ABSTRACT
ABSTRACT Propolis is a lipophilic resin extracted from plants by bees. The purpose of this case report was to show the importance of this substance as cause of allergic contact cheilitis. A 21-year-old female patient complained of pruritic perioral eczema for 5 years. In the past months it also affected the neck. After diagnosing contact dermatitis, she was submitted to a patch test with a Latin American baseline series. The result was strongly positive for propolis (++) and weakly positive for perfume mix I (+). After the test, the patient revealed she had been using propolis drops, per oris, for 10 years. The worsening of the condition was due to increased dose, aiming "to improve immunity", during the coronavirus disease 2019 (COVID-19) pandemic. The contact allergy to propolis might be increasing due to the widespread use of natural products. Propolis is a sensitizer to be considered in patients with long-lasting cheilitis.
Subject(s)
Humans , Female , Propolis/adverse effects , Cheilitis/complications , Cheilitis/diagnosis , Cheilitis/chemically induced , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/etiology , COVID-19 , SARS-CoV-2ABSTRACT
Los retinoides son muy eficaces en el tratamiento de diversas enfermedades cutáneas que se presentan en niños, como psoriasis, acné e ictiosis. Sus efectos adversos potenciales limitan su uso, especialmente en la población pediátrica. Revisamos la eficacia y riesgos de la terapia con retinoides orales en niños y adolescentes. La toxicidad mucocutánea es el efecto adverso más frecuente, siendo generalmente bien tolerada, fácilmente tratable y reversible al discontinuar el tratamiento. Los efectos adversos sistémicos más graves incluyen la teratogenicidad y los efectos musculoesqueléticos, neurológicos y del sistema gastrointestinal. La educación y control de los pacientes pueden minimizar la ocurrencia de complicaciones.