ABSTRACT
Cordomas são neoplasias raras que se originam dos remanescentes da notocorda primitiva 50% dos casos têm localização sacral, sendo mais frequente ao nível de S4/S5. Nós descrevemos um caso de cordoma sacral ao nível de S1 e discutimos a apresentação clínica, achados de imagem, tratamento cirúrgico e evolução.
Chordomas are rare neoplasias originating from the remaining primitive notochord. 50% of the cases have sacral localization, being more frequent at levels S4/S5. Here we report a case of sacral chordoma at level S1 and discuss its clinical presentation, imaging findings, surgical treatment, and progress.
Subject(s)
Humans , Female , Aged , Chordoma/complications , Chordoma/diagnosis , Chordoma/epidemiology , Chordoma/etiology , Chordoma/mortality , Chordoma/pathology , Chordoma/therapy , Diagnosis, Differential , Tomography, Emission-Computed , Magnetic Resonance Spectroscopy , Sacrococcygeal RegionABSTRACT
We present a rare case of skull base chordoma of extraosseous intradural type that presented as acute intratumoral hemorrhage. Surgical removal of the tumor was accomplished using a skull base approach.
Subject(s)
Adult , Chordoma/complications , Choroid Neoplasms/complications , Female , Humans , Review Literature as Topic , Subarachnoid Hemorrhage/etiologyABSTRACT
Crohn's disease is an inflammatory bowel disease characterized by remissions and exacerbations. Immunosuppressants are frequently used to induce and maintain remission in these patients. The use of the immunomodulator azathioprine has been associated to malignancies. Chordomas are rare, locally aggressive tumors arising from remnants of the notochord. A specific trigger for this tumor has not been identified and association to any medication has not been reported. The purpose of this report is to present the first case reported in the literature of Crohn's disease associated to a chordoma. The patient to be presented was on azathioprine therapy, among other medications. A review of literature revealed that Crohn's disease and chordoma have abnormalities in chromosomes 1 and 10. Inflammatory bowel disease and chordoma also have abnormalities in chromosomal regions 1p, 3p, and 7q. Despite these findings, a direct genetic relationship between these diseases is speculative.
Subject(s)
Humans , Female , Adult , Chordoma/complications , Crohn Disease/complications , Skull Base Neoplasms/complications , Chordoma/diagnosis , Chordoma/surgery , Crohn Disease/drug therapy , Crohn Disease/pathology , Immunosuppressive Agents/therapeutic use , Magnetic Resonance Imaging , Neurosurgical Procedures , Skull Base Neoplasms/diagnosis , Skull Base Neoplasms/surgery , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Paciente de 57 anos, homem, branco, examinado em maio/83 com a queixa de há 2 anos de dor cervical intermitente, irradiando-se para o crânio. Há um ano com embaçamento visual maior em olho esquerdo. Ao exame oftalmológico: Acuidade Visual: olho direito: 20:100; olho esquerdo: percepçäo de luz. Fundoscopia: olho direito - palidez acentuada temporal de papila; olho esquerdo - atrofia de papila. Reflexos: olho direito - fotomotor e consencual normais. olho esquerdo - fotomotor lento. Biomicroscopia e tonometria: normais. Campimetria - diâmetro pupilar: 3mm; cor: incoclor; olho direito - index usado 4mm2 com hemianoscopia temporal; olho esquerdo - näo vê index maior que 64 mm2