ABSTRACT
Neuroendocrine carcinoma of the colon can be classified into small cell carcinoma and large cell neuroendocrine carcinoma. The incidence of neuroendocrine carcinoma is so low that the guideline for the treatment of large cell neuroendocrine carcinoma of the colon are not established. The prognosis of large cell neuroendocrine carcinoma of the colon is worse than that of conventional adenocarcinoma of the colon. We report a case of large cell neuroendocrine carcinoma of the colon that treated with right hemicolectomy and 6th sequential combination chemotherapy of 5-fluorouracil and cisplatin. There has been no evidence of the recurrence or metastasis of tumor for 6 months.
Subject(s)
Adult , Humans , Male , Carcinoma, Large Cell/diagnosis , Carcinoma, Neuroendocrine/diagnosis , Colonic Neoplasms/diagnosis , Colonoscopy , Tomography, X-Ray ComputedSubject(s)
Female , Humans , Middle Aged , Carcinoma, Large Cell/secondary , Carcinoma, Neuroendocrine/secondary , Cerebellar Neoplasms/secondary , Lung Neoplasms/pathology , Meningeal Neoplasms/secondary , Pituitary Neoplasms/secondary , Cerebellopontine Angle , Carcinoma, Large Cell/diagnosis , Carcinoma, Neuroendocrine/diagnosis , Cerebellar Neoplasms/diagnosis , Magnetic Resonance Imaging , Meningeal Neoplasms/diagnosis , Pituitary Neoplasms/diagnosis , Skull Base Neoplasms/diagnosis , Skull Base Neoplasms/secondary , Tomography, X-Ray ComputedABSTRACT
Some breast neoplasms are classified as primary neuroendocrine carcinomas because they are positive for neuroendocrine markers. Although neuroendocrine carcinomas can originate from various organs of the body, primary neuroendocrine carcinomas of the breast are extremely rare. The diagnosis of primary neuroendocrine carcinoma of the breast can only be made if nonmammary sites are confidently excluded or if an in situ component can be found. Here we report a primary large-cell neuroendocrine carcinoma (LCNL) involving the left breast. Breast ultrasonography revealed a lobulated, heterogeneous, low-echoic mass in the left breast, and the lesion ap-peared as a well-defined, highly-enhancing mass on a chest computed tomography scan. Ultrasound-guided core needle biopsy was performed on the mass, and primary LCNC was confirmed by histopathologic examination.
Subject(s)
Adult , Female , Humans , Breast Neoplasms/diagnosis , Carcinoma, Large Cell/diagnosis , Carcinoma, Neuroendocrine/diagnosis , Diagnosis, Differential , Tomography, X-Ray ComputedABSTRACT
The aim of this study was to assess the usefulness of fine needle aspiration cytology (FNAC) as a diagnostic method in lung tumour as well as to determine the incidence of lung cancer in various age and sex group and in relation with smoking. Hundred cases of lung tumours were investigated. Out of 100 patients, 88 were male and 12 were female. The age of patients varies from 23-78 years most of the patient were in the age group of 50-70 years. The most common tumour was squamous cell carcinoma (45%) followed by adenocarcinoma (22%), small cell carcinoma (16%) and large cell carcinoma (8%). Eighty out of 100 patient had history of smoking. Diagnostic accuracy of cytology with final histopathological report was established with accuracy rate of 95%.
Subject(s)
Adenocarcinoma/diagnosis , Adult , Age Factors , Aged , Aged, 80 and over , Biopsy, Fine-Needle , Carcinoma, Large Cell/diagnosis , Carcinoma, Small Cell/diagnosis , Carcinoma, Squamous Cell/diagnosis , Cytodiagnosis , Female , Histocytochemistry , Humans , Lung Neoplasms/diagnosis , Male , Middle Aged , Predictive Value of Tests , Risk Factors , SmokingSubject(s)
Aged, 80 and over , Female , Humans , Carcinoma, Large Cell/diagnosis , Lung Neoplasms/diagnosis , Carcinoma, Ductal, Breast/pathology , Carcinoma, Large Cell/pathology , Diagnosis, Differential , Dyspnea/complications , Fatal Outcome , Hypercapnia/complications , Hypertension, Pulmonary/complications , Hypertension/drug therapy , Hyperthyroidism/drug therapy , Breast Neoplasms/pathology , Lung Neoplasms/pathology , Obesity, Morbid/complicationsABSTRACT
BACKGROUND: To define the final outcome of large cell carcinomas (LCC) after surgical treatment, the histopathology, clinical features and follow-up results of 28 cases were reviewed. METHODS: Twenty eight patients, with LCC that underwent a surgical resection between 1986 and 2001, at the Severance Hospital, were retrospectively reviewed. We analyzed clinical data, radiological findings, pathologic findings, treatment modalities, and survival. RESULTS: The prevalence of LCC was 2.9% (29 cases) among the surgically resected primary lung cancer cases (1003 cases) during the 15 year period of the study. The mean age of the patients was 59 years old, with 25 male cases. There were 23 smokers, smoking an average of 33 pack years. A cough was the most frequent symptom. There were 15 cases located in the peripheral part of the lung and 26 consisted of a lobulated mass. From a chest CT scan, 26 cases had necrotic portions, which appeared to be low density. The postoperative stages were IA, IB, IIB, IIIA and IV in 1 (3.6%), 11 (39.3%) 8 (28.5%), 7 (25%), 1 case (3.6%), respectively. The concordance rate of the pre- and postoperative stage was 43%. The median survival time and 5 year-survival rate were 54.5 months and 45%, respectively. CONCLUSION: Our results suggested that a LCC in the lung was predominant in males, and equally located at the center and periphery of the lung in the surgically resected cases. To define the treatment outcome and risk factors of a LCC of the lung, further multicenter studies are needed.