ABSTRACT
Early pathological changes of Bovine papilloma virus (BPV-2)-fern (Pteridium aquilinum and Onychium contiguum fern) interaction in hamsters were studied. In bracken-exposed cattle, BPV induces malignancy in gastrointestinal and urinary bladder mucosa. Cutaneous warts were transmitted successfully in hamsters approximately after 3 months post inoculation while urinary bladder tumour of enzootic bovine haematuria cases were not transmitted. Histologically, tumour was diagnosed as fibroma. Onychium produced more pronounced effects than bracken fern which was characterized by significant reduction in body weight and testicular atrophy. BPV-fern interaction was not appreciable during early period of tumour induction and requires long-term studies for 12 to 18 months.
Subject(s)
Animals , Bovine papillomavirus 1/pathogenicity , Carcinogenicity Tests/methods , Cattle , Cricetinae , Disease Models, Animal , Epithelium/pathology , Indans/analysis , Male , Mesocricetus , Papillomavirus Infections/physiopathology , Pteridaceae/adverse effects , Pteridium/adverse effects , Sesquiterpenes/analysis , Urinary Bladder Neoplasms/pathology , Warts/pathologyABSTRACT
En el presente trabajo se trató de determinar la acción condicionante de la Ciclofosfamida (CF) en la resistencia de los pollos a la acción del virus de la encefalitis equina venezolana (EEV). Se utilizó como inmunosupresor la CF inyectada vía intraperitoneal (ip) en cantidad de 60 mg/Kg de peso y administrada en grupos de pollos a razón de 1,2 y 3 dósis, previamente infectados con virus EEV (cepa V-38, subgrupo 1-A). Se orientó el estudio fundamentalmente hacia los cambios histológicos a nivel del S.N.C.; como también los cambios hemáticos y la respuesta inmunológica en la producción de anticuerpos neutralizantes