ABSTRACT
The acute effects of carbon disulphide (CS2) on liver between fasted and phenobarbital pretreated Fischer rats were studied. Histological examination showed extensive damage to the livers of Fischer strain rats. Free fatty acid (FFA) concentrations in plasma were significantly decreased in CS2 treated rats. Esterified fatty acid (EFA) concentrations and their rate of release by the liver were unchanged after acute administration of CS2. The hepatic uptake of 14C-labelled FFA was studied. CS2 treatment altered the distribution of radioactivity among neutral and phospholipids
Subject(s)
Rats , Animals , Carbon Disulfide/adverse effects , Carbon Disulfide/metabolism , Phenobarbital/administration & dosageABSTRACT
A teoria da inibiçäo da piridoxamina pelo CS2 e a conseqüência interferência no metabolismo do triptofano, tem sido estudada por alguns autores e se apresenta como muito promissora para a elucidaçäo de um dos mecanismos de açäo tóxica desse solvente industrial. A funçäo da Vitamina B6 no organismo humano, principalmente sobre o metabolismo do triptofano e a excreçäo do seu principal metabilito, o ácido xanturenico, é estudada no presente trabalho, correlacioando-se a exposiçäo ocupacional ao sulfeto de carbono