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1.
Article in English | WPRIM | ID: wpr-922536

ABSTRACT

BACKGROUND@#Functional constipation (FC) is one of the most prevalent functional gastrointestinal disorders. Dissatisfaction with medications prescribed to treat FC may lead patients to seek alternative treatments. Numerous systematic reviews (SRs) examining the use of acupuncture to treat FC have reported inconsistent results, and the quality of these studies has not been fully evaluated.@*OBJECTIVE@#In this overview, we evaluated and summarized clinical evidence on the effectiveness and safety of acupuncture for treating FC and evaluated the quality and bias of the SRs we reviewed.@*SEARCH STRATEGY@#The search strategy was structured by medical subject headings and search terms such as "acupuncture therapy" and "functional constipation." Electronic searches were conducted in eight databases from their inception to September 2020.@*INCLUSION CRITERIA@#SRs that investigated the effectiveness and safety of acupuncture for managing FC were included.@*DATA EXTRACTION AND ANALYSIS@#Two authors independently extracted information and appraised the methodology, reporting accuracy, quality of evidence, and risk of bias using the following critical appraisal tools: (1) A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2); (2) Risk of Bias in Systematic Reviews (ROBIS); (3) Preferred Reporting Items for Systematic Reviews and Meta-analyses for Acupuncture (PRISMA-A); and (4) the Grading of Recommendations, Assessment, Development and Evaluations (GRADE). A κ index was used to score the level of agreement between the 2 reviewers.@*RESULTS@#Thirteen SRs that examined the clinical utility of acupuncture for treating FC were identified. Using the AMSTAR 2 tool, we rated 92.3% (12/13) of the SRs as "critically low" confidence and one study as "low" confidence. Using the ROBIS criteria, 38.5% (5/13) of the SRs were considered to have "low risk" of bias. Based on PRISMA-A, 76.9% (10/13) of the SRs had over 70% compliance with reporting standards. The inter-rater agreement was good for AMSTAR 2, ROBIS, and PRISMA-A. Using the GRADE tool, we classified 22.5% (9/40) of the measured outcomes as "moderate" quality, 57.5% (23/40) as "low" quality, and 20.0% (8/40) as "very low" quality. The inter-rater agreement was moderate when using GRADE. Descriptive analyses indicated that acupuncture was more efficacious than sham acupuncture for improving weekly complete spontaneous bowel movements (CSBMs) and for raising the Bristol Stool Form Scale (BSFS) score. Acupuncture appeared to be superior to anti-constipation drugs for improving weekly spontaneous bowel movements, the total effective rate, and the Patient Assessment of Constipation Quality of Life score. Although ten SRs mentioned the occurrence of adverse events, serious adverse events were not associated with acupuncture treatment.@*CONCLUSION@#Acupuncture may be more efficacious than sham acupuncture for improving CSBMs and BSFS scores and may be superior to anti-constipation drugs for improving bowel movement frequency, as well as quality of life. Limitations to current studies and inconsistent evidence suggest a need for more rigorous and methodologically sound SRs to draw definitive conclusions.@*SYSTEMATIC REVIEW REGISTRATION@#PROSPERO CRD42020189173.


Subject(s)
Acupuncture Therapy , Constipation/therapy , Humans , Quality of Life , Systematic Reviews as Topic
2.
Rev. bras. ginecol. obstet ; 43(12): 919-925, Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1357095

ABSTRACT

Abstract Objective Endometriosis is a hormone-dependent chronic inflammatory disease with symptoms such as pelvic pain, which affect the physical, emotional, and social health of women in reproductive age. The current overview article aims to explore the effect of complementary medicine on the treatment or in mitigating the risk of endometriosis. Methods This is an overview article done in Iran. Two separate researchers systematically searched 3 databases (Medline, Scopus, and Cochrane Central Register Trials) until September 2020. The methodological quality of each study was assessed using the assessment of multiple systematic reviews (AMSTAR) tool. Results The results of two reviews suggested that physical activity, tobacco smoking, diet, coffee and caffeine intake had no effect on mitigating the risk of endometriosis or improving its treatment, but acupuncture successfully reduced pain and related marker (serum CA-125) levels. Conclusion As endometriosis is an annoying disease with many complications and is hard to diagnose and treat, related studies in complementary medicine can help patients with endometriosis. Based on the relevant literature review, among the complementary medicine available for the treatment or to mitigate the risk of endometriosis, only acupuncture seems to alleviate the pain of endometriosis.


Resumo Objetivo A endometriose é uma doença inflamatória crônica hormono-dependente com sintomas como dores pélvicas, que afetam a saúde física, emocional e social de mulheres em idade reprodutiva. O presente artigo de visão geral tem como objetivo explorar o efeito da medicina complementar no tratamento ou na mitigação do risco de endometriose. Métodos Trata-se de um artigo de visão geral feito no Irã. Dois pesquisadores separados pesquisaram sistematicamente 3 bancos de dados (Medline, Scopus e Cochrane Central Register Trials) até setembro de 2020. A qualidade metodológica de cada estudo foi avaliada usando a ferramenta avaliação da qualidade dos relatos de revisão sistemática (AMSTAR, na sigla em inglês). Resultados Os resultados de duas revisões sugeriram que atividade física, tabagismo, dieta, consumo de café e cafeína não tiveram efeito na redução do risco de endometriose ou na melhoria do tratamento, mas a acupuntura reduziu com sucesso a dor e os níveis de marcadores relacionados (CA-125 sérico). Conclusão Como a endometriose é uma doença incômoda, com muitas complicações e de difícil diagnóstico e tratamento, estudos relacionados em medicina complementar podem ajudar pacientes com endometriose. Com base na revisão da literatura relevante, entre os medicamentos complementares disponíveis para o tratamento ou risco de endometriose, apenas a acupuntura parece aliviar a dor da endometriose.


Subject(s)
Humans , Female , Complementary Therapies , Endometriosis/prevention & control , Exercise , Pelvic Pain/etiology , Pelvic Pain/prevention & control , Iran
3.
Article in Chinese | WPRIM | ID: wpr-905063

ABSTRACT

Alzheimer's disease (AD) is a neurodegenerative disease that leads to progressive memory and cognitive impairment and behavioral disorders, which has seriously threatened the health of the majority of middle-aged and elderly people. Traditional Chinese medicine (TCM) believes that the basic pathogenesis of AD is deficiency of kidney-essence, blood stasis and meridian stagnation. In recent years, many studies have shown that TCM has obvious value and advantages in the prevention and treatment of AD by multi-target mechanism. Therefore, it is of great significance to screen out effective anti-AD drugs from TCM compound prescriptions. Huangjingwan, also known as Jiuzhuan Huangjingwan, has the effects in tonifying kidney-essence, activating blood and removing stasis, with a potential effect in preventing AD. In this article, the feasibility of Huangjingwan in the prevention and treatment of AD was analyzed and discussed from the perspective of TCM theory, the study results of Huangjingwan in the prevention and treatment of AD were summarized, and the mechanism of its action was analyzed from the perspective of pharmacological mechanism. Based on TCM theory, Huangjingwan has the effect of anti-AD. According to relevant findings, Huangjingwan has many targets, such as anti-oxidation, anti-inflammatory, decrease of the level of oxidative stress in brain, activation of Wnt/β-catenin signal transduction in brain, regulation of glycogen synthase kinase-3β (GSK-3β), protein phosphatase 2A (PP2A) activity balance, reduction of amyloid β (Aβ) content and tau protein hyperphosphorylation in brain, so as to exert effects in improving neurological symptoms and increasing learning and memory ability, with an anti-AD neuroprotective function. This will provide new ideas for in-depth studies and clinical applications of Huangjingwan against AD.

4.
Journal of Integrative Medicine ; (12): 503-514, 2021.
Article in English | WPRIM | ID: wpr-922524

ABSTRACT

BACKGROUND@#Influenza places a heavy public health burden in numerous countries every year. In addition to vaccines, there are some interventions that are effective in preventing influenza.@*OBJECTIVE@#This overview of systematic reviews (SRs) aimed to evaluate the efficacy and safety of interventions for influenza prevention.@*SEARCH STRATEGY@#We searched the Cochrane Database of Systematic Reviews, 2020, Issue 1 for relevant Cochrane SRs using the keywords "common cold," "influenza," and "flu."@*INCLUSION CRITERIA@#Cochrane SRs that investigated the prevention of influenza were included. Participants included the general population without influenza or influenza-like symptoms, who were treated with preventative interventions and compared to individuals receiving no treatment or placebo.@*DATA EXTRACTION AND ANALYSIS@#Two reviewers independently screened citations against pre-defined inclusion criteria and extracted data. The methodological quality of these SRs was evaluated using the Assessing the Methodological Quality of Systematic Reviews-II (AMSTAR-II) guidelines. The primary outcome of our analysis was the incidence of influenza, and the secondary outcomes were the incidence of influenza-like illness and hospitalization. In addition to the narrative summary of SR findings, we also pooled data from homogeneous trials among these SRs and produced evidence mapping. We conducted a network meta-analysis to compare the effect across interventions and used the Cochrane approach to grading of recommendations, assessment, development, and evaluation (GRADE) to assess the quality of evidence.@*RESULTS@#Eleven Cochrane SRs were included, covering five medications, eleven vaccinations and four complementary therapies. Among these SRs, 73% scored "high" quality on AMSTAR-II rating. We found that eight interventions, including amantadine, garlic, and six different vaccines, were beneficial for reducing the incidence of influenza compared to placebo, while oseltamivir, zanamivir, Ganmao capsule, Echinacea, and another three types of vaccine were probably beneficial. Ganmao capsule ranked highest for influenza prevention in the network meta-analysis, followed by amantadine, garlic, and vaccines of all types. Monovalent inactivated parenteral vaccine was found to be beneficial in reducing the incidence of influenza-like illness. None of the interventions reduced the hospitalization rate.@*CONCLUSION@#High-quality evidence showed that garlic or vaccine had advantages in preventing influenza, and that vitamin C is not effective. The effect of other interventions needs to be further verified with high-quality evidence.


Subject(s)
Bayes Theorem , Humans , Influenza, Human/prevention & control , Network Meta-Analysis , Systematic Reviews as Topic , Vitamins
5.
Article in English | WPRIM | ID: wpr-922099

ABSTRACT

OBJECTIVE@#To evaluate the quality of the existing studies and summarize evidence of important outcomes of meta-analyses/systematic reviews (MAs/SRs) of CFS.@*METHODS@#Potentially eligible studies were searched in the following electronic databases from inception to 1 September, 2019: Chinese Biomedical Literature Database (CBM), China Science and Technology Journal Database (VIP), China National Knowledge Infrastructure (CNKI), WanFang Database (WF), Web of Science, Embase, PubMed and Cochrane Library. Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of evidence. The methodological quality of the literature was evaluated by A Measure Tool to Assess Systematic Reviews-2 (AMSTAR-2) and the quality of the report was assessed by Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). The intra-class correlation coefficient was used to assess the consistency of the reviewers, with an overall intraclass correlation coefficient score of 0.967.@*RESULTS@#Ten MAs/SRs were included. The overall conclusions were that acupuncture had good safety and efficacy in the treatment of CFS, but some of these results were contradictory. The GRADE indicated that out of the 17 outcomes, high-quality evidence was provided in 0 (0%), moderate in 3 (17.65%), low in 10 (58.82%), and very low in 4 (23.53%). The results of AMSTAR-2 showed that the methodological quality of all included studies was critically low. The PRISMA statement revealed that 8 articles (80%) were in line with 20 of the 27-item checklist, and 2 articles (20%) matched with 10-19 of the 27 items.@*CONCLUSION@#We found that acupuncture on treating CFS has the advantage for efficacy and safety, but the quality of SRs/MAs of acupuncture for CFS need to be improved.


Subject(s)
Acupuncture Therapy , China , Fatigue Syndrome, Chronic/therapy , Humans , Research Report
6.
Article in Chinese | WPRIM | ID: wpr-921791

ABSTRACT

Under the background of the Belt and Road Initiative, the exchange of traditional medicine has become inevitable. China and Thailand are amicable neighbors, and the cooperation between the two countries in the field of traditional medicine has become increasingly close in recent years. Nevertheless, on account of the differences in culture, region, politics, economy and so on, the two countries have common features and unique characteristics in the theoretical system of traditional medicine, quality standard control of medicinal materials, research and development and use of medicinal materials. This paper summarizes the similarities and differences as well as the development opportunities of traditional medicine between China and Thailand. The specific content involves the development history, resources, and use of medicinal resources in Thailand, the main achievements and existing problems of modern research of Thai medicine, the spread and development of Chinese medicine in Thailand, and the spread and development of Thai medicine in China. Furthermore, the paper outlines the recent situation of traditional medicine interflow and cooperation between the two countries, and predicts the prospects for cooperation and development of traditional medicine between China and Thailand in the context of the Belt and Road Initiative, especially in the joint research and development and the improvement of quality standards of important medicinal plant varieties commonly used by the two countries and circulated across the border. Through the exchange and mutual learning, we can step up the traditional medicine cooperation between China and Thailand, which will provide advantageous conditions for the safety of medicine use as well as political and social stability between the two countries.


Subject(s)
China , Medicine, Chinese Traditional , Medicine, Traditional , Plants, Medicinal , Research , Thailand
7.
Article in Chinese | WPRIM | ID: wpr-921650

ABSTRACT

To evaluate the efficacy and safety of Kuntai Capsules in the treatment of perimenopausal syndrome. Systematic reviews on Kuntai Capsules in the treatment of perimenopausal syndrome were retrieved from Chinese and English databases from database establishment to August 31, 2020. AMSTER-2 scale, GRADE scale and ROBIS tools were used respectively to evaluate the methodological quality, evidence quality level and bias risk of the finally included systematic reviews. A total of 6 systematic reviews with 28 outcome indicators were included. The results of AMSTER-2 methodological quality assessment showed that one of the six systematic reviews was of low quality, and the other five were of extremely low quality. GRADE scale showed that 28 clinical outcome indicators were evaluated, three of which were intermediate-level ones, and the rest were low-level or very low-level ones. Two evidences of the three intermediate evidences were total efficiency, and the other intermediate evidence was Kupperman score. ROBIS bias risk assessment showed all the included studies were of high risk. The results showed that, Kuntai Capsules were effective in the treatment of perimenopausal symptoms, such as hot flashes and sweating. The improvement of E_2 level was not as good as that in the menopause hormone therapy group, but the incidence of adverse reactions was lower than that in the menopause hormone therapy group. However, the quality of evidence needs to be improved due to the low quality of methodology and high risk of bias. It is suggested that systematic review and reasonable design should be carried out in the future, and attention should be paid to the registration of research schemes. In addition, the research reports shall be prepared according to PRISMA statement.


Subject(s)
Drugs, Chinese Herbal , Female , Hormone Replacement Therapy , Humans , Perimenopause , Syndrome , Systematic Reviews as Topic
8.
Article in Chinese | WPRIM | ID: wpr-888167

ABSTRACT

To overview of systematic reviews/Meta-analysis of Xingnaojing Injection(XNJ) in the treatment of intracerebral hemorrhage(ICH). The systematic reviews concerning XNJ in the treatment of ICH were retrieved from four Chinese databases, four English databases, Chinese Clinical Trial Registry and ClinicalTrail.gov, with the retrieval time set from their inception to September 2020. Following the independent screening and data extraction by two researchers, a measurement tool to assess systematic evaluation 2(AMSTAR 2) and grades of recommendation, assessment, development and evaluation(GRADE) system were used to evaluate the metho-dological, reporting and evidence qualities of the 10 included systematic reviews. The results showed that XNJ was superior to the wes-tern medicine or conventional treatment in improving the effective rate and National Institutes of Health stroke scale(NIHSS) score, Barthel index(BI), and Glasgow coma scale(GCS) score and Chinese stroke scale(CSS) score, and reducing the mortality and cerebral hematoma volume, without inducing obvious adverse reactions. In general, the methodological, reporting and evidence qualities of the 10 included systematic reviews were poor. The AMSTAR 2 scores showed that key items No. 2 and No. 16 failed to meet the stan-dard, resulting in poor methodological quality. There was only one outcome indicator graded by GRADE as intermediate quality, 43% indicators as low quality, 42% indicators as extremely low quality, and none as high quality. These available evidences have suggested that the methodological, reporting and evidence qualities of the systematic evaluation concerning XNJ for the treatment of ICH need to be improved. Most evidences support that XNJ was better than the western medicine or conventional treatment in the treatment of ICH, but the methodological quality and the reliability of outcome indicators in relevant systematic review were low. More high-quality studies are still required for further verification.


Subject(s)
Cerebral Hemorrhage/drug therapy , Drugs, Chinese Herbal , Humans , Meta-Analysis as Topic , Reproducibility of Results , Systematic Reviews as Topic , United States
9.
Article in Chinese | WPRIM | ID: wpr-888126

ABSTRACT

To summarize and evaluate the efficacy and safety of Shenmai Injection in the treatment of viral myocarditis, shock, pulmonary heart disease, coronary heart disease, neutropenia and tumor chemotherapy, so as to provide supportive evidences for clinical rational use of Shenmai Injection. By searching literatures about studies on the systematic reviews on Shenmai Injection in treatment of viral myocarditis, shock, pulmonary heart disease, coronary heart disease, neutropenia and tumor chemotherapy from the main Chinese and English databases. Primary efficacy and safety outcome measures were selected for comparative analysis and summary, and the appraisal tool of AMSTAR 2 was used to evaluate the included studies.A total of 36 systematic reviews(published from 2005 to 2020) were included, involving viral myocarditis, shock, pulmonary heart disease, malignant tumor and coronary heart disease. The number of cases included in each type of the above diseases was 3 840, 2 484, 12 702, 28 036 and 27 082, respectively. The comparison results showed that, Shenmai Injection combined with conventional/western medicine treatment groups had better efficacy than conventional/western medicine groups alone in the prevention and treatment of the above five diseases. The main adverse reactions of Shenmai Injection reported in the included studies were facial flushing, rash, palpitation, etc., but the incidence was low and the general symptoms were mild, so no special treatment was needed. Therefore, the application of Shenmai Injection on the basis of conventional treatment or western medicine treatment had better prevention and treatment efficacy of the diseases. It was suggested that more multi-center and larger sample-size randomized controlled trials should be carried out in the future, and the relevant reporting standards should be strictly followed in systematic reviews, so as to improve the scientificity and transparency of the study.


Subject(s)
Drug Combinations , Drugs, Chinese Herbal , Humans , Pulmonary Heart Disease , Systematic Reviews as Topic
10.
Article in Chinese | WPRIM | ID: wpr-888035

ABSTRACT

There have been many clinical trials, systematic reviews/Meta-analysis proving that Xingnaojing Injection has a good clinical efficacy in treatment of cerebral ischaemic stroke, but with fewer comprehensive descriptions. In this study, an overview of systematic reviews/Meta-analysis of Xingnaojing Injection in treating cerebral ischaemic stroke was performed to provide current situation of evidences and basis for clinical practice. CNKI, Wanfang, VIP, CBM, EMbase, PubMed, Cochrane Library, Web of Science were retrieved through computers. A total of 6 literatures were included in this study. By AMSTAR-2 checklist and GRADE, the quality of included systematic reviews and the efficacy of Xingnaojing Injection were evaluated. The results of AMSTAR-2 checklist showed an extremely low quality for all of the 6 systematic reviews. According to the results of GRADE evaluation, among 55 outcomes, there were 2 outcomes with a medium quality, 4 outcomes with a low quality and 49 outcomes with an extremely low quality. The 6 systematic reviews reached a consistent conclusion that Xingnaojing Injection was effective in the treatment of cerebral ischaemic stroke. This therapy could improve the total efficacy, neurological deficit scores, hemodynamic and hemodynamic parameters. However, the methodolo-gical quality of all literatures was extremely low. The evidence levels of outcomes were between extremely low to medium. The effectiveness of Xingnaojing Injection in the treatment of cerebral ischaemic stroke still needs to be further verified by more high-quality studies. In the future, relevant clinical studies and systematic reviews/Meta-analysis shall be carried out in a strict accordance with relevant regulations.


Subject(s)
Brain Ischemia/drug therapy , Drugs, Chinese Herbal , Humans , Ischemic Stroke , Stroke/drug therapy , Systematic Reviews as Topic
11.
Article in Chinese | WPRIM | ID: wpr-888034

ABSTRACT

To overview the systematic reviews of Panax notoginseng saponins in the treatment of acute cerebral infarction. CNKI, CBM, Wanfang, VIP, PubMed, Cochrane Library and EMbase databases were retrieved to collect the systematic reviews of the efficacy of P. notoginseng saponins in the treatment of acute cerebral infarction. The retrieval time was from the time of database establishment to January 2021. After two researchers independently screened out the literature and extracted the data, AMSTAR-2 scale was used to evaluate the methodological quality of the included systematic reviews, GRADE system was used to grade the quality of evidences of the outcome indicators, and the efficacy evaluation was summarized. A total of 5 systematic reviews were included. AMSTAR-2 evaluation results showed that 3 items were relatively complete, while 4 items had a poor overall quality. P. notoginseng saponins combined with conventional Western medicine therapy was superior to single conventional therapy in the recovery of neurological function, enhancement of the total effective rate in clinic, and improvement of activities of daily living. GRADE evaluation results showed that the quality of evidence was from low quality to very low quality. In conclusion, in the treatment of acute cerebral infarction, P. notoginseng saponins can improve the clinical efficacy, with a good safety but a not high methodological quality and a low evidence quality. It is suggested that high-quality clinical studies shall be further carried out to provide evidence-based basis for the application of P. notoginseng saponins in the treatment of acute cerebral infarction.


Subject(s)
Activities of Daily Living , Cerebral Infarction/drug therapy , Humans , Panax notoginseng , Saponins , Systematic Reviews as Topic
12.
Article in Chinese | WPRIM | ID: wpr-888025

ABSTRACT

This study aimed to analyze the methodological quality of systematic reviews of Shuxuening Injection and evaluate the efficacy and adverse reactions of Shuxuening Injection in the treatment of different diseases,in order to provide supportive evidence for clinical practice. Three Chinese databases and three English databases were retrieved to identify systematic reviews and Meta-analysis on the efficacy and safety of Shuxuening Injection in the treatment of diseases. The AMSTAR 2( a measurement tool to assess systematic reviews 2) tool was used to evaluate the methodological quality of the included systematic reviews,and tables were created to present the results of Meta-analyses. Twenty-four systematic reviews were included,all with very low methodological quality. Among the 16 AMSTAR-2 items,only 5 items had a compliance rate greater than 60. 0%,and 8 items had a compliance rate less than 50. 0%. For patients with cerebral infarction,Shuxuening Injection combined with conventional treatment was more effective than conventional treatment alone in terms of clinical efficiency and neurological deficit improvement. For patients with angina pectoris,Shuxuening Injection was superior to Danshen/Compound Danshen Injection in terms of the total effective rate of angina pectoris and total effective rate of ECG. The efficacy of Shuxuening Injection combined with conventional treatment is significantly better than conventional treatment.Shuxuening Injection( alone or combined with conventional treatments) was better than conventional treatments for cerebral hemorrhage,ischemic cerebrovascular disease,chronic pulmonary heart disease,vertigo and sudden deafness. Shuxuening Injection had better efficacy and lower incidence of adverse reactions,but the methodological quality of included systematic reviews was low. The results of this study still need to be verified by high-quality systematic reviews.


Subject(s)
Angina Pectoris/drug therapy , Drugs, Chinese Herbal , Humans , Injections , Salvia miltiorrhiza , Systematic Reviews as Topic
13.
Article in Chinese | WPRIM | ID: wpr-887995

ABSTRACT

Qingkailing Injection is one of the most commonly used traditional Chinese medicine injections with significant clinical application for the treatment of multiple diseases. This study aims to analyze the systematic reviews( SRs) of Qingkailing Injection,in order to provide reference for the clinical application of Qingkailing Injection and the development of relevant clinical practice guidelines. We searched CNKI,CBM,Wanfang,VIP,Pub Med,Cochrane Library and EMbase to collect SRs from the time of database establishment to August 2020. The eligible SRs were included according to the inclusion and exclusion criteria. AMSTAR 2 was used to assess the methodological quality. The diseases,drugs in combinations and results were extracted and analyzed. A total of 24 SRs were selected,including 10 for the treatment of acute cerebrovascular diseases,9 for respiratory infections,2 for viral hepatitis,1 for chronic obstructive pulmonary disease,and two for the adverse effects of Qingkailing Injection. Only three entries of AMSTAR 2 item were fully reported by over 70%,and the rest were reported by less than 70%,with no report about item 2,3 and 10. Twenty-nine outcome indicators were correlated with the included SRs,of which three mostly frequent outcomes were effectiveness,adverse reaction,and neurological deficit scores,showing a good efficacy of Qingkailing Injection. The common severe adverse reaction was anaphylaxis,and mild adverse reactions were skin and mucous membrane reactions. The most frequently combined drug was antibiotics,mainly Penicillin and Penicillin+Pioneeromycin. The existing evidences showed that the methodological quality of SRs of Qingkailing Injection needed to be improved and Qingkailing Injection had an obvious efficacy. However,the selection of outcome indicators for clinical trials and SRs shall be standardized,and the reporting of basic information,such as drug combination,shall be strengthened to provide more powerful clinical services.


Subject(s)
Drugs, Chinese Herbal/adverse effects , Humans , Injections , Medicine, Chinese Traditional , Systematic Reviews as Topic
14.
Article in English | WPRIM | ID: wpr-880527

ABSTRACT

Cupping therapy has been accepted worldwide, and many studies have been conducted to reveal its curative effects and mechanisms. To comprehensively evaluate the effect of cupping therapy, database including China Network Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database VIP, Wan Fang Database, Chinese Biomedicine (CBM), PubMed and Web of Science were searched from 2009-2019. We summarized all the meta-analyses, randomized controlled trials, clinical trials and the mechanisms studies of cupping therapy in the previous 10 years, hoping to provide a reference for the clinical applications and studies.

15.
Article in Chinese | WPRIM | ID: wpr-879080

ABSTRACT

The relevant laws and regulations of drug clinical trials were introduced in this paper. It is pointed out that with drug re-gulatory laws and technological advances, clinical trials have become an important link in the development of new drugs of traditional Chinese medicines(TCM). Clinical trials of new drugs of TCM must comply with the requirement of "Good Clinical Practice for Trial on Medicinal Products". In view of the particularities of clinical trials of new drugs of TCM, China has established an ethical review system for clinical research in TCM and carried out ethical review and certification of TCM research. In order to guide the development of clinical trials of new drugs of TCM, relevant departments have promulgated a series of guidelines for clinical trials of it, and established a new review system and technical requirements for clinical trials. Since 1983, the "national clinical pharmacology base" has been established. At present, there are 96 drug clinical trial institutions and 32 phase I clinical research wards in TCM hospitals, which can meet the development of clinical trials of new drugs of TCM. In the long-term practice, the technical team has continued to grow and develop, the research experience and technical strength have been significantly improved, and a large number of experts have become the backbone of clinical research in Chinese medicine. It is pointed out that we should attach importance to risk and benefit assessment, human experience, select scientific, objective and appropriate effectiveness indexes, evaluate the efficacy of TCM syndromes, and encourage the use of electronic methods in clinical research of new drugs of TCM. Based on the analysis of clinical trials of TCM in recent five years, it is pointed out that the active degree of clinical trials of new drugs of TCM is not high, the innovation ability of it is insufficient and the ability and enthusiasm of all aspects need to be improved. It is of great significance to carry out clinical trials of new traditional Chinese medicines to upgrade the TCM industry and produce high-level evidence-based medicine evidences. The high quality development of TCM can be promoted by strengthening clinical trials of new drugs of TCM.


Subject(s)
China , Drugs, Chinese Herbal , Evidence-Based Medicine , Humans , Medicine, Chinese Traditional , Syndrome
16.
Article in Chinese | WPRIM | ID: wpr-877640

ABSTRACT

To introduce the historical origin of five element acupuncture and its development after returning to China, including the domestic inheritance mode, the clinical application, the establishment and operation of the Society of Five Element Acupuncture. This paper analyzed the challenges and opportunities faced by the development of five element acupuncture in China, which provides reference for the further development and expansion of the five element acupuncture.


Subject(s)
Acupuncture Therapy , China , Moxibustion
17.
China Pharmacy ; (12): 1362-1369, 2021.
Article in Chinese | WPRIM | ID: wpr-877259

ABSTRACT

OBJECTIVE:To overview t he s ystematic revi ews on JAK inhibitors in the treatment of rheumatoid arthritis (RA), and to provide evidence-based basis for the treatment of RA with these drugs. METHODS :The Cochrane Library ,PubMed, Embase,CNKI,Wanfang database and VIP were electronically searched to collect systematic reviews of JAK inhibitors in the treatment of RA from inception to Dec. 2020. After data extraction of included systematic review ,PRISMA statement ,AMSTAR2 scale and GRADE were used to evaluate the report quality ,methodological quality and the level of evidence for outcome indicators. RESULTS :A total of 12 systematic reviews involving 103 outcomes were included. PRISMA score of systematic reviews was between 17.5 and 22.5,and the reported quality defects were mainly reflected in scheme ,registration and other aspects. AMSTAR 2 evaluation results showed that there were 6 studies of low quality and 6 studies of very low quality ,without high-quality study and medium-quality study. GRADE assessment results for outcome indicators showed low to medium quality of evidence. The summary of evidence showed that compared to placebo ,JAK inhibitor could alleviate various indicators of RA ; compared to adalimumab ,the advantage was not obvious. JAK inhibitors did not increase the incidence of serious adverse events , but the systematic reviews were inconsistent in their effects on the incidence of total adverse events and liver injury. CONCLUSIONS:The efficacy of JAK inhibitors in the treatment of RA has certain advantages over placebo ,but more studies are needed to demonstrate the efficacy of JAK inhibitors in the treatment of RA compared to other drugs ;the advantage of safety is uncertain.

18.
Rev. bras. oftalmol ; 79(4): 236-241, July-Aug. 2020. tab, graf
Article in Portuguese | LILACS | ID: biblio-1137974

ABSTRACT

Resumo Objetivo: Avaliar as funções visuais dos idosos e a relação com a visão funcional e quedas. Métodos: Trata-se de um estudo de caráter transversal, realizado no município de Anápolis-GO com 46 idosos de idade ≥ a 60 anos, que cumpriram com todos os requisitos de inclusão. Estes foram avaliados quanto a visão funcional, funções visuais, funcionalidade global e autorrelato de quedas. Foi realizada análise estatística para verificar a correlação entre caidores e não caidores com as funções visuais e a visão funcional. Resultados: Houve uma correlação estatisticamente significativa entre o autorrelato de quedas e a estereopsia em idosos (p=0,05). Do mesmo modo, foi encontrado uma relação entre a visão funcional e a acuidade visual (p=0,023). O medo de novas quedas afetou a grande maioria dos idosos. Todavia, não houve correlação entre o autorrelato da visão e as quedas. Conclusão: Os resultados encontrados evidenciam que há correlação entre a estereopsia e a incidência de quedas, sugerindo que a visão de profundidade pode estar diretamente relacionada ao risco de quedas. Houve também, correlação entre a visão funcional e a acuidade visual, sugerindo que a capacidade do olho em distinguir detalhes, contornos e formas pode influenciar na qualidade das atividades que envolvem a visão.


Abstract Objective: To evaluate the visual functions of the elderly and the relationship with functional vision and falls. Methods: This is a cross-sectional study conducted in the municipality of Anápolis-GO with 46 elderly aged ≥ 60 years, who met all inclusion requirements. These were evaluated for functional vision, visual functions, overall functionality and self-reported falls. Statistical analysis was performed to verify the correlation between fallers and nonfallers with visual functions and functional vision. Results: There was a statistically significant correlation between self-reported falls and stereopsis in the elderly (p=0.05). Similarly, a relationship was found between functional vision and visual acuity (p=0.023). Fear of further falls affected the vast majority of the elderly. However, there was no correlation between self-reported vision and falls. Conclusion: The results show that there is a correlation between stereopsis and the incidence of falls, suggesting that deep vision may be directly related to the risk of falls. There was also a correlation between functional vision and visual acuity, suggesting that the ability of the eye to distinguish details, contours and shapes may influence the quality of activities involving vision.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Vision, Ocular , Accidental Falls , Visual Acuity , Depth Perception , Cross-Sectional Studies
19.
Article | IMSEAR | ID: sea-210228

ABSTRACT

The observed devastating effects of cholera disease, usually instil fear in the population whenever a cholera outbreak is reported in a particular region. Cholera outbreaks have become key indicators of socialdevelopment and this is a course for concern, considering the stigmatization that accompanies it. The pathogenic V. choleraeO1/O139 (the watery diarrheal causing agent), is shed in feces, survive as free-living bacteria in water and enters a new host system through the fecoral route. There is therefor, every reason to conclude that, water and food (especially raw or undercooked shellfish), that is contaminated with feces, is the most implicated cause of outbreaks and epidemics in the endemic areas of the world. Cholera mortality rate can rise to about 50% if severe cases are left untreated, but rapid fluid replacement therapy and supportive treatment can reduce the mortality to around 1%. Prompt intervention strategies are therefore necessary if cholera deaths must be prevented and controlled. These strategies may include; getting access to good potable and clean Water, Sanitation and Hygiene (WASH) facilities, good surveillance/community education systems, Oral Cholera Vaccine (OCV), Oral Rehydration Therapy (ORS), and prompt Antibiotic treatment. However, it has been noted that most of the regions that are prone to this flesh eating diarrheal disease, are usually, low resource communities with little or no available road networks and infrastructural facilities. These major challenges render most of these cholera prone areas of the world in accessible. To assist these areas (for example the Nigerian population), in the cholera prevention and preparedness, free-of-cost cholera Vaccines have been sent from thestockpile to the affected areas. Thanks to the concerted efforts made by Gavi, WHO, and partners, who with the NCDC and Borno State Ministry of Health, have made the vaccine available (to Nigeria) and other hot spots. Moreover, the basic requirements for effective surveillance systems, (effective targeted prevention and control) and early warning units, (detection of the index cases, initiation of outbreak control measures through an integrated approach, identification of high risk areas/vulnerable populations and immediate dissemination of information with stakeholders for timely action), have now put been established in most vulnerable location/cholera hot spots in the world. Better still, the Solidarités International (SIs) which was established in Nigeria since 2016, has intervened in cholera outbreaks especially that which occurred in the Borno state in 2017. They make available to susceptible areas, multi-sectorial, life-saving humanitarian aid, especially to the internally displaced and host communities, who suffer from disease outbreaks. Combining the efforts to improve on water quality, sanitation, hygiene (WASH) and OCVs (targeting the highest risk groups first), would help overcome resource/logistical limitations and enable higher coverage. In thisreview, we seek to look at the prevention and control strategies put in place by the Government and other bodies, to reduce cholera burden in Nigeria and other cholera hotspots, and the level of effectiveness towards achieving their goals.

20.
Bol. latinoam. Caribe plantas med. aromát ; 19(3): 247-288, mayo 2020. tab
Article in English | LILACS | ID: biblio-1116290

ABSTRACT

Selaginella is the only genus from Selaginellaceae, and it is considered a key factor in studying evolution. The family managed to survive the many biotic and abiotic pressures during the last 400 million years. The purpose of this review is to provide an up-to-date overview of Selaginella in order to recognize their potential and evaluate future research opportunities. Carbohydrates, pigments, steroids, phenolic derivatives, mainly flavonoids, and alkaloids are the main natural products in Selaginella. A wide spectrum of in vitro and in vivo pharmacological activities, some of them pointed out by folk medicine, has been reported. Future studies should afford valuable new data on better explore the biological potential of the flavonoid amentoflavone and their derivatives as chemical bioactive entities; develop studies about toxicity and, finally, concentrate efforts on elucidate mechanisms of action for biological properties already reported.


Selaginella es el único género de Selaginellaceae, y se considera un factor clave en el estudio de la evolución. La familia logró sobrevivir a las muchas presiones bióticas y abióticas durante los últimos 400 millones de años. El propósito de esta revisión es proporcionar un resumen actualizado de Selaginella para reconocer su potencial y evaluar futuras oportunidades de investigación. Los hidratos de carbono, pigmentos, esteroides, derivados fenólicos, principalmente flavonoides, y alcaloides son los principales productos naturales en Selaginella. Se ha informado un amplio espectro de actividades farmacológicas in vitro e in vivo, algunas de ellas señaladas por la medicina popular. Los estudios futuros deberían proporcionar datos nuevos y valiosos para explorar mejor el potencial biológico de la amentoflavona flavonoide y sus derivados como entidades bioactivas químicas; desarrollar estudios sobre la toxicidad y, finalmente, concentrar los esfuerzos en dilucidar los mecanismos de acción para las propiedades biológicas ya informadas.


Subject(s)
Plant Extracts/pharmacology , Plant Extracts/chemistry , Selaginellaceae/chemistry , Flavonoids/analysis , Alkaloids/analysis , Medicine, Traditional
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