ABSTRACT
Recent studies have suggested an association between protein Z [PZ] deficiency and thrombosis. Profound haemostatic changes have been observed in patients with beta-thalassemia major with a higher incidence than normal of Ihromboembolic events, so our present study was carried to asses the role of PZ in hypercoagulable state in beta-thalassemia major with other coagulation factors inhibitors [protein C and S] and to compare the splenectomized versus non-splenectomized patients regarding the risk of thrombosis. The study included 44 patients with beta-thalassemia major [22 splenectomized and 22 non-splenectomized], their age ranged from 20-32 years. All were recruited from hematology department of Kaser ALAini hospital. Fifteen healthy subjects who were age and sex matched were included as controls. Complete blood picture, liver function tests, serum ferritin, PZ antigen, PC and PS activity and FDPs were measured for all participants. Study showed significant reduction of PZ antigen together with reduced PC and PS activity in thalassemic patients compared to controls [p<0.001], FDPs was higher in both thalassemic groups compared with control group [p<0.001]. The reduction of PZ antigen, PC and PS activity was more significant in splenectomized patients compared to non-splenectomized patients together with higher FDPs [All p values <0.001]. An inverse correlation between FDPs and PZ antigen, FDPs and PC and PS activity were detected. Reduced PZ antigen together with PC and PS activity may be a contributing factor for hypercoagulable state in thalassemia major. Splenectomized patients are at higher risk of thrombosis
Subject(s)
Humans , Male , Female , Blood Proteins/deficiency , Thrombosis , Blood Coagulation Factor Inhibitors , Protein S , Protein C , Fibrin Fibrinogen Degradation ProductsABSTRACT
The present study was carried out to investigate the role of epinephrine in modifying the radiation induced effects on serum protein as presented by total protein, protein fractions and albumin/globulin [A/G] ratio in adult albino rats. Epinephrine was intraperitoneally injected at a concentration of 200 microg/kg body weight, 15 min, pre-[or just after] whole body gamma-irradiation of rats at a dose of 6 Gy [single dose]. Studies have been undertaken at periods of 1 hr, 4 hrs, 1, 3 and 7 days after irradiation. Data of the present study revealed that whole body gamma-irradiation induced significant decreased in the total content of serum protein and albumin at 1, 3 and 7 days post radiation exposure alpha[1] -globulin significantly increased only on the 1[st] hr post-irradiation, however alpha[2]-globulin significantly increased along all the experimental periods. Beta-globulin insignificantly changed after irradiation but gamma-globulin significantly decreased during the experimental periods. These changes were associated with significant decreases in A/G ratio at 3 and 7 days post-irradiation. Administration of epinephrine pre-or after radiation exposure produced some amelioration in the radiation induced changes in the studied parameters. So, it could be concluded that epinephrine plays a beneficial radioprotective role through its pharmacologic properties
Subject(s)
Animals, Laboratory , Blood Proteins/deficiency , Serum Albumin/deficiency , Protective Agents , Epinephrine , RatsABSTRACT
O estado nutricional de 17 pacientes masculinos (52 a 78 anos) com doença pulmonar obstrutiva crônica foi estudado por meio de avaliaçäo dietética, antropometria, exames bioquímicos e hematológos. Nove pacientes tinham índice de Quetelet (QI) > 21 Kg/m* (Grupo II). Quinze pacientes foram acompanhados durante um ano e a avaliaçäo nutricional foi repetida após 6 e 12 meses. Pacientes do Grupo I permaneceram em condiçäo clínica estável durante todo o ano e apresentaram somente alteraçöes antropométricas discretas no fim do estudo. Pacientes do Grupo II apresentaram evidências antropométricas de desnutriçäo energético-proteíca do tipo marasmo e deteoraçäo clínica, a depleçäo nutricional näo foi associada com hipo-albuminemia e alteraçäo dos índices de funçäo pulmonar. Os dados da ingestäo nutricional sugeriram que nestes pacientes as alteraçöes nutricionais podem ser devidas à demanda energética aumentada relacionada a hipermetabolismo