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1.
Braz. j. biol ; 83: e244480, 2023. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1278535

ABSTRACT

Abstract The objective of this study was to evaluate the properties of garlic as a growth promoter in larvae of angelfish Pterophyllum scalare and its benefits during transport of juveniles of this species. The experiment was conducted in recirculation aquaculture system, consisting of 20 tanks of 40 L equipped with independent water input and output. We used 1,400 larvae distributed among five treatments, with four repetitions, which totaled 20 experimental units. The treatments were 0, 50, 100, 200, and 400 mg of garlic extract per kilo of feed. The results showed that the inclusion of levels of garlic extract in the feed did not significantly effect the fish's development or their transport. Neither did the inclusion of levels of garlic extract affect the survival of the larvae during the trial period. New research with extracts of higher dosages should be performed to elucidate the effect of garlic extract as a growth promoter.


Resumo O estudo teve como objetivo avaliar as propriedades do alho como promotor de crescimento em larvas de acará bandeira Pterophyllum scalare e seus benefícios no transporte de juvenis da mesma espécie. O experimento foi conduzido em sistema de recirculação composto por 20 aquários de 40 L de volume útil, dotado de entrada e saída de água independentes e teve a duração de 40 dias. O delineamento experimental adotado foi o inteiramente casualizado (DIC), com cinco tratamentos e quatro repetições, totalizando 20 unidades experimentais. Foram utilizadas 1.400 larvas de acará bandeira (Pterophyllum scalare) divididas entre os tratamentos. Os tratamentos consistiram em: 0, 50, 100, 200 e 400 mg de extrato de alho por quilo de ração. Os resultados mostraram que não houve efeito significativo dos níveis de inclusão do extrato do alho sobre os índices zootécnicos avaliados e posteriormente no transporte dos juvenis. Também não foi observado influência na sobrevivência das larvas durante o período experimental. Novas pesquisas com dosagens maiores de extratos devem ser realizados para melhor elucidação do efeito do extrato de alho como promotor de crescimento.


Subject(s)
Animals , Cichlids , Garlic , Plant Extracts/pharmacology , Aquaculture , Larva
2.
Ciênc. Saúde Colet ; 27(5): 1975-1988, maio 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1374978

ABSTRACT

Abstract This study aimed to analyze the association between the practice of different types of physical activity (PA) with perceived environmental factors in boys and girls adolescents. Were evaluated 1,130 adolescents from Porto Alegre, Brazil. To evaluate different PA, students answered whether or not they practiced walking, running, team sports, and others general PA. Perceived environmental factors were assessed through Neighborhood Environment Walkability Scale for Youth (NEWS-Y). Analyses were performed using logistic regression. Adolescents who reported perceiving a distance up to 20 minutes to walking/running track, had their chances of practicing all types of PA increased in the total sample and for girls. For walking, it was also found an association with access in adolescents. For girls, it was found an association between shortest distance to indoor recreation or exercise facility and other playing fields/court with running and team sports. Aesthetics and road safety were associated with team sports in adolescents. Other general PA were associated with park, bike/hiking/walking trails in the total sample and for girls. Therefore, for each type of PA, specific associations of perceived environmental factors were found.


Resumo Este estudo teve como objetivo analisar a associação entre a prática de diferentes tipos de atividade física (AF) com fatores ambientais percebidos em meninos e meninas adolescentes. Foram avaliados 1.130 adolescentes de Porto Alegre, Brasil. Para avaliar diferentes AF, os alunos responderam se praticavam ou não caminhada, corrida, esportes coletivos e outras AF em geral. Fatores ambientais percebidos foram avaliados pelo Neighborhood Environment Walkability Scale for Youth. As análises foram realizadas por meio de regressão logística. Adolescentes que relataram perceber uma distância de até 20 minutos para pista de caminhada/corrida tiveram suas chances de praticar todos os tipos de AF aumentadas na amostra total e para as meninas. Para caminhada, também foi encontrada associação com o acesso em adolescentes. Para as meninas, foi encontrada uma associação entre a menor distância para instalações de exercícios e outros campos de jogos/quadra com corrida e esportes coletivos. A estética e a segurança de ruas foram associadas com esportes coletivos em adolescentes. Outras AF gerais foram associadas com parque e trilhas de bicicleta/caminhada na amostra total e para meninas. Portanto, para cada tipo de AF, foram encontradas associações específicas de fatores ambientais percebidos.

3.
Ciênc. Saúde Colet ; 27(4): 1413-1422, abr. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1374936

ABSTRACT

Abstract This article aims to compare the prevalence of active commuting to work in adults in the Southern region of Brazil between 2006 and 2016 according to sociodemographic and labor characteristics. The data from the Brazilian System for the Surveillance of Risk and Protection Factors for Chronic Diseases - VIGITEL were compared in 2006 and 2016 (≥18 years). Active commuting to work, sex, age group, education and job characteristics were collected by telephone survey and transportation in the cities of Florianópolis, Curitiba and Porto Alegre, using absolute and relative frequencies with their respective 95% confidence intervals. Active commuting increased significantly in 2016 compared to 2006. Florianópolis had the highest prevalence in the two years analyzed. In all capitals, there was a significant increase in the prevalence of the outcome, mainly for women, with secondary education and only in Florianópolis for men, with low schooling. The prevalence has also increased for job characteristics in all capitals. Active commuting to work increased significantly among adults living in southern Brazil, with emphasis on Florianópolis. Expanding interventions in this context is a necessity in Brazil.


Resumo O objetivo deste artigo é comparar a prevalência de deslocamento ativo para o trabalho em adultos na região Sul do Brasil entre 2006 e 2016 de acordo com características sociodemográficas e laborais. Os dados do Sistema Brasileiro de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas (VIGITEL) foram comparados em 2006 e 2016 (≥18 anos). Deslocamento ativo para o trabalho, sexo, faixa etária, escolaridade e características laborais foram coletados por inquérito telefônico e analisados nas cidades de Florianópolis, Curitiba e Porto Alegre, utilizando as frequências absolutas e relativas com seus respectivos intervalos de confiança de 95%. O deslocamento ativo aumentou significativamente em 2016 em relação a 2006. Florianópolis apresentou as maiores prevalências nos dois anos analisados. Em todas as capitais houve aumento significativo na prevalência do desfecho, principalmente para mulheres, com ensino médio e apenas em Florianópolis para homens, com baixa escolaridade. A prevalência também aumentou para características laborais em todas as capitais. O deslocamento ativo para o trabalho aumentou expressamente entre os adultos que vivem no Sul do Brasil, com destaque para Florianópolis. Ampliar intervenções nesse contexto é uma necessidade no Brasil.

4.
Acta biol. colomb ; 27(1): 88-96, ene.-abr. 2022. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1360053

ABSTRACT

RESUMEN El objetivo de este estudio fue evaluar los efectos de diferentes niveles de dureza total del agua en la muda, calcificación del exoesqueleto, crecimiento y supervivencia de Cryphiops caementarius. Los camarones machos fueron colectados del río Pativilca (Lima, Perú) y cultivados en recipientes individuales dentro de acuarios (55 L). Se emplearon cuatro niveles de dureza total del agua (100, 200, 300 y 400 mg CaCO3 L-1), con tres repeticiones, respectivamente. Los camarones cultivados en agua con dureza de 300 mg L-1 tuvieron menor periodo de muda (26,7 días) y mayor frecuencia de mudas (tres mudas). El contenido de calcio del exoesqueleto del camarón incrementó (p < 0,05) de 25 a 31 % en agua con dureza de 100 y 400 mg L-1, respectivamente. El mayor grosor del exoesqueleto (144 -jm en cefalotórax y 131 μm en abdomen) fue obtenido en agua con dureza de 400 mg L-1 y el menor grosor (93 -jm en cefalotórax y abdomen) en 100 mg L-1. El crecimiento en longitud fue mayor (p < 0,05) en agua con durezas de 200 y 300 mg L-1. El crecimiento en peso fue similar (p > 0,05) entre tratamientos. La mayor supervivencia (> 94,4 %) se mantuvo en agua con durezas de hasta 300 mg L-1 y la menor supervivencia (77,8 %) fue con 400 mg L-1. La dureza total del agua de 200 y 300 mg L-1 es conveniente para el cultivo del camarón, pero dureza del agua mayor o menor a este rango afectan la muda, el crecimiento y la supervivencia por deficiencia o exceso de calcio acumulado, respectivamente en el exoesqueleto del camarón.


ABSTRACT The aim of this work was to evaluate the effects of different levels of total hardness on the molting, calcification of exoskeleton, growth and survival of Cryphiops caementarius prawn. Male prawns were collected from Pativilca river (Lima, Peru) and cultivated in individual containers inside aquariums (55 L). Four levels of the total hardness of water (100, 200, 300 and 400 mg CaCO3 L-1) were used, with three repetitions, respectively. Prawns cultured in water with hardness of 300 mg L-1 has a shorter molting period (26.7 days) and a higher frequency of molts (three molts). The calcium content of the prawn exoskeleton increased (p < 0.05) from 25 to 31 % in water with hardness of 100 and 400 mg L-1, respectively. The greatest thickness of the exoskeleton (144 -jm cephalothorax and 131 -jm abdomen) was obtained in water with a hardness of400 mg L-1 and the smallest thickness (93 -jm in the cephalothorax and abdomen) in 100 mg L-1. The growth in length was greater (p < 0.05) in water with hardness of 200 and 300 mg L-1. The weight growth was similar (p > 0.05) between treatments. The highest survival (> 94.4 %) was maintained in water with hardness up to 300 mg L-1 and the lowest survival (77.8 %) was at 400 mg L-1. The total hardness of 200 and 300 mg L-1 is suitable for prawn farming, but hardness high or lower than this range affects the molting, growth and survival due to deficiency or excess of accumulated calcium, respectively, in the prawn exoskeleton.

5.
Int. j. cardiovasc. sci. (Impr.) ; 35(1): 95-106, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1356307

ABSTRACT

Abstract Background: Type 2 diabetes mellitus (T2DM) is an independent risk factor for cardiovascular impairment, increasing the rates of atherosclerotic and non-atherosclerotic events. Additionally, adverse kidney events are directly linked with T2DM and cardiovascular diseases. In this context, the sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated both cardioprotective and renoprotective effects in patients with or without T2DM. Therefore, the present meta-analysis aims to evaluate cardiovascular outcomes involving SGLT2i as monotherapy or other add-on antidiabetic agents (ADA) in patients with or without T2DM. Objetive: The present meta-analysis aims to evaluate cardiovascular outcomes involving SGLT2i as monotherapy or add-on other ADA in patients with or without T2DM. Methods: The entrance criteria to SGLT2i studies were: describing any data regarding cardiovascular effects; enrolling more than 1,000 participants; being approved by either the FDA or the EU, and having available access to the supplementary data. The trial had to exhibit at least one of the following results: major adverse cardiovascular events (MACE), cardiovascular death or hospitalization for heart failure, cardiovascular death, hospitalization for heart failure, renal or cardiovascular adverse events, or non-cardiovascular death. The significance level of 0.05 was adopted in the statistical analysis. Results: Nine trials with a total of 76,285 participants were included in the meta-analysis. SGLT2i reduced MACE (RR 0.75, 95% CI [0.55-1.01]), cardiovascular death or hospitalization for heart failure (RR 0.72, 95% CI [0.55-0.93]), cardiovascular death (RR 0.66, 95% CI [0.48-0.91]), hospitalization for heart failure (RR 0.58, 95% CI [0.46-0.73]), renal or cardiovascular adverse events (RR 0.55, 95% CI [0.39-0.78]), and non-cardiovascular death (RR 0.88, 95% CI [0.60-1.00]). Conclusions: Conjunction overall data suggests that these drugs can minimize the risk of cardiovascular events, thus decreasing mortality in patients, regardless of the presence of T2DM.


Subject(s)
Humans , Cardiotonic Agents , Cardiovascular Diseases/mortality , Cardiovascular Diseases/drug therapy , Diabetes Mellitus, Type 2 , Sodium-Glucose Transporter 2 Inhibitors/therapeutic use , Reproducibility of Results , Outcome Assessment, Health Care , Sodium-Glucose Transporter 2 , Hospitalization , Kidney Diseases/drug therapy
6.
Acta Pharmaceutica Sinica B ; (6): 511-531, 2022.
Article in English | WPRIM | ID: wpr-929312

ABSTRACT

Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging and AD are associated with apparent metabolic alterations. As developing effective therapeutic interventions to treat AD is clearly in urgent need, the impact of modulating whole-body and intracellular metabolism in preclinical models and in human patients, on disease pathogenesis, have been explored. There is also an increasing awareness of differential risk and potential targeting strategies related to biological sex, microbiome, and circadian regulation. As a major part of intracellular metabolism, mitochondrial bioenergetics, mitochondrial quality-control mechanisms, and mitochondria-linked inflammatory responses have been considered for AD therapeutic interventions. This review summarizes and highlights these efforts.

7.
Acta Pharmaceutica Sinica B ; (6): 483-495, 2022.
Article in English | WPRIM | ID: wpr-929310

ABSTRACT

Alzheimer's disease (AD), the most prominent form of dementia in the elderly, has no cure. Strategies focused on the reduction of amyloid beta or hyperphosphorylated Tau protein have largely failed in clinical trials. Novel therapeutic targets and strategies are urgently needed. Emerging data suggest that in response to environmental stress, mitochondria initiate an integrated stress response (ISR) shown to be beneficial for healthy aging and neuroprotection. Here, we review data that implicate mitochondrial electron transport complexes involved in oxidative phosphorylation as a hub for small molecule-targeted therapeutics that could induce beneficial mitochondrial ISR. Specifically, partial inhibition of mitochondrial complex I has been exploited as a novel strategy for multiple human conditions, including AD, with several small molecules being tested in clinical trials. We discuss current understanding of the molecular mechanisms involved in this counterintuitive approach. Since this strategy has also been shown to enhance health and life span, the development of safe and efficacious complex I inhibitors could promote healthy aging, delaying the onset of age-related neurodegenerative diseases.

8.
Asian Journal of Andrology ; (6): 238-242, 2022.
Article in English | WPRIM | ID: wpr-928542

ABSTRACT

Cilium, an organelle with a unique proteome and organization, protruding from the cell surface, generally serves as a force generator and signaling compartment. During ciliogenesis, ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport (IFT) particles, where the inner counterparts undergo reverse trafficking. The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction. Much progress has been made on the mechanisms and functions of IFT; however, recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis. In this review, we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.


Subject(s)
Animals , Biological Transport , Carrier Proteins/metabolism , Cilia/metabolism , Flagella/metabolism , Male , Mammals/metabolism , Organogenesis , Proteins/metabolism , Signal Transduction
9.
Chinese Journal of Biotechnology ; (12): 578-591, 2022.
Article in Chinese | WPRIM | ID: wpr-927729

ABSTRACT

Microalgae are a group of photosynthetic microorganisms, which have the general characteristics of plants such as photosynthesis, and some species have the ability of movement which resembles animals. Recently, it was reported that microalgae cells can be engineered to precisely deliver medicine-particles and other goods in microfluidic chips. These studies showed great application potential in biomedical treatment and pharmacodynamic analysis, which have become one of the current research hotspots. However, these developments have been rarely reviewed. Here, we summarized the advances in manageable movement exemplified by a model microalgae Chlamydomonas reinhardtii based on its characteristics of chemotaxis, phototaxis, and magnetotaxis. The bottlenecks and prospects in the application of microalgae-based tactic movement were also discussed. This review might be useful for rational design and modification of microalgal manageable movement to achieve targeted transport in medical and other fields.


Subject(s)
Chlamydomonas reinhardtii , Microalgae , Microfluidics , Photosynthesis
10.
Rev. Esc. Enferm. USP ; 56: e20210432, 2022. graf
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1365416

ABSTRACT

Abstract Objective: To describe the experience of aeromedical interhospital transport of an adult patient with severe hypoxemic respiratory failure due to SARS-CoV-2, on extracorporeal membrane oxygenation. Method: This is a case report, guided by the tool Case Report Guidelines, with a descriptive approach. Data were collected from the digital medical record and field notes after the approval by the Institution and the Human Research Ethics Committee. Results: The transport of a critically ill, unstable patient with acute respiratory syndrome 2 on extracorporeal oxygenation was an opportunity for the team to acquire new knowledge. The proper preparation of the fixed-wing aircraft and the profile of the team of specialist nurses contributed to the safety and quality in the three phases of flight: preflight, in-flight and post-flight. Conclusion: Air transport of adults on cardiopulmonary bypass to referral centers, under the care of an experienced multidisciplinary team, can contribute to positive results. The nurses' autonomy, their leadership role and expertise in process management are highlighted. Thus, success was evidenced with the patient's discharge after 45 days from the Intensive Care Unit.


RESUMEN Objetivo: Describir la experiencia del transporte inter hospitalario aeromédico de un paciente adulto, con hipoxia grave por SARS-CoV-2, en uso de membrana de oxigenación extra corpórea. Método: Reporte de caso, guiado por la herramienta Case Report Guidelines, con abordaje descriptivo. Los datos fueron recolectados del historial clínico digital del paciente y de los apuntes de campo tras aprobación hecha por la Institución y por el Comité de Ética e Investigación con Seres Humanos. Resultados: El transporte del paciente en estado grave, instable, con síndrome respiratoria aguda 2 en uso de oxigenación extra corpórea fue una oportunidad para el equipo asimilar nuevos conocimientos. La preparación adecuada de la aeronave de ala fija y el perfil del equipo de enfermeros expertos contribuyeron para realizar con seguridad y calidad las tres etapas del vuelo: antes, durante y después del vuelo. Conclusión: El transporte aéreo de adultos a los centros de referencia en circulación extra corpórea, bajo los cuidados de un equipo con diversos profesionales experientes, puede ser contributivo para los resultados positivos. Se pone de relieve la autonomía de los enfermeros, el rol de liderazgo y la expertise en el manejo de procesos. Para tal, el éxito fue evidenciado por el alta al paciente después de 45 días en Unidad de Cuidados Intensivos.


RESUMO Objetivo: Descrever a experiência do transporte inter-hospitalar aeromédico de um paciente adulto, com insuficiência respiratória hipoxêmica grave por SARS-CoV-2, em uso de membrana de oxigenação extracorpórea. Método: Relato de caso, norteado pela ferramenta Case Report Guidelines, com abordagem descritiva. Os dados foram coletados do prontuário digital e do diário de campo após aprovação feita pela Instituição e pelo Comitê de Ética e Pesquisa com Seres Humanos. Resultados: O transporte do paciente em estado crítico, instável, com síndrome respiratória aguda 2 em uso de oxigenação extracorpórea foi uma oportunidade para a equipe assimilar novos conhecimentos. O preparo adequado da aeronave de asa fixa e o perfil da equipe de enfermeiros especialistas contribuíram para realizar com segurança e qualidade as três fases de voo: pré-voo, durante o voo e pós voo. Conclusão: O transporte aéreo de adultos para os centros de referência em circulação extracorpórea, sob os cuidados de uma equipe multiprofissional experiente, pode contribuir para os resultados positivos. Destaca-se a autonomia dos enfermeiros, o papel de liderança e a expertise no gerenciamento de processos. Para tal, o sucesso foi evidenciado pela alta do paciente após 45 dias do Centro de Terapia Intensiva.


Subject(s)
Extracorporeal Membrane Oxygenation , Transportation of Patients , Case Reports , Coronavirus Infections , Knowledge Management
11.
Nursing (Säo Paulo) ; 24(282): 6592-6596, nov. 2021. tab, ilus
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1371047

ABSTRACT

Objetivo: Descrever a experiência do processo de criação e compartilhamento dos treinamentos em formato de vídeos para capacitar as equipes de transporte inter-hospitalar aeromédico, no início da pandemia. Método: Trata-se de um relato de experiência, sendo realizado em abril de 2021, sobre a criação de vídeos educativos com intuito de capacitar as equipes no atendimento de casos suspeitos ou confirmados de COVID-19. Resultados: Os vídeos foram elaborados pela equipe multiprofissional, no início da pandemia. A capacitação por 'Ensino a Distância Emergencial' tornou-se a melhor escolha. Foram elaborados 10 vídeos, com tempo médio de elaboração de 639 minutos, utilizada a plataforma digital do YouTube®, disponibilizados para equipes, que aderiram 100%. Conclusão: Fica evidente a importância da qualificação, com a finalidade de reconhecer efetivamente as particularidades do atendimento no ambiente aeroespacial, alinhados a gestão do conhecimento(AU)


Objective: To describe the experience of the process of creating and sharing training in video format to train air medical inter-hospital transport teams at the beginning of the pandemic. Method: This is an experience report, carried out in April 2021, on the creation of educational videos to train teams in the care of suspected or confirmed cases of COVID-19. Results: The videos were prepared by the multidisciplinary team at the beginning of the pandemic. 'Emergency Distance Learning' training became the best choice. Ten videos were produced, with an average time of 639 minutes, using the YouTube® digital platform, made available to teams, which adhered 100%. Conclusion: The importance of qualification is evident, in order to effectively recognize the particularities of service in the aerospace environment, in line with knowledge management(AU)


Objetivo: Describir la experiencia del proceso de creación y puesta en común de capacitaciones en formato de video para capacitar a equipos de transporte aéreo médico interhospitalario al inicio de la pandemia. Método: Se trata de un informe de experiencia, realizado en abril de 2021, sobre la creación de videos educativos con el fin de capacitar a los equipos en la atención de casos sospechosos o confirmados de COVID-19. Resultados: Los videos fueron elaborados por el equipo multidisciplinario al inicio de la pandemia. La formación "Aprendizaje a distancia de emergencia" se convirtió en la mejor opción. Se produjeron diez videos, con un tiempo promedio de 639 minutos, utilizando la plataforma digital YouTube®, puestos a disposición de los equipos, que se adhirieron al 100%. Conclusión: La importancia de la calificación es evidente, para reconocer efectivamente las particularidades del servicio en el entorno aeroespacial, en línea con la gestión del conocimiento(AU)


Subject(s)
Case Reports , Air Ambulances , Instructional Film and Video , Knowledge Management , COVID-19
12.
Horiz. meÌüd. ; 21(4): e1276, oct.-dic. 2021. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1356249

ABSTRACT

RESUMEN La capacidad de propagación y letalidad del SARS-CoV-2 en todo el mundo motiva la urgente necesidad de desarrollar una estrategia terapéutica apropiada para controlar los casos de COVID-19. El desarrollo de nuevos fármacos frente a este nuevo virus es apremiante debido a su rápida diseminación. Se han propuesto alternativas paralelas empleando fármacos ya disponibles para fines similares. Esta revisión describe el potencial antiviral de la ivermectina, así como sus mecanismos de acción frente a algunos virus, y discute su probable aplicación contra el SARS-CoV-2.


ABSTRACT The global spread and lethality of SARS-CoV-2 prompt the urgent need to develop an appropriate therapeutic strategy to control COVID-19 cases. The development of new drugs to fight this novel virus is urgent due to its rapid spread. Parallel alternatives have been proposed by using drugs already available for similar purposes. This review article describes the antiviral potential of ivermectin as well as its mechanisms of action against some viruses, and discusses its probable use to fight SARS-CoV-2.

13.
Rev. medica electron ; 43(5): 1436-1444, 2021. graf
Article in Spanish | LILACS | ID: biblio-1352123

ABSTRACT

RESUMEN Las fracturas expuestas de tibia han sido uno de los problemas más importantes para los sistemas de atención en salud pública. Se caracterizan por tres factores de riesgo fundamentales: daño óseo y tejidos blandos, gran posibilidad de contaminación y dificultades para el tratamiento conservador y quirúrgico, debido al daño óseo y de partes blandas asociados, que implica un alto índice de complicaciones. El tratamiento de estas fracturas es un tema ampliamente discutido en cuanto a la técnica quirúrgica a utilizar. Debido la pobre vascularización y poca cantidad de tejidos blandos que cubren la tibia, este hueso es muy vulnerable a la pseudoartrosis y a la infección. El objetivo de este trabajo fue describir la técnica quirúrgica de transportación ósea con fijador externo Ilizarov y evaluar el resultado en defectos óseos de tibia de más de 6 cm, secundario a pseudoartrosis infectada. Como resultado, el paciente evolucionó con una pseudoartrosis séptica de tibia derecha secundaria a fractura expuesta. El seguimiento fue de 18 meses, la pérdida ósea de 6 cm, la velocidad de distracción de 1 mm/día, el período de transportación de 95 días, y el tiempo con fijador de 198 días. Fue necesario realizar un nuevo proceder quirúrgico en el sitio de contacto, con vistas a reavivar los extremos óseos. La transportación ósea con fijador Ilizarov es válida para el tratamiento de la pérdida ósea en fracturas expuestas de tibia o pseudoartrosis séptica (AU).


ABSTRACT Exposed tibia fractures have been one of the most important problems for public health care systems. They are characterized by three main risk factors: bone and soft tissue damage, high possibilities of contamination and difficulties for the surgical and conservative treatment, due to the associated bone and soft tissues damage implying a high rate of complications. The treatment of these fractures is a widely discussed topic regarding the surgical technique to be used. Due to poor vascularization and little quantity of soft tissue covering tibia, this bone is highly vulnerable to pseudoarthritis and infection. The aim of this work was to describe the surgical technique of bone transport with Ilizarov external fixator and to evaluate the result in tibial bone defects of more than 6 cm, secondary to infected pseudoarthritis. As a result, the patient evolved with septic pseudoarthritis of right tibia secondary to exposed fracture. The follow up lasted 18 months; the bone loss was 6 cm; the distraction speed was 1 mm/day; the transportation period was 95 days and the time with fixator was 198 days. It was necessary to perform a new surgical procedure at the contact site to recuperate the bone ends. Bone transport with Ilizarov fixator is valid for the bone loss treatment in tibia exposed fractures or septic pseudo arthritis (AU).


Subject(s)
Male , Pseudarthrosis/epidemiology , Tibial Fractures/surgery , Pseudarthrosis/surgery , Pseudarthrosis/complications , Surgical Procedures, Operative/methods , Tibial Fractures/diagnosis , Fractures, Open/surgery , Fractures, Open/diagnosis
14.
Ciênc. Saúde Colet ; 26(9): 4309-4320, set. 2021. tab, graf
Article in English | LILACS | ID: biblio-1339584

ABSTRACT

Abstract The purpose of this study is to determine the factors associated with negative self-rated health in Brazil. The sample consisted of 5,259 adults from five representative capitals of the five regions of Brazil. Data collection was achieved in the following municipalities: Palmas (North Region), João Pessoa (Northeast Region), Goiânia (Central-West Region), Vitória (Southeast Region) and Florianópolis (South Region). For the analysis of the data, Binary Logistic Regression for determine the factors associated with negative self-rated health was used. Negative self-rated health was identified in 31.43% of Brazilians. The factors that were significantly associated were bad air quality, does not have public spaces for leisure, older age group, insufficient salary to cover expenses, a rare practice of physical exercises, does not perform healthy eating, active commuting for study or employment and commuting time for above 30 minutes, dissatisfaction with health services and still, not working, not looking for a job and finally, reside in some Brazilian regions. The study presents the importance of socioenvironmental and behavioral factors for the self-rated health of Brazilian adults, as well as it shows high rates of negative self-rated health compared to other studies.


Resumo O objetivo deste estudo foi determinar os fatores associados à percepção negativa de saúde no Brasil. A amostra foi composta por 5.259 adultos de cinco capitais representativas das cinco regiões do Brasil. A coleta de dados foi realizada nos seguintes municípios: Palmas, João Pessoa, Goiânia, Vitória e Florianópolis. Para analisar os dados, utilizou-se da Regressão Logística Binária para determinar os fatores associados. Identificou-se percepção negativa de saúde em 31,43% dos brasileiros. Os fatores que foram significativamente associados foram: má qualidade do ar, não possuir espaços públicos de lazer, faixa etária mais avançada, salário insuficiente para cobrir despesas, prática rara de exercícios físicos, não realizar alimentação saudável, deslocamento ativo para estudo ou emprego, tempo de deslocamento acima de 30 minutos, insatisfação com os serviços de saúde, não trabalhar e não estar procurando emprego e, por fim, residir nas regiões Sul, Sudeste e Nordeste do Brasil. O estudo apresenta a importância de fatores socioambientais e comportamentais para a percepção da saúde de adultos brasileiros e mostra altos índices de percepção negativa de saúde em comparação com outros estudos.


Subject(s)
Humans , Adult , Aged , Exercise , Leisure Activities , Socioeconomic Factors , Brazil , Logistic Models , Cross-Sectional Studies , Cities
15.
Eng. sanit. ambient ; 26(3): 545-555, maio-jun. 2021. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1286317

ABSTRACT

ABSTRACT This paper presents a new computational tool called NH SEDIMENT AND STATISTIC which performs hydrosedimentological and statistical calculations using Visual Basic. This computational tool was developed for studies related to calculations of sediment transport in rivers. The tool includes hydrosedimentological methods for calculating suspension loads, bed loads, and total solid discharge. In addition, it provides the user with the possibility of performing statistical tests such as the Kolmogorov-Smirnov normality test, F test and χ2 test of variance, Student's t-test, non-parametric Wilcoxon test, and statistical parameter calculations. The NH SEDIMENT AND STATISTIC automatically calculates and provides the main results for each of the methods, allowing the user to draw their own conclusions. This proposed computational tool supports hydrosedimentological studies, and is reliable and easy to use, contributing to the reduction of sediment-related problems in the areas of hydraulic engineering, geology, and soil and water conservation. Furthermore, this tool may be used in transdisciplinary scientific areas for complete planning and management of water resources.


RESUMO Este artigo apresenta uma nova ferramenta computacional chamada NH SEDIMENT AND STATISTIC, que realiza cálculos hidrossedimentológicos e estatísticos usando o Visual Basic. Essa ferramenta computacional foi desenvolvida para estudos relacionados a cálculos de transporte de sedimentos em rios. A ferramenta inclui métodos hidrossedimentológicos para calcular cargas de suspensão, cargas de leito e descarga total de sólidos. Além disso, fornece ao usuário a possibilidade de realizar testes estatísticos, como o teste de normalidade Kolmogorov-Smirnov, teste F e teste de variância do χ2, teste T de Student, teste não paramétrico de Wilcoxon e cálculos estatísticos de parâmetros. O NH SEDIMENT AND STATISTIC calcula e fornece automaticamente os principais resultados para cada um dos métodos, permitindo que o usuário tire suas próprias conclusões. Essa ferramenta computacional proposta suporta estudos hidrossedimentológicos e é confiável e fácil de usar, contribuindo para a redução de problemas relacionados a sedimentos nas áreas de engenharia hidráulica, geologia, conservação de solo e água. Além disso, essa ferramenta pode ser usada em áreas científicas transdisciplinares para um planejamento e gerenciamento completos dos recursos hídricos.

16.
Eng. sanit. ambient ; 26(3): 495-504, maio-jun. 2021. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1286321

ABSTRACT

RESUMO Nas últimas décadas, têm-se observado o crescimento da demanda de água e o agravamento dos cenários de escassez hídrica, bem como a ampliação de alternativas de reuso de água de efluentes de qualidade inferior, em particular de esgotos domésticos tratados. Objetivou-se, com este trabalho, avaliar a influência do substrato de pó de coco no controle de transporte de solutos em solos irrigados com esgoto tratado doméstico. A água residuária doméstica tratada provém da Unidade Experimental de Tratamento e Reúso Hidroagrícola, no distrito de Mutuca-PE. O delineamento experimental foi em esquema fatorial (2 × 3), cujos fatores avaliados compreenderam dois tipos de solos típicos da região (Neossolo Litólico e Argissolo Amarelo) e três tratamentos (sem pó de coco, 1 cm de pó de coco e 2 cm de pó de coco), com cinco repetições. Os parâmetros de transporte dos íons sódio e potássio foram obtidos por ajuste numérico, utilizando-se o modelo STANMOD. Constatou-se a existência de interação com soluto, sódio e potássio, em solo arenoso. O modelo STANMOD apresentou ótimo desempenho na simulação do transporte de solutos no solo. A cobertura de pó de coco mostrou-se eficiente na diminuição da lixiviação de íons em ambos os solos estudados.


ABSTRACT In the last decades, there has been an increase in the demand for water and the aggravation of water scarcity scenarios, as well as the expansion of water reuse alternatives for lower quality effluents, in particular treated domestic sewage. The objective of this study was to evaluate the influence of coconut powder substrate on the control of solute transport in irrigated soils with treated sewage reuse. The treated domestic wastewater comes from the Experimental Unit for Treatment and Agricultural Reuse in the district of Mutuca, Pernambuco. The experimental design was in a factorial scheme (2 × 3), whose evaluated factors comprised two types of soils typical of the region (Leptosols and Yellow Argisol) and three treatments (no coconut powder, 1 cm coconut powder, and 2 cm coconut powder) with five replicates. The transport parameters of the sodium and potassium ions were obtained by numerical adjustment using the STANMOD model. It was found the existence of interaction with solute, sodium, and potassium in sandy soil. The STANMOD model presented excellent performance in the simulation of solute transport in the soil. Soil coverage with coconut powder was shown to be efficient in reducing leaching of ions in both studied soils.

17.
Arq. Ciênc. Vet. Zool. UNIPAR (Online) ; 24(1, cont.): e2403, jan-jun. 2021. tab, graf
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1252764

ABSTRACT

O Whatman FTA-Card® é um papel-filtro quimicamente tratado, destinado à coleta, transporte, armazenamento de amostras para posterior extração de ácidos nucléicos. A tecnologia FTA-Card® é utilizada para manter estável DNA e RNA em temperatura ambiente, podendo ser utilizados para fixação de uma ampla variedade de material orgânico ou tecidos. Foram realizados testes para certificar sua eficiência na conservação do material a ser analisado com o intuito de eliminar a cadeia fria de conservação, agilizando o processo e diminuindo os custos da execução de exames moleculares associados ao diagnóstico de patologias. Foram testadas oito amostras de felinos na forma de sangue total e soro, para a extração utilizou-se o kit Magazorb RNA Total mini-prep kit (Promega®, EUA), para o diagnóstico foi utilizada a técnica de PCR em tempo real para amplificar o gene CI2 de mamíferos, a fim de visualizar a eficácia na conservação de ácidos nucleicos. A utilização desse método torna possível que o material biológico seja enviado por serviços de transporte postais, reduzindo os custos e viabilizando diagnósticos provenientes de áreas mais remotas.(AU)


Whatman FTA-Card® is a chemically treated filter paper intended for the collection, transport, and storage of samples for later extraction of nucleic acids. FTA-Card® technology is used to keep DNA and RNA stable at room temperature and can be used to fix a wide variety of organic material or tissues. Tests were carried out to certify its efficiency in the conservation of the material to be analyzed in order to eliminate the cold conservation chain, speeding up the process and decreasing the costs of performing molecular tests associated with the diagnosis of pathologies. By using this method, biological material can be sent by postal transport services, reducing costs and making diagnoses from more remote areas feasible. Samples of feline specimens were tested in the form of whole blood and serum, using the Magazorb RNA Total mini-prep kit (Promega®, USA) for the extraction. Diagnosis was performed using real-time PCR technique to amplify the mammalian CI2 gene in order to visualize the effectiveness in conserving nucleic acids.(AU)


Whatman FTA-Card® es un papel de filtro tratado químicamente, destinado a la recogida, transporte, almacenamiento de muestras para su posterior extracción de ácidos nucleicos. La tecnología FTA-Card® se usa para mantener el ADN y el ARN estables a la temperatura ambiente y se puede usar para la fijación de una amplia variedad de materiales o tejidos orgánicos. Se realizaron pruebas para certificar su eficiencia en la conservación del material a analizar con el fin de eliminar la cadena de frío de conservación, agilizando el proceso y reduciendo los costos de realización de pruebas moleculares asociadas al diagnóstico de patologías. Se analizaron ocho muestras felinas en forma de sangre total y suero, para la extracción se utilizó el mini-prep kit Magazorb RNA Total (Promega®, USA), para el diagnóstico se utilizó la técnica de PCR en tiempo real para amplificar el CI2 de mamífero gen, con el fin de visualizar la efectividad en la conservación de ácidos nucleicos. El uso de ese método permite el envío de material biológico por los servicios de transporte postal, lo que reduce los costes y permite realizar diagnósticos desde zonas más remotas.(AU)


Subject(s)
Biocompatible Materials , DNA , Real-Time Polymerase Chain Reaction
18.
Rev. adm. pública (Online) ; 55(2): 502-511, mar.-abr. 2021.
Article in Spanish | LILACS | ID: biblio-1250864

ABSTRACT

Resumen Siguiendo la tendencia mundial y regional, Colombia liberalizó el sector o industria del transporte aéreo, a principios de década de 1990, y con ello dio inicio a una ininterrumpida (hasta el presente) batería de políticas públicas para dicho sector, paralelamente acompañadas de varias reformas a nivel institucional, todas ellas basadas en la concepción de que el estado colombiano considera el transporte aéreo un servicio público esencial, y que contribuye al desarrollo económico nacional. Por lo tanto, este trabajo, cuyo carácter es de análisis de un estudio de caso, presenta y analiza el impacto de las políticas públicas en el desarrollo y evolución de la industria del transporte aéreo en Colombia. Para ello el análisis se centra, por un lado, en el enfoque y planteamiento de las autoridades colombianas en el diseño e implementación de dichas políticas públicas, y por otro, en la evaluación del desarrollo y crecimiento del sector del transporte aéreo y su directa influencia en otras industrias relacionadas e indicadores socioeconómicos. El principal resultado de las políticas implementadas es: el alto y continuo crecimiento del tráfico aéreo, principalmente a nivel doméstico, lo que consolidó y fortaleció la conectividad y cohesión territorial; aportación a la riqueza nacional; generación de empleo; y apoyo a industrias muy relacionadas entre sí.


Resumo Seguindo a tendência mundial e regional, a Colômbia liberalizou o setor de transporte aéreo, ou indústria, no início da década de 1990, e assim deu início a uma bateria ininterrupta (até o momento) de políticas públicas para esse setor, acompanhada paralelamente por diversas reformas no nível institucional, todas baseadas no conceito de que o Estado colombiano considera o transporte aéreo um serviço público essencial e que contribui para o desenvolvimento econômico nacional. Portanto, este trabalho, cujo caráter é a análise de um estudo de caso, apresenta e analisa o impacto das políticas públicas no desenvolvimento e evolução da indústria do transporte aéreo na Colômbia. Para tanto, a análise se concentra, por um lado, na abordagem e abordagem das autoridades colombianas na formulação e implementação das referidas políticas públicas e, por outro, na avaliação do desenvolvimento e crescimento do setor de transporte aéreo e sua influência direta. em outros setores relacionados e indicadores socioeconômicos. O principal resultado das políticas implementadas é: o elevado e continuado crescimento do tráfego aéreo, principalmente a nível doméstico, que consolidou e reforçou a conectividade e a coesão territorial; contribuição para a riqueza nacional; geração de empregos; e apoio a setores intimamente relacionados.


Abstract Following the global and regional trend, Colombia liberalized the air transport sector at the beginning of the 1990s. This measure unleashed an uninterrupted (until now) set of public policies for the sector, accompanied by several reforms at the institutional level, all in the belief that the Colombian state considers air transport an essential public service that contributes to national economic development. This work uses the case study method to present and analyze the impact of public policies on the development and evolution of the air transport sector in Colombia. The analysis focuses on the approach of the Colombian authorities in the design and implementation of public policies, and the evaluation of the development and growth of the air transport sector and its direct influence on other related industries and socio-economic indicators. The main results of the implemented policies are: high and continued growth of air traffic, mainly at the domestic level, which consolidated and strengthened connectivity and territorial cohesion; contribution to national wealth; generation of employment; and support to closely related industries.


Subject(s)
Public Policy , Aviation , Colombia
19.
Rev. peru. med. exp. salud publica ; 38(1): 143-152, ene-mar 2021. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1280560

ABSTRACT

RESUMEN La Organización Mundial de la Salud (OMS) ubica a la tuberculosis (TB) como uno de los problemas de salud más preocupantes en la actualidad, y señala que se requieren de acciones novedosas para controlar su expansión y, de esta manera, alcanzar una de las metas establecidas en los Objetivos de Desarrollo Sostenible: reducir para 2030 la morbilidad e incidencia de TB. Para lograr este objetivo, está claro que las herramientas empleadas actualmente para su diagnóstico y tratamiento ya no son las adecuadas. En este sentido, es necesario desarrollar nuevos medicamentos y vacunas, así como novedosos procedimientos de administración de fármacos que generen una mejor respuesta, disminuyan el tiempo y optimicen los tratamientos. La nanotecnología ha incorporado en los últimos años un gran número de nuevas herramientas que incrementan considerablemente, la diversidad de mecanismos para la administración de tratamientos antituberculosos. Dicho esto, la presente revisión describe brevemente el estado actual de la farmacorresistencia en TB, así como las características generales de las nanopartículas que están evaluándose como herramientas para transportar antibióticos antituberculosos.


ABSTRACT The World Health Organization (WHO) places Tuberculosis (TB) as one of the most important health problems today. According to the WHO, this disease requires novel actions to control its expansion and, in this way, achieve one of the goals established in the sustainable development goals: to reduce TB morbidity and incidence by 2030 and regain control. To achieve this goal, the tools currently used for diagnosis and treatment are no longer adequate. In this sense, it is necessary to develop new drugs and vaccines, as well as novel drug administration procedures that generate a better response, reduce times, and optimize treatments. Nanotechnology has incorporated in recent years a considerable number of new tools that significantly increase the diversity of mechanisms for the administration of anti-tuberculosis drugs. Therefore, the present review briefly describes the current state of drug resistance in tuberculosis, as well as the general characteristics of nanoparticles being evaluated as tools to transport new antibiotics against tuberculosis.

20.
Rev. peru. med. exp. salud publica ; 38(1): 143-152, ene-mar 2021. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1280577

ABSTRACT

RESUMEN La Organización Mundial de la Salud (OMS) ubica a la tuberculosis (TB) como uno de los problemas de salud más preocupantes en la actualidad, y señala que se requieren de acciones novedosas para controlar su expansión y, de esta manera, alcanzar una de las metas establecidas en los Objetivos de Desarrollo Sostenible: reducir para 2030 la morbilidad e incidencia de TB. Para lograr este objetivo, está claro que las herramientas empleadas actualmente para su diagnóstico y tratamiento ya no son las adecuadas. En este sentido, es necesario desarrollar nuevos medicamentos y vacunas, así como novedosos procedimientos de administración de fármacos que generen una mejor respuesta, disminuyan el tiempo y optimicen los tratamientos. La nanotecnología ha incorporado en los últimos años un gran número de nuevas herramientas que incrementan considerablemente, la diversidad de mecanismos para la administración de tratamientos antituberculosos. Dicho esto, la presente revisión describe brevemente el estado actual de la farmacorresistencia en TB, así como las características generales de las nanopartículas que están evaluándose como herramientas para transportar antibióticos antituberculosos.


ABSTRACT The World Health Organization (WHO) places Tuberculosis (TB) as one of the most important health problems today. According to the WHO, this disease requires novel actions to control its expansion and, in this way, achieve one of the goals established in the sustainable development goals: to reduce TB morbidity and incidence by 2030 and regain control. To achieve this goal, the tools currently used for diagnosis and treatment are no longer adequate. In this sense, it is necessary to develop new drugs and vaccines, as well as novel drug administration procedures that generate a better response, reduce times, and optimize treatments. Nanotechnology has incorporated in recent years a considerable number of new tools that significantly increase the diversity of mechanisms for the administration of anti-tuberculosis drugs. Therefore, the present review briefly describes the current state of drug resistance in tuberculosis, as well as the general characteristics of nanoparticles being evaluated as tools to transport new antibiotics against tuberculosis.

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