. ilus
Article in English | LILACS, BBO | ID: biblio-1366230

ABSTRACT

Aim: To elaborate and validate an instrument for Brazilian Portuguese speakers, to assess dentists' knowledge about care of patients with diabetes mellitus (Dental-Diabetes). Methods: Methodological study comprising four stages: a) Elaboration of instrument; b) Content validation (computing Content Validity Index - CVI) based on Expert Committee assessment; c) Pre-test with 30 dentists, followed by assessment of suggestions by Expert Committee; d) Psychometric validation through instrument application in a sample of 127 dentists by means of the web tool e-Surv. Cronbach's alpha and intraclass correlation coefficients were used to evaluate, respectively, internal consistency and reproducibility. Results: The final version of the instrument consists of 22 questions (7 on sociodemographic data and 15 querying dentists' knowledge) and those submitted for validation attained a CVI of 0.95 [95% CI 0.916-0,981], showing satisfactory internal consistency, with 0.794 Cronbach's alpha [95% CI 0.741-0.842] and an intraclass correlation coefficient of 0.799 [95% CI: 0.746-0.846] between the test and retest scores. Conclusions: Dental-Diabetes is a comprehensive instrument, culturally adequate and validated to assess dentists' knowledge about care of patients with diabetes


Subject(s)
Humans , Male , Female , Health Knowledge, Attitudes, Practice , Surveys and Questionnaires , Dentists , Diabetes Mellitus , Psychometrics , Reproducibility of Results
4.
Rev. enferm. UERJ ; 30: e64079, jan. -dez. 2022.
Article in English, Portuguese | LILACS-Express | LILACS | ID: biblio-1371649

ABSTRACT

Objetivo: comparar o comportamento glicêmico dos pacientes em pós-operatório de cirurgia cardíaca valvar e de revascularização do miocárdio, submetidos ao mesmo protocolo de controle glicêmico, e avaliar a incidência de hipoglicemia e mortalidade intra-hospitalar dessa população. Método: estudo de coorte, retrospectivo, quantitativo, que avaliou 354 prontuários de cirurgias realizadas em 2016. Resultados: pacientes revascularizados apresentaram maiores médias glicêmicas (149,14±36,03), maior uso de insulina e coeficiente de variação (23,30%). Entretanto, a incidência de hipoglicemia foi maior entre valvares (35,32%), mais acometidos por lesão renal aguda (6,58%), terapia de substituição renal (11,97%) e mortalidade hospitalar (6,58%). Conclusão: evidenciou-se uma população heterogênea com desfechos clínicos que caracterizaram os valvares como mais criticos, devido a maior número de portadores de fibrilaçao atrial, maior tempo de CEC, e maior uso de vasoaminas e corticosteroides. Logo, é necessário conhecer as particularidades de cada população, para gerenciar protocolos específicos de controle glicêmico para diferentes perfis epidemiológicos.


Objective: to compare the glycemic behavior of patients in the postoperative period of valve heart surgery and myocardial revascularization, submitted to the same glycemic control protocol and to assess the incidence of hypoglycemia and mortality and in-hospital mortality in this population. Method: cohort, retrospective, quantitative study that evaluated 354 medical records of surgeries performed in 2016. Results: revascularized patients had higher blood glucose means (149,14±36.03), greater use of insulin and higher coefficient of variation (23.30%). However, the incidence of hypoglycemia was higher (35.32%) valve patients, more affected by acute kidney injury (6.58%), renal replacement therapy (11.97%) and hospital mortality (6.58%). Conclusion: a heterogeneous population with clinical outcomes that characterized the valves as more critical, due to a greater number of patients with atrial fibrillation, longer CEC time, and greater use of vasoamines and corticosteroids. It is necessary to know the particularities of each population, in order to manage specific glycemic control protocols for different epidemiological profiles.


Objetivo: comparar el comportamiento glucémico de pacientes en postoperatorio de cirugía valvular y revascularización miocárdica, sometidos al mismo protocolo de control glicémico y evaluar la incidencia de hipoglucemia y mortalidad hospitalaria en esta población. Método: estudio de cohorte, retrospectivo, cuantitativo que evaluó 354 historias clínicas, entre agosto y octubre de 2020, de cirugías realizadas en 2016. Resultados: pacientes revascularizados presentaron mayores medias de glucemia (149,14±36,03), mayor uso de insulina y mayor coeficiente de variación (23,30%). Aunque, la incidencia de hipoglucemia fue mayor (35,32%) entre las válvulas, que se vieron más afectadas por daño renal agudo (6,58%), terapia de reemplazo renal (11,97%) y mortalidad hospitalaria (6,58%). Conclusión: el estudio mostró una población heterogénea con resultados clínicos que caracterizaron a las válvulas como más críticas, debido a un mayor número de pacientes con fibrilación auricular, mayor tiempo de CEC y mayor uso de vasoaminas y corticoides. Por tanto, es necesario conocer las particularidades de cada población, para gestionar el control glucémico con protocolos específicos para diferentes perfiles epidemiológicos.

5.
An. Fac. Cienc. Méd. (Asunción) ; 55(2): 40-46, 20220801.
Article in Spanish | LILACS | ID: biblio-1380313

ABSTRACT

Introducción: El Síndrome Metabólico es de alta prevalencia en la población adulta y comprende un conjunto de factores de riesgo para el desarrollo de diabetes mellitus tipo 2 y cardiopatía isquémica. Objetivos: Determinar la frecuencia, componentes más frecuentes y la diferencia de las mediciones entre hombres y mujeres de Síndrome metabólico en pacientes jóvenes del ambulatorio de la Primera Cátedra de Clínica Médica del Hospital de Clínicas. Materiales y métodos: Diseño observacional, descriptivo, retrospectivo de corte transversal, que incluyó a pacientes adultos de 18 a 40 años que consultaron en el ambulatorio de la Primera Cátedra de Clínica Médica del Hospital de Clínicas de enero a diciembre de 2019. Se determinaron las variables demográficas (edad, sexo, procedencia), perímetro de cintura, presión arterial, c-HDL, triglicéridos y la glicemia. El Síndrome Metabólico se determinó de acuerdo a las definiciones de la NCEP-ATP III. Resultados: Se incluyeron en el estudio 312 pacientes, la edad media fue de 27,5± 6,2 años, en el sexo masculino fue de 27,4 ± 6,6 años y en sexo femenino de 27,9 ± 6,4 años. El 10,5% de los pacientes cumplieron con los criterios para el diagnóstico de Síndrome Metabólico, de los cuales 60,6% pacientes son del sexo femenino. Los componentes individuales más frecuentes son el perímetro de cintura aumentada y el c-HDL bajo. Conclusión: La frecuencia de Síndrome Metabólico es similar a otro estudio realizado en adultos jóvenes e inferior que, en adultos mayores, más en mujeres que en hombres y los componentes individuales más frecuentes fueron la obesidad y la dislipidemia.


Introduction: Metabolic syndrome is highly prevalent in the adult population and includes a set of risk factors for the development of type 2 diabetes mellitus and ischemic heart disease. Objectives: To determine the frequency, most frequent components and the difference of the measurements between men and women of Metabolic Syndrome in young patients of the ambulatory of the First Chair of Medical Clinic of the Hospital of Clinics. Materials and methods: Observational, descriptive, retrospective cross-sectional design, which included adult patients aged 18 to 40 who consulted in the outpatient clinic of the First Chair of Medical Clinic of the Hospital de Clínicas from January to December 2019. The demographic variables (age, sex, origin), waist circumference, blood pressure, HDL-C, triglycerides and glycemia. Metabolic syndrome was determined according to the NCEP-ATP III definitions. Results: 312 patients were included in the study, the mean age was 27.5 ± 6.2 years, in males it was 27.4 ± 6.6 years and in females 27.9 ± 6.4. years. 10.5% of the patients met the criteria for the diagnosis of metabolic syndrome, of which 60.6% patients are female. The most frequent individual components are increased waist circumference and low HDL-C. Conclusion: Frequency of metabolic syndrome similar to another study carried out in young adults and lower than in older adults, more in women than in men and the most frequent individual components were obesity and dyslipidemia.


Subject(s)
Metabolic Syndrome , Diabetes Mellitus, Type 2 , Dyslipidemias , Clinical Medicine , Risk Factors
6.
Int. j. cardiovasc. sci. (Impr.) ; 35(3): 342-353, May-June 2022. tab
Article in English | LILACS | ID: biblio-1375653

ABSTRACT

Abstract Background: Public programs that provide access to essential medications have played an important role in the care of hypertensive and diabetic patients. However, access in small municipalities has been poorly studied. Objectives: To describe the sociodemographic profile and the medication and health service usage of patients with systemic arterial hypertension and/or diabetes mellitus in a small municipality who use the public medication access programs Health has no Price (Saúde Não Tem Preço - SNTP) and the Minas Pharmacy Network. Methods: This cross-sectional study with 341 participants was conducted in 2019. Home interviews were conducted using a standardized, semi-structured questionnaire. The data are expressed as absolute and relative frequencies, and Pearson's chi-square test was used for comparisons between proportions (α = 5%). Results: Most of the participants (70.68%) had hypertension only, 11.14% had diabetes only, and 18.18% had both. Regarding the origin of the hypertension medications, 82.67% were provided by the Minas Pharmacy Network and/or SNTP programs. Regarding oral hypoglycemic agents and insulins, 88.61% were provided by the Minas Pharmacy Network and/or SNTP. Most participants were female (63.1%), at least 65 years of age (50.30%), non-White (66.96%), resided in an urban area (67.16%), were illiterate or had a low education level (89.94%), and had a maximum income ≤ 2 times the federal minimum salary (89.19%). Overall user perception was significantly better for SNTP (p=0.010). Conclusion: The results of this study indicate that programs which provide access to essential medications are important sources of hypertension and diabetes medications in the study area, especially for people with low incomes.


Subject(s)
Diabetes Mellitus/epidemiology , National Drug Policy , Access to Essential Medicines and Health Technologies , Hypertension/epidemiology , Pharmaceutical Services/supply & distribution , Cross-Sectional Studies , Diabetes Mellitus/drug therapy , Hypertension/drug therapy
7.
Rev. urug. enferm ; 17(1): 1-15, jun. 2022.
Article in Portuguese | LILACS, BDENF | ID: biblio-1367881

ABSTRACT

Objetivo: compreender as adversidades e habilidades adaptativas vivenciadas por pessoas com diabetes mellitus. Metodologia: estudo de caso único com abordagem qualitativa, realizado com pessoas com diabetes, participantes em um grupo de educação em saúde vinculado a um Hospital Universitário da região sul do Brasil. Para coleta de dados, entre maio e junho de 2019, foi aplicada a Escala Problems Areas in Diabetes, cujos dados foram analisados, conforme recomendação de pontuação do instrumento; entrevista semiestruturada e observação participante submetidas à análise de conteúdo. O suporte teórico deste estudo foi a Teoria da Resiliência Aplicada a Sistemas Socioecológicos e estudos que abordam as práticas de autocuidado. Resultados: o caso único inclui cinco participantes. O score médio segundo a Escala Problems Areas in Diabetes foi de 48,0. O score individual indicou elevado impacto emocional relacionado ao viver com diabetes. Dos cinco participantes, três ultrapassaram o score máximo desejável (40 pontos): 81,25; 65; 57,5, 28,75 e 7,5. Da análise de conteúdo emergiram duas categorias: "Desafios para o autocuidado", com destaque à alimentação, tratamento farmacológico e monitorização do diabetes; "Rede de suporte para o enfrentamento das adversidades", com destaque o apoio dos familiares, amigos e profissionais da saúde. Conclusão: o conhecimento das adversidades e habilidades adaptativas das pessoas com diabetes contribui para compreensão do processo de resiliência, práticas de autocuidado e melhores práticas de saúde.


Objetivo: comprender las adversidades y habilidades adaptativas que experimentan las personas con diabetes mellitus. Metodología: estudio de caso único con abordaje cualitativo, realizado con personas con diabetes, participantes de un grupo de educación en salud vinculado a un Hospital Universitario en el sur de Brasil. Para la recolección de datos, entre mayo y junio de 2019 se aplicó la Escala de Áreas de Problemas en Diabetes, cuyos datos fueron analizados de acuerdo con la recomendación de puntaje del instrumento; entrevista semiestructurada y observación participante sometida a análisis de contenido. El soporte teórico de este estudio fue la Teoría de la Resiliencia Aplicada a Sistemas Socioecológicos y estudios que abordan las prácticas de autocuidado. Resultados: el caso único incluyó a cinco participantes. La puntuación media según la Escala de áreas problemáticas en la diabetes fue de 48,0. La puntuación individual indicó un alto impacto emocional relacionado con vivir con diabetes. De los cinco participantes, tres superaron la puntuación máxima deseable (40 puntos): 81,25; sesenta y cinco; 57,5, 28,75 y 7,5. Del análisis de contenido surgieron dos categorías: "Desafíos para el autocuidado", con énfasis en la nutrición, el tratamiento farmacológico y el seguimiento de la diabetes; "Red de apoyo para afrontar la adversidad", destacando el apoyo de familiares, amigos y profesionales de la salud. Conclusión: el conocimiento de la adversidad y las habilidades de adaptación de las personas con diabetes contribuye a la comprensión del proceso de resiliencia, las prácticas de autocuidado y las mejores prácticas de salud.


Objective: to understand the adversities and adaptive skills experienced by people with diabetes mellitus. Method: single-case study with qualitative approach, carried out with people with diabetes, participating in a health education group linked to a University Hospital in the south of Brazil. For data collection, between May and June 2019, the Problems Areas in Diabetes Scale was applied, with analysis according to the instrument's scoring recommendation; semi-structured interview and participant observation submitted to content analysis. The theoretical support of this study was the Theory of Resilience Applied to Socio-ecological Systems and studies related to self-care practices. Results: the single-case included five participants. The average score according to the Problems Areas in Diabetes Scale was 50.75, the individual score indicated a high emotional impact related to living with diabetes. Of the five participants, three exceeded the maximum desirable score (40 points): 81.25; 67.5; 65; 32.5 and 7.5. From the content analysis, two categories emerged: "Challenges for self-care", with emphasis on food, pharmacological treatment and monitoring of diabetes; "Support network for coping with adversity", with emphasis on the support of family members, friends and health professionals. Conclusion: the knowledge of adversities and adaptive skills of people with diabetes contributes to understanding the resilience process, self-care practices and best health practices.


Subject(s)
Humans , Self Care , Social Support , Brazil , Diabetes Mellitus , Resilience, Psychological
8.
Säo Paulo med. j ; 140(3): 390-397, May-June 2022. tab, graf
Article in English | LILACS | ID: biblio-1377390

ABSTRACT

ABSTRACT BACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. OBJECTIVE: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN AND SETTING: Prospective study at a university hospital in Turkey. METHODS: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. RESULTS: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. CONCLUSION: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.


Subject(s)
Humans , Animals , Female , Pregnancy , Diabetes, Gestational , Sulfhydryl Compounds/analysis , Prospective Studies , Oxidative Stress/physiology , Milk/metabolism , Milk/chemistry , Disulfides/analysis , Fetal Blood/metabolism , Fetal Blood/chemistry , Antioxidants/analysis
9.
Saúde Redes ; 8(1): 85-100, 20220510.
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1378105

ABSTRACT

Este artigo objetivou estabelecer o perfil dos usuários com diabetes insulinizados e fatores associados ao autocuidado na sua terapêutica. Trata-se de um estudo quantitativo, descritivo, transversal, com amostra de 139 pessoas atendidas na Farmácia Municipal de São Leopoldo - RS. Utilizou-se a versão brasileira adaptada do "Questionário de Atividades de Autocuidado com o Diabetes". Foram incluídas perguntas para avaliar o perfil sociodemográfico desses pacientes. O perfil dos usuários investigados foi: população idosa na faixa de 61 a 70 anos (29,5%), feminina (58,3%), com diabetes mellitus tipo 2 (64,0%), aposentados (39,6%) e com nível de escolaridade até o ensino médio incompleto (52,5%). Nas atividades de autocuidado, a menor adesão foi a realização de atividade física, dieta saudável e monitorização da glicemia capilar. A maior aderência foi no uso de insulina (média 6,56 ± 1,26). Conhecer o perfil dos usuários com diabetes insulinizados pode contribuir com o fortalecimento do autocuidado e contribuir na qualidade de vida destes pacientes.

11.
Rev. Assoc. Med. Bras. (1992) ; 68(5): 610-615, May 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1376172

ABSTRACT

SUMMARY OBJECTIVE: This study aimed to translate, cross-culturally adapt, and validate the Heart Disease Fact Questionnaire into Brazilian Portuguese. METHODS: The Brazilian version of the Heart Disease Fact Questionnaire was developed through the processes of translation, back-translation, review committee, and pre-test. Test-retest reliability was measured using the intraclass correlation coefficient and the kappa coefficient. Internal consistency was measured using Cronbach's alpha. For construct validity, the total Heart Disease Fact Questionnaire score was correlated with the Diabetes Knowledge Scale and the Diabetes Attitudes Questionnaire. Ceiling and floor effects were also evaluated in this study. RESULTS: For construct validity and floor and ceiling effect measurements, a total of 100 participants were selected. Reliability was measured using a sub-sample of 30 participants from the total sample. We identified adequate values of reliability (kappa between 0.22 and 1.00 and ICC=0.75) and internal consistency (Cronbach's alpha=0.79). We observed adequate correlations of the Heart Disease Fact Questionnaire score with Diabetes Knowledge Scale (r=0.348) and Diabetes Attitudes Questionnaire (r=0.136). No ceiling or floor effects found. CONCLUSION: Brazilian Portuguese version of the Heart Disease Fact Questionnaire has adequate psychometric properties according to the best scientific recommendations.

12.
Rev. bras. med. esporte ; 28(2): 85-88, Mar-Apr. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1365681

ABSTRACT

ABSTRACT Introduction: There is an annual increase in type 2 diabetes (T2DM) incidence in middle-aged people. Aerobic exercise is known to influence glucose metabolic pathways positively. Few studies concerning calisthenic aerobic exercise and its influence on elderly patients with T2DM. Objective: To measure the therapeutic effect of calisthenic exercise in obese Middle-aged people with T2DM. Methods: A total of 86 patients with T2DM were selected from the physical examination of employees of the same unit. They were randomly divided into the exercise group and the control group. The exercise intervention lasted for 16 weeks, with sessions held 3-5 times per week, varying from 60 to 90 minutes per session. The markers evaluated were defined according to the literature and statistically verified. Results: After 16 weeks of calisthenic exercise intervention, compared to the control group or before the experiment, we observed significant reductions in variables VFA (visceral fat area), FPG (fasting glucose), Fins (fasting insulin), HOMA-IR (homeostasis model evaluation of insulin resistance), 2hPBG (postprandial two hours glucose) and HbAlc (hemoglobin Alc) of the exercise group were significantly reduced (P<0.01). Conclusion: Calisthenic exercise intervention can reduce the levels of VFA, FPG. FIns, HOMA-HR, 2hPBG and HbAlc in patients with T2DM. It was also found to reduce the visceral fat content of obese elderly patients with T2DM, reducing obesity risks. Level of evidence II; Therapeutic studies - investigation of treatment results.


RESUMO Introdução: Há um aumento anual na incidência de diabetes tipo 2 (T2DM) nas pessoas de meia idade. O exercício aeróbico é conhecido por influenciar positivamente as vias metabólicas da glicose. Porém há poucos estudos sobre o exercício aeróbico calistênico e sua influência em pacientes entre 40 a 60 anos com T2DM. Objetivo: Medir o efeito terapêutico do exercício calistênico em pacientes de meia idade com obesidade e T2DM. Métodos: Um total de 86 pacientes com T2DM foram selecionados a partir do exame físico dos funcionários da mesma unidade. Eles foram divididos aleatoriamente entre o grupo de exercícios e o grupo de controle. A intervenção do exercício durou 16 semanas, com sessões realizadas de 3 a 5 vezes por semana, variando de 60 a 90 minutos por sessão. Os marcadores avaliados foram definidos de acordo com a literatura e verificados estatisticamente. Resultados: Após 16 semanas de intervenção de exercício aeróbico calistênico, em comparação ao grupo controle ou antes do experimento, observamos reduções significativas nas variáveis VFA (área de gordura visceral), FPG (glicose de jejum), Fins (insulina em jejum), HOMA-IR (avaliação do modelo de homeostase de resistência à insulina), 2hPBG (glicose pós-prandial de duas horas) e HbAlc (hemoglobina Alc) do grupo exercício foram significativamente reduzidas (P<0,01). Conclusão: A intervenção de exercício aeróbico calistênico pode reduzir os níveis de VFA, FPG. FIns, HOMA-HR, 2hPBG e HbAlc em pacientes com T2DM. Também foi constatado que reduz o conteúdo de gordura visceral de pacientes idosos obesos com T2DM, reduzindo os riscos de obesidade. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción: Cada año aumenta la incidencia de la diabetes tipo 2 (T2DM) en personas de mediana edad. Se sabe que el ejercicio aeróbico influye positivamente en las vías metabólicas de la glucosa. Pero hay pocos estudios sobre el ejercicio aeróbico calisténico y su influencia en pacientes de 40-60 años con T2DM. Objetivo: Medir el efecto terapéutico del ejercicio calisténico en pacientes de mediana edad con obesidad y T2DM. Métodos: Se seleccionó un total de 86 pacientes con T2DM a partir de la exploración física de los empleados de la misma unidad. Se dividieron aleatoriamente entre el grupo de ejercicio y el grupo de control. La intervención de ejercicios duró 16 semanas, con sesiones realizadas de 3 a 5 veces por semana, de 60 a 90 minutos por sesión. Los marcadores evaluados se definieron según la literatura y se verificaron estadísticamente. Resultados: Después de 16 semanas de intervención de ejercicio aeróbico calisténico, en comparación con el grupo de control o antes del experimento, observamos reducciones significativas en las variables VFA (área de grasa visceral), FPG (glucosa en ayunas), Fins (insulina en ayunas), HOMA-IR (evaluación del modelo de homeostasis de resistencia a la insulina), 2hPBG (glucosa postprandial de dos horas) y HbAlc (hemoglobina Alc) del grupo de ejercicio se redujeron significativamente (P<0,01). Conclusión: La intervención de ejercicio aeróbico calisténico puede reducir los niveles de AGV, FPG. FIns, HOMA-HR, 2hPBG y HbAlc en pacientes con T2DM. También se ha comprobado que reduce el contenido de grasa visceral en pacientes ancianos obesos con T2DM, reduciendo el riesgo de obesidad. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

13.
REME rev. min. enferm ; 26: e-1433, abr.2022.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1377624

ABSTRACT

Objetivo: sintetizar a produção científica sobre a técnica da autoaplicação de insulina em adultos com diabetes Mellitus no contexto domiciliar Método: revisão integrativa realizada entre dezembro de 2019 e janeiro de 2020, a partir da busca de publicações em periódicos indexados no PubMed, CINAHL, EMBASE, SCOPUS, Web of Science, LILACS e BDENF utilizando-se os termos controlados diabetes Mellitus, self care, insulin, health education, disposable equipment, medical wastedisposal e self administration e seus correspondentes em português, combinados com o operador booleano AND. Foram incluídos artigos originais publicados entre 2009 e 2019, nos idiomas inglês, português e espanhol e que responderam à questão norteadora: qual a produção científica sobre a técnica da autoaplicação de insulina em adultos com diabetes Mellitus no contexto domiciliar nos últimos 10 anos? Resultados: compuseram a amostra final oito artigos. Predominaram estudos realizados no Brasil, por enfermeiros no contexto da atenção primária à saúde. Em relação à técnica de autoaplicação de insulina, os resultados foram agrupados em quatro eixos: pré-aplicação, técnica de preparo da insulina, aplicação e pós-aplicação. Observaram-se ações inadequadas em todos os eixos tais como: transporte, armazenamento, autoaplicação, reutilização de agulhas e descarte incorreto. Tais inadequações podem resultar em procedimentos dolorosos, prejuízos no controle glicêmico e complicações para a saúde da pessoa com diabetes Mellitus. Conclusão: os resultados evidenciaram que a realidade da autoaplicação de insulina em adultos com diabetes Mellitus no domicílio pode ser modificada a partir da educação em saúde pelo enfermeiro, bem como colaborar para o planejamento das ações estratégicas para diminuir tais problemas.(AU)


Objective: to synthesize the scientific production on the technique of self-administration of insulin in adults with diabetes Mellitus in the home context. Method: integrative review carried out between December 2019 and January 2020, based on the search for publications in journals indexed in PubMed, CINAHL, EMBASE, SCOPUS, Web of Science, LILACS and BDENF using the controlled terms diabetes Mellitus, self-care, insulin, health education, disposable equipment, medical waste disposal and self-administration and their corresponding words in Portuguese, combined with the Boolean operator AND. Original articles published between 2009 and 2019, in English, Portuguese and Spanish, were included, which answered the guiding question: what is the scientific production on the technique of self-administration of insulin in adults with diabetes Mellitus in the home context in the last 10 years? Results: the final sample comprised eight articles. Studies carried out in Brazil by nurses in the context of primary health care predominated. Regarding the insulin self-administration technique, the results were grouped into four axes: pre-administration, insulin preparation technique, administration, and post-administration. Inadequate actions were observed in all axes such as: transport, storage, self-application, reuse of needles and incorrect disposal. Such inadequacies can result in painful procedures, impaired glycemic control, and health complications for the person with diabetes Mellitus. Conclusion: the results showed that the reality of self-administration of insulin in adults with diabetes Mellitus at home can be modified based on health education by nurses, as well as collaborating in the planning of strategic actions to reduce such problems.(AU)


Objetivo: sintetizar la producción científica sobre la técnica de autoadministración de insulina en adultos con diabetes Mellitus en el contexto domiciliario. Método: revisión integradora realizada entre diciembre de 2019 y enero de 2020, a partir de la búsqueda de publicaciones en revistas indexadas en PubMed, CINAHL, EMBASE, SCOPUS, Web of Science, LILACS y BDENF utilizando los términos controlados diabetes Mellitus, self care, insulin, health education, disposable equipment, medical wastedisposal y self administration y sus equivalentes en portugués, combinados con el operador booleano AND. Se incluyeron artículos originales publicados entre 2009 y 2019, en inglés, portugués y español, que respondieron a la pregunta orientadora: ¿cuál es la producción científica sobre la técnica de autoadministración de insulina en adultos con diabetes Mellitus en el contexto domiciliario en los últimos 10 años? Resultados: la muestra final estuvo formada por ocho artículos. Predominaron los estudios realizados en Brasil por enfermeros en el contexto de la atención primaria de salud. En cuanto a la técnica de auto aplicación de insulina, los resultados se agruparon en cuatro ejes: antes de la aplicación, técnica de preparación de insulina, aplicación y post aplicación. Se observaron acciones inadecuadas en todos los ejes, tales como: transporte, almacenamiento, auto aplicación, reutilización de agujas y disposición incorrecta. Tales deficiencias pueden resultar en procedimientos dolorosos, deterioro del control glucémico y complicaciones de salud para las personas con diabetes Mellitus. Conclusión: los resultados mostraron que la realidad de la insulina autoadministrada en adultos con diabetes Mellitus en el hogar puede modificarse a partir de la educación en salud brindada por enfermeros, además de ayudar a planificar acciones estratégicas para reducir dichos problemas.(AU)


Subject(s)
Humans , Adult , Self Care , Diabetes Mellitus , Insulin/therapeutic use , Primary Health Care , Health Education , Glycemic Control
14.
Arch. endocrinol. metab. (Online) ; 66(2): 214-221, Apr. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1374262

ABSTRACT

ABSTRACT Objective: A study at Centro Hospitalar Universitário do Porto in 2011 revealed suboptimal control of inpatient hyperglycemia and a similar one was carried out in 2020. This study compares the results of 2011 and 2020 regarding prevalence of hyperglycemia, metabolic control, treatment and glycemic profile by infection/non-infection diagnosis. Subjects and methods: We performed two cross-sectional studies on 13th December 2011 and 9th October 2020 that included all non-critical adults with at least 24 hours of hospitalization, with no specific intervention between them. Glycemic control evaluated by minimum and maximum capillary blood glucose (CBG) in the previous day categorized as hypoglycemia (<70 mg/dL), normoglycemia (70-179 mg/dL) and hyperglycemia (≥180 mg/dL) (SPSS v.20). Results: A total of 418 and 445 patients were respectively included in 2011 and 2020 studies and the prevalence of hyperglycemia was similar. Glycemic control improved numerically although not significantly in 2020: increase in normoglycemia, reduction in hyperglycemia and reduction in hypoglycemia. There was an increase in the use of basal-bolus regimens (19.6% vs. 7.3%, p = 0.009) and a decrease in human basal (p < 0.01) and rapid-acting insulin use (p = 0.001) with a proportional increase in long-acting (p = 0.002) and rapid-acting analogs (p < 0.001) use. There was a higher prevalence of infection (39.8% vs. 23.1%, p = 0.006) in 2020 and, in the infection subgroup, there were higher insulinization rates (37.3% vs. 10.7%, p = 0.017) and a trend to glycemic control improvement. Conclusion: Despite the higher insulinization rates, the preference for new insulin analogs and a trend to better glycemic control, we have not yet reached targets, so education still remains necessary.

15.
Arch. endocrinol. metab. (Online) ; 66(2): 182-190, Apr. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1374268

ABSTRACT

ABSTRACT Objective: Post-transplant diabetes mellitus (PTDM) is a common metabolic complication after liver transplant that negatively affects a recipient's survival and graft function. This study aims to identify risk factors associated with diabetes after liver transplant. Materials and methods: This is a cross-sectional study conducted from September to November 2019. Data collection was performed by chart review, and patients were divided into 3 groups: patients without diabetes mellitus (DM), patients with pre-transplant diabetes mellitus, and patients with PTDM. Results: Two hundred and forty-seven patients' medical charts were screened, and 207 patients were included: 107 without DM, 42 with pre-transplant DM, and 58 with PTDM. The leading cause for liver transplant was hepatitis C, followed by hepatocellular carcinoma secondary to alcohol. There was a higher exposure to tacrolimus in patients without DM ( P = 0.02) and to ciclosporin in patients with pre-transplant DM, compared to others ( P = 0.005). Microscopic interface inflammatory activity was more severe in patients without DM as well as those with PTDM ( P = 0.032). There was a higher prevalence of steatosis in recipients with pre-transplant DM than there was in others ( P < 0.001). Multivariate logistic regression identified the following independent risk factors for DM: cirrhosis due to alcohol, hepatitis C, and triglycerides. For PTDM, these independent risk factors were cirrhosis due to alcohol, hepatitis C, and prednisone exposure. Conclusion: Alcoholic cirrhosis is a risk factor for PTDM in liver recipients. Liver transplant recipients with a pre-transplant history of cirrhosis due to alcohol, hepatitis C, and prednisone exposure deserve more caution during PTDM screening.

16.
Arq. bras. cardiol ; 118(4): 768-777, Apr. 2022. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1374337

ABSTRACT

Resumo A produção de ceramida ocorre em todo o corpo e desempenha um papel importante na manutenção da fisiologia normal. No entanto, os níveis de ceramidas são alterados em estados de doença, principalmente durante o desenvolvimento de diabetes e dislipidemia. A produção de ceramidas também está associada à instabilidade das placas ateroscleróticas. Estudos recentes revelam que pacientes com doença arterial coronariana instável apresentam níveis plasmáticos aumentados de ceramidas (principalmente C16, C18 e C24:1). Atualmente, são consideradas biomarcadores emergentes nas doenças cardiovasculares, sendo utilizadas na predição de instabilidade da placa aterosclerótica e eventos cardiovasculares adversos de forma independente aos fatores de risco tradicionais. Com o objetivo de descrever e discutir o papel das ceramidas na estratificação das doenças cardiovasculares, o desenvolvimento desta revisão narrativa contextualiza a importância desse biomarcador no cenário atual da cardiologia.


Abstract Ceramide production takes place throughout the body and plays a key role in the maintenance of normal physiology. However, ceramide levels are altered during disease states, particularly considering the development of diabetes and dyslipidemia. Ceramide production is also associated with atherosclerotic plaque instability. Recent studies revealed that patients with unstable coronary artery disease (CAD) presented increased plasma ceramide levels (especially C16, C18, and C24:1). These molecules are currently considered emerging biomarkers of cardiovascular diseases (CVD), being used for predicting atherosclerotic plaque instability and adverse cardiovascular events independently from traditional risk factors. With the aim of describing and discussing the role of ceramides in the stratification of cardiovascular diseases, this narrative review contextualizes the importance of this biomarker in the present cardiology scenario.

17.
Ciênc. Saúde Colet ; 27(4): 1653-1667, abr. 2022. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1374926

ABSTRACT

Resumo Este artigo tem como objetivo apresentar uma metodologia de monitoramento dos procedimentos preconizados no protocolo de atenção ao paciente diabético a partir do indicador de razão entre a oferta e a demanda de exames, segundo nível nacional, macrorregiões, UF e municípios. A prevalência de diabetes mellitus (DM) e suas complicações foi estimada a partir de modelo multinomial. A oferta de procedimentos para DM foi obtida a partir do Sistema de Informações Ambulatoriais (SIA/SUS) e a demanda a partir do número de exames definidos no protocolo como necessários por ano, segundo categorias de risco da doença. A partir disso foi criado o indicador de razão entre oferta e demanda. A inovação que ora apresentamos consiste em analisar conjuntamente a demanda por cuidado ao diabético segundo parâmetros estabelecidos e a oferta de serviços de saúde. A conexão entre o protocolo de tratamento preconizado e a existência do serviço ofertado em relação da demanda de cuidado baseada na prevalência da doença disponibiliza uma ferramenta chave de monitoramento. E, quando analisado conjuntamente ao indicador de razão entre oferta e demanda de procedimentos, essas medidas tornam-se proxy da qualidade da prevenção e atenção ao portador da doença.


Abstract This article aims to present a methodology for monitoring the procedures recommended in the care protocol for diabetic patients, based on the indicator of the ratio between supply and demand for exams, according to Brazil, macro-regions, federative units (FUs), and municipalities. The prevalence of diabetes mellitus (DM) and its complications were estimated using a multinomial model. The offer of DM procedures was obtained from the Ambulatory Information System (SIA/SUS) and the demand from the number of tests defined in the protocol as necessary per year, according to disease risk categories. Based on this, the supply-demand ratio indicator was created. The innovation here consists of analyzing the demand for diabetic care according to established parameters and the supply of health services together. The connection between the recommended treatment protocol and the existence of the service offered concerning the demand for care based on the prevalence of the disease provides a key monitoring tool. And, when analyzed together with the indicator of the ratio between supply and demand for procedures, these measures become a proxy for the quality of prevention and care for patients with the disease.

18.
Rev. colomb. cardiol ; 29(2): 185-198, ene.-abr. 2022. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1376877

ABSTRACT

Resumen Objetivo: Realizar un metaanálisis de la frecuencia de hiperreactividad plaquetaria (HPR) para aspirina y clopidogrel con diferentes agregómetros, en pacientes con diabetes mellitus (DM) e hipertensión (HTA) sometidos a intervención coronaria percutánea (ICP). Método: Revisión sistemática con metaanálisis a partir de 40 búsquedas en tres bases de datos multidisciplinarias (PubMed, ScienceDirect y SciELO), siguiendo las fases de la guía PRISMA entre los años 2005 y 2021. Se garantizaron la reproducibilidad y la calidad metodológica por parte de dos investigadores que usaron la guía STROBE. Los análisis se basaron en frecuencias y metaanálisis de razón de disparidad, para lo cual se empleó el software Epidat con un intervalo de confianza del 95%. Resultados: Se incluyeron 22 estudios. La frecuencia de hiperreactividad plaquetaria para la aspirina fue desde el 18.8% hasta el 81.8% y para el clopidogrel desde el 18.2% hasta el 71.3%, lo que denota una importante heterogeneidad. Se observó que la frecuencia de hiperreactividad plaquetaria en pacientes diabéticos varió del 21% al 78.7%, mientras que en los pacientes hipertensos fue del 17.6% al 76.8%, y finalmente, la hiperreactividad plaquetaria fue 1,38 veces mayor en los pacientes diabéticos que en aquellos que no lo eran y 1,23 veces mayor en los pacientes hipertensos que en aquellos que no lo eran. Conclusiones: La diabetes mellitus y la hipertensión arterial, como enfermedades de base en pacientes sometidos a intervención coronaria percutánea, están asociadas a hiperreactividad plaquetaria, y esta, a su vez, como demostraron estudios previos, al desarrollo de eventos vasculares a largo plazo. De ahí que una valoración posterior al procedimiento con pruebas de agregometría plaquetaria resultaría potencialmente útil en el marco de la terapia personalizada.


Abstract Objective: To perform a metaanalyze of the frequency of platelet hyperreactivity for aspirin and clopidogrel with different aggregometers, in patients with diabetes mellitus and hypertension undergoing percutaneous coronary intervention. Method: Systematic review with metaanalysis using 40 searches in three multidisciplinary databases (PubMed, ScienceDirect and SciELO), following the phases of the PRISMA guide between the years 2005 and 2021. Reproducibility and methodological quality were guaranteed by two researchers using the STROBE guide. The analyzes were based on frequencies and odds ratio metaanalysis, using Epidat software with a 95% confidence interval. Results: 22 studies were included, the frequency of platelet hyperreactivity was from 18.8% to 81.8% in the case of aspirin, and in the case of clopidogrel from 18.2% to 71.3%, which denotes an important heterogeneity. It was observed that the frequency of platelet hyperreactivity in diabetic patients ranged from 21% to 78.7% and in hypertensive patients from 17.6% to 76.8%, and finally it was observed that the platelet hyperreactivity was 1.38 times higher in diabetic patients than in those who were not and 1.23 times higher in hypertensive patients than in those who were not. Conclusions: Diabetes mellitus and hypertension as underlying pathologies in patients undergoing percutaneous coronary intervention are associated with the presence of platelet hyperreactivity, and this in turn -as shown by previous studies-, with the development of long-term vascular events, therefore a subsequent assessment. The procedure with platelet aggregometry tests would be potentially useful in the context of personalized therapy.

20.
Rev. bras. med. esporte ; 28(1): 59-61, Jan.-Mar. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1357119

ABSTRACT

ABSTRACT Introduction: Type 2 diabetes mellitus (T2DM), also known as non-insulin-dependent diabetes mellitus (NIDDM), accounts for more than 90% of the total number of diabetes mellitus cases and often occurs in middle-aged and elderly people. Objective: To investigate the effect of exercise intervention on insulin resistance in obese type 2 diabetes patients. Methods: Eighty-six obese diabetic patients were screened as experimental subjects in physical examinations and randomly divided into observation and control groups. Visceral fat volume, fasting blood glucose, and fasting insulin of all subjects were measured before and after completion of the 6-month experimental implementation. The insulin resistance was calculated for both groups and the values for each indicator were compared statistically between groups. Results: Control of body weight, body mass index, blood glucose, blood lipids and insulin resistance index were better in the observation group than in the control group, and the difference was statistically significant (P < 0.05). Conclusions: Basal intervention with quantitative exercise can significantly improve insulin resistance in obese type 2 diabetes patients and the effect is better than treatment with diet and conventional exercise. Level of evidence II; Therapeutic studies - investigation of treatment results.


RESUMO Introdução: O diabetes mellitus tipo 2 (T2DM), também conhecido como diabetes mellitus não insulino-dependente (NIDDM), é responsável por mais de 90% do total de casos de diabetes mellitus e, com frequência ocorre em pessoas de meia-idade e idosos. Objetivo: Investigar o efeito da intervenção com exercícios sobre a resistência à insulina em pacientes obesos com diabetes tipo 2. Métodos: Oitenta e seis pacientes diabéticos obesos foram selecionados como participantes experimentais em exames físicos e foram divididos randomicamente em grupos de observação e controle. Gordura visceral, glicose e insulina sanguíneas em jejum de todos os indivíduos foram medidas antes e depois do término do experimento de seis meses. A resistência à insulina foi calculada para ambos os grupos e os valores de cada indicador foram comparados estatisticamente entre os grupos. Resultados: O controle de peso, índice de massa corporal, glicose e lípides sanguíneos e o índice de resistência à insulina foram melhores no grupo observação do que no grupo controle, e a diferença foi estatisticamente significativa (P < 0,05). Conclusões: A intervenção basal com exercícios quantitativos pode melhorar significativamente a resistência à insulina em pacientes obesos com diabetes tipo 2 e seu efeito é melhor do que a dieta e a terapia com exercícios convencionais. Nível de Evidência II; Estudos terapêuticos - Investigação dos resultados do tratamento.


RESUMEN Introducción: La diabetes mellitus tipo 2 (DMT2), también conocida como diabetes mellitus no insulinodependiente (DMNID), representa más del 90% de todos los casos de diabetes mellitus y suele afectar a personas de mediana edad y ancianos. Objetivo: Investigar el efecto de la intervención con ejercicios sobre la resistencia a la insulina en pacientes obesos con diabetes tipo 2. Métodos: Se seleccionaron 86 pacientes diabéticos obesos como participantes experimentales en exámenes físicos y se dividieron aleatoriamente en grupos de observación y control. Se midieron la grasa visceral, la glucosa y la insulina en ayunas de todos los individuos antes y después de finalizar el experimento de seis meses. Se calculó la resistencia a la insulina en ambos grupos y se compararon estadísticamente los valores de cada indicador entre los grupos. Resultados: El control del peso, el índice de masa corporal, la glucosa y los lípidos en la sangre y el índice de resistencia a la insulina fueron mejores en el grupo de observación que en el grupo de control, y la diferencia fue estadísticamente significativa (P < 0,05). Conclusiones: La intervención inicial con ejercicios cuantitativos puede mejorar significativamente la resistencia a la insulina en pacientes obesos con diabetes tipo 2 y su efecto es mejor que la dieta y la terapia con ejercicios convencionales. Nivel de Evidencia II; Estudios terapéuticos - Investigación de los resultados del tratamiento.

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