ABSTRACT
INTRODUÇÃO: Ancylostoma sp é um geo-helminto potencialmente zoonótico. MÉTODOS: O objetivo deste trabalho foi avaliar in vitro a ação do extrato bruto enzimático de Pochonia chlamydosporia (VC4) sobre ovos de Ancylostoma sp, em meio ágar-água 2 por cento e em cultura de fezes. RESULTADOS: Observou-se um percentual de redução na eclosão dos ovos de Ancylostoma sp, de 76,8 por cento na placas de Petri do grupo tratado em relação ao grupo controle. CONCLUSÕES: O extrato bruto enzimático de Pochonia chlamydosporia foi eficiente na redução da eclosão dos ovos de Ancylostoma sp, podendo ser utilizado como controlador biológico desse nematoide.
INTRODUCTION: Ancylostoma sp is a potentially zoonotic geohelminth. METHODS: This study aimed to evaluate in vitro the action of crude enzyme extract of Pochonia chlamydosporia (VC4) on eggs of Ancylostoma sp in 2 percent water-agar and in fecal cultures. RESULTS: The percentage reduction in Ancylostoma sp egg eclosion was 76.8 percent in Petri dishes of the treated group compared to the control group. CONCLUSIONS: The crude enzyme extract of Pochonia chlamydosporia was effective at reducing Ancylostoma sp egg eclosion and can be used as biological control of this nematode.
Subject(s)
Animals , Ancylostoma/drug effects , Complex Mixtures/pharmacology , Hypocreales/enzymology , Complex Mixtures/isolation & purification , Ovum/drug effects , Pest Control, Biological/methodsABSTRACT
Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis in rats and cysticercoids of Hymenolepis nana in grain beetles. The test compound offered better action than mebendazole except against H. nana cysticercoids where the activity of the compound and mebendazole was comparable, but was inferior to the standard cestodicidal drug, praziquantel. The results suggest that the action was better by ip route compared to per os route of drug administration.
Subject(s)
Ancylostoma/drug effects , Animals , Anthelmintics/pharmacology , Coleoptera , Hymenolepis/drug effects , Larva , Mebendazole/analogs & derivatives , Nippostrongylus/drug effects , Praziquantel/pharmacology , RodentiaABSTRACT
Dicarboxylic acids and a few amino acids were found to support mitochondrial phosphorylation in A. ceylanicum. Anaerobiasis markedly reduced this activity. Maximum effect was observed on succinate supported phosphorylation which in anaerobic atmosphere yielded only 2% ATP compared to that in the presence of air. Known as well as candidate anthelmintics significantly inhibited ATP formation. Mebendazole, amongst them, registered greatest effect. Oxygen consumption by the mitochondria exhibited poor response to the action of anthelmintics other than praziquantel.
Subject(s)
Adenosine Triphosphate/metabolism , Ancylostoma/drug effects , Animals , Anthelmintics/pharmacology , Mitochondria/metabolism , Oxygen Consumption/drug effectsABSTRACT
Os autores descrevem sua experiência com albendazol no tratamento de 74 pacientes com parasitoses intestinais por nematelmintos. Eles concluem que o albendazol tem grande eficácia e é uma droga bem tolerada. Ele deve ser preferido especialmente quando um ou mais nematelmintos estäo associados ao Strongyloides stercoralis.
Subject(s)
Albendazole/therapeutic use , Ancylostomiasis/drug therapy , Ancylostoma/drug effects , Ascariasis/drug therapy , Ascaris/drug effects , Enterobius/drug effects , Strongyloidiasis/drug therapy , Nematode Infections/drug therapy , Oxyuriasis/drug therapy , Strongylus/drug effects , Trichuris/drug effects , Anthelmintics , MebendazoleABSTRACT
En una investigación prospectiva con grupo control llevada a cabo en 386 escolares de un barrio periférico de la ciudad de Santa Cruz, se evidenció la eficacia del mebendazol sobre la reducción a los seis meses de las cargas parasitarias para Ancylostomidae sp. y T. trichiura, mientras que no se observó tal efecto para A. lumbricoides. El resultado fue similar entre el esquema clásico (3 x 2 tab. de 100 mg) y el de la dosis única de 300 mg. (3 tab.)