ABSTRACT
Objective: to determine the association between the presence of anticardiolipin antibody and a history of recurrent spontaneous abortion. Study design: clinical controlled study Location: Department of Gynecology and Obstetrics - University of Campinas (UNICAMP) Subjects: 52 individuals with recurrent spontaneous abortion were included in Group 1 and 104 individuals with at least one live born child in Group 2. Elapsed time from last delivery to blood sampling varied from six months to two years. Method: Between November 1993 and November 1994, patients'blood samples were screened for anticardiolipin antibody by ELISA, as described by Triplett, Barna and Unger (1993). Analysis: Chi-square and Fisher's Exact tests were used for statistical analysis. Student's "t" test was used to compare the means. Results: There was no statistical difference in the presence of the anticardiolipin antibody between Group I (zero and 2.9 per cent) and Group 2 (7.7 and 5.8 per cent). Concluison: There was no association between the presence of anticardiolipin antibody and recurrent spontaneous abortion.
Subject(s)
Humans , Female , Pregnancy , Abortion, Habitual/immunology , Antibodies, Anticardiolipin/isolation & purification , Fertility , Immunoglobulin M , Antibodies, Anticardiolipin/bloodABSTRACT
Os autores apresentam o caso de uma paciente com 34 anos de idade, com cinco eventos de abordamento, fetal, livedo reticular, acidente vascular cerebral e positividade para os anticorpos anticardiolipina idiotipos IgG e IgM. A paciente preenche os critérios par síndrome Sneddon, associado às manifestaçoes clínicas e positividade para os anticorpos anticardiolipina. Chama-se atençao para a investigaçao dos anticorpos anticardiolipina na síndrome de Sneddon.
Subject(s)
Humans , Female , Adult , Antibodies, Anticardiolipin/isolation & purification , Sneddon Syndrome/immunology , Immunoglobulin G/isolation & purification , Immunoglobulin M/isolation & purification , Skin Diseases, Vascular/diagnosisABSTRACT
Los anticuerpos antifosfolípidos comprenden varias poblaciones de inmunoglobilinas, que pueden ocasionar falsos positivos biológicos con el VDRL, interferiri con el complejo activador de la protrombina ("anticoagulante lupico") o reaccionar con el fosfolipido cardiolipina en una prueba de enzimoinmunoanalisis (EIA). El "sindrome anticardiolipina" esta configurado en un grupo de pacientes que tiene estos autoanticuerpos y que son susceptibles de presentar trombosis arteriales y/o venosas, perdida fetal recurrente, trobocitopenia y manifestaciones neurologicas variadas. Si bien inicialmente las manifestaciones clinicas fueron descritas en el lupus eritematoso sistemico (LES) se ha encontrado que la mayoria de los casos tienen anticuerpos antifosfolipidos como unico marcador (sindrome antifosfolipido primario). Aunque generalmente los fosfolipidos estan distribuidos ampliamente en el organismo, son mas abundatntes en la sustacia blanca del sistema nervioso, endotelio vascular y membranas plaquetaria y celular y desempenan un papel activador en los procesos de coagulacion y fibrinolisis. En esta revision se discute minuciosamente esta familia de anticuerpos, su significado fisiopatologico y las necesidades asociadas