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1.
China Pharmacy ; (12): 592-596, 2022.
Article in Chinese | WPRIM | ID: wpr-920730

ABSTRACT

OBJECTIVE To optimize th e p rocessing technology of Portulaca oleracea charcoal,and to investigate its improvement effect on the symptom of hemorrhoid model rats. METHODS The effects of roasting temperature ,dosage and roasting time on the processing technology of P. oleracea charcoal were investigated with Box-Behnken response surface methodology using comprehensive score of tannin content ,water-soluble extract content and appearance properties as the index. The optimal process parameters are selected and verified. The hemorrhoid model rats were treated with P. oleracea charcoal(0.8 g/mL)prepared by the optimal processing technology ,once a day ,for 11 days. After last medication ,the perianal pathological score of hemorrhoid model rats were performed ;serum levels of tumor necrosis factor α(TNF-α),interleukin 6(IL-6)and IL- 1β were detected. RESULTS The optimal processing technology of P. oleracea charcoal included roasting temperature of 200 ℃, dosage of 150 g and roasting time of 14 min. Results of validation test showed that the comprehensive score of P. oleracea charcoal was 92.57,and relative error of it with predicted value (96.59)was -4.13%. External use of P. oleracea charcoal 0.8 g/mL prepared by the optimal processing technology could significantly promote the wound healing of hemorrhoid model rats ,reduced the amount of exudate ,and decreased the levels of TNF-α,IL-6 and IL-β in serum. CONCLUSIONS The optimized processing technology of P. oleracea charcoal is feasible. P. oleracea charcoal prepared by the optimized processing technology has good curative effect on the symptom of hemorrhoid model rats.

2.
Article in Chinese | WPRIM | ID: wpr-940855

ABSTRACT

As a traditional Chinese medicinal material, Citri Sarcodactylis Fructus is often used as medicine after steaming to reduce its pungency and give full play to its medicinal effects. By consulting the relevant literature, this paper intends to sort out the related researches on the processing history, modern processing standard records, flavor and meridian tropism, efficacy, processing and taking methods, processing technology, chemical composition, pharmacological effects and quality analysis of Citri Sarcodactylis Fructus. It is found that the processing methods of Citri Sarcodactylis Fructus in the past dynasties are mainly roasting, distilled into dew, aging, frying, salting and steaming, of which steaming is the most common. In modern times, steaming is mainly used in Guangdong and Sichuan. The descriptions of flavor and meridian tropism and efficacy of Citri Sarcodactylis Fructus in the past dynasties are basically consistent with the modern descriptions. Its taste is pungent, bitter and acidic, and it is warm in nature. It belongs to the liver, spleen, stomach and lung meridians. Citri Sarcodactylis Fructus contains volatile oil, flavonoids and their glycosides, coumarins and limonins and other compounds. In recent years, high performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS) and ultra performance liquid chromatography-mass spectrometry (UPLC-MS) and other methods are commonly used for the chemical composition analysis. Citri Sarcodactylis Fructus has the activities of relieving cough, reducing phlegm, relieving asthma, anti-inflammation, anti-bacteria and anti-oxidation, etc. After processing, its volatile and non-volatile components, and pharmacological effects all have a certain change. However, the current research on processing of Citri Sarcodactylis Fructus is not in-depth enough. It is necessary to further analyze the material basis of steaming to reduce dryness, explore its dryness medicinal substances and dryness-effect quantitative correlation, so as to clarify its processing mechanism, and provide basis for the subsequent processing research, resource development and comprehensive application of Citri Sarcodactylis Fructus in the future.

3.
Article in Chinese | WPRIM | ID: wpr-928085

ABSTRACT

With the rice-steamed Rehmanniae Radix unearthed from the tomb of Haihunhou in the Western Han Dynasty as the re-ference, the present study evaluated the quality of Rehmanniae Radix and investigated the processing technology of rice-steamed Rehmanniae Radix to lay the foundation for the research on rice-steamed Rehmanniae Radix products. With catalpol and rehmannioside D as the investigation indexes, the quality and grade of Rehmanniae Radix from different producing areas were evaluated with the methods in 2020 edition of Chinese Pharmacopoeia. UPLC method was established for the determination of catalpol and rehmannioside D in the rice-steamed Rehmanniae Radix. The effects of steaming time, the amount of supplementary rice, and steaming times in the rice-steamed processing on the quality of products were investigated by L_9(3~4) orthogonal test and multi-index comprehensive balance scoring method combined with the content of catalpol and rehmannioside D and appearance characteristics. At last, the stability of the processing technology was tested. The results showed that the optimal processing technology for rice-steamed Rehmanniae Radix was as follows: Rehmanniae Radix and rice(200 g∶4 g) were steamed twice at atmospheric pressure, four hours each time. The mass fractions of catalpol and rehmannioside D were 0.184% and 0.335%, respectively, and the character score was 6.5. The processing conditions are reaso-nable, stable, and feasible. It can provide a basis for the restoration of the ancient rice-steamed processing technology and references for the development of rice-steamed Rehmanniae Radix products in the future.


Subject(s)
Drugs, Chinese Herbal/pharmacology , Oryza , Plant Extracts , Rehmannia , Technology
4.
Article in Chinese | WPRIM | ID: wpr-906536

ABSTRACT

Citri Reticulatae Semen is a traditional Chinese medicine in our country. By referring to the relevant literature and materials such as the works of ancient and modern materia medica, this paper summarizes the historical evolution of processing, quality analysis, pharmacological effects and other aspects of Citri Reticulatae Semen. The results showed that the processing methods of Citri Reticulatae Semen in the past dynasties mainly included stir-frying, processing with wine, baking with wine, etc. The modern stir-baking with salt solution was developed on the basis of the ancient stir-frying with green salt, most of the national and provincial processing standards contained crude and salt-processed products of Citri Reticulatae Semen. The properties and flavors of Citri Reticulatae Semen in the past dynasties were basically consistent with those in modern times. It is bitter in taste and neutral in nature. It belongs to the liver and kidney meridians and has the effects of regulating Qi, dispersing knots and relieving pain. Citri Reticulatae Semen contains limonins, fatty acids, proteins and mineral elements, etc. High performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS) and thin layer chromatography (TLC) were commonly used to detect and analyze Citri Reticulatae Semen. Citri Reticulatae Semen has anti-tumor, anti-inflammatory, analgesic and antibacterial activities, and processing can change the content of its chemical components to a certain extent. In a word, the current research about Citri Reticulatae Semen is not enough in-depth, it is necessary to further analyze the material basis of efficacy of Citri Reticulatae Semen and its processed products, explore the change law of chemical components before and after processing and the relationship between chemical composition and activity, and clarify the processing mechanism for providing scientific basis for its standardized processing, quality control and clinical rational use.

5.
Article in Chinese | WPRIM | ID: wpr-906229

ABSTRACT

Sojae Semen Germinatum was firstly recorded in Shennong Bencaojing, and it has a long history of edible and medicinal use. Most ancient medical practitioners described that Sojae Semen Germinatum was processed with black soya bean, while some others recorded that Sojae Semen Germinatum was processed with black soya bean and soybean or with soybean only. In modern times, black soya bean and soybean are both used. Before the Northern and Southern dynasties, the germination process of Sojae Semen Germinatum was mostly soil culture, and then changed into water culture later. The medicinal part of Sojae Semen Germinatum may also change from the initial aboveground part to the whole processed products including the soybean and the bud. The bud length was used to control the processing ending of Sojae Semen Germinatum, but there were different views of the bud length in ancient and modern times. Before the Tang dynasty, Sojae Semen Germinatum was mostly used directly. Since the Tang dynasty, various subsequent processed products of Sojae Semen Germinatum appeared. Most ancient medical practitioners confirmed that Sojae Semen Germinatum was sweet flavor, neutral in nature and non-toxic, and the mainstream believed that it belonged to the spleen, lung and stomach meridians. However, there were different opinions on its efficacy of relieving exterior syndrome by diaphoresis. In this paper, the evolution of Sojae Semen Germinatum was explored after consulting all kinds of ancient books, its historical name, processing history, quality evaluation and others were systematically summarized in order to clarify its historical development and lay a good foundation for the clinical use and further development of Sojae Semen Germinatum.

6.
Article in Chinese | WPRIM | ID: wpr-906040

ABSTRACT

As a new technology with unique drug delivery advantages, nanoemulsion has been widely used in the field of traditional Chinese medicine (TCM) preparations. By searching, classifying and sorting out the literature reports at home and abroad in recent years, this paper systematically expounded the application advantages and production mechanism of nanoemulsion in delivering effective components of TCM from three aspects of improving oral bioavailability, enhancing targeting effect and delaying drug release. The current formulation optimization strategies, preparation processes and quality evaluation indicators commonly used in TCM nanoemulsion were summarized. Based on the research status of TCM nanoemulsion with different active components, the common problems and possible solutions in the development of TCM nanoemulsion were discussed, and the future research hotspots and directions of TCM nanoemulsion were prospected. This article clarifies the feasibility of nanoemulsion for enriching the selection of TCM dosage forms, which can provide reference for the subsequent rational design and improvement of TCM preparations. At the same time, it is revealed that the research focus of TCM nanoemulsion in the future lies in the integrated research of TCM compounds, and shows a trend of multi-disciplinary joint and targeted research.

7.
Article in Chinese | WPRIM | ID: wpr-888172

ABSTRACT

China has a long history of Salviae Miltiorrhizae Radix et Rhizoma processing with multiple methods available. The pre-sent study collated and summarized the Salviae Miltiorrhizae Radix et Rhizoma processing methods recorded in 23 related herbal medicine books, all editions of Chinese Pharmacopoeia, the 1988 edition of National Regulations for Processing of Chinese Medicine, and 20 current local processing specifications and standards. The results demonstrated various processing methods of Salviae Miltiorrhizae Radix et Rhizoma, such as removing residual part of stem, plantlet, or soil, smashing, filing, cutting, decocting, washing with wine, soaking in wine, and stir-frying with wine or blood from pig heart, while raw and wine-processed products are mainly used in modern times. Due to the lack of unified standards, the phenomena of multiple methods adopted in one place and different methods in different places have led to uneven quality of Salviae Miltiorrhizae Radix et Rhizoma pieces, even affecting the safety and effectiveness of its clinical medication. This study is expected to provide a reference for the development of Salviae Miltiorrhizae Radix et Rhizoma processing and its rational medication.


Subject(s)
Animals , China , Drugs, Chinese Herbal , Plant Roots , Rhizome , Salvia miltiorrhiza , Swine
8.
Article in Chinese | WPRIM | ID: wpr-887966

ABSTRACT

Indigo Naturalis has a long history of medicinal use with particularity and complexity in its processing. Before the Ming dynasty,Indigo Naturalis was extracted from the top layer of zymotic fluid,called " purified Indigo Naturalis". In modern processing,the precipitate " crude Indigo Naturalis" is dried to produce Indigo Naturalis after impurity removal. The form of Indigo Naturalis slices has undergone significant changes in ancient and modern times. In view of this,the quality comparison between crude Indigo Naturalis and purified Indigo Naturalis was conducted in this study with modern analytical techniques. Firstly,chemical composition was analyzed with UPLC-Q-TOF-MS,and the chemical composition of scent with HS-SPME/GC-MS/MS. The content of indigo,indirubin,total ash,and water-soluble extract was determined as well as the inorganic composition in crude Indigo Naturalis and purified Indigo Naturalis. Then,their microscopic morphology was observed and the surface element composition was investigated. Finally,the antipyretic activities of crude Indigo Naturalis and purified Indigo Naturalis were compared in the fever rat model induced by lipopolysaccharide and 2,4-dinitrophenol. The results demonstrated that the purified Indigo Naturalis had a faster and more lasting antipyretic effect,while the crude Indigo Naturalis had almost no antipyretic effect. This study is of great significance to the research on processing technology of Indigo Naturalis and provides reference for the formulation of its quality standards,production specifications and calibration procedures.


Subject(s)
Animals , Indigo Carmine , Indigofera , Plant Extracts , Rats , Tandem Mass Spectrometry
9.
China Pharmacy ; (12): 2223-2229, 2021.
Article in Chinese | WPRIM | ID: wpr-886803

ABSTRACT

OBJECTIVE:To establish the microwave processing technology of yellow wine-processed Curculigo orchioides , and compare it with traditional technology. METHODS :HPLC method was adopted to determine the contents of curculigoside , orcinol glucoside and orcinol gentiobioside in C. orchioides . Based on the single factor tests ,microwave processing technology was optimized and validated with orthogonal test combined with comprehensive weighted scoring method ,with the amount of yellow wine,microwave power ,wetting time and microwave time as factors ,using the contents of curculigoside ,orcinol glucoside , orcinol gentiobioside and ethanol soluble extract as the indexes. The contents of C. orchioides decoction pieces and processed products were compared. RESULTS :The optimal microwave processing technology included that the amount of yellow wine was 20%(the weight of C. orchioides decoction pieces was 20%),microwave power was 300 W,wetting time was 3 h,microwave time was 2 min. After 3 times of validation tests ,average contents of curculigoside,orcinol glucoside ,orcinol gentiobioside and ethanol soluble extract were 0.095 6%,0.723 9%,0.406 6%,10.115 3%,and RSD were 0.71%,0.54%,0.99%,1.44%(n=3). Average comprehensive score were 99.08(RSD=0.69%,n=3). Except for the content of ethanol soluble extract in traditional wine-processed product ,the contents of curculigoside and orcinol gentiobioside in traditional wine-processed product and microwave processed product as well as the content of ethanol soluble extract in microwave processed product were all significantly higher than C. orchioides decoction pieces ;the contents of curculigoside and orcinol gentiobioside in microwave processed product were both significantly higher than traditional wine-processed product (P<0.05). The contents of orcinol glucoside in 2 processed product were significantly lower than C. orchioides decoction pieces ,while the microwave processed product was significantly higher than traditional wine-processed product (P<0.05). CONCLUSIONS :Optimized microwave processing technology is stable and feasible ,and can be used for the processing of yellow wine-processed C. orchioides .

10.
Article in Chinese | WPRIM | ID: wpr-878886

ABSTRACT

To standardize the processing technology of Polygoni Multiflori Radix Praeparata and stabilize its quality, the similar change laws of Polygoni Multiflori Radix Praeparata with different processing methods and time were analyzed. The processing time of Polygoni Multiflori Radix Praeparata was studied at 24, 32, 40, 48 h, and 4 different processing methods were studied, namely stewed with black bean sauce, steamed, steamed with black bean sauce, and steamed with black bean sauce and rice wine. The content of stilbene glycosides and anthraquinones were determined by HPLC-DAD method. UV method was used to determine the content of polysaccharides, and HPLC-ELSD method was used to determine the monosaccharides and oligosaccharides. The comparative chart of content determination, cluster analysis and entropy weight TOPSIS model was used to find the similar change laws and time interval of different processing methods of Polygoni Multiflori Radix Praeparata. The results demonstrated that around 32 h, the content of nine components in Polygoni Multiflori Radix Praeparata with different processing methods had similar change laws, and the decoction pieces had a high quality, indicating that the four processing methods of Polygoni Multiflori Radix Praeparata are likely to be used as one type of decoction piece with the same name.


Subject(s)
Chromatography, High Pressure Liquid , Drugs, Chinese Herbal , Glycosides , Plant Roots , Polygonum
11.
Article in Chinese | WPRIM | ID: wpr-872835

ABSTRACT

Objective:To optimize the processing technology of salt-processed products of Plantaginis Semen with the specific process parameters, and verify the obtained processing technology by pharmacodynamic research, so as to provide experimental basis for the standardized production and quality control of this decoction pieces. Method:Taking composite score of appearance character score, dry extract yield and contents of three components (geniposidic acid, acteoside and isoacteoside) as index, the analytic hierarchy process (AHP)-criteria importance through intercrieria correlation (CRITIC) mixed weighting method was used to determine the weight coefficient of each index. Based on single factor tests, the response surface method was used to investigate the effects of frying time, frying temperature, salt amount and water amount on the processing technology of salt-processed products of Plantaginis Semen, and the processing technology was verified by diuretic experiment with furosemide tablets as the positive drug (administration dose of 0.01 g·kg-1). Result:The weight coefficients of geniposidic acid content, acteoside content, appearance character score, isoacteoside content and dry extract yield were 0.319, 0.193, 0.207, 0.273 and 0.008, respectively. The optimal process parameters were as following:fried at 150-180 ℃ for 10 min (obtained from the single factor tests), 100 g of Plantaginis Semen sprayed evenly with 2 g of salt (2 g of salt dissolved in 20 mL of water), and fried at 150-180 ℃ for 15 min. Compared with the blank group, both of the raw products group and the salt-processed products group could significantly increase the secretion of urine volume (P<0.01), but the excretion of Na+ in the urine of rats in the salt-processed products group was significantly higher than that in the raw products group (P<0.05). Conclusion:The optimized processing technology is simple and feasible, which can provide reference for standardizing the industrial production of salt-processed products of Plantaginis Semen. At the same time, combined with inherent quality and appearance of the salt-processed products, and verified by pharmacodynamic test, the obtained results are reasonable and reliable, which can be used for quality control of this decoction pieces.

12.
Article in Chinese | WPRIM | ID: wpr-872810

ABSTRACT

Platycodonis Radix, which was first recorded in the Agriculture God's Canon of Materia Medica. It is a multi-functional drug with a wide range of applications. The processing of Platycodonis Radix has been recorded as early as in the Jin dynasty, and has a long history of processing. Today, in addition to the washing, cutting and stir-frying with honey, there have also been more than 20 kinds of processing methods, such as stir-frying with wine, stir-frying with bran, stir-frying with Lilii Bulbus juice and so on. The ancients believed that Platycodonis Radix could enhance the effect of diffusing the lung, promoting pharynx and relieving cough by processing. In terms of the chemical compositions in Platycodonis Radix, more than 100 compositions, like triterpenoid saponins, flavonoids, phenols, sterols, polysaccharides and polyacetylenes, have been isolated and identified from it. Among them, triterpenoid saponins are the essential compositions. In addition, Platycodonis Radix has the pharmacological effects of expectorant, antitussive, anti-inflammatory, anti-tumor, etc. The medicinal ingredients of Platycodonis Radix are mainly triterpenoid saponins and polysaccharides. Among them, triterpenoid saponins have diverse biological activities, which lead it to be one of the hotspots of current researches. Platycodonis Radix has a good role in promoting lung and removing phlegm. After being processed, its medicinal effects are enhanced. It is complex and diverse in compositions of Platycodonis Radix so that has rich pharmacological activities. On the basis of sorting out the literature, this paper discusses the processing history, chemical composition and pharmacological effect of Platycodonis Radix, in order to provide reference for the special processing and modern research of Platycodonis Radix. Furtherly, it provides a theoretical basis for the research of its processing mechanism and quality control.

13.
China Pharmacy ; (12): 2503-2507, 2020.
Article in Chinese | WPRIM | ID: wpr-829358

ABSTRACT

OBJECTIVE:To optimize the microwave processing technology of yellow wine-processed Corydalis yanhusuo . METHODS:The contents of opioid alkaloid ,berberine hydrochloride and tetrahydropalmatine in C. yanhusuo processed with yellow wine were determined by HPLC. The contents of the extracts were determined by hot dipping method. Based on the single factor tests ,using the appearance of yellow wine-processed C. yanhusuo with microwave processing technology ,the contents of extract,opioid alkaloid ,berberine hydrochloride and tetrahydropalmatine as indexes ,with the amount of yellow wine ,wetting time,microwave power and microwaving time as factors ,the processing technology was optimized with orthogonal test combined with comprehensive weighted scoring method ,and then validated and compared with traditional yellow wine-processed C. yanhusuo . RESULTS:The linear ranges of opioid alkaloid ,berberine hydrochloride and tetrahydropalmatine were 0.100-1.500 μg(R2=0.999 6), 0.012-0.188 μg(R2=0.999 5),0.050-0.750 μg(R2=0.999 8). RSDs of precision ,stability(12 h)and repeatability tests were all less than 2% . The recoveries were 99.15% -100.34%(RSD=0.54% ,n=6),99.52% -100.78%(RSD=0.69% ,n=6), 99.26%-99.79%(RSD=0.28%,n=6). The optimum microwave processing technology included that the amount of yellow wine was 4 g(about 20% of medicinal material amount ),microwave power was 40%,wetting time was 3 hour,processing time was 3 min. The results of three verification tests showed that the contents of extract ,opioid alkaloid ,berberine hydrochloride and tetrahydropalmatine were 15.7%-16.1%,0.061%-0.063%,0.003%-0.004% and 0.061%-0.063%. The comprehensive scores were 97.916,94.730 and 97.217,and RSD were 0.42%,0.38%,0.46%(n=3),respectively. Compared with traditional yellow wine processing technology ,there was no significant difference in the contents of opioid alkaloid and other components ,but no scorched spot and crumbs was found in yellow wine-processed C. yanhusuo with microwave processing technology. CONCLUSIONS:Established method for content determination is simple ,accurate,reliable and reproducible ,and can be used for quantitative analysis of active components in yellow wine-processed C. yanhusuo . Optimized microw ave processing technology is stable and feasible ,and can be used for the processing of yellow wine-processed C. yanhusuo .

14.
Article in Chinese | WPRIM | ID: wpr-827977

ABSTRACT

The iterative innovation of processing technology is one of the important tasks in studies on processing of traditional Chinese medicine(TCM). It is also the prerequisite for modern, refined, automatic and intelligent manufacturing of TCM pieces. Microwave processing is a new fire processing technique developed in the recent 30 years, with a unique thermodynamic form, and energy transfer and transformation laws. Moreover, it owns the advantages of a high processing efficiency, good product properties and low production energy consumption, with great application prospects. This paper introduced the study overview of microwave expansion technology in the food industry, reviewed the origin of microwave processing technology of TCM, and expounded the basic concept, principle and main purpose of microwave processing technology used in TCM. Then, the impacts of drug factors and microwave factors on the microwave processing effect were summarized, the industrial equipment that could be used for microwave processing was listed, and the impacts of microwave heating on starch, polysaccharide, protein and other components in Chinese herbal medicines were analyzed. Furthermore, the study advance of microwave processing of 14 herbs was investigated, including Aconiti Lateralis Radix Praeparaia, Galli Gigerii Endothelium Corneum and Asini Corii Colla; and the appearance and components of herbs processed by traditional processing method and microwave processing method were compared, so as to reveal the opportunities and challenges of microwave processing technology in the industrial transformation. We hoped that the systematic study of microwave processing technology could provide new ideas and techniques for the high-quality and high-level development of the TCM pieces industry in the new era, and promote its inheritance, innovation and transformation.


Subject(s)
Aconitum , Drugs, Chinese Herbal , Medicine, Chinese Traditional , Microwaves , Quality Control
15.
Article in Chinese | WPRIM | ID: wpr-846659

ABSTRACT

Objective: Based on response surface methodology, HPLC was applied to quantitatively determine the optimal processing technology of Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (GRRPM) from the perspective of multi-index and comprehensive evaluation. Methods: HPLC was used for quantitative analysis, and the content of liquiritin, liquiritigenin, licochalcone A and glycyrrhetinic acid was used as inspection indexes. Response surface methodology was used to investigate the effects of the adding amount of honey, steaming and soaking time, frying temperature and frying time on the processing technology of GRRPM, and to optimize the optimal processing technology of GRRPM. Results: The chromatographic column was Diamonsil C18 (2) (4.6 mm × 200 mm, 5 μm); mobile phase was acetonitrile-0.1% phosphate aqueous solution, gradient eluting: 0-20 min, 12%-32% acetonitrile; 20-45 min, 32%-70% acetonitrile; 45-75 min, 70%-97% acetonitrile, with detection wavelength of 260 nm, column temperature of 20 ℃, and flow rate of 1 mL/min; Using liquiritin as internal standard, the relative correction factors of glycyrrhizin, licochalcone A, glycyrrhizinic acid and their relative correction factors were determined and calculated to be 0.56, 0.64 and 1.42, respectively. The optimum processing process of GRRPM was as follows: the amount of honey was 1/4, the soaking time was 15 min, frying pan bottom temperature was 160 ℃, and frying time was 13 min. Conclusion: The results of systematic adaptability investigation of the experimental content determination method meet the requirements. The best processing scheme of GRRPM optimized by response surface methodology is feasible and provides scientific basis for formulating quality standards and modern research of GRRPM.

16.
Article in Chinese | WPRIM | ID: wpr-846094

ABSTRACT

The nine times steaming and nine times shining processing method of Polygonatum cyrtonema was originated in ancient China and developed in modern times. The historical evolution of its processing technology includes raw-used, single-steamed, re-steamed, nine times steaming and nine times shining. It can eliminate toxicity, enhance curative effect, change meridians, facilitate storage and eliminate bacteria and so on. After nine times steaming and nine times shining, the chemical composition and drug efficacy of P. cyrtonema changed significantly, and it is widely used in medicine, health care products, common food, cosmetics and other fields. The historical evolution, processing mechanism, composition change, and clinical application of P. cyrtonema are reviewed in this paper, which provide a scientific basis for optimizing the nine times steaming and nine times shining technology of P. cyrtonema, lay the foundation for establishing the quality control standard control system, and provide a reference for the study of observing the ancient processing.

17.
Article in Chinese | WPRIM | ID: wpr-825623

ABSTRACT

Objective To establish the best wine steaming process for morinda officinalis with monotropein as indicator. Methods Response surface methodology was used to optimize the wine steaming process for morinda officinalis with the amount of rice wine, stewing time, moistening time and the monotropein content as evaluation indexes. Results The best condition was identified with rice wine (rice wine/herbs, g/g) 10%, moistening time 1.0 h, fully steamed and dried. Conclusion The Star dot design-response surface method can be used to optimize the wine steaming process for morinda officinalis.

18.
China Pharmacy ; (12): 1830-1835, 2020.
Article in Chinese | WPRIM | ID: wpr-823352

ABSTRACT

OBJECTIVE:To optimize the primary processing technology of Gentiana rigesce ns. METHODS :HPLC method was adopted for content determination of loganic acid ,swertiamarin and gentiopicroside in G. rigescens ,and overall desirability value (OD value ) of the contents of above 3 components was taken as index to carry out single factor test on blanching temperature,blanching time and drying temperature. Based on that ,Box-Behnken design-response surface methodology was used to optimize primary processing technology of G. rigescens . Validation test was also performed. The samples prepared by optimized technology were compared with those dried in the shade. RESULTS :The optimal primary processing technology of G. rigescens included blanching time of 5 min,blanching temperature of 40 ℃ and drying temperature of 60 ℃. Validation test showed that the average OD value of the 3 components was 0.565 2,with a deviation of 0.94% from the predicted value (0.570 6). Compared with samples dried in the shade ,OD value of 3 components in samples prepared by optimized technology were increased significantly , indicating the quality of the samples prepared by the optimized technology was better. CONCLUSIONS :The optimal technology is stable and feasible ,and can be used for the primary processing of G. rigescens .

19.
China Pharmacy ; (12): 1601-1607, 2020.
Article in Chinese | WPRIM | ID: wpr-822626

ABSTRACT

OBJECTIVE:To establish the fingerprint of raw produc ts and different processed products of Pinellia pedatisecta , to determine the contents of 5 kinds of nucleosides ,and to compare the differences of components between the raw products and processed products. METHODS :P. pedatisecta raw products ,processed products by Processing Standard of Chinese Medicine in Henan Province (called“Standard processed product ”for short )and processed products by new integrated processing technology in the production area (called“new integrated processed product ”for short )were collected as investigation objects (12 batches of each). The determination was performed on SymmetryShield RP 18 column with mobile phase consisted of acetonitrile (A)-0.1% acetic acid aqueous water solution (B)(gradient elution )at the flow rate of 0.8 mL/min,with the column temperature of 30 ℃, the detection wavelength of 270 nm,and the injection volume of 15 µL. HPLC fingerprints of 3 kinds of P. pedatisecta samples were established by using Similarity Evaluation System of TCM Chromatographic Fingerprints (2004 A version ) ,and the similarity of fingerprints was evaluated. The chromatographic peaks were identified by comparing with the reference chromatogram. Five nucleosides (adenine,hypoxanthine,uridine,xanthine,inosine)were quantitatively analyzed. SPSS 21.0 software was used for cluster analysis of 36 batches of samples. RESULTS :The results of fingerprint and content determination met the relevant requirements. The similarity of 3 kinds of sample with their control fingerprint were all greater than 0.990. There were 22 common peaks in the raw products of P. pedatisecta ,and 16 common peaks were identified in the 2 kinds of processed products (the same 6 peaks disappeared from 2 kinds of processed products ). Fivecomponents were identified in 3 kinds of samples ,such as adenine(peak 3),hypoxanthine(peak 7),uridine(peak 8), 1064056472@qq.com xanthine(peak 9)and inosine (peak 11). Results of content determination showed that total contents of 5 kinds of nucleosides in 2 kinds of proc essed products were all· decreased;the contents of them in descending order w as raw product >new i ntegrated processed products >Standard processed products. Results of cluster analysis showed that 36 batches of samples could be clustered into 2 categories,i.e. raw product was clustered into one category and 2 kinds of processed products into other one . CONCLUSIONS :Established method is stable , feasible and suitable for the quality evaluation of raw products and different processed products of P. pedatisecta . Fingerprints have changed significantly and the total content of 5 kinds of nucleosides in P. pedatisecta are all decreased after processing ,but that of new integrated processed products is slightly higher than that of Standard processed products .

20.
Rev. bras. farmacogn ; 29(6): 744-748, Nov.-Dec. 2019. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1057858

ABSTRACT

ABSTRACT This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism.

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