ABSTRACT
Primary adrenal lymphoma is a very rare extranodal lymphoma; its clinical features consist of a high incidence of bilateral adrenal involvement and diffuse large B-cell lymphoma. We report a patient with primary bilateral adrenal diffuse large B-cell lyphoma who achieved complete remission with R-CHOP (rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy. A 52-yr-old man presented with fever and progressive fatigue for 3 months. Computed tomography (CT) scans of the abdomen and pelvis demonstrated large bilateral adrenal masses, and a needle biopsy of the left adrenal mass revealed diffuse large B-cell lymphoma. After 6 cycles of R-CHOP chemotherapy, CT scans showed no residual disease. To our knowledge, this is the second report to date of a patient with primary bilateral adrenal diffuse large B-cell lymphoma who achieved complete remission using R-CHOP chemotherapy.
Subject(s)
Humans , Male , Middle Aged , Adrenal Gland Neoplasms/drug therapy , Antibodies, Monoclonal/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Drug Therapy, Combination , Lymphoma, Large B-Cell, Diffuse/drug therapy , Positron-Emission Tomography , Prednisone/therapeutic use , Tomography, X-Ray Computed , Vincristine/therapeutic useABSTRACT
We report a case of non-Hodgkin's lymphoma(NHL) with simultaneous involvement of both thyroid and bilateral adrenal glands. Literature review on a computerized search showed that this is an extremely rare condition. The final diagnosis of diffuse large B cell lymphoma was confirmed by biopsies of thyroid gland, enlarged cervical lymph node, and adrenal gland. The significant endocrine dysfunction of the thyroid, adrenal or other endocrine glands was absent in our case. The patient responded dramatically to three cycles of chemotherapy with no complication or endocrine dysfunction and continues to be followed.
Subject(s)
Aged , Female , Humans , Adrenal Gland Neoplasms/drug therapy , Adrenal Gland Neoplasms , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy, Needle , Cyclophosphamide , Doxorubicin , Follow-Up Studies , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse , Prednisolone , Thyroid Neoplasms/drug therapy , Thyroid Neoplasms , Treatment Outcome , VincristineABSTRACT
Two patients with pheochromocytoma initially responded to oral or sublingual nifedipine with marked reduction in systolic blood pressure (range 50-160 mmHg) without concomitant increment in the heart rate or clinical consequences. This could possibly be due to the combination of hypovolemia and negative inotropism.
Subject(s)
Adrenal Gland Neoplasms/drug therapy , Adult , Fatal Outcome , Female , Humans , Hypotension/chemically induced , Nifedipine/adverse effects , Pheochromocytoma/drug therapySubject(s)
Humans , Hypertension , Adrenal Gland Neoplasms/drug therapy , Adrenal Gland Neoplasms/etiology , Coronary Disease/drug therapy , Eclampsia/drug therapy , Eclampsia/etiology , Hypertension/classification , Hypertension/complications , Hypertension/drug therapy , Pheochromocytoma/drug therapy , Pheochromocytoma/etiology , Pulmonary Edema/drug therapy , Pulmonary Edema/etiologyABSTRACT
Los tumores adrenales virilizantes son una rara patología que se desarrolla especialmente en la infancia. Generalmente son productores de dehidroepiandrosterona (DHEA) y androsternidiona (A2)(1); ocasionalmente, sin embargo, se han descrito tumores de este tipo productores de testosterona en mujeres adultas (2-20). Presentamos la historia clínica y los hallazgos endocrinológicos, mediante diversas pruebas, en una paciente de 58 años con un tumor virilizante productora de testosterona que fue estudiada por nuestro grupo en el Hospital Militar Central. Igualmente se muestran los hallazgos histopatológicos y se comenta la literatura reciente sobre el tema.