ABSTRACT
Cardiospermum halicacabum extracts have been evaluated for their antipyretic activity against yeast-induced pyrexia in rats. The ethanol as well as n-hexane extracts (400 mg/kg) of the whole plant powder showed potent antipyretic activity. The water extract was devoid of significant activity. The antipyretic activity of the ethanol extract was concentration dependent.
Subject(s)
Analgesics, Non-Narcotic/isolation & purification , Animals , Fever/drug therapy , Male , Plant Extracts/isolation & purification , Plants, Medicinal , Rats , Rats, WistarABSTRACT
Antipyretic activity of methanolic extract of rhizome of N. nucifera was studied on normal body temperature and yeast induced pyrexia in rats. Yeast suspension (10 ml/kg, s.c.) increased rectal temperature after 19 hr of administration. The extract, in doses of 200, 300 or 400 mg/kg (po) produced significant dose dependent lowering of normal body temperature and yeast provoked elevation of body temperature in rats. The effect produced was comparable with the standard antipyretic drug, paracetamol (150 mg/kg, i.p.).