ABSTRACT
OBJECTIVE: This study aimed to develop a new histological scoring system for use in a partial-thickness cartilage repair animal model. Although previous papers have investigated the regeneration of articular cartilage, the good results achieved in small animals have not been replicated in large animal models or humans, possibly because of the frequent use of models with perforation of the subchondral bone plates. Partial-thickness lesions spare the subchondral bone, and this pattern is the most frequent in humans; therefore, new therapies should be tested using this model. However, no specific histological score exists to evaluate partial-thickness model results. METHODS: Histological sections from 30 ovine knees were reviewed to develop a new scoring system. The sections were subjected to H&E, Safranin O, and Masson's trichrome staining. RESULTS: This paper describes a new scoring tool that is divided into sections in detail: repair of tissue inside the lesion, cartilage around the lesion and degenerative changes at the base of the lesion. Scores range from 0 to 21; a higher score indicates better cartilage repair. DISCUSSION: Unlike existing tools, this new scale does not assign points for the positioning of a tidemark; we propose evaluation of the degenerative changes to the subchondral bone and calcified cartilage layer. It is necessary to remove the whole joint to access and study the evolution of the lesion as well as the surrounding tissue. CONCLUSION: This article emphasizes the importance of a partial-thickness animal model of cartilage repair and presents a new histological scoring system.
Subject(s)
Animals , Regeneration/physiology , Cartilage, Articular/injuries , Cartilage, Articular/pathology , Tissue Engineering/methods , Disease Models, Animal , Reference Standards , Time Factors , Biopsy , Bone and Bones/physiology , Bone and Bones/pathology , Sheep , Cartilage Diseases/physiopathology , Cartilage Diseases/pathology , Reproducibility of Results , Chondrocytes/physiology , Chondrocytes/pathology , HindlimbABSTRACT
Chondrodermatitis nodularis chronica helicis [CNCH] is a condition characterized by spontaneously evolving tender single or multiple nodules over the apex of helix or antihelix of the external ear. Various factors have been proposed to be the causative agents and different medical /surgical modalities of treatment have been devised. We review this disease in detail and present one such case which was managed on conservative lines.
Subject(s)
Humans , Male , Ear Diseases/diagnosis , Ear Diseases/therapy , Cartilage Diseases/pathologyABSTRACT
A pericondrite do pavilhão auricular é uma infecção grave que pode comprometer toda a estrutura cartilaginosa e a pele circunjacente a esta estrutura. É uma entidade rara mesmo em cirurgias otológicas contaminadas e leva a uma considerável morbidade e alguma deformidade da orelha. É relatado o caso de um paciente com pancreatite crônica e diabetes mellitus insulino-dependente desconpensada e pericondrite rebelde à terapia clínica. A etiologia, patogênese, sintomas, diagnóstico e os princípios de tratamento desta rara afecção são apresentados.
Subject(s)
Humans , Male , Middle Aged , Diabetes Mellitus, Type 1/complications , Cartilage Diseases/etiology , Ear Cartilage/pathology , Cartilage Diseases/pathology , Otitis Externa/pathologyABSTRACT
A displasia fibrocartilaginosa é uma forma benigna e rara de displasia fibrosa óssea, comumente a poliostótica, na qual de observa componente encondromatoso extenso formando nódulos de tamanhos variado. Manifesta-se através de dor, fraturas e deformaçoes, em especial de ossos tubulares de membros inferiores. O estudo radiológico e histológico cuidadoso é fundamental para o diagnóstico dessa condiçao, evitando-se erros graves de interpretaçao do quadro e permitindo o estabelecimento de conduta mais conservadora. Neste trabalho. é descrito um caso de displasia fibrocartilaginosa numa jovem de 20 anos de idade, seguindo-se discussao sobre sua origem, incidência, diagnósticos diferenciais e complicaçoes.
Subject(s)
Humans , Female , Adult , Fibrous Dysplasia of Bone/diagnosis , Cartilage Diseases/diagnosis , Fibrous Dysplasia of Bone/pathology , Fibrous Dysplasia of Bone , Cartilage Diseases/pathology , Cartilage Diseases , Femur , Ischium , Knee , Pubic Bone , TibiaABSTRACT
Se realizó una Revisión Bibliográfica sobre Condromalacia y Síndrome de Hiperpresión Externa de la Rótula. Se recalca la importancia del papel que juega el cartílago articular y las causas que pueden producir condromalacia, seguida de las manifestaciones clínicas y radiológicas como el diagnóstico diferencial con las múltiples condiciones bien definidas que pueden causar dolor en la parte anterior de la rodilla. Se comentan los diferentes tipos de tratamientos para esta patología, tanto ortopédicos como quirúrgicos. Finaliza con una revisión del Síndrome de Hiperpresión Externa desde el punto de vista etiológico, manifestaciones clínica y radiológicas, diagnósticos y tratamiento