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1.
Article in Chinese | WPRIM | ID: wpr-940204

ABSTRACT

ObjectiveTo investigate the protective effect of Zhizi prescription (ZZP) on carbon tetrachloride (CCl4)-induced acute and subacute liver injury and its mechanism. MethodAcute and subacute liver injury animal models were induced. C57 mice were randomly divided into a normal group, model group, obeccholic acid group, ZZP high-dose (0.5 g·kg-1) group, and ZZP low-dose (0.25 g·kg-1) group. According to the experiment design, the serum and liver tissue of mice were collected after the last administration. Hematoxylin-eosin (HE) and Sirius staining was used to observe the liver pathological changes. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), liver homogenate hydroxyproline (Hyp), malondialdehyde (MDA), and superoxide dismutase (SOD) levels were determined by kit. The levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the liver tissue were determined by enzyme-linked immunosorbent assay (ELISA). Real-time fluorescence quantitative polymerase chain reaction (Real-time PCR) was used to detect the mRNA expressions of collagen 1A1 (Col1a1), collagen 3A1 (Col3a1), fibronectin (FN), transforming growth factor β receptor Ⅱ (Tgfbr2) and α-smooth muscle actin (α-SMA) in the liver tissue. ResultIn terms of the acute liver injury, as compared with the normal group, the levels of ALT, AST, TBIL and MDA in the model group were significantly increased (P<0.01), while the activity of liver SOD was significantly decreased (P<0.01). Compared with model group, the ZZP high-dose and low-dose groups both significantly reduced the degree of liver cell injury, and protected the acute liver injury induced by CCl4. The ZZP high-dose group had a better effect than the ZZP low-dose group. In terms of the subacute liver injury, the levels of ALT, AST, MDA,TNF-α and IL-6 in the model group were significantly increased (P<0.01), while the activity of liver SOD was significantly decreased (P<0.01). As compared with the model group, liver Hyp content in the ZZP high-dose and low-dose groups was significantly decreased (P<0.01), and the collagen deposition in liver of both groups was significantly reduced. The ZZP high-dose group also significantly down-regulated the mRNA expressions of α-SMA, Col1a1, Col3a1, FN, and Tgfbr2 in the liver of mice (P<0.05, P<0.01). ConclusionZZP effectively protects the acute and subacute liver injury induced by CCl4, and the protective effect is proportional to its concentration. The mechanism may be related to the increase of the activity of antioxidant enzymes in the liver tissue, the decrease of the level of lipid peroxidation, and the inhibition of inflammatory response, thus reducing collagen deposition and improving early liver fibrosis.

2.
Article in Chinese | WPRIM | ID: wpr-940107

ABSTRACT

ObjectiveTo investigate the protective effect of Zhizi prescription (ZZP) on carbon tetrachloride (CCl4)-induced acute and subacute liver injury and its mechanism. MethodAcute and subacute liver injury animal models were induced. C57 mice were randomly divided into a normal group, model group, obeccholic acid group, ZZP high-dose (0.5 g·kg-1) group, and ZZP low-dose (0.25 g·kg-1) group. According to the experiment design, the serum and liver tissue of mice were collected after the last administration. Hematoxylin-eosin (HE) and Sirius staining was used to observe the liver pathological changes. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), liver homogenate hydroxyproline (Hyp), malondialdehyde (MDA), and superoxide dismutase (SOD) levels were determined by kit. The levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the liver tissue were determined by enzyme-linked immunosorbent assay (ELISA). Real-time fluorescence quantitative polymerase chain reaction (Real-time PCR) was used to detect the mRNA expressions of collagen 1A1 (Col1a1), collagen 3A1 (Col3a1), fibronectin (FN), transforming growth factor β receptor Ⅱ (Tgfbr2) and α-smooth muscle actin (α-SMA) in the liver tissue. ResultIn terms of the acute liver injury, as compared with the normal group, the levels of ALT, AST, TBIL and MDA in the model group were significantly increased (P<0.01), while the activity of liver SOD was significantly decreased (P<0.01). Compared with model group, the ZZP high-dose and low-dose groups both significantly reduced the degree of liver cell injury, and protected the acute liver injury induced by CCl4. The ZZP high-dose group had a better effect than the ZZP low-dose group. In terms of the subacute liver injury, the levels of ALT, AST, MDA,TNF-α and IL-6 in the model group were significantly increased (P<0.01), while the activity of liver SOD was significantly decreased (P<0.01). As compared with the model group, liver Hyp content in the ZZP high-dose and low-dose groups was significantly decreased (P<0.01), and the collagen deposition in liver of both groups was significantly reduced. The ZZP high-dose group also significantly down-regulated the mRNA expressions of α-SMA, Col1a1, Col3a1, FN, and Tgfbr2 in the liver of mice (P<0.05, P<0.01). ConclusionZZP effectively protects the acute and subacute liver injury induced by CCl4, and the protective effect is proportional to its concentration. The mechanism may be related to the increase of the activity of antioxidant enzymes in the liver tissue, the decrease of the level of lipid peroxidation, and the inhibition of inflammatory response, thus reducing collagen deposition and improving early liver fibrosis.

3.
Article in Chinese | WPRIM | ID: wpr-879001

ABSTRACT

Phyllanthus emblica is a kind of traditional medicine and medicinal and edible plant, with rich variety resources and high development value. It is a key poverty alleviation variety in China at present. As P. emblica processing industry is rising gradually in recent years, in order to fully develop and utilize its industrial resources, this paper systematically introduces current comprehensive development and utilization of P. emblica, discusses the problems in P. emblica processing industry, and puts forward comprehensive development and utilization strategies and industrial models in terms of cultivation, breeding, grading, quality evaluation and waste recycling, so as to provide a certain reference for promoting the high-quality development of P. emblica industry in China.


Subject(s)
China , Medicine , Medicine, Traditional , Phyllanthus emblica , Plant Breeding , Plant Extracts
4.
Article in Chinese | WPRIM | ID: wpr-906322

ABSTRACT

The homology of medicine and food has long been recognized in China, and the medicinal and edible resources are often employed to prevent and treat diseases or maintain health in traditional Chinese medicine (TCM). Due to the unique geographical and climatic conditions, the Xinjiang Uygur Autonomous Region (hereinafter referred to as Xinjiang) is blessed with abundant medicinal and edible resources, like Rosae Rugosae Flos, Punica granatum, and Amygdalus communis, which have been widely used by local ethnic communities as medicine in light of the remarkable pharmacological activities, guaranteeing their health condition to some extent. This paper collected the relevant articles from China National Knowledge Infrastructure (CNKI) database through the keyword and full-text search with the medicinal and edible resource Rosae Rugosae Flos as the search term, and the subsequent analysis revealed that the medicinal and edible resources in Xinjiang has a wide range of applications in food, medicine, and ecological protection. This paper further explored their research value, status, and prospects, so as to provide some references for the rational, effective, and sustainable development and utilization of these medicinal and edible resources in Xinjiang, thus better achieving "poverty alleviation" and "rural revitalization", popularizing TCM culture, and building a healthy China.

5.
Article in Chinese | WPRIM | ID: wpr-846420

ABSTRACT

Poria cocos is a traditional Chinese medicine with homology of medicine and food in China. It has the effects of promoting diuresis, eliminating dampness, invigorating spleen, calming heart and so on. It is widely used in medicine, food and health care products. With the in-depth study of P. cocos, its triterpenes, polysaccharides and other major chemical components, as well as its wide range of pharmacological effects and application development research have attracted much attention. This paper systematically reviewed the chemical components and pharmacological effects of P. cocos, according to the concept of quality markers, the quality markers of P. cocos were predicted and analyzed from the aspects of the biosynthetic approach and specificity of chemical components, traditional medicinal efficacy, traditional medicinal properties, measurable components, different processing methods and so on, which provides a scientific basis for quality evaluation and product development of P. cocos.

6.
Article in Chinese | WPRIM | ID: wpr-846371

ABSTRACT

Ipomoea batatas is a kind of both edible and medicinal plant, which provides a dietary source of vitamins, minerals, carbohydrates, proteins, anthocyanins, essential fatty acids, trace elements and other nutrients, and these active substances play a role in many pharmacological activities such as antitumor, immune regulation, hepatoprotective effect, hypoglycemic, hypolipidemic, anti-aging, intestinal regulation, anti-obesity, anti-radiation, anti-fatigue, etc, and promote health in many aspects. The Dictionary of Traditional Chinese Medicine and Chinese Materia Medica recorded that I. batatas have the characteristics of tonifying deficiency and replenishing qi, strengthening spleen and kidney. In recent years, it has become a research hotspot in multidisciplinary fields for its rich nutritional components and functional characteristics. In this paper, the research progress of biological activity of I. batatas in vivo was reviewed from aspects of basic and clinical researches, which may provide references for its further development, research and comprehensive utilization.

7.
Article in Chinese | WPRIM | ID: wpr-873009

ABSTRACT

Piperis Fructus is the dried nearly ripe or ripe fruit of Piperaceae, which is an important spice material and a traditional Chinese medicine (TCM), it is widely used in the world. It is recorded to possess the efficacy of warming spleen and stomach for dispelling cold, depressing Qi and dissolving phlegm. Piperis Fructus mainly contains amide alkaloids with piperine as the main ingredient and volatile oil dominated by monoterpenoids and sesquiterpenoids, which have a wide range of biological activities, such as anti-cancer, anti-oxidation, anti-inflammatory, etc. By referring to relevant papers at home and abroad, the researches on chemical compositions from different parts and pharmacological effects of Piperis Fructus in recent 5 years were summarized and analyzed. It was found that Piperis Fructus has great potential for drug development as a TCM with homology of medicine and food, which can provide a reference for further research and comprehensive utilization of Piperis Fructus.

8.
Article in Chinese | WPRIM | ID: wpr-846647

ABSTRACT

Yitang, warm in property and sweet in taste, is a popular product with medicinal and edible value in China. Yitang has very important research value, but there are still some problems, such as name confusion and imperfect quality standards. Through consulting relevant literatures and “Synopsis of Golden Chamber” and other monographs, we aimed to provide a comprehensive review on the efficacy of Yitang, and its application both for food and medicine, as well as the ancient and modern processing methods and related quality standards. In conclusion, the research may be valuable to provide a theoretical basis for the new development and new application of Yitang.

9.
Article in Chinese | WPRIM | ID: wpr-851143

ABSTRACT

Areca catechu is a traditional Chinese medicine and an important medicine and food homologous variety, it’s widely distributed in tropical and subtropical provinces in southern China and other countries in South Asia and Southeast Asia. The fruitage of A. catechu is not only a kind of great fruit widely eaten to welcome guests, but also its peels and seeds can be used as medicines. Arecae Semen is one of the four precious “Southern Medicine” in China. Modern studies have shown that A. catechu contains alkaloids, tannins, flavonoids, terpenoids and other chemical constituents. It has multiple activities in promoting digestion, lowering blood pressure and anti-depressant, anti-oxidation, anti-inflammatory, anti-parasitic and bacteriostatic activities etc. In this paper, the research progress of chemical constituents and pharmacological activities of A. catechu in recent years was summarized, which provided research basis for the edible safety, research and development of traditional Areca products.

10.
Chinese Pharmaceutical Journal ; (24): 543-547, 2017.
Article in Chinese | WPRIM | ID: wpr-858756

ABSTRACT

OBJECTIVE: To study the safety and feasibility of using stems and leaves of Panax notoginseng and flowers of Panax notoginseng as new food ingredients. METHODS: The edible history, nutrition and quality standards of Panax notoginseng's stems, leaves and flowers were summarized. Then toxicological test was conducted in mice to investigate the toxicity. RESULTS: The stems and leaves of Panax notoginseng and flowers of Panax notoginseng have a long edible history, rich in vitamins, minerals, proteins, amino acids and other nutrients. Pharmacological experiment results showed that they were safe and nontoxic, without obvious organ damages. CONCLUSION: It is of great value to use the stems, leaves and flowers of Panax notoginseng as new food ingredients under the recommended dosage. This study provides reference to the utilization of the non-medicinal parts of other Chinese herbal medicines.

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