ABSTRACT
Carcinoma of the breast is the most common malignancy in adult women, and attention to it often overshadows that given other breast lesions. Angiogenesis is essential for breast cancer progression and high microvessel density [MVD] within a primary tumor has been associated with stronger likelihood of nodal metastasis and poor prognosis. In this study 50 cases of invasive ductal carcinoma of the breast were selected that had been diagnosed and archived in the Pathology Department of Mashhad Ghaem Hospital. Paraffin blocks, were cut and stained for CD34 immunohistochemical marker. Immunohistochemical slides were evaluated for microvascular density in hot spot within the tumoral and normal paratumoral tissue. Correlation between MVD with other parameters such as, age, histologic grade, lymph node involvement and tumoral sizes analyzed by parametric and nonparametric statistical evidence. MVD in normal tissue was adjusted to the tumor, and the ductal carcinoma had significant difference [12.42 +/- 2.5 and 46.76 +/- 23.4 respectivly]. MVD had relative correlation with increased histologic grade [42.3 +/- 25.1 for grade I and 63.75 +/- 36.5 for grade III]. Results of this study shows markedly differences between MVD in normal and tumoral breast tissue, also increase of histological grade have correlation with MVD increment