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1.
China Pharmacy ; (12): 5091-5094, 2017.
Article in Chinese | WPRIM | ID: wpr-704482

ABSTRACT

OBJECTIVE:To investigate the effects of doxorubicin perfusion therapy on therapeutic efficacy and related indexes in patients with superficial bladder cancer underwent transurethral resection of bladder tumor (TURBT).METHODS:Medical records of 96 patients with superficial bladder cancer were analyzed retrospectively and divided into observation group and control group according to drug use,with 48 cases in each group.Observation group was given perfusion therapy of 0.9% Sodium choride solution 40 mL containing 20 mg doxorubicin 7 d after surgery.Control group was given TURBT combined with equal amount of 0.9% Sodium chloride solution.Both groups received treatment for consecutive 10 months,once a week in first 8 weeks,later once a month.The recurrence rate and disease progression of 2 groups were observed and compared,and the levels of sICAM-1 and sVCAM-1,the levels of tumor marker DKK1 and VEGF were observed before and after treatment.The occurrence of ADR was recorded.RESULTS:After 24 months of treatment,remission rate and control rate of observation group were significantly higher than control group,with statistical significance (P<0.05).There was no statistical significance in the progressive survival rate between 2 groups (P>0.05).Before treatment,there was no statistical significance in the levels of sICAM-1、sVCAM-1、DKK1 and VEGF between 2 groups (P>0.05);after treatment,the levels of sICAM-1、sVCAM-1 、DKK1 and VEGF in 2 groups were significantly lower than before treatment,the observation group was significantly lower than the control group,with statistical significance (P< 0.05).The recurrence rate,the incidence of frequent/urgent urination,hematuria and dysuria in observation group after treatment were significantly lower than control group,with statistical significance (P<0.05).CONCLUSIONS:For patients with superficial bladder cancer underwent TURBT,doxorubicin perfusion therapy can significantly reduce recurrence rate,relieve tumor deterioration and reduce tumor activity with good safety.

2.
Chinese Journal of Neuromedicine ; (12): 1034-1036, 2012.
Article in Chinese | WPRIM | ID: wpr-1033647

ABSTRACT

Objective To investigate the traumatic cerebral infarction treatment in patients with severe craniocerebral trauma combined with cerebral hernia after performing large decompressive craniectomy.Methods Thirty-two patients with cerebral infarction after receiving decompressive craniectomy for severe traumatic brain injury combined with brain hernia,admitted to our hospital from January 2009 to April 2012,were chosen in our study; these patients were given saline (35 mL) +dopamine (100 mg)+Aramine (50 mg) micro-pump infusion for 2-3 mL/h,24 hours of high perfusion combined with fasudil and prostaglanddin E1 for antispasmodic therapy.The clinical data and treatment efficacy of these patients were retrospectively analyzed.Results Postoperative head CT confirmed the disappearance of infarction focuses and good recovery of brain tissues,including cure in 17 patients,good recovery in 12,mild disability and severe disability in 1; no persistent vegetative state or death were noted.Conclusion Under the premise of full blood volume,high perfusion combined with fasudil and prostaglanddin E1 for antispasmodic treatment enjoys good effect in patients with severe craniocerebral trauma combined with cerebral hernia after performing large decompressive craniectomy,which is economical,practical,and worthy to be popularized.

3.
Article in Chinese | WPRIM | ID: wpr-528072

ABSTRACT

Objective To evaluate the clinical value bronchofiberscope and perfusion in the treatment of multi- drug resistant pulmonary tuberculosis (MDR-TB).Methods Forty-two cases were treated by injecting amikacin (0.4 g), ofloxacin (0.4 g), after cleaning up exudation through bronchofiberscope and catheter intervention combined with chemotherapy therapy, while 37 controls were treated by chemotherapy only.Results By the end of 9 months, the sputum tubercle bacillus conversion rate, radiographical improvement rate were 92.9% and 90.5% respectively in the treated groups,while all these indications were higher than those of control group 62.2% and 59.5% (P

4.
Article in Chinese | WPRIM | ID: wpr-537810

ABSTRACT

Objective To investigate methods and feasibility of percutaneous regional isolated hepatic perfusion combined with charcoal hemoperfusion(PRIHP-CHP).Methods Four out of 12 dogs underwent the procedure of routine transhepatic arterial infusion(TAI) as control group, 8 underwent PRIHP-CHP as experimental group. Adriamycin was used in our study, the concentration of plasma in hepatic vein and systemic vein was detected in both groups. Results All the procedures were successful in the PRIHP-CHP group eight, but 1 dog died because of air embolization. The average procedure duration for each was (132.3?15.3) minutes. The peak level of adriamycin concentration in hepatic vein and systemic in TAI were (3709.676?385.723) ng/ml and (1576.140?226.933) ng/ml respectively. In PRIHP-CHP, the peak level were (4653.420?430.204) ng/ml and (433.612?40.501) ng/ml. There were statistically significant differences between TAI and PRIHP-CHP (?

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