ABSTRACT
Hyperphagia was induced in mice by p.o. administration of different types of CNS depressant drugs, like chlordiazepoxide 25 mg/kg diazepam 2.5 mg/kg, cyproheptadine 2 mg/kg and phenobarbitone 25 mg/kg. Such hyperphagia was abolished by pretreatment with naloxone 0.1 mg/kg sc. Naloxone per se at this dose produced no significant effect on the food intake. This is suggestive of the role of peptidergic mechanisms in the feeding behaviour in mice.
Subject(s)
Animals , Anti-Anxiety Agents/toxicity , Central Nervous System Depressants/administration & dosage , Chlordiazepoxide/administration & dosage , Cyproheptadine/administration & dosage , Diazepam/administration & dosage , Eating/drug effects , Feeding Behavior/drug effects , Female , Histamine Antagonists/toxicity , Hypnotics and Sedatives/toxicity , Male , Mice , Naloxone/administration & dosage , Phenobarbital/administration & dosage , beta-Endorphin/physiologySubject(s)
Adult , Chlordiazepoxide/administration & dosage , Drug Combinations/administration & dosage , Female , Humans , Male , Oxyphenonium/pharmacology , Parasympatholytics/pharmacology , Propantheline/pharmacology , Quaternary Ammonium Compounds/administration & dosage , Quinuclidines/administration & dosage , Salivation/drug effects , Trifluoperazine/administration & dosageABSTRACT
The time-and dose-dependent uptake of chlordiazepoxide by the brain of rats was investigated and correlated with the blood levels of the drug. Peak concentration in the brain was reached in 10 min after i.p. injection of 25 mg/kg, and in 5 min with a dose of 50 mg/kg of the drug. Retention of chlordiazepoxide by the brain showed different characteristics dependeing on the size of the dose used.