ABSTRACT
A esteatose Hepatica Aguda na gestacao e uma patologia que ocorre no terceiro trimestre, que acarreta prejuizo ao figado materno podendo gerar graves complicacoes. Acreditava-se que fosse uma patologia rara, porem trabalhos realizados nas decadas de 80 e 90 tem constatado o seu diagnostico mais frequente. A etiopatogenia permanece desconhecida. Varios estudiosos tem correlacionado com alteracao da beta-oxidacao dos acidos graxos por deficiencia na cadeia longa da 3-hidroxiacyl coenzima A dehidrogenase. O tratamento desta patologia consiste na antecipacao do parto, conduta que vem reduzindo a mortalidade materna e fetal
Subject(s)
Humans , Female , Pregnancy Complications/enzymology , Liver Diseases/diagnosis , Necrosis , 3-Hydroxysteroid Dehydrogenases/analysis , Acute Disease , Fetal Mortality , Liver/chemistry , Infant Mortality , Liver Diseases/complications , Maternal MortalityABSTRACT
Intraperitoneal administration of methylmercury chloride (MMC) and mercuric chloride (MC) to male rats in doses of 5, 10 micrograms MMC/kg or 50, 100 micrograms MC/kg for 90 days induced cellular disintegration of Leydig cells which was conspicuous on day 30 and onwards in the exposed groups. Progressive degeneration of Leydig cells and decrease in their nuclear diameter and population were associated with gradual increase in deposition of mercury. Gradual diminution of 3 beta-hydroxy-delta 5-steroid dehydrogenase activity in Leydig cells after MMC or MC treatment was correlated with different structural deformations of the cells over 90 days. Moreover, a significant decrease in serum testosterone levels by day 90 confirmed steroidogenic impairment after MMC or MC treatment.