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1.
Article in Chinese | WPRIM | ID: wpr-912565

ABSTRACT

Objective:From the perspective of medical institutions and enterprises, based on the current situation in China, starting from the breakthrough the bottleneck of industrial development, discuss possible measures to promote the industrialization of stem cells.Methods:The factors that affect the stem cell industrialization were studied by sorting and analyzing the current stem cell industrialization policy and environment, current situation and existing problems, etc.Results:From the perspective of medical institutions and enterprises, combined with the connotation and characteristics of the stem cell industry and the author's experience and practice during the past 10 years, it is recommended to consider the promotion of the industrialization of stem cells comprehensively from the three levels that including " three transformations" , " three doubles" and " three integrations" .Conclusions:Integrate and play the role of medical institutions as the main body of stem cell clinical research and enterprises as the main body of stem cell industrialization, strengthen the multi-stakeholder cooperation among government, industry, academia, research and funding agencies, accelerate the development, transformation and application of stem cell products and derivative products.Promoting the coordinated development of the upstream, midstream, downstream and related supporting industries of the stem cell industry is of great practical significance for seizing a new round of industrial translation and historical development opportunities in the biomedical field, seizing the commanding heights of the international stem cell industry, and helping the country's major development strategy.

2.
Rev. cienc. salud (Bogotá) ; 17(3): 111-131, dic. 2019. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1058225

ABSTRACT

Resumen Introducción: Las brechas entre la investigación en salud y su aplicación práctica constituyen un objeto de estudio y un campo de intervención en la esfera sanitaria. La traducción y uso del conocimiento basado en investigación se consideran cruciales para mejorar la salud pública y los sistemas de salud. Desarrollo: El objetivo de este trabajo es revisar y comparar los enfoques conceptuales investigación traslacional (trans-lational research), traslación del conocimiento (knowledge translation) y movilización del conocimiento (knowledge mobilization). Estos enfoques se han desarrollado teórica e institucionalmente en países con fuertes sistemas de investigación en salud, como Estados Unidos, Canadá y Reino Unido, mientras que en Latinoamérica han sido poco trabajados. Se identifican sus objetivos, concepción de los procesos de transferencia de conocimiento, principales aportes y limitaciones. El enfoque movilización del conocimiento en salud se destaca como una propuesta más amplia, que aborda el carácter social de la producción, transferencia y uso del conocimiento. Conclusiones: El enfoque de movilización de conocimiento puede ser un marco útil para el estudio y sistematización de experiencias sobre el uso del conocimiento en salud en la región latinoamericana, a fin de fortalecer los sistemas nacionales de investigación en salud.


Abstract Introduction: The gaps between health research and its practical application constitute an object of study and a field of intervention in the health sphere. The translation and use of research-based knowledge are considered crucial to improve public health and health systems. Development: The aim of this paper is to review and compare the conceptual approaches translational research, knowledge translation, and knowledge mobilization. These approaches have been theoretically and institutionally developed in countries with strong health research systems such as the United States, Canada, and the United Kingdom, while in Latin America, they have not been sufficiently studied. To analyze the knowledge transfer processes conception and their main contributions and limitations. The knowledge mobilization approach stands out as a wider framework, which includes the social nature of the production, transfer, and use of knowledge. Conclusions: The knowledge mobilization approach is a suitable framework for studying and systematizing experiences on the use of health knowledge in Latin America, aiming at strengthening National Health Research Systems.


Resumo Introdução: As brechas entre a pesquisa em saúde e a sua aplicação prática constituem um objeto de estudo e um campo de intervenção na esfera sanitária. A tradução e uso do conhecimento baseado em pesquisa consideram-se cruciais para melhorar a saúde pública e os sistemas de saúde. Desenvolvimento: O objetivo deste trabalho é revisar e comparar os enfoques conceituais pesquisa translacional (translational research), translação do conhecimento (knowledge translation) e mobilização do conhecimento (knowledge mobilization). Estes enfoques se têm desenvolvidos teórica e institucionalmente em países com fortes sistemas de pesquisa em saúde, como os Estados Unidos, a Canadá, e o Reino Unido enquanto na Latino-América têm sido pouco trabalhados. Se identificam seus objetivos, concepção dos processos de transferência de conhecimento, principais aportes e limitações. O enfoque mobilização do conhecimento em saúde destaca-se como uma proposta mais ampla, que aborda o carácter social da produção, transferência e uso do conhecimento. Conclusões: O enfoque de mobilização do conhecimento pode ser um marco útil para o estudo e sistematização de experiências sobre o uso do conhecimento em saúde na região latino-americana, com o objetivo de fortalecer os sistemas nacionais de pesquisa em saúde.


Subject(s)
Humans , Translational Medical Research , Knowledge , Health Services Research
3.
Chinese Journal of Oncology ; (12): 648-653, 2019.
Article in Chinese | WPRIM | ID: wpr-797942

ABSTRACT

Malignant peripheral nerve sheath tumor (MPNST) is a rare invasive soft tissue sarcoma that originates from peripheral nerve branches and peripheral nerve sheaths. Early radical surgery is an effective treatment for MPNST. Since it is insensitive to radiotherapy and chemotherapy, the disease manifests a rapid progression, poor prognosis and high mortality. In recent years, the translational researches on the driving factors and therapeutic targets of MPNST have been rapidly developed, including the pathways of NF1-Ras, Raf-MEK-ERK, PI3K-AKT-mTOR, Wnt signaling, and abnormal expressions of apoptotic proteins, the general loss of polycomb repressive complex 2 (PRC2), upregulation of the HDAC family, abnormal expressions of receptor tyrosine kinases, expressions of programmed cell death ligand (PD-L1), aurora kinase and various microRNAs.This review summarizes the current translational researches on potential therapeutic targets of MPNST, and the clinical trials which provide helpful information for MPNST targeted therapy.

4.
Article in Korean | WPRIM | ID: wpr-740277

ABSTRACT

There has been much efforts to facilitate healthcare innovation and many desirable outcomes were produced in Korea. However, some structural deficiencies were found. They are misalignment of research and development (R&D) subjects with healthcare system, lack of flexibility of current healthcare system to accommodate the radically innovative products, and lack of cooperation among innovation agent. Some suggestions to correct these deficiencies are discussed. The suggestions are as follows: relating Korean healthcare R&D to healthcare system, enhancement of institutional flexibility to allow innovative application of new technology, improvement of the R&D process, and reexamination of the role of academic medical centers.


Subject(s)
Academic Medical Centers , Delivery of Health Care , Health Services Research , Korea , Pliability , Translational Medical Research
5.
International Journal of Surgery ; (12): 482-487, 2018.
Article in Chinese | WPRIM | ID: wpr-693266

ABSTRACT

Tumor models are required to keep the most original characteristics of the primary tumor in precision treatment.Patient-derived xenograft models are established when cancerous cells or tissues directly from patients'primary tumors are transplanted into immunodeficient mice to mimic human tumor biology in vivo,which have been widely used in cancer research.In this review,we initially summarize the methodology and its progress to create patient-derived xenograft models from three aspects including grafts,hosts and grafting regions,and then go over recent applications of patient-derived xenograft models in basic cancer research on the areas of tumorigenesis,metastasis and drug resistance and in translational medical research of tumor,such as exploring cancer biomarkers,screening anti-cancer drugs and personalized therapy for neoplasm.Finally,we propose the problems of patientderived xenograft,which must be solved urgently.

6.
Article in Chinese | WPRIM | ID: wpr-732762

ABSTRACT

With the rapid development of nanotechnology,nanomaterials have received more and more attention in the application of medical transformation researches.As a new type of multifunctional inorganic nanomaterial with particle size between 1 to 100 nm,zinc oxide nanoparticles not only has common nano-effects including high specific surface area,quantum size and macroscopic tunneling,but also has some important special effects in optical,catalytic and biological aspects showing a wide range of application prospects.In recent years,with the deepening of the physicochemical properties and special effects of zinc oxide nanoparticles,its application in biomedical fields has gradually become a research hotspot in the field of biomedicine,such as molecular fluorescence probe,antibacterial,biosensor,drug carrier,and photochemical therapy of tumor.In this paper,the special effects of zinc oxide nanoparticles on optical,catalytic and biological aspects were highlighted,and its research progress was reviewed in medical imaging applications such as molecular imaging localization,biosignal sensing and molecular recognition,drug carrier development and tumor therapy.Furthermore,the problems in the translational application of zinc oxide nanoparticles were discussed.

7.
Article in Chinese | WPRIM | ID: wpr-819323

ABSTRACT

@#Derived from the neural crest, dental stem cells (DSCs) are a population of cells with the characteristics of mesenchymal stem-ness, which under certain appropriate conditions can differentiate into multiple cells such as osteocytes, chondrocytes, hepatocyte and neuronal-like cells. DSCs are consist of odontogenic stem cells mainly include dental pulp stem cells, periodontal ligament stem cells, stem cells from deciduous teeth, stem cells from apical papilla, as well as dental follicle progenitor cells. DSCs have been widely used in the field of regenerative medicine research and preclinical research, including nervous system diseases, oral diseases, immune diseases, heart and lung diseases, etc. This review will focus on the storage of DSCs and current translational and clinical studies regarding DSCs in tissue regeneration.

8.
Article in Chinese | WPRIM | ID: wpr-505853

ABSTRACT

Rituximab in the combination of CHOP regimen has been widely used as the standard treatment of several kinds of B cell non-Hodgkin lymphoma (B-NHL),but there are still about 1/3 of the late B-NHL patients become primary and secondary resistant to the drug.Recently,many translational research progress in malignant lymphoma promoted the development of promising candidate drugs for the treatment of lymphoma.The advances in translational research field were summarized in this manuscript.

9.
Article in Chinese | WPRIM | ID: wpr-606477

ABSTRACT

Vascular calcification is a common pathology frequently occurred in the process of atherosclerosis ,hypertension , diabetes,chronic kidney disease,vascular injury and aging,resulting in an increased prevalence of cardiovascular events. Along with the social aging process,the incidence becomeshigher,andthis attract more attention. This review summarized a series of our works on vascular calcification in recent years ,including the update concept of vascular calcification ,recent classification and mechanism,and the confusion and hope in experimental and translational researches. This article aiming to promote further studies on the mechanisms and prevention of vascular calcification.

10.
Article in Chinese | WPRIM | ID: wpr-616775

ABSTRACT

Based on the translational research measurement and backtracking model put forward in this paper,it takes the new drug approved to enter into the market by American FDA from 2006-2015 as the fundamental data to measure the knowledge relations among new drug products-core patent-scientific paper-fund assistance,and puts forward the policies and suggestions for promoting innovation of pharmaceutical products in China.

11.
Article in Chinese | WPRIM | ID: wpr-664853

ABSTRACT

As one the research hotspots in recent years,radiomics,allowing a high-throughput extraction of quantitative imaging features from medical imaging with computer software,has the promising potential in assisting individualized treatment for tumor patients.Though radiomics could quantify the heterogeneity of tumor and show potential values in clinical decision making to promote precision medicine for tumor patients,there are still lots of challenges in clinically translational research of radiomics.Thus,a joint effort should be made by researchers to promote the clinical application of radiomics to assist personalized management for patients.

12.
Univ. psychol ; 15(2): 51-60, abr.-jun. 2016.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-963142

ABSTRACT

La investigación traslacional representa un esfuerzo por integrar los hallazgos derivados de la investigación básica y aproximarlos al ámbito aplicado. El presente trabajo plantea al área de investigación relativa al Efecto de Consecuencias Diferenciales (ECD) como un caso de investigación traslacional caracterizada por su contribución en el aprendizaje de discriminaciones condicionales. Se realiza una revisión que parte de algunos de los trabajos germinales con animales de laboratorio y que continúa con los primeros estudios con humanos. Posteriormente, se revisan algunos estudios que destacan el potencial de aplicación de los Procedimientos con Consecuencias Diferenciales (PCD) como herramienta para el tratamiento de personas con diversos padecimientos asociados a deficiencias en el aprendizaje y la memoria, así como su empleo en el ámbito educativo en situaciones que implican el aprendizaje de discriminaciones condicionales.


Translational research represents an effort to integrate the results derived from basic research in order to approach them to the applied field. This paper sets out the area of research in regards to the Differential Outcomes Effect (DOE) as a case of translational research, characterized by its contribution to conditional discrimination learning. A revision starting from several germinal works with laboratory animals and that moves into the first studies with humans. Afterwards, some studies that highlight the potential of the application of the Differential Outcomes Procedures (DOP) are revised as a tool for the treatment of persons with several ailments related to learning and memory deficits, as well as their application to the educational field under situations that involve conditional discrimination learning.

13.
Article in English | IMSEAR | ID: sea-177019

ABSTRACT

Translational research using small laboratory animals is being done to demonstrate proof of concept, to study pharmacokinetics as well as to understand efficacy and safety of new drug molecules. During the evaluation of a drug candidate, the assessment of efficacy and safety is normally performed in different experiments using various animal models. In such experiments, efficacy is assessed by mimicking the disease state in animal model while safety is investigated in healthy animals. Inventing new drugs using biotechnological and nanotechnological approaches is becoming a major thrust area in drug research. Apart from this, the development of medicine from traditional knowledge like Ayurveda has emerged as major area for drug industry. Use of conventional in-vivo approaches may not prove useful to answer many questions. Transgenic/knock-out/knock-in animals are now getting space in pharmaceutical research for target identification and validation. Predictability of in-vivo research depends on scientific protocols and methods adopted for model selection and development. Various alternative approaches for in-vivo research are being followed. It is a fact that no animal model is 100 % capable of mimicking the complex human body but still, researchers have not yet found any alternative model which can completely replace in-vivo models. This review is a holistic approach explaining the various animal models being used for translational research, animal ethical issues, alternative approaches available and provides a critical analysis of major issues/challenges faced in translational research using in-vivo approaches.

14.
Article in Chinese | WPRIM | ID: wpr-491047

ABSTRACT

BACKGROUND:Stem cel conversion technology has become an active area in the field of stem cel research, and it also has a tremendous boost on both the stem cel basic research and clinical study. OBJECTIVE:To review the research status and the current progress of stem cel conversion technology. METHODS:In the titles and summaries, the “stem cels, conversion, differentiation” in Chinese and English served as the search terms to search articles related to stem cels technology published from January 2000 to April 2015 in CNKI and PubMed databases. The latest articles or articles published on the authoritative journals were preferred. Totaly 121 articles were obtained after initial survey, and according to the inclusion criteria, 64 articles were selected for overview. RESULTS AND CONCLUSION:The progress of stem cels conversion technology has driven the development of the entire stem cel research, including modifying the ratio of culture medium, increasing specific inducers, proteins, enzymes or receptors, injecting specific genes, using new oxidizing agents, modifying culture microenvironment, culture under hypoxia, scaffold usage, applying transgenic technology, three-dimensional spherical culture or co-culture. Stem cel conversion technology wil definitely increase the conversion rate of stem cels, which can bring hope for the treatment of refractory diseases. Cite this article:Tu XS. Stem cel conversion technology is a footstone for stem cel basic and clinical research in the future. Zhongguo Zuzhi Gongcheng Yanjiu. 2016;20(1):128-134.

15.
Chinese Journal of Epidemiology ; (12): 1164-1168, 2016.
Article in Chinese | WPRIM | ID: wpr-737547

ABSTRACT

Since the development of high-throughput technology,electronic medical record system and big data technology,the value of medical data has caused more attention.On the other hand,the proposal of Precision Medicine Initiative opens up the prospect for medical big data.As a Tool-related Discipline,Epidemiology is,focusing on exploitation the resources of existing big data and promoting the integration of translational research and knowledge to completely unlocking the "black box" of exposure-disease continuum.It also tries to accelerating the realization of the ultimate goal on precision medicine.The overall purpose,however is to translate the evidence from scientific research to improve the health of the people.

16.
Chinese Journal of Epidemiology ; (12): 1164-1168, 2016.
Article in Chinese | WPRIM | ID: wpr-736079

ABSTRACT

Since the development of high-throughput technology,electronic medical record system and big data technology,the value of medical data has caused more attention.On the other hand,the proposal of Precision Medicine Initiative opens up the prospect for medical big data.As a Tool-related Discipline,Epidemiology is,focusing on exploitation the resources of existing big data and promoting the integration of translational research and knowledge to completely unlocking the "black box" of exposure-disease continuum.It also tries to accelerating the realization of the ultimate goal on precision medicine.The overall purpose,however is to translate the evidence from scientific research to improve the health of the people.

17.
Rev. cuba. salud pública ; 41(1)ene.-mar. 2015.
Article in Spanish | LILACS, CUMED | ID: lil-735399

ABSTRACT

En un hospital universitario, la asistencia, la educación y la investigación están ligadas entre sí. Es propósito de este trabajo destacar la significación de la investigación científica como misión académica de los hospitales públicos universitarios. La integración de la investigación con la práctica clínica garantiza mayor calidad en los servicios de salud, mejor implantación de los avances médicos en la prevención y tratamiento de las enfermedades y un cuidado más ético y eficiente para los pacientes. Lograr tal integración implica una asistencia médica de excelencia, unos profesionales mejor formados y más reconocidos en su quehacer investigativo, un financiamiento suficiente y claro, la integridad del sistema institucional que da soporte a la actividad investigativa y la incorporación sostenida de investigadores jóvenes. Son necesarios cambios en la enseñanza de la medicina, en la organización de la investigación y en la organización hospitalaria. A esta última le corresponde afrontar el reto de la investigación traslacional. El hospital universitario reúne las características para nuclear la investigación traslacional y brindar una alternativa de acción efectiva a la compleja relación existente entre la investigación en salud y la toma de decisiones a nivel político, para lograr finalmente el acercamiento entre la asistencia y la investigación. Los responsables hospitalarios han de tomar conciencia de que la investigación biomédica es también un producto hospitalario. Los hospitales universitarios y otros, de menor o mayor complejidad, deben realizar actividades asistenciales, docentes y de investigación, para brindar una asistencia de calidad haciendo uso de la mejor evidencia científica disponible(AU)


Assistance, education and research are mutually linked in a university hospital. The objective of this paper is to underline the meaning of the scientific research as an academic mission of the public university hospitals. The integration of research with the clinical practice assures higher quality of health services, better implementation of medical advances in the prevention and treatment of diseases and more ethical and efficient care to patients. Reaching such integration involves medical assistance of excellence, better prepared and more acknowledged professionals in their research work, adequate financing and the integrity of the institutional system that supports the research activity, without ignoring the sustained involvement of young researchers. The abovementioned involves changes in medical education, in the organization of the research activity and of the hospitals as well. The university hospital has the right characteristics to face the translational research challenge, to serve as a core and to provide effective alternative to the complex relationship between health research and decision taking at the political level, so that assistance and research can finally get closer. The hospital officials must be aware of the fact that biomedical research is also a hospital product. The university hospitals, either more or less complex, should perform assistance, teaching and research activities to offer quality care and to make the best use of the scientific evidence at its disposal(AU)


Subject(s)
Humans , Professional Role , Biomedical Research/methods , Scientific Research and Technological Development , Translational Medical Research/methods , Hospitals, University
18.
Article in Korean | WPRIM | ID: wpr-35611

ABSTRACT

PURPOSE: The purpose of this paper was to discuss the need for translation studies in dementia care and current translational endeavors, and to provide recommendations for evolving evidence-based dementia care. METHODS: A literature review yielded current evidence and translational efforts. RESULTS: Dementia care interventions need to be implemented at various service levels. Barriers to translation include evidence gaps, lack of the use of a conceptual framework to explain the implementation process, and unsupportive funding mechanisms for applying innovations. CONCLUSION: There is clear evidence of the need for and benefits of evidence-based dementia care for patients with dementia, family caregivers, and care professionals. The urgent need now is finding ways to advance translational activities and facilitate future research into translation science.


Subject(s)
Caregivers , Dementia/pathology , Evidence-Based Practice , Humans , Translational Medical Research
19.
Article in Korean | WPRIM | ID: wpr-217691

ABSTRACT

Tendon and ligament disorders are common and lead to significant disability, pain, healthcare cost, and lost productivity. To study the pathogenesis and management strategies of tendon and ligament injury, appropriate choice and analysis of research models is essential. A number of animal models for tendon and ligament injuries are designed to mimic distinct clinical diseases to better evaluate underlying mechanisms and potential treatments. In this review, we discuss the common methods used for inducing animal models related to tendon and ligament injury as well as the variables for assessing outcome that may be used in animal researchs.


Subject(s)
Animal Experimentation , Animals , Efficiency , Health Care Costs , Ligaments , Models, Animal , Tendons , Translational Medical Research
20.
Article in Chinese | WPRIM | ID: wpr-477626

ABSTRACT

China has the largest human biological and pathological tissue resource in terms of both quantity and diversity, whichis true for oral cancer as well. However, this unique and valuable resource did not yield expected results in clinical translational research.On one side, clinicians lack experience in identification of research topics, even with plenty of clinical specimens. On the otherside, researchers consider high impact publications as the top priority instead of clinical significance. The disalignment of the interestsbetween these two sides led to inefficient and inadequate communications and collaborations. To change the current situation, we needto encourage clinicians to raise questions and generate research topics from clinical practice and to actively participate in translationalresearch. Meanwhile, researchers need to understand basics of clinical medicine and design research projects with a focus on clinicalproblems. Closer collaborations between clinicians and researchers will help to identify new biomarkers of clinical significance throughsystematic clinical studies, which have the potential to translate into practical knowledge in diagnosis, treatment and prognosis of diseases.We can further evaluate and validate these translational results systematically by large-scale random clinical trials.

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