Kimura's disease an unusual glandular involvement with blood and tissue esinophilia.

Kimura's disease is a rare cause of a progressive neck swelling associated with blood and tissue esinophilia. Though it is a benign disease, however, its unrelating course and unpredictable response to the therapeutic interventions, poses a great challenge to the treating physician, the patients and the caregiver. Here is one such case of Kimura's disease.

[Report of a case: Kimura disease]

Kimura is a rare disease that its etiology is not defined exactly. Immunologic and allergic responses are the probable cause of disease. Kimura is most often reported mostly in Asian men. Kimura is presented by subcutaneous nodule or multiple nodules in head and neck region. This Disease is benign. The Kimura disease is rare and until 1994 about 120 were reported. In our literature research one documented case was reported in Iran. Treatment of disease include surgery, corticosteroid and cyclosporine. The presented case was a 36 years old man with right parotid gland and submentum lymph nodes enlargement. Excision of mass was done and Kimura was documented by pathological examination. Recurrence of disease was happened and treatment was done by cyclosporine, prednisolon and cetirizine. Kimura is a very rare disease that may be mistaken with malignancy. Therapy includes surgical excision and medical treatment. Correct diagnosis of disease can prevent radical surgery

Recurrent Kimura's disease: excellent response to cyclosporine.

Kimura's disease is a chronic inflammatory disorder involving the skin, subcutaneous tissues and lymph nodes, predominantly in the head and neck region. Though surgery, intralesional or systemic steroids or radiation therapy have been the mainstay of treatment recurrence is a common problem. On the basis of occasional case report of Kimura's disease responding to cyclosporine, we attempted oral cyclosporine in our patient with dramatic improvement.

Hiperplasia angiolinfoide con eosinofilia: casos clínicos y revisión de la literatura / Angiolymphoid hyperplasia with eosinophilia: report of 2 cases and a review of the literature

La hiperplasia angiolinfoide con eosinofilia (HALE) es una entidad clínica benigna, infrecuente, que se manifiesta con nódulos subcutáneos únicos o múltiples localizados de preferencia en la cabeza y cuello de adultos jóvenes. Se caracteriza en su histopatología por células endoteliales prominentes y un infiltrado inflamatorio con predominio de linfocitos, eosinofilos e histiocitos. La observación de dos pacientes con HALE, nos permite precisar la clínica, características histopatológicas e inmunología

Angiolymphoid hyperplasia with eosinophilia.

A 51-year-old Thai man had had a 5 cm x 7 cm swelling of the right upper eyelid and forehead for 4 months. There was a deep trench-like skin ulcer at the upper tarsal border, exuding thick, very foul smelling pus. The mass did not respond to treatment with massive, multiple antibiotics, although the pus and foul smelling improved after treatment directed against anaerobic organisms. The correct diagnosis of angiolymphoid hyperplasia with eosinophilia was finally made after the fourth biopsy. The swelling disappeared after four weekly intralesional injections of triamcinolone.