ABSTRACT
Se presenta el caso de una gestante con antecedentes patológicos personales de hipertensión arterial leve y toxemia grave en su último embarazo y antecedentes patológicos familiares de hipertensión. En su última gestación en el año 1995 presentó toxemia grave y se le practicó una interrupción de su embarazo por el método de rivanol, a las 29 semanas de gestación. En un cuadro de hiperuricemia, oligoanuria, epigastralgia, hiperrreflexia y oligoamnios severo, se decidió la interrupción en beneficio materno. En el curso de la gestación actual de 12 semanas y como parte del estudio de las posibles etiologías de la hipertensión, se detectó en el examen físico una tumoración renal que fue confirmada por ultrasonografía como una tumoración sólida en el riñón izquierdo que ocupaba las dos terceras partes del mismo. Se decidió la interrupción de la gestación ante la sospecha de un hipernefroma. La TAC corroboró el diagnóstico. Se realizó nefrectomía izquierda; no se encontraron metástasis ganglionares y se confirmó el diagnóstico por anatomía patológica. Actualmente el seguimiento ultrasónico hepático y ganglionar no reflejan recidivas de la enfermedad
Subject(s)
Female , Pregnancy , Humans , Carcinoma, Renal Cell/diagnosis , Carcinoma, Renal Cell/etiology , Hypertension , Pregnancy ComplicationsABSTRACT
BACKGROUND: Involvement of the pancreas in Von Hippel-Lindau disease that is a tumor predisposing syndrome mentioned in literature with some morbid and mortal progression. AIMS: For evaluation the faith of the pancreatic involvement in VHL disease we analysed our patient population with VHL disease. MATERIALS AND METHODS: 12 of the 56 patients that were evaluated in our institute with the diagnosis of Von Hippel-Lindau disease had pancreatic involvement. They are periodically examined for 5 years follow up period. Their retrospective analysis was accomplished. RESULTS AND CONCLUSIONS: Pancreatic involvement in our patient population disclosed lesions that were multicysts or serous cystadenomas. During follow up period, we did not observe significant morbidity related to pancreatic involvement. Repeated radiological examination of pancreatic lesions disclosed insignificant modifications such as slight increase or decrease in size. Whereas we considered morbidity and mortality related to renal and central nervous system pathologies in VHL disease. Shortly, even pancreatic involvement in VHL disease requires close clinical follow up, morbidity and mortality in this case is not severe as in renal and the central nervous system involvement.
Subject(s)
Adolescent , Adult , Aged , Carcinoma, Renal Cell/etiology , Cystadenoma, Serous/etiology , Female , Humans , Male , Middle Aged , Pancreatic Cyst/etiology , Pancreatic Diseases/etiology , Pancreatic Neoplasms/etiology , Retrospective Studies , von Hippel-Lindau Disease/complicationsABSTRACT
We describe a case of renal cell carcinoma in a patient with systemic lupus erythematosus [SLE]. The patient had been prescribed prednisolone and azathioprine for the preceding 8 years. It is difficult to be certain if the tumor occurrence was de novo or secondary to the effect of immunosuppressive drugs. In view of the renal insufficiency, conservative surgery was performed. A literature survey suggests that this is the second reported case of renal cell carcinoma in a patient with SLE