Spectrophotometric and potentiometric methods for the determination of cefprozil, dropropizine and tizanidine hydrochloride in pharmaceutical preparations

Two simple, accurate spectrophotometric and potentiometric methods were developed for the determination of cefprozil, dropropizine and tizanidine hydrochloride in their pharmaceutical preparations. The spectrophotometric method is based on the selective oxidation of cefprozil or tizanidine with N-bromosuccinimide in an alkaline medium to given an intense yellow product with a maximum absorption at 396 or 384 nm, respectively. The reaction conditions were studied and optimized. The reaction obeyed Beer's law over the concentration range 5-40 and 10-80 micro g mI[-1] for cefprozil and tizanidine hydrochloride, respectively. The potentiometric method involves the direct titration of cefprozil and dropropizine with N-bromosuccinimide in sulphuric acid medium and the end point is determined potentiometrically using platinum electrode. Cefprozil and dropropizine can be determined quantitatively in the concentration range of 0.13-1.30 and 0.118-1.180 mg with recovery values of 98.46-100.77 and 99.58-100.85% and relative standard deviations 0.39-0.54 and 0.52-0.87% for cefprozil and dropropizine, respectively. The proposed methods are applied for the determination of these drugs in pure forms and in pharmaceutical preparations

Medicación preanestésica con clonidina

Clonidina, droga alfa-2-adrenérgica actúa en receptores de la médula oblongada, presinápticamente en las terminaciones nerviosa periféricas y receptores a nivel central para causar una reducción de la actividad del sistema nervioso simpático. Está usándose como premedicación para proveer sedación y ansiolisis ymejorar las cualidades de la inducción mantenimiento y recuperación de la anestesia...