ABSTRACT
AIM: The mechanisms responsible for bowel disturbances in celiac disease are still unknown. Small bowel motor abnormalities may be involved in this pathological condition; however, there is no study addressing small bowel transit in patients of celiac disease from Northern India. METHOD: The mouth-to-cecum transit time was studied in 80 celiac patients and 80 age and sex matched apparently healthy controls. RESULTS: Orocecal transit time in celiac patients was significantly delayed being 180+/-10.6 minutes (Mean+/-SE) as compared to 105+/-12.4 minutes in apparently healthy controls. CONCLUSION: This prolonged orocecal transit time could be due to impaired small bowel function (deranged motility) in patients with celiac disease.
Subject(s)
Adult , Aged , Case-Control Studies , Cecal Diseases/physiopathology , Cecum/physiopathology , Cohort Studies , Female , Gastrointestinal Transit/physiology , Humans , Male , Middle Aged , Myoelectric Complex, Migrating/physiology , Young AdultABSTRACT
Sepsis and its complications are the leading causes of mortality in intensive care units, accounting for 10-50 percent of deaths. Intensive care unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration, and/or global loss of cognitive function. In the present study, we investigated behavioral alterations in sepsis-surviving rats. One hundred and ten male Wistar rats (3-4 months, 250-300 g) were submitted to cecal ligation and puncture (CLP), and 44 were submitted to sham operation. Forty-four rats (40 percent) survived after CLP, and all sham-operated animals survived and were used as control. Twenty animals of each group were used in the object recognition task (10 in short-term memory and 10 in long-term memory), 12 in the plus-maze test and 12 in the forced swimming test. Ten days after surgery, the animals were submitted individually to an object recognition task, plus-maze and forced swimming tests. A significant impairment of short- and long-term recognition memory was observed in the sepsis group (recognition index 0.75 vs 0.55 and 0.74 vs 0.51 for short- and long-term memory, respectively (P < 0.05). In the elevated plus-maze test no difference was observed between groups in any of the parameters assessed. In addition, sepsis survivors presented an increase in immobility time in the forced swimming test (180 vs 233 s, P < 0.05), suggesting the presence of depressive-like symptoms in these animals after recovery from sepsis. The present results demonstrated that rats surviving exposure to CLP, a classical sepsis model, presented recognition memory impairment and depressive-like symptoms but not anxiety-like behavior.
Subject(s)
Animals , Male , Rats , Anxiety Disorders/etiology , Avoidance Learning/physiology , Cecal Diseases/physiopathology , Depressive Disorder/etiology , Intestinal Obstruction/physiopathology , Intestinal Perforation/physiopathology , Shock, Septic/physiopathology , Anxiety Disorders/physiopathology , Disease Models, Animal , Depressive Disorder/physiopathology , Maze Learning , Memory, Short-Term/physiology , Rats, Wistar , Swimming , Shock, Septic/psychologyABSTRACT
O comportamento biológico distinto dos demais carcinóides do intestino e as dúvidas existentes no tratamento cirúrgico dos carcinóides apendiculares motivaram a realizaçäo deste estudo retrospectivo. De 20 pacientes operados no HSPE-FMO entre 1970 e 1990, 14 (setenta por cento) eram mulheres e 6 (trinta por cento) homens, com média de idade de 26,8 anos. Quatorze (setenta por cento) foram operados com diagnóstico de apendicite aguda, confirmada pelo exame histopatológico em todos, após apendicectomia clássica. Três (quinze por cento) tiveram seus carcinóides descobertos acidentalmente por ocasiäo de outras cirurgias e outros 3 (quinze por cento) apresentaram dor, febre, massa palpável e quadro séptico, sendo submetidos à colectomia direita. Esses 3 doentes tinham tumores > 2cm, todos apresentando invasäo neoplásica do meso apendicular e um tinha linfonodo comprometido. O tumor era < 1cm em 14 (setenta por cento) doentes e media entre 1 e 2 cm em outros três (quinze por cento). O local preferencial foi a extremidade distal (sessenta por cento) e em setenta por cento dos doentes os carcinóides estavam confinados à túnica muscular. Houve 1 (cinco por cento) óbito hospitalar motivado pela doença e um segundo, dois anos após por infarto miocárdio. Os demais doentes (noventa por cento) estavam vivos cinco a dezoito anos após, sem sinais de recidiva. Os autores acreditam que tumores < 1 cm säo adequadamente tratados pela simples retirada do apêndice, assim como a grande maioria daqueles com 1 a 1,5 cm. Doentes com tumores > 2cm e jovens com tumores entre 1,5 e 2,0 cm, com achados histopatológicos de agressividade, devem ser submetidos à colectomia direita
Subject(s)
Humans , Appendix/pathology , Carcinoid Tumor/physiopathology , Cecal Diseases/physiopathology , Appendiceal Neoplasms/physiopathologyABSTRACT
Objetivo. Describir dos pacientes con diagnóstico de diverticulitis cecal. Sede. Hospital General. Descripción de los casos. Se trató de una mujer de 25 años y un hombre de 39, presentaban cuadro clínico compatible con apendicitis aguda; los estudios de laboratorio y gabinete coincidieron con la impresión diagnóstica clínica. La cirugía mostró en ambos, un apéndice vermicular normal y una formación sacular única en el ciego con datos de inflamación; en los dos se practicó diverticulectomía y apendicectomía. Su evolución postoperatoria fue favorable. Conclusión. La diverticulitis cecal en una entidad poco frecuente, su diagnóstico es difícil de hacer en forma preoperatoria, su tratamiento se presta a la controversia
Subject(s)
Humans , Male , Female , Adult , Cecal Diseases/diagnosis , Cecal Diseases/physiopathology , Cecal Diseases/surgery , Diverticulitis/diagnosis , Diverticulitis/physiopathology , Diverticulitis/surgery , Signs and SymptomsABSTRACT
Introducción. La tiflitis es una colitis necrozante con inflamación del ciego en pacientes neutropénicos, usualmente diagnosticada en la autopsia. Material y métodos. identificamos 18 niños hospitalizados en el Hospital Infantil de México Federico Gómez en un período de 10 años, con presencia de fiebre, dolor e hipersensibilidad abdominal sugestiva de tiflitis neutropénica. Resultados. Ocho de los 18 pacientes tenían evidencia radiológica de tiflitis en las radiografías de abdomen. Todos los pacientes presentaron neutropenia al momento del diagnóstico y 9 tenían bacteriemia documentada. Los 18 pacientes fueron tratados con diversos antibióticos, 4 de ellos sometidos a cirugía y 1 a colonoscopia. Once pacientes murieron, 10 se mejoraron médicamente y 1 quirúrgicamente. En orden de frecuencia, la tiflitis fue identificada en 9 pacientes con leucemia aguda no linfoide, en 6 con leucemia aguda linfoide; en 1 con anemia aplásica, neutropenia cíclica y carcinoma renal, respectivamente. Sólo 4 pacientes recibieron factor estimulador de colonias de granulocitos; y en todos los pacientes que sobrevivieron se observó un aumento de leucocitos polimorfonucleares a más de 500/mm3 documentado entre el cuarto y el décimosexto día de manejo médico y/o quirúrgico. Conclusiones. Recomendamos que ante un paciente con fiebre y neutropenia, con dolor e hipersensibilidad abdominal, además de datos como diarrea hematemesis se debe plantear como diagnóstico tiflitis neutropénia e instaurarse el manejo general y específico que incluye la valoración quirúrgica
Subject(s)
Child , Adolescent , Humans , Male , Female , Anemia, Aplastic/complications , Bacteremia/complications , Bacteremia/etiology , Cecal Diseases/etiology , Cecal Diseases/mortality , Cecal Diseases/physiopathology , Enterocolitis/diagnosis , Enterocolitis/mortality , Enterocolitis/therapy , Leukemia/complications , Necrosis/etiology , Necrosis/physiopathology , Neutropenia/complications , Neutropenia/physiopathologyABSTRACT
Os autores apresentam de forma sucinta as doenças que mais comumente acometem o ceco. O estudo é complementado com a apresentaçäo de aspectos da anatomia, fisiologia, histologia, embriologia, propedêutica e cirurgia do mesmo