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1.
Acta Pharmaceutica Sinica ; (12): 2695-2701, 2020.
Article in Chinese | WPRIM | ID: wpr-837522

ABSTRACT

Heavy metals and other harmful elements in traditional Chinese medicines inflict serious damage on public health. Therefore, risk assessment of Chinese raw materials has gained increasing attention. To date, few reports have been published on the health risk assessment of heavy metals and harmful elements in Chinese patent medicines. To gain a comprehensive understanding of heavy metals and other harmful elements in Chinese patent medicines and to establish proper limits, residual Pb, Cd, As, Hg, Cu and Cr in 15 054 samples of 295 drugs was analyzed with regard to distribution and variation between elements and dosage forms. In addition, in accord with procedures including hazard identification, hazard characterization, exposure assessment and risk characterization, basic procedures and specific parameters for risk assessment of heavy metals and harmful elements in Chinese patent medicines were clarified based on the health risk assessment of 14 787 samples and 276 drugs. A method and equation for establishing residual limits is proposed. The results show that content and target hazard quotients (THQs) of the investigated elements in all samples showed a skewed distribution approaching 0. Content of Pb, As, Cu, Hg, Cd or Cr in the samples exceeded 100 mg·kg-1 and the content of Pb, As, or Cu in individual samples exceeded 1 000 mg·kg-1. THQs of 586 samples and four drugs were above 1. We believe that the health risk of Hg, Pb and As in Chinese patent medicines with dosage forms of pill, capsule, tablet and powder, especially those in raw powder preparations, warrant concern.

2.
Chinese Pharmaceutical Journal ; (24): 99-103, 2015.
Article in Chinese | WPRIM | ID: wpr-859343

ABSTRACT

More and more people have realized the problems of exogenous harmful residues in traditional Chinese medicines (TCMs). In this review, the current development in studies on and construction of drug standard was reviewed. Moreover, the sample census result and degree of harm were analyzed. It is proposed that the concept of risk management should be integrated into the control of exogenous harmful residues in TCMs. And we should follow the scientific principles of risk control and develop new supervision system to ensure the quality and safety of TCMs as well as the development of the industry.

3.
Chinese Pharmaceutical Journal ; (24): 1682-1686, 2014.
Article in Chinese | WPRIM | ID: wpr-860012

ABSTRACT

OBJECTIVE: To review the development of colloidal gold chromatographic technique and its application in rapid detection of exogenous harmful residues.

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