ABSTRACT
Background: Signet ring cell carcinoma of the stomach corresponds to 3 to 39 percent of all gastric malignant tumors, and its prognostic significance is not well known. Aim: To compare the prognosis of signet ring cell carcinoma of the stomach with other types of gastric cancer. Material and Methods: Review of 451 patients operated for gastric carcinoma. Signet ring cell carcinomas were compared with the rest of tumors. Results: One hundred twenty tumors (27 percent) were signet ring cell carcinoma, they were more commonly located in the lower third of the stomach, were less differentiated, bigger and had more lymph nodes involved. Patients with this variety of tumor were younger, more often women and their survival was lower, even when separating incipient and advanced tumors. Conclusions: Signet ring cell carcinoma of the stomach had a worst prognosis that other type of gastric tumors.
Introducción: La incidencia de carcinoma gástrico (CG) de células en anillo de sello (CAS) varía de 3 por ciento a 39 por ciento. Trabajos de supervivencia en pacientes con tumores gástricos reportan resultados contradictorios en cuanto a la importancia pronostica del tipo histológico CAS respecto a los otros tipos histológicos. El objetivo del estudio es describir y evaluar la importancia pronostica del tipo histológico CAS comparado con los carcinomas no anillo de sello (CNAS). Material y Método: Estudio de cohorte retrospectiva. Se estudiaron variables clínicas y morfológicas de 451 pacientes operados por CG en el Hospital Hernán Henríquez Aravena de Temuco entre Enero/1986-Diciembre/2001 agrupándose para el análisis según el diagnóstico histopatológico en CAS y CNAS. Se realizó un análisis exploratorio de los datos y posteriormente se aplicó estadística descriptiva con cálculo de medidas de tendencia central y extrema; y estadísticas analíticas, aplicando Chi cuadrado de Pearson y test exacto de Fisher para variables categóricas, T-Student para variables continuas, Kaplan-Meier y Log-rank test para análisis de supervivencia. Resultados: Un 27 por ciento (120) correspondió a CAS observándose diferencias estadísticamente significativas entre los grupos CAS y CNAS para las siguientes variables: género, edad, localización y tamaño tumoral, grado de diferenciación histológico y compromiso ganglionar linfático. El análisis de supervivencia demostró un peor pronóstico para el grupo de CAS (p = 0,02). En el análisis por separado de tumores incipientes y avanzados respecto del tipo histológico, no observamos diferencias significativas para lesiones incipientes (p = 0,07) mientras que para lesiones avanzadas el CAS se asocia a un pronóstico desfavorable (p < 0,0001). Conclusiones: Observamos en nuestra serie un peor pronóstico asociado al tipo histológico CAS respecto a los otros tipos histológicos (CNAS), información crucial que, aportada al clínico, deberá ser...
Subject(s)
Humans , Male , Female , Middle Aged , Carcinoma, Signet Ring Cell/mortality , Carcinoma, Signet Ring Cell/pathology , Stomach Neoplasms/mortality , Stomach Neoplasms/pathology , Cohort Studies , Carcinoma, Signet Ring Cell/surgery , Gastrectomy , Lymphatic Metastasis , Stomach Neoplasms/surgery , Prognosis , Retrospective Studies , Survival AnalysisABSTRACT
Objetivo: Comparar la sobrevida del cáncer gástrico en anillo de sello (AS) con los otros tipos de adenocarcinoma (no anillo de sello (ÑAS)), según el compromiso en profundidad de la pared gástrica (T) y los números de linfonodos comprometidos (N). Material y Métodos: Se realizó un estudio de cohorte retrospectivo, en el cuál se seleccionó a todos los pacientes gastrectomizados por adenocarcinoma gástrico en el Hospital Base Valdivia entre los años 1988-2005. Se compararon los pacientes cuyo informe histopatológico concluía que el cáncer gástrico era un AS (más del 50 por ciento de sus células son anillo de sello) con los que no lo eran (ÑAS). En el análisis estadístico se utiliza el test de por ciento, Método de Kaplan Meier, test de Log Rank. Resultados: Total 287 casos. 60 AS y 227 ÑAS. No hubo diferencias estadísticamente significativas en cuanto a la profundidad tumoral entre ambos grupos. Los AS presentaron mayor compromiso linfonodal. Al comparar la sobrevida a 5 años de los AS con los ÑAS por estadio (TNM), no encontramos diferencias significativas. Conclusión: A la luz de este trabajo el tipo histológico anillo de sello no parece constituir un factor de mal pronóstico en el cáncer gástrico.
Background: Signet ring cell (SRC) carcinoma of the stomach corresponds to 3 to 39 percent of all cases of gastric cancer. It tends to be less differentiated, infiltrative and diffuse. It is not clear if it has a different prognosis than other types of gastric cancer. Aim: to compare the survival of SRC gastric carcinoma with other types of gastric cancer, considering depth of gastric wall involvement and number of infiltrated lymphnodes. Material and Methods: Retrospective review of pathology samples of all gastric cancers operated between 1988 and 2005. Survival of patients with and without SRC gastric cancer was compared. Results: A total of 287 cases were reviewed. Of these 60 had a SRC gastric cancer. No differences in gastric wall infiltration between SRC and non SRC gastric cancer was observed. SRC gastric cancer has a higher frequency of lymph node involvement. No differences in survival between SRC and non SRC gastric cancer, were observed. Conclusions: In this retrospective series of patients, no differences in survival were observed between SRC and non SRC gastric cancer.
Subject(s)
Humans , Male , Adult , Female , Middle Aged , Aged, 80 and over , Carcinoma, Signet Ring Cell/mortality , Carcinoma, Signet Ring Cell/pathology , Stomach Neoplasms/mortality , Stomach Neoplasms/pathology , Cohort Studies , Carcinoma, Signet Ring Cell/surgery , Gastrectomy , Neoplasm Staging , Stomach Neoplasms/surgery , Prognosis , Retrospective Studies , Survival AnalysisABSTRACT
BACKGROUND AND AIMS: The aim of this study was to calculate survival rates and analyze patterns of survival in gastric cancer. METHODS: A total number of 746 patients with gastric cancer registered in the Cancer Registry Center of Research Center of Gastroenterology and Liver Disease of Shahid Beheshti University of Medical Sciences, Iran, from Dec 21, 2001 to Dec 21, 2006 were investigated. 1- to 5-year survival rates were estimated using life-table method and compared by Wilcoxon (Gehan) test. P<0.05 was considered as statistically significant. All calculations were carried out with SPSS (version 13.0) statistical software. RESULTS: There were 530 male patients with a mean age of 60.5+/-12.6 years and 216 females with a mean age of 57.5+/-13.5 years. Of the total, 454 died and 285 were censored during the investigation. The median survival time was 24.2 months and survival rates at one, two, third, fourth and five years after diagnosis were 73.6, 50.2, 40.6, 33.2 and 29.7%, respectively. Stages of tumor, histology grade, histologic type of cancer, tumor size, age at diagnosis and surgery approach were independent prognostic factors . However, variables such as sex (P=.533), body mass index (P=.214), ethnicity (P=.092), and level of education (P=.762) did not shown significant effects on survival. CONCLUSION: Early detection of patients at lower age and with primary stages and grades of tumor is important to increase patient's life expectancy.