ABSTRACT
Benign Prostatic Hyperplasia is one of the most important desease with a high frequency in urology. There is no doubt that the main stream of treatment is transurethral resection. of the prostate, however, marked improvement in drug therapy has been observed in recent years. Allylestrenol is a synthetic gestagen which was known to act directly on the prostate to exhibit its effect of reducing the size of the prostate by inhibiting the selective uptake of serum testosterone, inhibition of metabolism of testosterone to 5a-DHT (dihydrotestosterone) reductase, inhibition of 5a-DHT receptor binding. Our present study was carried out on 108 patients with benign prostatic hyperplasia to evaluate the efficacy and safety of antiandrogen therapy with allylestrenol. Allylestrenol was administered in a dose of 25 mg twice a day in the morning and evening after meal for 12 weeks to the patients and its efficacy was evaluated with peak urinary flow rate, Madsen Symptom Score at 4, 12 weeks after treatment and prostate volume at 12 weeks after treatment. Of these patients 46 completed the study and only 2 patients withdrew from the study owing to side effects. However,these side effects were not serious. At baseline (mean +SD) the mean peak urinary flow rate was 11.0+/-3.7 ml/sec, mean symptom score 10.2+4.0 and mean ultrasonic assessment of prostatic volume 36.8 +/-9.6 gm. At 4 weeks after treatment(mean + SD) mean peak urinary flow rate was 12+/-3.5 ml/sec, mean symptom score 7.7+/-4.2 (p > .0.05, p 0.05).
Subject(s)
Humans , Allylestrenol , Drug Therapy , Meals , Metabolism , Oxidoreductases , Prostate , Prostatic Hyperplasia , Rivers , Testosterone , Ultrasonics , UrologyABSTRACT
Foram estudadas 79 mulheres pos-menopausais na Clinica Ginecologica da Faculdade de Medicina da Universidade de Sao Paulo com o objetivo de avaliar o teste do progestogenio correlacionando-o com os niveis de gonadotropinas, e os indices menopausal de Kupperman e Quetelet. A media etaria foi 51,4 anos e a media do tempo de menopausa foi 3,6 anos. As pacientes foram divididas em 2 grupos: A e B. O grupo A, composto por 49 pacientes, recebeu acetato de medroxiprogesterona 5mg/dia durante 10 dias. O grupo B com 30 mulheres, recebeu alilesterol na dose de 5mg/dia, durante 10 dias. Os resultados revelaram que os testes de progestogenio foi positivo em 16 pacientes do grupo A e 1 do grupo B. A media do tempo de menopausa foi 1,6 e 4,2 anos, nos grupos A e B, respectivamente. O indice menopausal de Kupperman nao mostrou correlacao com a positividade do teste, mas o indice de Quetelet revelou que houve maior percentual da positividade do teste quando o indice esteve acima de 30.