ABSTRACT
La penicilina ha sido considerada el antibiótico de elección para tratar las faringoamigdalitis por EBHA. En el último tiempo se han desarrollado drogas alternativas para aquellos pacientes alérgicos a penicilina, que tengan eficacia y erradiquen el agente infeccioso. Con el objeto de probar la eficacia y la erradicación del EBHA en faringoamigdalitis aguda en niños entre 2 y 15 años, se realiza un ensayo clínico randomizado controlado en 43 niños consultantes, con diagnóstico acreditado, ingresados al servicio de urgencia del Hospital Sótero del Río. Se compara el uso de claritromicina 15 mg/K/día en dosis diarias por vía oral con penicilina 250 mg tres veces al día por vía oral. Exito clínico se encontró en 86,4 por ciento de los casos tratados con claritromicina y 85,7 por ciento en los tratados con penicilina cuya diferencia no es significativa. Tampoco se encontró diferencias entre ambas terapias respecto a erradicación bacteriológica con 86,4 por ciento en el caso de los tratados con claritromicina versus un 85,7 por ciento en los tratados con penicilina. No se observaron efectos adversos serios en ambos grupos, Este estudio sugiere que la claritromicina es igualmente efectiva y bien tolerada que penicilina para el tratamiento de faringoamigdalitis aguda por EBHA, pudiendo considerarse un antibiótico de alternativa
Subject(s)
Humans , Male , Female , Child, Preschool , Adolescent , Clarithromycin/pharmacology , Penicillins/pharmacology , Pharyngitis/drug therapy , Tonsillitis/drug therapy , Age Distribution , Antistreptolysin/analysis , Clinical Protocols , Colony Count, Microbial , Double-Blind Method , Immunoenzyme Techniques , Patient Selection , Streptococcus pyogenes/drug effects , Streptococcus pyogenes/pathogenicity , Treatment OutcomeABSTRACT
Sero-immunological study was carried out on 111 patients with acute rheumatic fever [ARF] in comparison with patients' controls and normal group. Using streptococcal antibodies tests [antistreptolysin O [ASO], antistreptokinase [ASK] and antideoxyribonucleotidase B [ADNAseB tests]. Seropositivity for the antecedent streptococcal infection was raised from about 79.2% using the conventional antistreptolysin O [ASO] test to as high as 96.3% when two additional streptococcal antibody test was measured. In chorea patients ADNAse B was proved to be the only marker for the detectipn of the antecedent streptococcal infection. Mean serum ASO, ASK and ADNAse B titers in individual manifestation of ARF patients were studied
Subject(s)
Humans , Male , Female , Acute Disease , Antistreptolysin/analysis , Streptococcal Infections/immunology , Streptococcus/immunology , Streptokinase , DeoxyribonucleasesABSTRACT
Com o objetivo de verificar os valores de referencia para a determinacao dos niveis sericos de Antiestreptolisina "O" na regiao da Grande Florianopolis foram analisados 100 amostras de soro provenientes de individuos sadios e em bom estado nutricional. As amostras foram classificadas de acordo com a procedencia em relacao a idade e sexo, enquadrando em duas faixas etarias (15-34) e (35-50) anos. Os resultados foram processados por metodos estastisticos para a verificacao do efeito do sexo e da idade em uma das variaveis (50 unidades Todd) que comportou o maior numero de soros, nao sendo notificado alteracao em relacao a estes parametros. Na grande maioria das dosagens, 98 poe cento, os niveis sericos da Antiestreptolisina "O" determinados foram inferiores a 250 unidades Todd.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Antistreptolysin/analysis , Blood/immunologyABSTRACT
Se registraron los títulos de anticuerpos antiestreptocócios, mediante pruebas de antiestreptolisina O y antiDNAsa B en ambos sexos, por grupos de edad, en una muestra de 135 personas de la población general del servicio de salud metropolitano suroriente de la región metropolitana, Santiago, Chile. Se calculó de las muestras la media geométrica de los títulos. En el conjunto de las muestras la media geométrica de antiestreptolisina O fue 110 UT y 194 U para anti-DNAsa B. Los valores por grupos etarios para antiestreptolisina O fueron: 62 UT de 5 a 9 años; 127 UT de 10 a 14 años y 114 UT de 15 años y más. Los valores para antiDNAsa B fueron: 158 U, 240 U y 198 U en los mismos grupos, repectivamente. Los resultados obtenidos fueron comparados con un estudio similar realizado entre 1978 y 1980 en el mismo servicio, sin encontrar diferencias significativas entre ambos período, a excepción de los títulos de antiDNAsa B en el grupo de 5 a 9 años de edad que resultaron significativamente menores en el más reciente de los rastreos
Subject(s)
Child, Preschool , Child , Adolescent , Humans , Male , Female , Antibodies, Antinuclear/analysis , Antistreptolysin/analysis , Streptococcal Infections/diagnosis , Streptococcus pyogenes/immunology , Age FactorsABSTRACT
Foi determinado o título de antiestreptolisina O no soro de 450 pacientes da cidade de Paiçandú, Estado do Paraná. Foi obtido título médio de 263 U.I./ml (média aritmética). Os maiores valores de título médio foram nas faixas etárias dos cinco aos nove e dos dez aos quatorze anos. Näo houve diferença significativa entre títulos médios de pacientes do sexo masculino e feminino. A bimodalidade (picos em 125 e 333 U.I./ml) na distribuiçäo da freqüência de títulos deverá ser objeto de novos estudos
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Humans , Male , Female , Antistreptolysin/analysis , Streptococcal Infections/immunology , Antibody Formation , BrazilSubject(s)
Adolescent , Adult , Antistreptolysin/analysis , Child , Child, Preschool , Deoxyribonucleases/antagonists & inhibitors , Female , Humans , India , Infant , Male , Rheumatic Heart Disease/bloodABSTRACT
This study was made to evaluate the value of the IHA test for streptococcal antibodies in children with acute rheumatic fever in comparison with the conventional ASO titer. The upper limit titers of ASO and IHA in control group were 170 and 640 respectively. All sera from 37 patients with rheumatic fever had IHA titers over 640. In contrast, the level of ASO titer above upper normal limits was found in only 62% of these cases. This report present data which favours the use of IHA test. Its sensitivity is very similar to that of the commercial Anti Streptozyme test. In addition, the test is simple and could be performed economically. More studies are needed to evaluate the test further. If the results proved as favourable as this report a negative test would be of a considerable value in excluding the diagnosis of acute, rheumatic fever especially in questionable cases.
Subject(s)
Acute Disease , Adolescent , Antibodies, Bacterial/analysis , Antistreptolysin/analysis , Child , Female , Hemagglutination Tests , Humans , Male , Rheumatic Fever/diagnosis , Streptococcus pyogenes/immunologyABSTRACT
This study evaluated the usefulness of determining antistreptolysin O(ASO) titers in filariasis. The ASO titers were elevated in most convalescence sera, but did not reflect comparable pathology resulting from dual Brugia-streptococcal infections in cats.
Subject(s)
Animals , Antistreptolysin/analysis , Brugia , Cats , Filariasis/complications , Streptococcal Infections/complicationsABSTRACT
This prospective study showed that thalassaemic patients, though susceptible to streptococcal infection, as evident from their elevated A.S.O. titres, are not, as has been suggested, more likely to develop acute glomerulonephritis than the rest of the population. The incidence of thalassaemic trait found among typical cases of acute glomerulonephritis does not exceed that of the general Thai population. There were 5 out of 56 cases of thalassaemic patients having transient microscopic haematuria.