ABSTRACT
ABSTRACT PURPOSE: To investigate whether topically administered hemostatic agents ankaferd blood stopper and microporous polysaccharide hemospheres can decrease epidural fibrosis after laminectomy in rats. METHODS: Eighteen adult male Sprague-Dawley rats were equally and randomly divided into three groups. In the treatment groups, ankaferd blood stopper and microporous polysaccharide hemospheres topically administrated upon duramater surface after laminectomy. Fibroblast count, epidural fibrosis and arachnoidal involvement were evaluated and graded histopathologically. RESULTS: Our data revealed that the count of fibroblasts, the grading of epidural fibrosis and arachnoideal involvement in the rats treated with microporous polysaccharide hemospheres were significantly less than the control group. Although the arachnoideal involvement in ankaferd blood stopper group were significantly less than the control group, there were no statistical differences when comparing the grading of epidural fibrosis and the fibroblasts count between the treatment groups and the control group. CONCLUSION: The ankaferd blood stopper and microporous polysaccharide hemospheres reduced epidural fibrosis and arachnoideal involvement after laminectomy in rats.
Subject(s)
Animals , Male , Epidural Space , Hemostatics/administration & dosage , Plant Extracts/administration & dosage , Polysaccharides/administration & dosage , Postoperative Complications/pathology , Administration, Topical , Arachnoid/pathology , Fibroblasts/pathology , Fibrosis/pathology , Fibrosis/prevention & control , Laminectomy/adverse effects , Models, Animal , Random Allocation , Rats, Sprague-DawleyABSTRACT
Gliomas are the most common infiltrative neoplasms of the optic nerve and can present as two distinct growth patterns: intraneural glial proliferation and perineural arachnoidal gliomatosis (PAG). It has been suggested that perineural arachnoidal gliomatosis is seen almost exclusively in the setting of neurofibromatosis type 1 (NF1). We describe a child with perineural arachnoidal gliomatosis occurring without neurofibromatosis type 1, supported by both radiographic and histological findings. A 4-year-old female without neurofibromatosis type 1 presented with rapidly progressive right-sided proptosis. Magnetic resonance imaging (MRI) revealed an enhancing fusiform intraconal lesion, which was hypointense on T1 and hyperintense on T2-weighted images: characteristic of perineural arachnoidal gliomatosis, the optic nerve was visualized coursing the tumor. Histopathologic study was consistent with perineural arachnoidal gliomatosis. Perineural arachnoidal gliomatosis can develop independent of neurofibromatosis type 1, as demonstrated by this case.
Gliomas são as neoplasias infiltrativas mais freqüentes do nervo óptico e podem se apresentar através de dois padrões distintos de crescimento: proliferação glial intraneural e gliomatose aracnoidal perineural. Existem evidências de que a gliomatose aracnoidal perineural é vista quase exclusivamente em pacientes com neurofibromatose tipo 1. Descrevemos um caso de gliomatose aracnoidal perineural ocorrendo em criança sem neurofibromatose tipo 1, comprovado tanto por achados radiológicos quanto histológicos. Uma criança de quatro anos de idade, do sexo feminino, sem evidências de neurofibromatose tipo 1, apresentou quadro de proptose à direita rapidamente progressiva. Ressonância magnética revelou lesão intraconal fusiforme hipointensa em T1 e hiperintensa em T2 - característico de gliomatose aracnoidal perineural, o nervo óptico pôde ser observado atravessando o tumor. O estudo histológico foi consistente com gliomatose aracnoidal perineural. Gliomatose aracnoidal perineural pode se desenvolver independente da presença de neurofibromatose tipo 1, como demonstrado por esse caso.
Subject(s)
Child, Preschool , Female , Humans , Arachnoid/pathology , Neurofibromatosis 1/pathology , Optic Nerve Glioma/pathology , Arachnoid , Biopsy , Magnetic Resonance Imaging , Neurofibromatosis 1 , Optic Nerve GliomaABSTRACT
Post-contrast MR is considered to be a greatly sensitive noninvasive method for detection of different patterns and subtle findings of leptomeningeal carcinomatosis, with or without parenchymal involvement and due to the inherent advantages of such modality it can cover the full extent of the meningeal lesions in continuity along wide segments of the spinal and/or the cranium. This has its useful impact on the management, where rapid diagnosis and treatment can be established even when no malignant cells are detected in the CS fluid, and in some cases MR can guide the surgical biopsy towards the area involved
Subject(s)
Humans , Male , Female , Carcinoma/diagnosis , Magnetic Resonance Imaging/methods , Skull Neoplasms/diagnosis , Meninges , Spinal Neoplasms/diagnosis , Arachnoid/pathologyABSTRACT
Se analiza la correlación transoperatoria de lactancia y amplitud del componente positivo principal de potenciales evocados visuales y la variación del cuadro oftalmológico preoperatorio y posoperatorio (agudeza visual, campo visual y potenciales evocados visuales a patrón), en 14 pacientes con adenomas hipofisiarios y aracnoidoceles intervenidos quirúrgicamente por vía transesfenoidal en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras" . Se comprobó que el aumento de amplitud transoperatoria es tá asociada a un mejor pronóstico oftalmológico
Subject(s)
Humans , Adolescent , Adult , Middle Aged , Adenoma/surgery , Evoked Potentials, Visual , Meningeal Neoplasms/surgery , Pituitary Neoplasms/surgery , Visual Fields , Arachnoid/pathology , Intraoperative Care , Surgical Procedures, OperativeABSTRACT
Por microscopia óptica foram estudados os componentes fibrosos das granulaçöes aracnódes de indivíduos acometidos por hemorragia subaracnóide de tipo moderado ou severo. Os eritrócitos estavam presentes nos canais delimitados por feixes de fibras elásticas, colágenas e células aracnóides. Os canais tortuosos e intercomunicantes eram observados desde o pediculo até a cápsula fibrosa da granulaçäo aracnóide. O principal trajeto dos eritrócitos e do líquido cáfalo-raquidiano ocorria no interior do pedículo e centro da granulaçäo aracnóide. Na hemorragia severa, os compoentes fibro-musculares estavam desorganizados e os canais extra-celulares aumentados. A presença de células com grandes núcleos, observada no material hemorrágico, é sugestiva de transformaçöes das células aracnóides em células fagocitárias, para promover a digestäo intracelular dos eritrócitos
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Arachnoid/pathology , Subarachnoid Hemorrhage/complications , Granulation Tissue/pathology , Subarachnoid Hemorrhage/pathologyABSTRACT
Se presentó un caso de meningitis recurrente con antecedentes de trauma craneano. Se deduce que la vía de infección fue orofaringe vía trompa de Eustaquio. Los estudios tomográficos demuestran quiste aracnoideo que se insinúa en la fractura del peñasco. Se repara la zona de fractura, se extirpa el quiste, se reconstruye la duramadre. La evolución fue altamente satisfactoria, con seguimiento asintomático de 17 meses