ABSTRACT
@#AIM: To study the serum lipids changes and lipid ratiosin patients with pterygium. <p>METHODS: Based on the retrospective study, 500 pterygium patients who were admitted to the department of ophthalmology and had finished physical examination in the physical examination center of Zhongnan Hospital of Wuhan University from January 2016 to February 2019 were included. As well as 500 people who underwent health examination and were matched in age and gender at the same time. The serum levels of triglycerides(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), and high-density lipoprotein cholesterol(HDL-C), were measured by professionals in hospital. TG/HDL, TC/HDL, LDL/HDL were calculated and analyzed statistically between the two groups.<p>RESULTS: Among the 500 patients with pterygium, abnormal serum lipid content accounted for 68.2%(341/500). TG, TC, LDL-C level and TG/HDL, TC/HDL and LDL/HDL were higher in pterygium group than control, and with statistically significant differences(<i>P</i><0.001). While serum HDL level was lower than that in control group and with no statistically significant differences(<i>P</i>>0.05). According to Logistic analysis, TG(<i>OR</i>=4.132), TC(<i>OR</i>=2.194), TG/HDL(<i>OR</i>=2.184)and TC/HDL(<i>OR</i>=2.007)were risk factors for pterygium(<i>P</i><0.05). <p>CONCLUSION: Dyslipidemia is an important factor in the pathogenesis of pterygium. It is very necessary for the patients with pterygium to control the level of blood lipids because it has important clinical significance for the attack and treatment of them.
ABSTRACT
Atherosclerosis is the pathological basis of coronary heart disease, ischemic stroke and peripheral vascular disease (atherosclerotic cardiovascular disease, ASCVD). Blood cholesterol levels are closely related to ASCVD. The preva-lence and mortality of cardiovascular disease are increasing in China, which is a difficult task. The lipid management goal is to reduce the risk of ASCVD. Atherogenic cholesterol-non-high-density lipoprotein cholesterol (non-HDL-C) and low-den-sity lipoprotein cholesterol (LDL-C) are used as the primary targets of therapy, which may be more appropriate for lipid man-agement setting dislipidaemia value applied to Chinese clinic. Lifestyle intervention is the basis of lipid management. Effec-tive prevention and treatment of ASCVD require the comprehensive intervention of risk factors.