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1.
Arab Journal of Pharmaceutical Sciences. 2004; 2 (9): 25-31
in Arabic | IMEMR | ID: emr-65335

ABSTRACT

Aminophylline is a bronchodilator used in the management of the reversible airway obstruction due to asthma, chronic bronchitis, and emphysema. The incidence of toxicosis due to the treatment by Aminophylline has a remarkable frequency, and a great importance especially in elderly patients, so that the study has carried out to determine the lethal dose of 50% [LD 50%] of mice after inject them in the peritoneum by increasing doses of Aminophylline. The study has been shown that Aminophylline has an acute toxic effect which appears during the first hour


Subject(s)
Male , Animals, Laboratory , Aminophylline/toxicity , Aminophylline/pharmacokinetics , Mice
2.
Ars cvrandi ; 21(7): 52-5, ago. 1988. tab
Article in Portuguese | LILACS | ID: lil-68926

ABSTRACT

Como conseqüência do uso freqüente de medicaçäo simultânea podem advir tanto complicaçöes leves quanto reaçöes colaterais sérias e até fatais. A farmacologia tem progredido no sentido de permitir um melhor conhecimento da interaçäo das drogas, prevenindo a maioria destes efeitos adversos. Entretanto, a prevençäo é limitada, tendo em vista a discrepância entre o número de interaçöes publicadas e o número de possíveis combinaçöes de medicamentos em doentes


Subject(s)
Humans , Drug Interactions , Receptors, Adrenergic, beta/pharmacokinetics , Adrenal Cortex Hormones/pharmacokinetics , Aminophylline/pharmacokinetics , Anti-Bacterial Agents/pharmacokinetics , Anticoagulants/pharmacokinetics , Antitubercular Agents/pharmacokinetics , Cardiotonic Agents/pharmacokinetics , Lung Diseases/drug therapy , Parasympatholytics/pharmacokinetics , Theophylline/pharmacokinetics
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