ABSTRACT
Twenty six non insulin dependent diapetic [NIDD] patients and ten healthy controls are included in the present work. To all subjects included in the study, urine analysis for clinical proteinuria has been done. None of the diabetics have overt nephropathy [all with normal serum creatinine and no macroalbuminuria]. All patients have neither pyuria, nor evidence of cardiovascular disease. All patients are maintained on the same oral hypoglycaemic drug previously taken before the study. Fasting and two hours postprandial blood glucose, serum creatinine, urinary creatinine, microalbuminuria in ug albumin/mg urinary creatinine were determined to all subjects and contrals. Trental was adminstered in a dose of 800 mg for fifteen days to all diabetics and all the parameters are determined after the drug intake. The results revealed no significant change in microalbuminuria after pentoxifylline [Trental] therapy. However, individual data revealed that in twelve diabetics the microalbuminuria decreased and in fourteen diabetics the microalbuminuria increased after Trental. The increase in microalbuminuria has been explained on the basis of the mechanism of action of Trental on large vessels of the kidney while the decreasing effect of Trental on the microalbuminuria is probably due to its action on the red cell rheology with improvement of the microcirculation. The work clarifies that Trental has neither deleterious effect on the kidney function nor on the glucose tolerance. It is sugggested that Trental is useful on long term use in incipient diabetic nephropathy