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1.
Article in Chinese | WPRIM | ID: wpr-906517

ABSTRACT

Objective:To discuss the efficacy of Bushen Huoxue decoction for recovery in patients with intra uterine adhesions (IUA) after trans cervical resection adhesions (TCRA) operation, and to investigate its effect on fibrosis factor. Method:The 110 patients were randomly divided into two groups by random number table (55 cases for control group and 55 cases for observation group). The patients in both groups got TCRA, and after the operation, they got estradiol valerate tablets+progesterone capsules. The patients in control group additionally got Jinfengwan before meals, 10 g/time, 2 times/day. Patients in observation additionally got syndrome differentiation and treatment by Bushen Huoxuetang, 1 dose/day. The treatment course was 3 months in both groups, and 6 months' follow-up was recorded. Before and after treatment, menstrual volume, period and cycle were recorded. During the follow-up, pregnancy, ectopic pregnancy and abortion were also recorded. Endoscopy and vagina color Doppler ultrasound were conducted to detect endometrial thickness, uterine volume, resistance index (RI), pulsation index (PI) and blood flow index (FI). Scores of IUA and syndrome of kidney deficiency and blood stasis were graded. At the 6<sup>th</sup> months after treatment, rate of intrauterine re-adhesion was recorded. Levels of transforming growth factor-<italic>β</italic><sub>1 </sub>(TGF-<italic>β</italic><sub>1</sub>), connective tissue growth factor (CTGF), matrix metalloproteinase inhibitor-1 (TIMP-1), platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-1) and matrix metalloproteinase-9 (MMP-9) were detected, and safety was evaluated. Result:Total effective rate of clinical efficacy was 96.36% (53/55) in observation group, higher than 83.64% (46/55) in control group (<italic>χ</italic><sup>2</sup>=4.959, <italic>P</italic><0.05). Recovery rate of menstrual volume, period and cycle were 92.73% (51/55), 90.91% (50/55), and 94.55% (52/55) in observation group, higher than 72.73% (40/55), 76.36% (42/55), and 76.36% (42/55) in control group(<italic>χ</italic><sup>2</sup>=7.698,<italic>χ</italic><sup>2</sup>=4.245,<italic>χ</italic><sup>2</sup>=7.313,<italic>P</italic><0.05, <italic>P</italic><0.01). During the follow-up, rate of intrauterine re-adhesions was 23.64% (13/55) in observation group, lower than 43.64% (24/55) in control group (<italic>χ</italic><sup>2</sup>=4.927,<italic>P</italic><0.05). Pregnancy rate was 45.45% (25/55), higher than 25.45% (14/55) in control group(<italic>χ</italic><sup>2</sup>=4.807,<italic>P</italic><0.05). Score of syndrome of kidney deficiency and blood stasis and IUA scores in observation group were lower than those in control group (<italic>P</italic><0.01). Endometrial thickness, uterine volume, and FI were higher than those in control group (<italic>P</italic><0.01). Levels of RI, PI, TGF-<italic>β</italic><sub>1</sub>, CTGF, PDGF, IGF-1 and TIMP-1 were lower than those in control group (<italic>P</italic><0.01), while level of MMP-9 was higher than that in control group (<italic>P</italic><0.01). No adverse reactions related to traditional Chinese medicine were found. Conclusion:Bushen Huoxue decoction can promote the recovery of menstruation, increase the thickness of endometrium, improve the blood circulation of uterus, regulate the expression of fibrogenic factors<italic> in vivo</italic>, prevent and treat intrauterine adhesions, reduce the rate of intrauterine re-adhesions, and improve the rate of pregnancy, with a good comprehensive effect and high safety for clinical use.

2.
Article in Chinese | WPRIM | ID: wpr-906430

ABSTRACT

Objective:To observe the clinical efficacy of Yishen Tongluofang in treating oligosperm type male infertility with kidney deficiency and blood stasis syndrome and explore its effect on serum sex hormones and seminal plasma microenviro. Method:One hundred and four patients were randomly divided into observation group and control group with 52 cases each. Patients in control group took compound Xuanju capsules orally, 3 capsules/time, 3 times/day. Patients in observation group took Yishen Tongluofang, 1 dose/day. Treatment courses continued three months and followed up for three months in both groups. The pregnancy situations of spouses within six months were recorded. Examination of semen parameters before and after treatment and score of kidney deficiency and blood stasis syndrome were conducted. The levels of seminal plasma zinc, fructose, elastase, acid phosphatase and <italic>α</italic>-glucosidase, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRT) and testosterone (T) were detected before and after treatment. Result:During the observation period of six months, the pregnancy rate of spouses in the observation group was 22.00%, higher than 10.00% in the control group, but the difference was not statistically significant (<italic>χ</italic><sup>2</sup>=2.678,<italic>P</italic>>0.05). The clinical efficacy in the observation group was better than that of the control group (<italic>Z</italic>=2.326,<italic>P</italic><0.01). Sperm concentration, sperm motility, sperm motility, normal morphological sperm and linear movement speed of the observation group were all superior to those of the control group<italic> </italic>(<italic>P</italic><0.01). The levels of zinc and fructose in seminal plasma of the observation group were higher than those of the control group (<italic>P</italic><0.01), and the score of kidney deficiency and blood stasis syndrome was lower than that of the control group (<italic>P</italic><0.01). Serum FSH, LH and PRT levels in the observation group were lower than those in the control group (<italic>P</italic><0.01), and the T level was higher than that in the control group (<italic>P</italic><0.01). The seminal plasma elastase of the observation group was lower than that of the control group, while the levels of acid phosphatase and <italic>α</italic>-glucosidase were higher than those of the control group (<italic>P</italic><0.01). Conclusion:Yishen Tongluofang can significantly improve sperm parameters, regulate the level of sex hormones and seminal plasma environment in patients with oligosperm type male infertility, and improve the tendency of spouse pregnancy. Its clinical efficacy is better,so it is worthy of further research and application.

3.
Article in Chinese | WPRIM | ID: wpr-710153

ABSTRACT

AIM To investigate the clinical therapeutic effects of modified Shenqi Decoction in treating earlyto-middle stage nontraumatic osteonecrosis of femoral head (NONFH) due to kindey deficiency and blood stasis syndrome,and its impacts on serum TNF-α,CRP,NO,SOD as well.METHODS Totally,104 cases of eligible patients were randomly divided into traditional Chinese medicine (TCM) group,chemical medicine group and TCM combined with chemical medicine group,38 cases in each group,for a three-month course of treatment.The TCM group was dosed with modified Shenqi Decoction,the chemical medicine group with sodium alendronate,and the TCM combined with chemical medicine group with both modified Shenqi Decoction and sodium alendronate.The Harris SF-36,SF-36,FPS-R and TCM symptoms assessment were applied to estimating the efficacy of three groups before and after the treatment.So were the check of the serum TNF-α,CRP,NO,SOD levels,and rates of efficiency after treatments and six-month follow-ups,and incidence of adverse reactions during the treatment among all the three groups.RESULTS The efficiency rates were found to be in the following sequence:the chemical medicine group (76.5%) < the TCM group (83.8%) < the TCM combined with chemical medicine group (97.2%) (P < 0.05).The TCM combined with chemical medicine group had its post-treatment scores of Harris SF-36,FPS-R,FPS-R,TCM symptom and the serum TNF-α,CRP,NO,SOD levels significantly improved as compared with other two groups (P < 0.05).And the revealed incidence of adverse reactions was ranked as the TCM group (2.7%) < the TCM combined with chemical group (30.6%) < the chemical medicine group (70.6%) (P < 0.05).CONCLUSION Modified Shenqi Decoction is superior to sodium alendronate in the treatment of NONFH due to kidney deficiency and blood stasis syndrome for its better performance in both the efficacy and the incidence of adverse reactions,and its synergistic effect with use of sodium alendronate may associate with its capability in offsetting the adverse reactions of sodium alendronate.

4.
Article in Chinese | WPRIM | ID: wpr-614190

ABSTRACT

Objective To observe the efficacy and safety of Bushen Huoxue Prescription in the treatment of kidney deficiency and blood stasis type primary osteoporosis. Methods Totally 50 patients with kidney deficiency and blood stasis type primary osteoporosis were collected. They were given Bushen Huoxue Prescription granules twice a day, taking with water, for 12 weeks. Before and after treatment, the femoral neck, Ward's area, L1–4 bone mineral density (BMD) were measured. VAS and TCM syndrome integrals were evaluated before and 4, 8 and 12 week of treatment. The level of serum osteocalcin (OC), β-C-terminal telopeptides of type I collagen (β-CTX) and osteoprotegerin (OPG) were detected before and after treatment. Hematuria routine, liver and kidney function were under safety testing before and after treatment. Results Bushen Huoxue Prescription could significantly increase BMD of left femoral neck and Ward's triangle (P=0.001, P=0.044). L1–4 BMD increased, without statistical significance (P=0.172). The total effective rate was 60.870% (28/46) for L1–4 and left femoral neck and 58.696% (27/46) for Ward's triangle. The VAS and TCM syndrome integral decreased significantly 4 weeks treatment compared with that before the treatment (P<0.01), and the scores decreased significantly with the prolongation of treatment time (F=159.690, P<0.001; F=163.970, P<0.001). After 12 weeks, treatment, the total effective rate for TCM syndromes was 78.26% (36/46). Serum levels of OC and β-CTX showed a tendency to increase, while serum levels of OPG showed a tendency to decrease, without statistical significance (P=0.087, P=0.091, P=0.419). There was no serious adverse reaction in hematuria routine and liver and kidney function. Conclusion Bushen Huoxue Prescription has obvious clinical efficacy for kidney deficiency and blood stasis type primary osteoporosis, which can improve the patients' BMD, improve bone metabolism, relive bone pain, with high level of safety.

5.
Article in Chinese | WPRIM | ID: wpr-667655

ABSTRACT

Objective To investigate the efficacy and safety of Bushen Huoxue Decoction in the treatment of carotid atherosclerotic plaque. Methods Totally 50 patients of carotid atherosclerotic plaque were collected to conduct health education. At the same time, they were given Bushen Huoxue Decoction, one dosage a day, twice a day, decoction, for 12 weeks. The correlation indexes of carotid artery before and after treatment were observed, and TCM syndrome integrals were evaluated before and after 4, 8 and 12 weeks treatment. FBG, TC, LDL-C, CRP HCY, IL-6, IGF-1, and OPG were detected before and after treatment. Hematuria routine, liver and renal function were monitored. Results After treatment, the Crouse score and the plaque grade score of carotid atherosclerotic plaque showed a tendency to decrease, without statistical significance (P=0.060, P=0.336). Carotid maximal plaque area and modified total score of carotid atherosclerotic plaque were significantly reduced compared with that before treatment (P<0.05). TCM syndrome integrals were significantly reduced compared with that before treatment (P<0.05), and the scores decreased significantly with the prolongation of treatment time. TCM syndrome integrals after 4, 8, and 12 weeks were significantly reduced compared with that before treatment (F=160.352, P<0.001). Total effective rate of treatment in the efficacy of TCM syndrome was 85.11% (40/47). Serum levels of FBG and TC decreased significantly after the treatment compared with that before the treatment, with statistical significance (P<0.05). Serum levels of LDL-C, HCY, CRP, IL-6, IGF-1, and OPG all showed a tendency to decrease, without statistical significance (P>0.05). No abnormality in hematuria routine, liver and renal function examinations were found during the research. Conclusion Bushen Huoxue Decoction has obvious clinical efficacy for carotid atherosclerotic plaque, which can improve clinical symptoms of patients, it also could stabilize and reduce plaque with high safety.

6.
Article in Chinese | WPRIM | ID: wpr-338254

ABSTRACT

Kidney deficiency and blood stasis is the main cause of ovulatory dysfunctional infertility. Kidney deficiency is the main pathological mechanism. Blood stasis is the main pathological manifestation, and it is an important factor throughout. Bushen Culuan Chongji is under the guidance of traditional Chinese medicine(TCM) theory, previous years of clinical experience, combined with the etiology and pathogenesis of anovulatory infertility and modern pharmacological research results, selected, not only maintains the TCM syndrome differentiation and different diseases features, but also reflects the superiority of the combination of disease. In the study of Bushen Culuan Chongji in the treatment of anovulatory infertility, there was no acute toxicity and no LD50 was detected. No adverse effects and side effects were found in the reproductive, genetic, toxicity, teratogenic, and perinatal tests in their high and low dose groups. In pharmacodynamics experiments, it can promote the development and maturation of follicles and the formation of corpus luteum in rats. Taking the kidney deficiency and blood stasis syndrome as the breakthrough point, systematically study the efficacy, safety and mechanism of six ovulatory dysfunctional infertility diseases, including abnormal uterine bleeding-ovulatory disorders, polycystic ovary syndrome, high prolactin, luteinized unruptured follicle syndrome, luteal phase defect and diminished ovarian reserve/premature ovarian failure. It verified the contribution degree of reinforcing kidney and resolving stasis TCM, reflected the characteristics of combination between disease differentiation and syndrome differentiation, interpreted the treatment principles of treating different diseases with the same method, and provided scientific basis for clinical treatment.

7.
Article in Chinese | WPRIM | ID: wpr-462565

ABSTRACT

Objective To observe the clinical efficacy of Bushen Huoxue Decoction on elderly hypertension of kidney deficiency and blood stasis syndrome. Methods Totally 106 patients with elderly hypertension of kidney deficiency and blood stasis syndrome were divided into control group (53 cases) and treatment group (53 cases), according to random number table method. The control group was treated with routine western medicine, while the treatment group was given Bushen Huoxue Decoction along with western medicine treatment for 8 weeks. The changes of TCM syndrome, blood pressure, TG, TC, LDL-C, HDL-C, high sensitivity C reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) before and after treatment of the two groups were observed. Results The total effective rate of anti-hypertension was 94.33%(50/53) in the treatment group and was 77.35% (41/53) in the control group. The total effective rate of clinical symptoms was 96.22%(51/53) in the treatment group and was 79.24%(42/53) in the control group. After treatment, TG, TC, LDL-C, HDL-C, hs-CRP, IL-6, and TNF-α were improved significantly in the treatment group, with statistical significance compared with the control group (P<0.05). Conclusion Bushen Huoxue Decoction combined with western medicine achieves the good efficacy on elderly hypertension of kidney deficiency and blood stasis syndrome.

8.
Chinese Pharmaceutical Journal ; (24): 436-441, 2013.
Article in Chinese | WPRIM | ID: wpr-860442

ABSTRACT

OBJECTIVE: To study the effect of Kelong capsule on kidney deficiency and blood stasis rats prostatic hyperplasia and the prostatic hyperplasia related protein and cell factors. METHODS: Establish rat model for benign prostate hyperplasia with kidney deficiency and blood stasis syndrome and observe rats prostate and prostate correlation factors of blank control (A), model (B), the finateride (C), high, medium and low dose kelong (D, E, F). RESULTS: (1) The prostate wet weight and prostate index of rats in groups C-F were significantly lower than that in group B (P<0.05). (2) Compared with group B, Ki-67integral optical density in prostate tissue obviously decreased in group C, E, F (P<0.01), group D has no significant difference (P≤0.05). (3) Compared with group B, bFGF integral optical density in prostate tissue in group C, D, E and F decreased obviously (P<0.01) but compared with group C, those in group D, E and F were significantly increased (P<0.05). (4) Compared with group B, VEGF mRNA expression in prostate tissue in group C, D, E and F were reduced (P<0.05). but those in group D, E and F were more than in C group (P<0.05). CONCLUSION: Kelong capsule can dose-dependently inhibit prostatic hyperplasia in rats possibly through the inhibition of prostatic hyperplasia related protein and cell factors.

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