ABSTRACT
Epithelial alterations in pancreatic ducts may have a premalignant nature. We compared the incidence of different lesions in 49 pancreatic cancer specimens comapred to 100 controls. Simple hyperplasia, mucosecretory metaplasia and pyloric metaplasia were evenly distributed among groups. In contrast, papillary hyperplasia, intestinal metaplasia and dysplasia were significantly more frequent in pancreas with carcinoma. Therefore, these lesions may have a precancerous nature
Subject(s)
Humans , Male , Female , Pancreatic Neoplasms/pathology , Adenocarcinoma/analysis , Pancreatic Ducts/pathology , Pancreatic Neoplasms/secondaryABSTRACT
Apresentaçäo de 1 caso de adenocarcinoma de cólon em uma criança de 11 anos de idade, sem antecedentes familiares da patologia e sem antecendentes pessoais de retocolite ulcerativa, síndrome polipóide ou tratamento por radioterapia, que apresentou invaginaçäo intestinal no curso da doença. Após revisäo da literatura, tecem consideraçöes acerca da apresentaçäo e do diagnóstico dessa patologia nesse grupo etário
Subject(s)
Humans , Male , Child , Adenocarcinoma/analysis , Colitis, Ulcerative/diagnosis , BrazilABSTRACT
Plasma lipids of 24 euthyroid subjects with thyroid adenoma and non-toxic primary differentiated thyroid carcinoma (papillary and follicular types) were assessed and compared with a similar investigation conducted on 20 normal subjects. A parallel study with thyroid tumor tissues examined the lipid changes which occurred in the same group of patients. These were compared with the picture seen in 5 normal thyroids. The investigations examined the changes in total lipids; total, free and esterified cholesterol; total phospholipids; lecithin; cephalin and sphingomyelin; triglycerides and free fatty acids in both serum and thyroid tissue. Compared with normal subjects, the serum lipids were almost identical except for the concentration of free fatty acids which showed significantly lower values in the group with neoplastic changes. Tissue analysis of the cancerous thyroid however revealed a marked rise in virtually all lipid fractions but the cholesterol seemed to dominate the picture. The differential studies of total phospholipids for thyroid tissue membrane lipids further revealed a significant increase in the lecithin and sphingomyelin components of total phospholipids as well as the esterified cholesterol fraction in thyroid carcinoma. The changes in thyrophospholipids were more marked in females normal thyroids than males. An attempt has been made through evaluation of the results derived from differential lipid studies to elucidate the role of some of the various fractions determined and the possible effect of the changes described on thyroid hormone metabolism.
Subject(s)
Adenocarcinoma/analysis , Adenoma/analysis , Cholesterol/analysis , Fatty Acids/analysis , Female , Humans , Lipids/analysis , Male , Phospholipids/analysis , Thyroid Gland/analysis , Thyroid Neoplasms/analysis , Triglycerides/analysisABSTRACT
Se relata el caso de una primigesta de 18 años, con embarazo de 24 semanas a quien se diagnostica carcinoma de ovario concomitante. Se destaca la baja frecuencia de esta asociación. Se realza la importancia de la ultrasonografía como método de diagnóstico y seguimiento de estas pacientes. Se comenta la importancia de la correcta clasificación por etapas, tipo histológico y grado de diferenciación del cáncer de ovario, con el objeto de asignar un tratamiento adecuado. Se expone el manejo conservador de cáncer de ovario y embarazo, cuando se encuentra en etapa 1A1. Se enfatiza el tratamiento quirúrgico radical en etapas avanzadas
Subject(s)
Pregnancy , Adolescent , Humans , Female , Adenocarcinoma/analysis , Ovarian Neoplasms/surgery , Pregnancy Complications, NeoplasticABSTRACT
Os autores apresentam um caso raro de autopsia de adenocarcinoma gástrico com componente coriocarcinomatoso. A pesquisa de antígeno carcinoembriônico (CEA) e gonadotrofina coriônica (HCG) no tecido, pela técnica de imunoperoxidase, revelou CEA no elemento glandular do tumor e HCG no componente coriocarcinomatoso. Esses marcadores tumorais säo úteis tanto no esclarecimento diagnóstico de neoplasias indeferenciadas, quanto no seguimento de pacientes tratados cirurgicamente, com dosagens séricas. Esta é uma neoplasia de prognóstico extremamente reservado. Comenta-se, também, aspectos com relaçäo à histogênese desse tumor gástrico
Subject(s)
Middle Aged , Humans , Male , Adenocarcinoma/pathology , Cell Transformation, Neoplastic , Choriocarcinoma/pathology , Stomach Neoplasms/pathology , Adenocarcinoma/analysis , Carcinoembryonic Antigen/analysis , Chorionic Gonadotropin/analysis , Stomach Neoplasms/analysisABSTRACT
O tratamento paliativo do adenocarcinoma metastático de próstata constitui um importante problema médico. Sete pacientes com este tipo de câncer foram tratados com 1,8 mCi oral de 32P por 7 dias, após suspensäo do uso de estrógenos e administraçäo de testosterona pré-tratamento. Após um período inicial de piora, devido à testosterona, 5 paciente melhoraram dos sintomas, por período de tempo variável entre 3 3 13 meses. Dois pacientes desenvolveram paraplegia por compressäo medular por tumor no decurso do tratamento. Apenas 3 pacientes permanecem ainda vivos