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1.
Article in Chinese | WPRIM | ID: wpr-906161

ABSTRACT

Zexietang is derived from Jingui Yaolue (《金匮要略》), which is composed of Alismatis Rhizoma and Atractylodis Macrocephalae Rhizoma, and has the effect of inducing diuresis and invigorating the spleen to produce water. Compared with western medicine in the treatment of related diseases, Zexietang can not only improve the curative effect, but also reduce the occurrence of adverse reactions, so as to achieve long-term stable administration. The authors sorted out and analyzed the chemical composition, pharmacological effect and clinical application of Zexietang in recent years. It was found that the main active components of Zexietang were alismol A and B, 23-acetyl-alismol B and C, atractylenolides (atractylenolide Ⅰ, Ⅱ, Ⅲ) and polysaccharides. Pharmacological experiments showed that they had diuretic, hypolipidemic, anti-inflammatory and others. And it can be used in the treatment of hypertension, hyperlipidemia, vertigo, cerebral vascular insufficiency and other diseases combined with other Chinese materia medica, and the curative effect is obvious. By summarizing the research status of Zexietang in recent years, its active components and pharmacological mechanism can be further clarified, which provides the basis for the clinical application of Zexietang and guides the direction of its further research.

2.
Pensar mov ; 18(2)dic. 2020.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1386739

ABSTRACT

Resumen Actualmente, se recomienda el ejercicio contra resistencia (ECR) como una de las estrategias no farmacológicas para el control y tratamiento de la presión arterial (PA). Sin embargo, es necesario profundizar esta línea de investigación. El propósito del estudio fue comparar el efecto del tipo de descanso al realizar ECR sobre la PA de participantes normotensos. Participaron nueve hombres; siguiendo un diseño de investigación de medidas repetidas, realizaron tres condiciones experimentales en orden aleatorio: a) Descanso Activo (DA), b) Descanso Pasivo (DP), c) Sesión Control. En las 3 sesiones, se midió la PA y la frecuencia cardíaca (FC) pre-tratamiento, 1 minuto post-sesión y cada 10 minutos post-tratamiento durante 120 minutos. Las sesiones experimentales estuvieron precedidas por: mediciones antropométricas, familiarización y aplicación del test de 1RM. En el análisis estadístico se aplicó ANOVA de 2 vías para medidas repetidas, análisis de efectos simples y post hoc de Tukey. Entre los principales resultados, se encontró que, en comparación con la sesión control, los valores de PA disminuyen de forma significativa (p < .05): 1) al realizar ECR utilizando DP y DA a los 50, 100, 110 minutos post-ejercicio; 2) posterior a ejecutar ECR utilizando DA a los 20, 30, 70, 80,100, 120 minutos; 3) después de finalizada la sesión ECR con DP a los 10, 40 y 120 minutos. Respecto a la medición pre-test, los valores de PA disminuyeron de forma significativa (p < .05) a los 10, 20, 40, 50, 60, 100 y 120 minutos post ECR utilizando DP. En conclusión, al comparar con los valores de PA mostrados en un día de control, la ejecución de ECR aplicando DP y DA es funcional en el control de la PA de hombres jóvenes normotensos. En relación al pre-test, se podría indicar que el DP es el que promueve el efecto hipotensivo del ECR.


Abstract Resistance exercise is currently recommended as a non-pharmacological strategy to control and treat blood pressure, but further research is necessary concerning this topic. The purpose of this paper is to compare the effect of types of rest on the blood pressure of normotensive individuals while performing resistance exercise. Following a random methodological design with repeated measurements, nine men performed three experimental conditions on different days: a) Active Rest, b) Passive Rest, and c) Control Session. During the three sessions, blood pressure and heart rate measurements were taken pre-treatment, one-minute post-session, and every 10 minutes post-treatment for 120 minutes. Experimental sessions were preceded by anthropometric measurements, familiarization, and taking the 1RM test. The statistical analysis was conducted using two-way ANOVA with repeated measurements and Tukey post-hoc analysis. One of the main results indicated that, compared to the control session, blood pressure decreased significantly (p<0.05): 1) When performing resistance exercise with active and passive rest at 50, 100, 110 minutes post-exercise; 2) After executing resistance exercise with active rest at 20, 30, 70, 80,100, and 120 minutes; 3) After performing resistance exercise session with passive rest at 10, 40, and 120 minutes. With respect to pre-test levels, blood pressure decreased significantly (p<0.05) at 10, 20, 40, 50, 60, 100, and 120 minutes after performing resistance exercise with passive rest. In conclusion, compared with a control day, in the case of young normotensive males, the inclusion of both passive and active rest is functional for controlling blood pressure. In relation to the pre-test, passive rest promotes a hypotensive effect in the study population.


Resumo Recomenda-se, atualmente, o exercício contrarresistência (ECR) como uma das estratégias não farmacológicas para o controle e tratamento da pressão arterial (PA). Não obstante, é preciso aprofundamento nesta linha de pesquisa. O propósito do estudo foi comparar o efeito do tipo de descanso ao realizar ECR sobre a PA de participantes normotensos. Participaram nove homens; seguindo um desenho de pesquisa de medidas repetidas, realizaram três condições experimentais em ordem aleatória: a) Descanso Ativo (DA), b) Descanso Passivo (DP) e c) Sessão Controle. Nas 3 sessões, foram solicitadas a PA e a frequência cardíaca (FC) pré-tratamento, 1 minuto pós-sessão e a cada 10 minutos pós-tratamento durante 120 minutos. As sessões experimentais foram precedidas por: medições antropométricas, familiarização e aplicação do teste de 1RM. Na análise estatística aplicou-se a ANOVA de 2 vias com medidas repetidas, a análise de efeitos simples e o teste pós-hoc de Tukey. Entre os principais resultados, observou-se que, em comparação com a sessão controle, os valores de PA diminuíram de maneira significativa (p < 0,05): 1) ao realizar ECR, usando DP e DA nos 50, 100, 110 minutos pós-exercício; 2) posterior à execução do ECR usando DA nos 20, 30, 70, 80,100, 120 minutos; 3) depois de finalizar a sessão ECR com DP nos 10, 40 e 120 minutos. Com relação à medição pré-teste, os valores de PA diminuíram de maneira significativa (p < 0,05) nos 10, 20, 40, 50, 60, 100 e 120 minutos pós-ECR usando DP. Em conclusão, ao fazer a comparação com os valores de PA mostrados em um dia de controle, a execução de ECR aplicando DP e DA é funcional no controle da PA de homens jovens normotensos. Com relação ao pré-teste, poderia indicar-se que o DP é o promotor do efeito hipotensivo do ECR.

3.
Article in English | WPRIM | ID: wpr-886295

ABSTRACT

@#OBJECTIVE: This study aimed to calculate and compare the costs of different brands of ocular hypotensive eye drops available in the Philippines. METHODS: This was a single-center research conducted at a local laboratory. Triplicate samples of 21 different brands of locally-available ocular hypotensive drops were tested. The mass of ten drops, total usable mass, number of drops per bottle, and mass of 200-µL aliquots were measured for each sample. These were used to calculate for the total usable bottle volume, drop volume, and number of drops per milliliter of each sample. Lastly, the daily, monthly, and annual costs were computed and compared. RESULTS: Available brands of β-blockers were the most affordable options for topical glaucoma therapy, with costs ranging from Php1,838 to 8,472 per year. Innovator brands of α-agonists and carbonic anhydrase inhibitors were the most expensive, with annual costs ranging from Php7,641 to 24,295 and Php7,361 to 25,327, respectively. Fixed-combination preparations, with yearly costs ranging from Php4,307 to 22,200, were generally more costeffective than individual preparations. The cost of topical anti-glaucoma therapy can amount up to 3.3 to 66.9% of a minimum-wage earner’s annual income depending on the number and combination of drugs being used. CONCLUSIONS: The price range of ocular hypotensive eye drops available in the Philippines is wide. Cost of therapy is an important consideration for patients who acquire medications through out-of-pocket expenditure. Optimization of bottle designs and volumes is crucial to maximize the cost-effectiveness of eye drop solutions. Information on the cost of therapy should be available to both patients and physicians.


Subject(s)
Glaucoma , Tetrahymenina , Eye , Ophthalmic Solutions , Costs and Cost Analysis
4.
Acta cir. bras ; 34(11): e201901107, Nov. 2019. graf
Article in English | LILACS | ID: biblio-1054678

ABSTRACT

Abstract Purpose: To establish a hypotensive brain death pig model and observe the effects of hypotension on small bowel donors. Methods: The hypotensive brain death model was produced using the modified intracranial water sac inflation method in ten domestic crossbred pigs. Effects of hypotensive brain death on small bowel tissue morphology were evaluated through changes in intestinal tissue pathology, tight junction protein of the intestinal mucosa and plasma intestinal fatty acid-binding protein (i-FABP) levels. The pathophysiological mechanism was examined based on changes in superior mesenteric artery (SMA) blood flow and systemic hemodynamics. Results: After model establishment, SMA blood flow, and the mean arterial pressure (MAP) significantly decreased, while heart rate increased rapidly and fluctuated significantly. Small bowel tissue morphology and levels of tight junction protein of the intestinal mucosa showed that after model establishment, small bowel tissue injury was gradually aggravated over time (P<0.05). Plasma i-FABP levels significantly increased after brain death (P<0.05). Conclusions: A hypotensive brain death pig model was successfully established using an improved intracranial water sac inflation method. This method offers a possibility of describing the injury mechanisms more clearly during and after brain death.


Subject(s)
Animals , Male , Female , Brain Death/physiopathology , Disease Models, Animal , Hypotension/physiopathology , Intestine, Small/pathology , Intestine, Small/transplantation , Swine , Time Factors , Biopsy , Enzyme-Linked Immunosorbent Assay , Blotting, Western , Reproducibility of Results , Microscopy, Electron, Transmission , Fatty Acid-Binding Proteins/blood , Zonula Occludens-1 Protein/analysis , Hemodynamics , Intestine, Small/blood supply
5.
Article | IMSEAR | ID: sea-202316

ABSTRACT

Introduction: This randomized placebo controlled study wasdesigned to evaluate the effectiveness of magnesium sulphateas an agent to induce hypotensive anaesthesia in lumbar spinesurgery.Material and Methods: The study included 100 patients ofboth sexes who were equally distributed in two groups, theGroup Mg(Magnesium sulphate group) and Group C (controlgroup). The Magnesium group received magnesium sulphate40mg/kg administered as a slow IV bolus over a period of 10minutes before induction and 15mg/kg/hr by continuous IVinfusion during surgery. The same volume of isotonic salinewas administered to the control group. Surgical time, heartrate and mean arterial blood pressure was measured.Results: In the magnesium group there was reduction insurgical time (103.54 mins vs 117.34 mins), although theanaesthestic time was 9 minutes longer in the Magnesiumgroup denoting a longer emergence time. The mean arterialpressure and heart rate were significantly reduced inMagnesium group(p<0.005). Postoperative shivering was alsoless in Magnesium group.Conclusion: Magnesium infusion resulted in a steady andsmooth reduction in mean blood pressure and reduced heartrate, with no episodes of severe hypotension. Furthermoremagnesium causes reduction in duration of surgical time andpostoperative shivering

6.
Article | IMSEAR | ID: sea-206571

ABSTRACT

Pregnancy is a normal physiological state with hyperdynamic circulation that is characterised by important physiological changes, many of which take place in the cardiovascular system. Few patients with physiological bradycardia may, in the second trimester, feel symptomatic as their blood pressure drops due to a reduction in systemic vascular resistance however, treatment is rarely required. Pathological bradycardia in pregnant women is rare and usually secondary to either Congenital heart block, Myocarditis, or Severe Hypocalcaemia with an incidence as low as 1:20 000 women. Authors present a rare case of severe bradycardia during peripartum period who required LSCS in view of IUGR with Anhydroamnios. On admission her general condition was good her pulse was 42 beats per mins and BP was 170/100 mm of Hg with 1+ protinuria.  A clinical impression of preeclampsia was made. ECG showed sinus bradycardia with no irregularity. 2 DEcho showed no structural lesion in the heart and normal functional capacity so dilated peripartum cardiomyopathy was ruled out. Her serum electrolytes were normal and serum calcium and magnesium was markedly reduced which was corrected. Post operatively on day 4 pulse was mor than 60 and she was transferred out of ICU. The ECG performed on day 6 was normal.

7.
Bol. latinoam. Caribe plantas med. aromát ; 18(2): 204-222, mar. 2019. ilus
Article in English | LILACS | ID: biblio-1007819

ABSTRACT

To explore the mechanistic basis behind smooth muscle relaxant prospective of Bismarckia nobilis in gastrointestinal, respiratory and cardiovascular ailments. The methanolic extract of B. nobilis and sub-fractions have been evaluated in vitro rabbit isolated tissues, in vivo castor oil-induced diarrhea in rats and charcoal meal activity in mice. The B. nobilis extract relaxed spontaneous and K+(80 mM)- induced contractions in rabbit isolated jejunum preparations, CCh (1 µM) and K+ (80 mM)-induced contractions in tracheal and bladder preparations, PE (1 µM) and K+ (80 mM)-induced concentrations in aorta preparations, likewise verapamil. Spasmolytic activity of dichloromethane fraction is stronger as compared to aqueous fraction. In vivo castor oil-induced diarrhea in rats and charcoal meal activity in mice further supported spasmolytic activity. B. nobilis extract possess anti-spasmodic, anti-diarrheal, airway relaxant and vasodilator activities possible mediated through calcium channel blocking mechanism, justifying therapeutic utility of B. nobilis in diarrhea, asthma and hypertension.


El objetivo de trabajo fue explorar el mecanismo de acción relacionado con el efecto relajante del músculo liso inducido por Bismarckia nobilis (B. nobilis) en enfermedades gastrointestinales, respiratorias y cardiovasculares. El extracto metanólico de B. nobilis y subfracciones fue evaluado in vitro en tejidos aislados de conejos. Además se evaluó diarrea in vivo inducida con aceite de ricino en ratas y la actividad de harina de carbón vegetal en ratones. El extracto de B. nobilis relajó tanto las contracciones espontáneas como las inducidas por K+(80 mM) en preparaciones de yeyuno aisladas de conejos, las contracciones inducidas por PE (1 µM) y K+(80 mM) inducidas en preparaciones de aorta; de manera similar a verapamilo. La actividad espasmolítica de la fracción de diclorometano es más potente en comparación con la fracción acuosa. La diarrea inducida in vivo por el aceite de ricino en ratas y la actividad de la harina de carbón vegetal en ratones apoyaron aún más la actividad espasmolítica. El extracto de B. nobilis posee actividades antiespasmódicas, antidiarreicas, relajantes de las vías respiratorias y vasodilatadoras, posibles a través del mecanismo de bloqueo de los canales de calcio, lo que justifica la utilidad terapéutica de B. nobilis en la diarrea, el asma y la hipertensión.


Subject(s)
Animals , Rabbits , Rats , Plant Extracts/pharmacology , Anti-Asthmatic Agents/pharmacology , Arecaceae , Antidiarrheals/pharmacology , Antihypertensive Agents/pharmacology , Aorta/drug effects , Asthma/metabolism , Trachea/drug effects , Calcium Channel Blockers/pharmacology , Diarrhea/metabolism , Methanol , Hypotension/metabolism , Jejunum/drug effects , Muscle Relaxation/drug effects , Muscle, Smooth/drug effects
8.
European J Med Plants ; 2018 Jul; 24(3): 1-11
Article | IMSEAR | ID: sea-189401

ABSTRACT

Aims: To evaluate preparation herbal mixed of Pouteria campechiana, Chrysophyllum cainito, Citrus limonum and Annona muricata (PCCA) on vasorelaxant and hypotensive effect on rat model and toxicological data after acute oral administration to give scientific support to the use ethnomedical and to explore their potential damaging on oral intake. Study Design: Experimental. Place and Duration of Study: Sample female and male Wistar rats. Pharmacology laboratory of Chemistry School and Department of Clinical and Epidemiological Research of Medicine School, Autonomous University of Yucatán. Between October 2014 and July 2016. Methodology: An ethanolic extract of PCCA was prepared at a ratio of 1:1:1:1 of each plant plus individual extracts were prepared. Vasorelaxant effect was assessed (3.03 to 100 μg/mL), hypotensive effect ((100, 200, 300 mg/Kg) and median lethal dose (LD50) by oral acute toxicity method (OECD 423 guide). Results: PCCA extract induced a significant vasorelaxation (medium effective concentration (EC50)=463.43 μg/mL) in a concentration-dependent manner in aorta’s endothelium-intact rings and this effect was partially endothelium-dependent. Acute oral administration of 200 and 300 mg/kg of PCCA exhibited significant decrease in systolic blood pressure in normotensive rats. PCCA did not show clinical toxicity of acute oral administration. Only 2000 mg/kg show histopathological inflammatory responses on gut and liver. Conclusion: PCCA induces a significant cardiovascular effect and was not toxic for rodents. The results support the popular use of some Mayan Medicinal plants as antihypertensive agents; however, clinical studies are necessary.

9.
Mundo saúde (Impr.) ; 42(2): 269-282, jun. 2018. tab, ilus
Article in English, Portuguese | LILACS | ID: biblio-1000102

ABSTRACT

The genus Eugenia sp. (Myrtaceae) comprises plants with reported antioxidant and antidiarrheal capability among other therapeutic potentials. The aim of this study was to evaluate the antimicrobial activity of essential oil; diuretic and hypotensive activities of aqueous extracts from leaves of Eugenia uniflora. The antimicrobial activity was evaluated . The diuretic and hypotensive activities were evaluated in normotensive Wistar rats by measuring blood pressure and urine flow after received four different concentrations of aqueous extracts (10%, 15%, 20% and 25%). Essential oil inhibited the growth of Candida parapsilosis and Candida albicans with MIC values lower than 14.41 mg/mL, equal to 57.75 mg/mL for Candida krusei. Among antibacterial effect, essential oil inhibited growth with a MIC equals to 153.93 mg/mL for all strains tested, except for Escherichia coli (MIC equals to 307.96 mg/mL. Aqueous extracts showed powerful reductions of the arterial pressure (34% and 31% lower than the control), after administration of 10% and 25% of aqueous extract, respectively. However, the animals that received the aqueous extract at the 15% and 20% concentrations presented a discrete hypotensive effect (20% and 21% lower than control group, respectively) concomitantly to powerful diuretic effect (280% and 91% higher than control group, respectively). These data confirmed the potential biological effect of this species, and represents an important step toward a depth study on the therapeutic properties of this species


O gênero Eugenia sp. (Myrtaceae) compreende plantas com capacidade antimicrobiana e antioxidante entre outros potenciais terapêuticos. O objetivo deste estudo foi avaliar a atividade antimicrobiana de óleo essencial; atividade diurética e hipotensora de extrato aquoso de folhas de Eugenia uniflora. A atividade antimicrobiana foi avaliada pela determinação da concentração inibitória mínima (MIC) e concentração mínima bactericida (MBC) de cepas bacterianas e concentração fungicida mínima (MFC) para fungos. A atividade diurética e hipotensora foi avaliada em ratos Wistar normotensos pela mensuração da pressão sanguínea e fluxo urinário após administração de quatro diferentes concentrações de extrato aquoso (10%, 15%, 20% e 25%). Óleo essencial inibiu o crescimento de Candida parapsilosis e Candida albicans com valores de MIC menores que 14,41 mg/mL, igual a 57,75 mg/mL para Candida krusei. A respeito do efeito antimicrobiano, o óleo essencial inibiu o crescimento de todas as cepas testadas, com MIC igual a 153,93 mg/mL, exceto para Escherichia coli (MIC igual a 307.96 mg/mL). O extrato aquoso mostrou redução importante da pressão arterial (34% e 31% quando comparado ao controle), após administração de 10% e 25% do extrato aquoso, respectivamente. Contudo, os animais que receberam o extrato aquoso na concentração de 15% e 20% apresentaram discreto efeito hipotensor (20% e 21% menor que o grupo controle, respectivamente) concomitantemente ao importante efeito diurético (280% e 91% maior quando comparado ao grupo controle, respectivamente). Esses achados confirmam o potencial efeito biológico dessa espécie, e representa um importante embasamento para estudos relacionados as propriedades terapêuticas da Eugenia uniflora


Subject(s)
Humans , Oils , Diuretics , Eugenia , Hyperglycemia , Anti-Infective Agents , Antifungal Agents , Antihypertensive Agents , Brazil , DNA-Directed DNA Polymerase , Antioxidants
10.
Article in Chinese | WPRIM | ID: wpr-687289

ABSTRACT

This paper aimed to predict the active ingredients and action targets of Compound Uncaria Hypotensive Tablet for hypertension based on network pharmacology, and discuss its possible "multi-components, multi-targets, and multi-pathways" mechanism for treatment of hypertension. The integrative pharmacological platform of traditional Chinese medicine (TCM-IP) was used to construct the component target-disease target network of Compound Uncaria Hypotensive Tablet, and the internet analysis method was used to screen the key nodes, on which the pathway enrichment analysis was carried out to explore its possible biological process in the treatment of hypertension. Target network analysis showed that, 35 predicted active ingredients of Compound Uncaria Hypotensive Tablet had a strong interaction with the prostaglandin endogenous peroxidase synthase (PTGS1, PTGS2), ATP synthetase (ATP1A1, ATP5A1, ATP5C1, ATP5B) and other 29 major proteins. Network enriched analysis showed that Compound Uncaria Hypotensive Tablet participated in the regulation of hypertension in different processes of pathology, through 15 pathways such as regulating blood pressure, G protein coupled receptor activation, adrenergic myocardial cell signal transduction and platelet activation. This study revealed the potential active compounds and possible mechanism of Compound Uncaria Hypotensive Tablet for treatment of hypertension, providing theoretical references for further systematic laboratory experiments on effective compounds and action mechanism of Compound Uncaria Hypotensive Tablet.

11.
China Pharmacist ; (12): 391-393, 2017.
Article in Chinese | WPRIM | ID: wpr-507543

ABSTRACT

Objective:To fast detect hypotensive drugs illegally added to the flower buds of Panax notoginseng. Methods:A laser Raman spectrometer was used to detect several chemical drugs added to the flower buds of Panax notoginseng, and the spectrum was qualitatively analyzed. Results:Raman spectroscopy could detect chemical antihypertensive drugs added to the flower buds of Panax notoginseng, and the test results were in accordance with those of the traditional method. Conclusion: Raman spectroscopy can be used for the determination of illegal additives in the flower buds of Panax notoginseng.

12.
Article in Chinese | WPRIM | ID: wpr-852763

ABSTRACT

The plants of Chimonanthus Lindl. are endemic traditional medicinal plants in China. As the important components of these plants, the Chimonanthus alkaloids showed biological activities such as hypotensive activity, anticonvulsant, antifungal, antiviral, analgesia, antitumor, and melanogenesis inhibitory properties. In this paper, the types, bioactivities, and synthesis of alkaloids in plants of Chimonanthus Lindl. were reviewed systematically for providing reference in the further research and development of Chimonanthus alkaloids.

13.
Article in Chinese | WPRIM | ID: wpr-852634

ABSTRACT

The chemical components reached 138 types in Eucommia ulmoides, including mainly lignans, iridoids, phenylpropanoids, flavonoids, polysaccharides, gutta-percha, and antifungal protein. Modern pharmacological actions included lowering blood pressure, enhancing immunity function, reducing blood fat, lowering blood sugar, protecting liver, cholagogic, diuresis, protecting nerve cells, regulating bone metabolism, tonifying kidney and so on. Research progress on E. ulmoides was reviewed in the fields of chemical components, pharmacological actions and quality status. The quality status analysis found that some E. ulmoides on sale was not up to the pharmacopoeia standard, and processing methods have effect on the quality for E. ulmoides.

14.
Article in English | WPRIM | ID: wpr-819403

ABSTRACT

OBJECTIVE@#To investigate the pharmacological basis of its uses of Phyla nodiflora (P. nodiflora) for the treatment of anomalies predominantly by smooth muscle containing tissues such as gastrointestinal/vascular/broncho spasm and cardiovascular modulation.@*METHODS@#The crude hydroalcoholic extract of P. nodiflora (Pn.Cr) and its fractions were evaluated on isolated rabbit jejunum, rat trachea, aorta and atrium. To access the contractile or relaxant effects of testing materials, the tissues were mounted in isolated organ bath and responses were recorded with transducers coupled with data acquisition system. BALB/c mice were challenged with castor oil for the assessment of in-vivo antidiarrheal activity. Normotensive rats were used for in-vivo hypotensive study.@*RESULTS@#Hydroalcoholic extract of Pn.Cr at variable concentrations inhibited the natural spontaneous rhythm and 80 mmol/L K mediated contractions in isolated segment of jejunum with EC values of 3.18 and 1.91 mg/mL respectively. Verapamil, a Ca channel blocker, demonstrated akin pattern in jejunum and therefore possibly suggesting calcium blocking activity. On isolated rat tracheal tissue, Pn.Cr showed relaxation of high-K and carbachol mediated contractions (EC values: 1.24 and 2.42 mg/mL). Pn.Cr treatment relaxed the rat aortic ring in a cumulative doses with high-K and phenylephrine-induced contractions (EC values 0.25 and 0.92 mg/mL). Activity based fractionation of Pn.Cr showed that dichloromethane fraction was more potent for relaxing the tissues spasm compared to aqueous fraction. In-vivo experiments, significant protection by Pn.Cr (P < 0.05) was observed in castor oil-induced diarrhea (50-500 mg/kg) whereas hypotensive effect in anesthetized rats was seen at the dose range of 1-10 mg/kg of Pn.Cr (P < 0.05).@*CONCLUSION@#This study suggests the blockage of calcium channel in the smooth muscles as a pharmacological application to make usage of P. nodiflora in the management of diarrhea, asthma and hypotensive effect.

15.
Article | IMSEAR | ID: sea-186049

ABSTRACT

Introduction The deficiency of monoaminergic neurotransmission is important key pathology of depression. With these changes in excitatory neurotransmission in brain it can be hypothesised that this alteration may result into changes in various sympathetic and parasympathetic parameters like Blood pressure, Heart rate and expiratory and inspiratory ratio. Methodology It is a Case Control Observational Study done in collaboration with department of Psychaitry and all patients of depression satisfying the inclusion and exclusion criteria were studied for the changes in Blood pressure using handgrip test and Orthostatic Hypotensive Test while changes resting heart rate was recorded. Result and Conclusion There was increase in heart rate found in depression whereas blood pressure diastolic and systolic were found to be lower than a normal individual.

16.
Rev. bras. farmacogn ; 26(5): 619-626, Sept.-Oct. 2016. tab, graf
Article in English | LILACS-Express | LILACS | ID: lil-796142

ABSTRACT

ABSTRACT Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic vegetables and part of the daily diet around the world. In this study, aqueous-ethanolic and hexane extracts of celery seed were prepared and the amount of n-butylphthalide, as an active component, was determined in each extract. Then the effects of hexanic extract on systolic, diastolic, mean arterial blood pressure and heart rate were evaluated in an invasive rat model. The vasodilatory effect and possible mechanisms of above mentioned extracts on aorta ring were also measured. High performance liquid chromatography analysis revealed that hexanic extract contains significantly higher amounts of n-butylphthalide, compared to aqueous-ethanolic extract. The results indicated that hexanic extract significantly decreased the systolic, diastolic, mean arterial blood pressure and heart rate in normotensive and hypertensive rats. Our data revealed that celery seed extract exerts its hypotensive effects through its bradycardic and vasodilatory properties. Moreover, the active components in celery seed extracts could induce their vasodilatory properties through Ca2+ channel blocking activity in endothelial and non-endothelial pathways and particularly by interference with the extra or intracellular calcium.

17.
Article in Chinese | WPRIM | ID: wpr-498513

ABSTRACT

Objective To observe the effects of Compound Uncaria Hypotensive Tablets on expressions of MCP-1 and MMP-9 of vascular remodeling in spontaneously hypertensive rats (SHR); To discuss it possible mechanism of action. Methods Totally 24 12-week old male SHR were randomly divided into SHR model group, Compound Uncaria Hypotensive Tablets group, and positive medicine group, with 8 rats in each group. Another 8 WKY rats were set as normal control group. Medication groups were given relevant medicine for gavage for successive 6 weeks. Noninvasive tail cuff method was used to observe blood pressure; morphological changes in thoracic aorta and renal artery were observed by HE staining; immunohistochemistry was used to detect the protein expressions of MCP-1 and MMP-9 in thoracic aortic wall. Results Protein expressions of MCP-1 and MMP-9 in thoracic aortic wall of SHR model group were significantly higher than those of normal control group (P<0.01); Compared with the SHR model group, protein expressions of MCP-1 and MMP-9 in thoracic aortic wall decreased significantly in the medication groups (P<0.05, P<0.01); Compared the Compound Uncaria Hypotensive Tablets group and positive medicine group, there was no obvious difference in protein expressions of MCP-1 and MMP-9 in thoracic aortic wall. Conclusion Compound Uncaria Hypotensive Tablets can reduce the blood pressure of SHR, reduce inflammation reaction, and regulate vascular remodeling, which mechanism may be related to down-regulation of expressions of MCP-1 and MMP-9 in SHR aortic endothelial cells.

18.
Article in Chinese | WPRIM | ID: wpr-497620

ABSTRACT

Objective To systematically review the efficacy of hypotensive resuscitation for traumatic-hemorrhagic shock.Methods Randomized controlled trails (RCTs) or quasi-Randomized controlled trails (qRCTs) were searched in Pubmed,Embase and the Corchrane Library from inception to August 2015.Two reviewers respectively picked out the useful data and performed quality evaluation.Metaanalysis was carried out with RevMan 5.3 software,risk ratio (RR) and its 95% confidence interval (CI) were pooled to estimate the enumeration data,and GRADE 3.6.1 software was used to rate the level of evidence.Results The results of meta-analysis and GRADE rating system which included 4 studies showed that:compared with conventional resuscitation,hypotensive resuscitation was associated with lower total mortality [RR =0.77,95% CI:0.62-0.95,P =0.01;n =984,GRADE rating:moderate],and 24-hour mortality [RR =0.47,95% CI:0.24-0.91,P =0.03;n =281,GRADE rating:moderate],but the subgroup analysis of total mortality showed that there were no significant differences in mortality between the subgroup of blunt or penetrating trauma and the subgroup of penetrating trauma.Conclusions Hypotensive resuscitation reduced total mortality and 24-hour mortality,and the quality of the evidence was moderate.The future studies should do further research to explore the efficacy of hypotensive resuscitation for different types of trauma.

19.
Article in Chinese | WPRIM | ID: wpr-304861

ABSTRACT

In this research, a combined method of ligand-based pharmacophore (LBP), structure-based pharmacophore (SBP), and molecular docking was applied for virtual screening potential ATP-sensitive potassium channel (KATP) openers from Chinese herbs. LBP models were generated by 3D-QSAR pharmacophore(hypogen) program, based on the training set composed of 48 KATP agonists. The best LBP model consisted of one hydrogen-bond acceptor, one hydrogen-bond donor, one hydrophobic feature, one aromatic ring and five excluded volumes. Besides, the correlation coefficient of training set and test set, N, and CAI value of the model were 0.876 4, 0.705 8, 3.304, and 2.616 respectively. Meanwhile, SBP models were also generated based on a 3D structure of KATP (PMID: PM0079770). The best SBP model consisted of six hydrogen-bond acceptors, eight hydrogen-bond donors, seven hydrophobic features and eighteen excluded volumes. The corresponding N and CAI value were 2.200 and 2.017. Then, the best LBP model and SBP model were applied to identify potential KATP openers from Traditional Chinese Medicine Database(TCMD), respectively. 349 hits were obtained after analyzed by drug-likeness rules. Moreover, 12 compounds with high docking scores were reserved after molecular docking evaluation. Interestingly, part of the results had been verified as hypotensive active ingredients by literatures. Therefore, this study uncovers a specific target effect contained in TCMD, and provides candidates for new KATP openers' research.

20.
Article in Chinese | WPRIM | ID: wpr-465522

ABSTRACT

ObjectiveTo establish a surface location method and acupuncture manipulation standard by dissecting the local structure of rat point Renying(ST9)and make a validation through the hypotensive effect of acupuncture.MethodA Wistar rat was sacrificed and fixed by cryogenic freezing. According the anatomical characteristics of human point Renying, cervical point Renying region was dissected layer by layer, and the common carotid artery, the internal carotid artery and the external carotid artery were bluntly separated. Location and measurement were made using vernier calipers and digital photographs were taken. Body surface location and acupuncture point depth were statistically analyzed to establish acupuncture manipulation standards. Point Renying and a non-acupoint were separately acupunctured to treat rat spontaneous hypertension. The changing tendency of blood pressure was statistically analyzed after four weeks.ResultAccording to the 95% reference value range, the surface location of rat point Renying was determined to be (8±0.3)mm below a line connecting bilateral mandibular angles and (5.5±0.4)mm lateral to the anterior midline, one on each side. Acupuncture manipulation standards were perpendicular insertion (5.5±0.4)mm and cautious lifting and thrusting to avoid injuring the artery. Acupuncture at point Renying had a marked hypotensive effect as compared with a non-acupoint (P<0.05).ConclusionThe surface location of rat point Renying is reliable and can be applied to animal experimental study.

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