Subject(s)
Humans , Female , Pregnancy , Adult , Pregnancy Complications, Cardiovascular/diagnosis , Prenatal Diagnosis/methods , Arrhythmogenic Right Ventricular Dysplasia/diagnosis , Pregnancy Complications, Cardiovascular/pathology , Pregnancy Complications, Cardiovascular/diagnostic imaging , Autopsy , Echocardiography/methods , Ultrasonography, Prenatal/methods , Arrhythmogenic Right Ventricular Dysplasia/pathology , Arrhythmogenic Right Ventricular Dysplasia/diagnostic imaging , Fetal DeathABSTRACT
Felino de 3,3kg, fêmea, oito anos de idade, castrada, sem definição racial, foi atendida no Hospital Veterinário da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (HOVET-USP), com histórico de dispneia, prostração, hiporexia e consequente emagrecimento progressivo, havia uma semana. Foram realizados exames de sangue: hemograma com contagem de plaquetas, função renal, função hepática e dosagens séricas de sódio e potássio, eletrocardiograma (ECG), radiografia torácica, ecoDopplercardiograma, e os resultados dos exames indicaram diagnóstico presuntivo de cardiomiopatia arritmogênica do ventrículo direito. O diagnóstico foi confirmado pela necropsia e pela constatação da presença de tecido fibroadiposo no miocárdio no exame histopatológico, possibilitando, assim, o relato do primeiro caso de cardiomiopatia arritmogênica do ventrículo direito, em gato, no Brasil.(AU)
A female 3.3kg feline, eight years-old, spayed, without racial definition, was submitted to the Veterinary Hospital of the School of Veterinary Medicine and Animal Science, São Paulo University (HOVET-USP) with dyspnea, prostration, hyporexia, and consequent progressive weight loss a week ago. Blood count with platelet count, renal and hepatic profiles, and serum sodium and potassium, chest radiography, electrocardiogram (ECG), and echocardiography were performed and diagnosis of arrhythmogenic right ventricular cardiomyopathy was assumed. The diagnosis was confirmed by necropsy findings and by the presence of fibro-fatty tissue infiltration observed in histopathology, thus featuring the first report of arrhythmogenic right ventricular cardiomyopathy in a cat in Brazil.(AU)
Subject(s)
Animals , Cats , Arrhythmogenic Right Ventricular Dysplasia/pathology , Arrhythmogenic Right Ventricular Dysplasia/veterinary , Dyspnea/veterinary , Myocardium/pathologyABSTRACT
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease of unknown etiology characterized by fatty or fibrofatty infiltration of the right ventricular myocardium. It is well known that ARVC is one of the important causes of sudden death in young individuals. The significant pathological change of ARVC is atrophy and fibrofatty myocardial replacement of the right ventricular free wall. According to the histopathological substrate ARVC could be divided into 2 types: fatty and fibrofatty myocardial replacement. Possible etiology including: (1) apoptosis or programmed cell death; (2) inflammatory; (3) myocardium dysplasia and (4) myocyte transdifferentiation theory.
Subject(s)
Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , Adipose Tissue/pathology , Apoptosis , Arrhythmias, Cardiac/etiology , Arrhythmogenic Right Ventricular Dysplasia/pathology , Death, Sudden, Cardiac/etiology , Forensic MedicineABSTRACT
Se informa el caso de un niño de seis años con cardiopatía congénita cianótica e insuficiencia cardiaca congestiva; al efectuar la autopsia, el corazón mostró características morfológicas de la anomalía de Ebstein con hipoplasia de la porción trabecular del ventrículo derecho. El desplazamiento distal del orificio tricuspídeo, con fusión de las valvas septal y posterior de la pared ventricular fue el criterio morfológico más útil para diferenciarla de otras cardiopatías que cursan con hipoplasia miocárdica del ventrículo derecho como la anomalía de Uhl, y la displasia del ventrículo derecho, entre otras cardiopatías secundarias. Se analiza el diagnóstico diferencial entre las anomalías que presentan ausencia parcial o difusa del miocardio del ventrículo derecho.